Review
Oncology
Grzegorz Slawinski, Maja Hawryszko, Aleksandra Lizewska-Springer, Izabela Nabialek-Trojanowska, Ewa Lewicka
Summary: The assessment of global longitudinal strain (GLS) plays a crucial role in the early diagnosis of anticancer treatment-related cardiotoxicity in cardio-oncology. Baseline left ventricular (LV) GLS and right ventricular (RV) GLS assessments can identify patients at risk for systolic dysfunction and heart failure. Serial echocardiography with GLS assessment should be performed during anticancer therapy to promptly initiate and adjust cardioprotection for subclinical myocardial contractile dysfunction.
Article
Cardiac & Cardiovascular Systems
Katarina Yaros, Benay Eksi, Alvin Chandra, Kartik Agusala, Lorenz H. Lehmann, Vlad G. Zaha
Summary: Cardiovascular imaging plays an important role in the care of cancer patients, as they face increased risks of cardiovascular complications. Currently established imaging modalities are evolving towards increased specificity, while new modalities are emerging to target earlier stages of cardiovascular disease. Choosing suitable imaging modalities for individual patients is crucial for successful risk stratification. Future imaging tools have the potential to provide insights into the molecular pathology of cardiovascular complications associated with cancer and oncological therapies.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Johanna E. J. Jacobs, Ipek Guler, Jurgen Duchenne, Stefan Janssens, Lucas N. L. Van Aelst
Summary: Cardiovascular morbidity and mortality are common in cancer patients and survivors, highlighting the need for adequate risk prediction tools for systematic screening and rigorous cardiovascular follow-up. Existing risk scores for cardiotoxicity are suboptimal and should be interpreted with caution.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Review
Oncology
Shruti Rajesh Patel, Giselle Alexandra Suero-Abreu, Angela Ai, Maya K. K. Ramachandran, Kelly Meza, Narjust Florez
Summary: Cardio-oncology focuses on reducing cardiovascular risks, detecting and treating cardiovascular diseases in cancer patients. Disparities in cardio-oncologic care exist among different populations due to factors such as cancer screening rates, genetic risk factors, cultural stressors, tobacco exposure rates, and physical inactivity. Barriers to care also exist in minority groups and low-income populations. Urgent efforts are needed to address these disparities.
FRONTIERS IN ONCOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Ivan Stankovic, Marc R. Dweck, Nina Ajmone Marsan, Jutta Bergler-Klein, Espen Holte, Robert Manka, Jeanette Schulz-Menger, Marta Sitges, Kristina H. Haugaa
Summary: Early and late cardiovascular toxicities related to cancer treatments can complicate the clinical course of patients, making early detection and treatment essential. Cardiac imaging plays a pivotal role in detecting and monitoring cardiac toxicity in oncology patients in Europe and beyond, although there are gaps between guidelines recommendations and everyday clinical practice.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2021)
Review
Cardiac & Cardiovascular Systems
Yinghui Wang, Yonggang Wang, Xiaorong Han, Jian Sun, Cheng Li, Binay Kumar Adhikari, Jin Zhang, Xiao Miao, Zhaoyang Chen
Summary: Cardiovascular disease (CVD) and cancer are leading causes of death worldwide. The adverse effects of anti-tumor therapy, particularly on the cardiovascular system, have gained significant attention. Incidence of cardiovascular events is higher than tumor recurrence rate, and CVD and malignant tumors share common risk factors. Clinicians should understand this relationship, provide primary and secondary prevention strategies, and follow proper treatment methods.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, Research & Experimental
Carlos D. Vera, Agustin Rodriguez Lopez, Alex S. Ewaneewane, Kasey Lewis, Sophia Parmisano, Gema Mondejar-Parreno, Chandan Upadhyaya, Mckay Mullen
Summary: Cancer and cardiovascular diseases are the top two causes of death in the United States. While novel therapies have slowed down cancer mortality rate, there has been an increase in cardiac failures due to the toxicity of cancer treatments. Understanding the mechanisms behind this relationship is crucial in properly treating patients at risk of developing cardiac failure. Currently, early-stage biomarkers of inflammation and angiogenesis are used to detect cardiotoxicity before it becomes irreversible, with the aim of minimizing the adverse effects of cancer therapies. In the field of cardio-oncology, there is growing focus on gender and racial disparities in cardiotoxicity and their impact on disease outcomes, although data on variations in cardiotoxicity across diverse populations is limited.
Review
Cardiac & Cardiovascular Systems
Jean C. Bikomeye, Janee D. Terwoord, Janine H. Santos, Andreas M. Beyer
Summary: Anticancer therapies can have cardiotoxic side effects, with mitochondrial damage being a key factor. Further research is needed to understand the secondary signaling events that occur in response to such damage, as mitochondria also play important roles in other pathologies.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Flavio D'Ascenzi, Francesca Anselmi, Caterina Fiorentini, Roberta Mannucci, Marco Bonifazi, Sergio Mondillo
Summary: This review focuses on investigating the origin, prevention, and reversal strategies of cardiac damage, and explores the beneficial effects of physical exercise on cancer patients. It suggests personalized exercise prescriptions and emphasizes the importance of cardiac evaluation in prescribing exercise for these patients.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Sarath Babu Nukala, Jordan Jousma, Yoonje Cho, Won Hee Lee, Sang-Ging Ong
Summary: Cancer survivors have an increased risk of cardiovascular diseases, leading to the emergence of the field of cardio-oncology. The review summarizes the role of non-coding RNAs in cancer therapy-induced cardiotoxicities and discusses potential therapeutic strategies.
CELL AND BIOSCIENCE
(2022)
Review
Oncology
Drishti Tolani, Julia Wilcox, Sharvari Shyam, Neha Bansal
Summary: As chemotherapy improves, understanding the effects on the cardiovascular system is increasingly important. Cardiotoxicity is a major determinant of morbidity and mortality in cancer survivors. New imaging modalities and biomarkers may detect subclinical cardiotoxicity earlier. Dexrazoxane remains the most effective therapy for preventing anthracycline-induced cardiomyopathy. Neurohormonal modulating drugs have not been effective in preventing cardiotoxicity. Advanced cardiac therapies, like heart transplant, should be considered for cancer survivors with end-stage HF. Research on genetic associations may produce treatments to reduce cardiovascular morbidity and mortality.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2023)
Review
Medicine, General & Internal
Juan A. Quintero-Martinez, Sandra N. Cordova-Madera, Hector R. Villarraga
Summary: Radiation therapy is a common treatment modality for cancer patients, but it can have adverse effects on the heart. Understanding the mechanisms and risk factors of radiation-induced heart disease is crucial for early detection and prevention. Echocardiography is the preferred imaging tool, while other modalities can provide additional diagnostic value.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Carlo G. Tocchetti, Alessandra Ghigo, Emilio Hirsch
Summary: This editorial discusses the study conducted by Lu et al. on the protective effect of circular RNA derived from the insulin receptor locus against doxorubicin-induced cardiotoxicity.
EUROPEAN HEART JOURNAL
(2022)
Review
Medicine, General & Internal
Shawn Simek, Brian Lue, Anjali Rao, Goutham Ravipati, Srilakshmi Vallabhaneni, Kathleen Zhang, Vlad G. Zaha, Alvin Chandra
Summary: Gender differences exist in the medical field, including cardio-oncology. Gender may influence cancer susceptibility, cardiotoxicities, healthcare, and cancer treatments.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Dong-Woo Kang, Rebekah L. Wilson, Cami N. Christopher, Amber J. Normann, Oscar Barnes, Jordan D. Lesansee, Gyuhwan Choi, Christina M. Dieli-Conwright
Summary: Anthracycline-induced cardiotoxicity is a serious clinical problem that needs to be addressed. Exercise therapy, as a non-pharmacological intervention, has potential benefits in preventing and managing cardiotoxicity caused by anthracyclines. However, the underlying mechanisms of exercise and its implementation in clinical settings to improve long-term cardiovascular outcomes require further research.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)