Review
Biochemistry & Molecular Biology
Ana Mata, Susana Cadenas
Summary: This article describes the transcriptional regulation of Nrf2, its role in cardiac ischemia-reperfusion injury, and the protective effects and potential clinical applications of compounds that induce Nrf2 activation against injury in the heart and other organs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Alex Gallinat, Guiomar Mendieta, Gemma Vilahur, Teresa Padro, Lina Badimon
Summary: Cardiovascular diseases, especially acute myocardial infarction (MI), are major causes of death worldwide. DJ-1 protein has been found to play a crucial role in cardioprotection, and systemic administration of recombinant DJ-1 has been shown to reduce infarct size, leukocyte infiltration, apoptosis, and oxidative stress in a mouse model of MI. These effects may be mediated by G-protein-coupled receptor signaling and modulation of immune response. This study provides the first evidence for the extracellular activity of DJ-1 in regulating cardiac injury in vivo.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Qian Wang, Coert J. Zuurbier, Ragnar Huhn, Carolin Torregroza, Markus W. Hollmann, Benedikt Preckel, Charissa E. van den Brom, Nina C. Weber
Summary: Pharmacological conditioning aims to protect the heart from myocardial ischemia-reperfusion injury. This review updates the recent developments in pharmacological conditioning and summarizes the clinical evidence of these strategies in the perioperative setting. It discusses the cellular processes during ischemia and reperfusion that contribute to acute injury and explores promising interventions targeting these processes.
Review
Biochemistry & Molecular Biology
Christopher Lotz, Johannes Herrmann, Quirin Notz, Patrick Meybohm, Franz Kehl
Summary: Mitochondria play a crucial role in myocardial ischemia/reperfusion injury and pharmacological cardiac conditioning, including maintaining cellular function, regulating calcium balance and cell death, participating in aging and mitochondrial regeneration, etc.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Hanbyeol Moon, Jung-Won Choi, Byeong-Wook Song, Il-Kwon Kim, Soyeon Lim, Seahyoung Lee, Gyoonhee Han, Ki-Chul Hwang, Sang Woo Kim
Summary: This study found that high-thermogenic beige adipocytes (HBACs) secrete FGF21, which contributes to antioxidative and antiapoptotic effects mediated through NRF2 activation. Treatment with HBAC-conditioned medium (HBAC-CM) can attenuate ischemic rat heart tissue injury by activating NRF2. Therefore, HBAC-CM has the potential to be a promising therapeutic agent for myocardial infarction.
Article
Pharmacology & Pharmacy
Zexuan Hong, Jun Cao, Dandan Liu, Maozhu Liu, Mengyuan Chen, Fanning Zeng, Zaisheng Qin, Jigang Wang, Tao Tao
Summary: Stroke is a major cause of death, with oxidative stress playing a key role. Celastrol has strong antioxidant properties, but its effect on oxidative reactions in cerebral ischemic-reperfusion injury (CIRI) is unclear. This study aimed to investigate the impact of celastrol on oxidative damage during CIRI and the underlying mechanisms. The findings revealed that celastrol reduced oxidative injury in CIRI by upregulating Nrf2. Celastrol directly bound to Nedd4, releasing Nrf2 in astrocytes, thus inhibiting Nrf2 degradation and reducing astrocytic ROS production. Celastrol also rescued neurons from damage and apoptosis by inhibiting oxidative stress and astrocyte activation.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2023)
Article
Pharmacology & Pharmacy
Mi Bao, Weiyi Huang, Yang Zhao, Xinzhe Fang, Yanmei Zhang, Fenfei Gao, Danmei Huang, Bin Wang, Ganggang Shi
Summary: The study demonstrated that verapamil reduces myocardial I/R-induced oxidative stress through modulation of SIRT1 signaling, resulting in decreased ROS and MDA levels, and subsequently protecting against cardiac dysfunction and myocardial infarction.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ganesan Padmavathi, Kunka Mohanram Ramkumar
Summary: Ischemia/reperfusion injury (IRI) is caused by oxidative stress from lack of blood supply, leading to sterile inflammation, cell death, and microvascular dysfunction. Dysregulation of the Nrf2 pathway is a significant factor in IRI, with miRNAs regulating Nrf2 expression. Compounds that modulate Nrf2-regulating miRNAs have shown protective effects against IRI in various organs.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Multidisciplinary Sciences
Eman Gouda, Fawzi Babiker
Summary: This study investigated the antioxidant and anti-inflammatory effects of Gum Arabic in protecting the heart against ischemia/reperfusion injury. The results showed that GA significantly reduced infarct size and cardiac enzyme levels, and decreased pro-inflammatory cytokine levels.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Shaorong Li, Hua Jin, Guangyong Sun, Chunmei Zhang, Jinsong Wang, Hufeng Xu, Dong Zhang, Songlin Wang
Summary: Nitrate intake may prevent HIRI by increasing nitric oxide levels, upregulating the NRF2 pathway, and modulating oxidative stress. This study provides a novel therapeutic compound for potentially preventing HIRI during liver transplantation or surgery.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Critical Care Medicine
Zhenqian Lv, Feng'e Wang, Xingfeng Zhang, Xiting Zhang, Jing Zhang, Ran Liu
Summary: Etomidate (Eto) attenuated myocardial ischemia reperfusion injury (MIRI) by inhibiting ferroptosis via the Nrf2 pathway, demonstrating anti-inflammatory and anti-fibrotic effects in MIRI rats.
Article
Medicine, Research & Experimental
Shengyang Ding, Xinyu Duanmu, Lingshan Xu, Liang Zhu, Zhouquan Wu
Summary: Myocardial ischemia-reperfusion injury (MIRI) refers to the additional damage that occurs during the restoration of blood flow to the heart tissue after ischemic damage. Ozone therapy has been shown to reduce myocardial injury and protect against oxidative stress. In this study, ozone pretreatment was used in in vitro and in vivo models of ischemia-reperfusion injury, and it was found that ozone regulates the expression levels of ferroptosis-related proteins and transcription factors, leading to the protection of the myocardium. The Nrf2/Slc7a11/Gpx4 signaling pathway was identified as the mechanism responsible for the protective effects of ozone.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Plant Sciences
Xiaoqi Zhao, Yutong Liu, Lei Wang, Chaolong Yan, Han Liu, Wenxin Zhang, Hongting Zhao, Chen Cheng, Zhipeng Chen, Tianze Xu, Kuanyu Li, Jing Cai, Tong Qiao
Summary: Oridonin exhibits a protective effect on hindlimb ischemia-reperfusion injury, possibly through Nrf2-mediated oxidative stress and NLRP3-mediated inflammasome activation.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Tao Zheng, Jun Yang, Jing Zhang, Chaojun Yang, Zhixing Fan, Qi Li, Yuhong Zhai, Haiyin Liu, Jian Yang
Summary: The study found that downregulation of miR-327 could inhibit oxidative stress and apoptosis induced by H/R and TBHP in vitro experiments. Additionally, the downregulation enhanced the expression of fibroblast growth factor 10 (FGF10), activated p-PI3K and p-Akt, and promoted the translocation of Nrf2.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Sebastian Roth, Carolin Torregroza, Katharina Feige, Benedikt Preckel, Markus W. Hollmann, Nina C. Weber, Ragnar Huhn
Summary: Pharmacological conditioning aims to protect the heart from myocardial I/R injury, but there remains a gap between basic research and clinical practice. This review covers new developments in experimental research and clinical evidence, highlighting the challenges of applying pharmacological conditioning in a clinical setting.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)