Article
Chemistry, Multidisciplinary
Chih-Wei Chu, Daniel L. Stares, Christoph A. Schalley
Summary: This study presents a light-responsive molecular structure that can be switched between two different conformations under light, showing potential for various applications.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Susumu Tsuda, Yoshitsugu' Komai, Shin-ichi Fujiwara, Yutaka Nishiyama
Summary: In this study, a [c2]daisy chain rotaxane with two diarylacetylene cores was efficiently synthesized, demonstrating that the two independent cores were insulated by permethylated alpha-cyclodextrins. The rotaxane showed stable absorption wavelengths in different solvents and exhibited fluorescence emission from both diarylacetylene monomers and the excimer, suggesting the ability for contraction and extension. This is the first example showing that excimer formation between two pi-conjugated molecules within an isolated space can be controlled by the unique motion of a [c2]daisy chain rotaxane.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Adrian Saura-Sanmartin, Tomas Nicolas-Garcia, Aurelia Pastor, David Quinonero, Mateo Alajarin, Alberto Martinez-Cuezva, Jose Berna
Summary: This paper reports the synthesis of a ditopic interlocked building-block and its self-assembly into a cyclic dimer. NMR studies identified a cyclic hetero[4]pseudorotaxane as the main supramolecular structure in solution. Computational studies revealed that the assembly is the result of positive cooperativity in the hydrogen-bonding-driven assembly of this mechanically interlocked supramolecule. The disassembly of the cyclic dimer was achieved through a Diels-Alder reaction and competitive molecular recognition.
Article
Agricultural Engineering
Manni Ren, Fangong Kong, Cunshan Zhou, Olugbenga Abiola Fakayode, Jiakang Liang, Haoxin Li, Man Zhou, Xingyu Fan
Summary: In this study, a green and one-pot strategy was developed to fractionate sugarcane pith cellulose and lignin. The obtained lignin-containing cellulose nanofibrils (LCNFs) had well-defined structure and uniform size distribution, while the fractionated lignin showed reduced heterogeneity and condensation under acidic conditions. Furthermore, multi-functional LCNF papers with excellent properties were successfully prepared. This study demonstrated the hierarchical biomass utilization and production of high-value building blocks using a tailored deep eutectic solvent and ultrasonic pretreatments.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Su-Bin Ju, Min-Ju Seo, Soo-Jin Yeom
Summary: In this study, the enzymatic synthesis of 3-hydroxypropanal (3-HPA) was achieved from formaldehyde and acetaldehyde, which are cheap and abundant substrates. The 3-HPA can be used in the production of value-added natural chemicals, such as 3-hydroxypropionic acid and 1,3-propanediol, used in the manufacturing of biocompatible plastic. The cascade reaction using DERA(Tma) and MDHLx allows for one-pot 3-HPA production from methanol and ethanol.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Organic
Tyll Freese, Lukas J. Patalag, J. Luca Merz, Peter G. Jones, Daniel B. Werz
Summary: This study reports an improved direct access to red-emitting BOIMPY fluorophores, starting from easily available benzimidazole-2-carboxylic acids, which greatly enhances yields and saves costs, facilitating the synthesis of novel unsymmetrical BOIMPY motifs. As a result, the BOIMPY scaffolds derived from the BODIPY core become more accessible for applications as fluorophores at the appealing red edge of the visible spectrum.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Analytical
Yong Chen, Xiaoling Xu, Jiachun Wang, Yibin Zhang, Wentao Zeng, Yizhen Liu, Xueji Zhang
Summary: A photoactivated CRISPR/Cas12a strategy was proposed in this study to achieve high-sensitivity nucleic acid detection in one pot, avoiding amplicon contamination and lowering the threshold for molecular diagnostics in POC.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Organic
Kai-Xiang Feng, Cheng-Ke Tang, Qiao-Yu Shen, Ai-Bao Xia, Li-Sha Huang, Zhan-Yu Zhou, Xing Zhang, Xiao-Hua Du, Dan-Qian Xu
Summary: The catalytic diastereo- and enantioselective syntheses of C-2-symmetric axially chiral 1,4-dicarbonyl derivatives with 2,3-quaternary stereocenters were successfully achieved utilizing an organo-/iodine binary catalytic strategy. The reactions proceeded well under mild conditions without metals or strong bases.
Article
Chemistry, Organic
Zhilong Chen, Jiao Kang
Summary: A concise method for the direct synthesis of halophenols from (hetero)aryl boronic acids/esters has been developed. This method demonstrates a broad substrate scope, good functional group tolerance, and formal synthesis of bioactive molecules. By utilizing environmentally friendly reagents and green solvents, the reaction can be carried out at room temperature in the open air, making it economically efficient.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Nanoscience & Nanotechnology
Nguyen Thanh Trung, Pham Quoc Nhien, Tu Thi Kim Cuc, Chia-Hua Wu, Bui Thi Buu Hue, Judy I. Wu, Yaw-Kuen Li, Hong-Cheu Lin
Summary: Bistable [c2] daisy chain rotaxanes with tunable emission from blue to orange, including bright-white-light emissions, were synthesized via click reaction. The fluorescence changes were modulated by aggregation-induced emission (AIE) and Fo''rster resonance energy transfer (FRET) processes through altering water fractions and shuttling processes.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Physical
Alicia De San Luis, Maximilian Kleinsteuber, Timo Schuett, Stephanie Schubert, Ulrich S. Schubert
Summary: This study developed a miniemulsion polymerization technique at low temperature using poly(2-ethyl-2-oxazoline) as a surfactant to produce poly(hydroxyethyl methacrylate-lactic acid) and poly (hydroxyethyl methacrylate-lactic-co-glycolic acid) nanoparticles. The results showed that this technique can achieve monodisperse spherical particles ranging between 170 and 250 nm in diameter in long-term stable and non-toxic waterborne dispersions, with drug encapsulation efficiencies up to 66%.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Nathaniel S. Greenwood, Nicholas P. Cerny, Anthony P. Deziel, Jonathan A. Ellman
Summary: A general one-pot approach for the synthesis of diverse N-acylsulfenamides is reported. This method utilizes C-S bond formation without the need for thiol inputs. The approach has a broad scope, including approved drugs and drug precursors, and can introduce high oxidation state sulfur groups in complex bioactive compounds.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Physical
Shouning Yang, Xiaoyang Liu, Sijia Lu, Zhuo Li, Yanmin Zhang, Shaoning Yu, Jian Song, Chuanfan Ding, Huayan Yang
Summary: The study synthesized a novel Bi2S3-BiOCl heterostructure, which can effectively separate photogenerated electron-hole pairs and enhance the photocatalytic efficiency for the selective oxidation of aromatic alcohols to aldehydes. The oxygen vacancies formed on the 001 facet of ultrathin BiOCl facilitate electron trapping to form active radicals, further promoting the photocatalytic reaction.
Article
Chemistry, Multidisciplinary
Dayong Li, Wenting Cheng, Zhiqiang Hou, Chengjie Duan, Yanheng Yao, Yan Chen, Gang Yang, Zhouxiang Cheng, Yang Xiang
Summary: In this study, a simple method using a functional RNA/DNA circuit is proposed for the detection of SARS-CoV-2 RNA. By integrating nucleic acid circuit technology and CRISPR/cas12a system, this method can achieve femtomolar detection of the target RNA in one step and successfully distinguish COVID-19 positive cases from clinical samples, demonstrating its great potential for clinical application.
CHEMICAL COMMUNICATIONS
(2022)
Review
Chemistry, Physical
Marco Kruppa, Thomas J. J. Mueller
Summary: The Masuda borylation-Suzuki coupling (MBSC) sequence enables the direct formation of (hetero)biaryls from readily available (hetero)aryl halides under mild conditions, providing access to diverse symmetric and asymmetrically substituted scaffolds. This review summarizes the development and improvements of the MBSC sequence over the past two decades.
Article
Multidisciplinary Sciences
Chen-Yu Shi, Dan-Dan He, Qi Zhang, Fei Tong, Zhao-Tao Shi, He Tian, Da-Hui Qu
Summary: A robust underwater adhesive material is achieved by coupling natural thioctic acid with mussel-inspired iron-catechol chemistry, showing high-strength, tunable, and reusable adhesion to diverse surfaces. The strategy combines natural thioctic acid and mussel-inspired iron-catechol complexes to enable ultra-strong adhesive materials that can be used underwater and exhibit unprecedentedly high adhesion strength on diverse surfaces. The robust crosslinking interaction of the iron-catechol complexes and high-density hydrogen bonding contribute to the ultra-high interfacial adhesion strength.
NATIONAL SCIENCE REVIEW
(2023)
Article
Chemistry, Multidisciplinary
Chen-Yu Shi, Qi Zhang, Bang-Sen Wang, Dan-Dan He, He Tian, Da-Hui Qu
Summary: Controlling dynamic molecular self-assembly offers solutions for rational material design. In this study, the combination of disulfide-mediated ring-opening polymerization and H-bonding self-assembly resulted in the assembly of small molecules into layered ionic networks with tunable architectural properties and controllable functions as ion-transport membranes. The resulting membranes exhibited high efficiency in ion transportation due to the formation of interlayer water channels.
Article
Chemistry, Multidisciplinary
Guogang Liu, Yujian Liu, Chengxi Zhao, Yan Li, Zhaohui Wang, He Tian
Summary: In this study, a molecular carbon C-204 featuring 12-fold [5]helicenes around four cores was successfully constructed, and one pair of enantiomers with D-3 symmetry was obtained. The results suggest that choosing PDIs as building blocks can realize the stereoselectivity and chirality of molecular carbons.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Bang-Sen Wang, Qi Zhang, Zhi-Qiang Wang, Chen-Yu Shi, Xue-Qing Gong, He Tian, Da-Hui Qu
Summary: Poly(1,2-dithiolane)s can be efficiently synthesized by cationic ring-opening polymerization using disulfide bond as a proton acceptor and non-coordinating anion salts as initiators under acidic conditions. This method allows for the recycling of bulk materials into original monomers without the need for inert protection. The reaction is completed within minutes at room temperature, resulting in high-molecular-weight poly(disulfide)s.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Chen-Yu Shi, Dan-Dan He, Bang-Sen Wang, Qi Zhang, He Tian, Da-Hui Qu
Summary: This study reports a supramolecular poly(disulfides) network with tunable clusteroluminescence, which exhibits mechanical adaptivity and robustness due to the reticular H-bonds. Efficient clusteroluminescence and phosphorescence at 77 K are achieved through slow backbone disulfide exchange and fast side-chain metal coordination, enabling orthogonally tunable luminescence. Further exploration on reprocessability and chemical closed-loop recycling of dynamic networks is feasible for sustainable materials. The synergistic strategy of dynamic chemistry provides a novel pathway and potential opportunities for smart emissive materials.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Nanoscience & Nanotechnology
Hui Xu, Chang-Shun Ma, Cheng-Yuan Yu, Fei Tong, Da-Hui Qu
Summary: In this study, the reversible inversion of circularly polarized luminescence (CPL) was achieved in a coassembly supramolecular system by introducing an achiral dye molecule. The chirality of CPL in the coassemblies could be efficiently regulated and inverted by adjusting the amount of the dye. Experimental characterization suggested that the dye could coassemble with the chiral molecules and ionic surfactant to establish a new stable supramolecular structure. The negative-sign CPL could be converted back to the positive-sign CPL using titanium dioxide nanoparticles.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Qi Zhang, Ryojun Toyoda, Lukas Pfeifer, Ben L. Feringa
Summary: By merging static homochiral amino acids with dynamic chiral disulfides, a new class of building blocks with supramolecular helical single-crystal self-assembly and unusual stereodivergency is produced. The study provides an atom-precision understanding of chirality transfer from the molecular to the supramolecular level and reveals the mechanisms behind the homochiral and heterochiral helical supramolecular self-assembly in the solid state. These findings open up new possibilities in the field of supramolecular chemistry and may lead to the development of supramolecular helical polymers with dynamic functions.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Physical
Ruirui Gu, Cai-Xin Zhao, Da-Hui Qu
Summary: The burgeoning of mechanically interlocked molecules (MIMs) has attracted great interest in the chemical science community. The development of synthetic methods provides more opportunities to delve into MIMs, especially the motions in response to external stimuli. In addition to the traditional analytical strategies, such as NMR and UV-vis spectroscopy, facile and efficient characterization methods are urgently needed to recognize or even visualize the nanoscopic motions.
MOLECULAR SYSTEMS DESIGN & ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Shasha Zhang, Wenfang Yang, Xiao Lu, Xinyi Zhang, Zhichao Pan, Da-Hui Qu, Dong Mei, Ju Mei, He Tian
Summary: In this study, three AIE-active PSs with D-pi-A structures were designed to achieve efficient O-1(2) generation, mitochondria-targeting capability, low dark cytotoxicity, and satisfactory biocompatibility. The results demonstrate good antitumor efficacy for the mouse tumor model. This work will contribute to the development of high-performance AIE-PSs with high PDT efficiency.
Article
Materials Science, Multidisciplinary
Yuanxin Deng, Qi Zhang, Da-Hui Qu
Summary: Hydrogen bond is a simple and versatile noncovalent interaction that is crucial for dynamic functions in living systems. In recent years, the interest in dynamic polymeric materials has led to emerging applications of hydrogen bond chemistry in material design. This Perspective discusses the design principles of hydrogen bond-based dynamic materials by summarizing the state of the art of hydrogen bond chemistry and materials. It also provides an overview of this research topic, possible future directions, and potential material applications.
ACS MATERIALS LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Xuanying Chen, Shideng Yuan, Mengyuan Qiao, Xin Jin, Jiacheng Chen, Lifang Guo, Jianhua Su, Da-Hui Qu, Zhiyun Zhang
Summary: In this study, a series of fluorophore-substituted surfactants were developed by functionalizing different alkyl-trimethylammonium bromides with a viscosity sensor. The immersion depth of the sensor units in micelles depends on the alkyl chain lengths, and the distribution of viscosity inside the micelles was quantified. This research provides a tailored approach to explore the microviscosity of micellar interiors.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Alexander M. Prophet, Kritanjan Polley, Gary J. Van Berkel, David T. Limmer, Kevin R. Wilson
Summary: The oxidation kinetics of iodide by ozone at the air-water interface is studied in single microdroplets. Molecular simulations and kinetic modeling are used to understand the underlying multiphase mechanism.
Article
Chemistry, Multidisciplinary
Rong Zhang, Jiajing Lan, Fei Wang, Shumei Chen, Jian Zhang
Summary: By utilizing 1,1'-ferrocene dicarboxylic acid as a chelating and surface protection ligand, we have synthesized multi-nuclear indium oxide clusters with varying nuclear sizes, including heptanuclear and thirteen-nuclear clusters. These clusters possess labile coordination sites, allowing for structural modification and self-assembly, resulting in the formation of various cluster structures.
Article
Chemistry, Multidisciplinary
Hui Wang, Hui Liu, Mingsen Wang, Jiaheng Hou, Yongjun Li, Yuancheng Wang, Yingjie Zhao
Summary: Two supramolecular complexes were prepared using CBs and M1, and their single-crystal structures were analyzed by SCXRD. The unexpected 1:2 self-assembly structure between M1 and CB[8] was discovered for the first time. These complexes exhibit unique photophysical properties and provide valuable information about the structure and photophysical properties of supramolecular complexes.
Article
Chemistry, Multidisciplinary
Chang-Hee Lee, Sookil Park, Sanggil Kim, Ji Young Hyun, Hyun Soo Lee, Injae Shin
Summary: The epidermal growth factor receptor (EGFR) is a cell-surface glycoprotein involved in cell proliferation and tumor development. This study used a fluorescently labeled EGFR to investigate its time-dependent endocytosis in live cells and found that appended glycans affect EGFR internalization. Additionally, the study detected sialic acid residues attached to EGFR on the live cell surface using FRET-based imaging. This research provides valuable insights into the cellular functions of EGFR.
Article
Chemistry, Multidisciplinary
Subhankar Sahu, Lokesh Kumar, Sumita Das, Dipti Gupta, Ruchi Anand
Summary: This study proposes a strategy that combines organic electronics with biosensor scaffolds to create a compact device for monitoring environmental aromatic pollution. By coupling biosensing protein MopR with an organic electrochemical transistor (OECT), a sensor module capable of efficient detection of phenol was designed. Exclusive phenol detection with minimal loss of sensitivity could be achieved in complex pollutant mixtures and real environmental samples.
Review
Chemistry, Multidisciplinary
Changseok Lee, Hyung-Joon Kang, Sungwoo Hong
Summary: The formation of C-N bonds through hydroamination reactions catalyzed by nickel hydrides has been a topic of recent interest. This approach offers a way to efficiently transform a variety of alkene and alkyne substrates into compounds enriched with C-N bonds. The review provides a concise overview of the underlying reaction mechanisms and aims to stimulate further progress in NiH-catalytic techniques and catalyst design.
Article
Chemistry, Multidisciplinary
Yueci Wu, Lu-Lu Sun, Hai-Hao Han, Xiao-Peng He, Weiguo Cao, Tony D. James
Summary: Drug-induced liver injury (DILI) is a common cause of acute liver failure in the USA and Europe, but most cases can be recovered or prevented by discontinuing the offending drug. Recent research has found that peroxynitrite (ONOO-) can be used as a potential indicator for early diagnosis of DILI, and there is an urgent need to establish a method to detect and track peroxynitrite in DILI cases. In this study, a FRET-based nano fluorescent probe CD-N-I was developed, which showed high selectivity and sensitivity in detecting peroxynitrite. The probe successfully detected exogenous peroxynitrite in live cells and endogenous peroxynitrite in APAP-induced liver injury of HepG2 cells.
Article
Chemistry, Multidisciplinary
Dmitry L. Lipilin, Mikhail O. Zubkov, Mikhail D. Kosobokov, Alexander D. Dilman
Summary: This article describes a direct photocatalytic method for the thiolation of unprotected acids, which was previously challenging. By using a thionocarbonate reagent with an N-O bond, the efficient conversion of carboxylic acids to thiols is achieved.
Article
Chemistry, Multidisciplinary
Jason Malenfant, Lucille Kuster, Yohann Gagne, Kouassi Signo, Maxime Denis, Sylvain Canesi, Mathieu Frenette
Summary: Raman microscopy can reveal compound-specific vibrational fingerprints without sample preparation. The combination of efficient theoretical calculations and a user-friendly software can accurately predict peak positions and provide match scores to assist with structure determination.
Article
Chemistry, Multidisciplinary
Jayoh A. Hernandez, Paul S. Micus, Sean Alec Lois Sunga, Luca Mazzei, Stefano Ciurli, Gabriele Meloni
Summary: Essential trace metals play crucial roles in the survival and virulence of bacterial pathogens. Helicobacter pylori requires nickel for colonization and persistence in the stomach, and NixA is an essential nickel transporter in this process. This study characterizes the selectivity and electrogenic nature of NixA-mediated nickel transport.
Article
Chemistry, Multidisciplinary
Tarali Devi, Kuheli Dutta, Jennifer Deutscher, Stefan Mebs, Uwe Kuhlmann, Michael Haumann, Beatrice Cula, Holger Dau, Peter Hildebrandt, Kallol Ray
Summary: This study emphasizes the importance of subtle electronic changes and secondary interactions in the stability of biologically relevant metal-dioxygen intermediates. It also shows that the role of the chloride ligand in stabilizing the Fe-III-(OOBu)-Bu-t moiety can extend to other anions, including the thiolate ligand.
Article
Chemistry, Multidisciplinary
Jacqueline R. Santhouse, Jeremy M. G. Leung, Lillian T. Chong, W. Seth Horne
Summary: By studying the folding kinetics and mechanism of the BdpA sequence, researchers found that altering the backbone connectivity can affect protein folding. This suggests that protein mimetic chains have a significant degree of plasticity in transitioning between unfolded and folded states.
Article
Chemistry, Multidisciplinary
Divanshu Gupta, Ralf Einholz, Holger F. Bettinger
Summary: This study presents the first direct spectroscopic evidence of a cyclic seven-membered iminoborane. Compared to linear amino-iminoboranes, this cyclic iminoborane exhibits weakened bond strength and lower Lewis acidity value. The study suggests that the reduced ring strain of cyclic iminoborane prevents nitrogen fixation but allows facile (2 + 2) cycloaddition reaction with C2H4.
Article
Chemistry, Multidisciplinary
Renny Mathew, Aniruddha Mazumder, Praveen Kumar, Julie Matula, Sharmarke Mohamed, Petr Brazda, Mahesh Hariharan, Brijith Thomas
Summary: This study reveals the packing arrangement of partially disordered nitro-perylenediimide (NO2-PDI) using a synergistic approach that combines 3D ED, ssNMR, and DFT techniques. By overcoming these challenges, this methodology opens up new avenues for material characterization, driving exciting advancements in the field.