Article
Surgery
A. Cozette Killian, Alexis J. Carter, Rhiannon D. Reed, Brittany A. Shelton, Haiyan Qu, Chandler McLeod, Babak J. Orandi, Robert M. Cannon, Douglas Anderson, Paul A. MacLennan, Vineeta Kumar, Michael Hanaway, Jayme E. Locke
Summary: Community-level vulnerability is associated with poor fidelity in the Living Donor Navigator Program, and factors such as community unemployment rate, single-parent households, minority population, and households without vehicles are associated with increased risk of self-advocacy.
Article
Surgery
Ugo Boggi, Fabio Vistoli, Axel Andres, Helmut P. Arbogast, Lionel Badet, Walter Baronti, Stephen T. Bartlett, Enrico Benedetti, Julien Branchereau, George W. Burke, Fanny Buron, Rossana Caldara, Massimo Cardillo, Daniel Casanova, Federica Cipriani, Matthew Cooper, Adamasco Cupisti, Jose Davide, Cinthia Drachenberg, Eelco J. P. Koning, Giuseppe Maria Ettorre, Laureano Fernandez Cruz, Jonathan A. Fridell, Peter J. Friend, Lucrezia Furian, Osama A. Gaber, Angelika C. Gruessner, Rainer W. G. Gruessner, Jenny E. Gunton, Duck-Jong Han, Sara Iacopi, Emanuele Federico Kauffmann, Dixon Kaufman, Takashi Kenmochi, Hussein A. Khambalia, Quirino Lai, Robert M. Langer, Paola Maffi, Lorella Marselli, Francesco Menichetti, Mario Miccoli, Shruti Mittal, Emmanuel Morelon, Niccolo Napoli, Flavia Neri, Jose Oberholzer, Jon S. Odorico, Robert Ollinger, Gabriel Oniscu, Giuseppe Orlando, Monica Ortenzi, Marcelo Perosa, Vittorio Grazio Perrone, Henry Pleass, Robert R. Redfield, Claudio Ricci, Paolo Rigotti, R. Robertson, Lainie F. Ross, Massimo Rossi, Frantisek Saudek, Joseph R. Scalea, Peter Schenker, Antonio Secchi, Carlo Socci, Donzilia Sousa Silva, Jean Paul Squifflet, Peter G. Stock, Robert J. Stratta, Chiara Terrenzio, Pablo Uva, Christopher C. E. Watson, Steven A. White, Piero Marchetti, Raja Kandaswamy, Thierry Berney
Summary: Pancreas transplantation, whether simultaneous pancreas-kidney or pancreas alone, can improve long-term survival and quality of life for diabetic patients. Preemptive SPK may lead to better outcomes.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Anjana Pillai, Elizabeth. C. C. Verna, Neehar. D. D. Parikh, Matthew Cooper, Carrie Thiessen, Julie Heimbach, Elisa. J. J. Gordon, Gonzalo Sapisochin, Nazia Selzner, Amit Mathur, Emily. R. R. Perito, Michelle Jesse, AnnMarie Liapakis, Vineeta Kumar
Summary: In October 2021, the American Society of Transplantation (AST) held a virtual consensus conference to address barriers preventing the expansion of living donor liver transplantation (LDLT) in the United States. A multidisciplinary group of experts identified financial implications on donors, crisis management, policies and regulations, and ethical considerations as significant barriers. They proposed strategies to overcome these barriers and highlighted the importance of donor safety and the need for appropriate crisis management plans in transplant programs.
CLINICAL TRANSPLANTATION
(2023)
Article
Gastroenterology & Hepatology
Alyson N. Fox, AnnMarie Liapakis, Ramesh Batra, Therese Bittermann, Juliet Emamaullee, Sukru Emre, Yuri Genyk, Hyosun Han, Whitney Jackson, Elizabeth Pomfret, Muhammad Raza, Manuel Rodriguez-Davalos, Susan Rubman Gold, Benjamin Samstein, Akhil Shenoy, Timucin Taner, John P. Roberts
Summary: This article reviews the increasing interest in anonymous nondirected living organ donation in the United States, discusses current transplant policy and emerging data in living donor liver transplantation, and aims to provide consensus guidance for safe evaluation and selection of nondirected living liver donors and just allocation of grafts.
Review
Gastroenterology & Hepatology
Joerg M. Pollok, Pascale Tinguely, Marina Berenguer, Claus U. Niemann, Dimitri A. Raptis, Michael Spiro
Summary: Enhanced recovery for liver transplant recipients has been controversial. This review aims to summarize current knowledge, identify key components, and establish internationally accepted guidelines. Expert statements were prepared based on systematic literature reviews and a consensus conference, resulting in 80 final recommendations.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Joerg M. Pollok, Pascale Tinguely, Marina Berenguer, Claus U. Niemann, Dimitri A. Raptis, Michael Spiro
Summary: There is significant controversy surrounding enhanced recovery for liver-transplant recipients, and this review aimed to summarize current knowledge, identify key components, and create internationally accepted guidelines. A collaborative effort by the ERAS4OLT.org partnership and specialists from around the world resulted in 80 final recommendations covering various aspects of enhanced recovery for liver transplantation. These guidelines provide a comprehensive overview and can guide the development of enhanced recovery programs globally.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Spyridon Vernadakis, Smaragdi Marinaki, Maria Darema, Ioanna Soukouli, Ioannis El. Michelakis, Chrysoula Beletsioti, Georgios Zavvos, Ioannis Bokos, Ioannis N. Boletis
Summary: Minimally invasive laparoscopic nephrectomy for living kidney donors resulted in shorter surgical duration, decreased length of hospital stay, and higher postoperative quality of life compared to open nephrectomy. The complication rates were similar, with a slight difference in surgical complications between the two groups.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Surgery
Rachel A. Davis, Tyler Branagan, Christopher D. Schneck, Jesse D. Schold, Thida Thant, Bruce Kaplan
Summary: Nearly 10,000 people are removed from the kidney transplant waiting list each year due to illness or death. Live donor kidney transplant (LDKT) provides better outcomes and survival benefit, but the number of LDKT has decreased in recent years. It is important to use the best available data and avoid biases when evaluating potential living kidney donors.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Surgery
Babak J. Orandi, Rhiannon D. Reed, Haiyan Qu, Grace Owens, Sydney Brooks, A. Cozette Killian, Vineeta Kumar, Saulat S. Sheikh, Robert M. Cannon, Douglas J. Anderson, Cora E. Lewis, Jayme E. Locke
Summary: This study surveyed living kidney donors to understand their perspectives on follow-up laboratory testing. The completion of 6-month testing was strongly associated with the completion of 12-month testing. Donors who did not prioritize testing and forgot to get labs drawn until reminded were more likely to complete the testing.
CLINICAL TRANSPLANTATION
(2022)
Article
Medicine, General & Internal
Emerentia Q. W. Spoon, Kirsten Kortram, Sohal Y. Ismail, Daan Nieboer, Frank C. H. d'Ancona, Maarten H. L. Christiaans, Ruth E. Dam, Hendrik Sijbrand Hofker, Arjan W. J. Hoksbergen, Karlijn Ami van der Pant, Raechel J. Toorop, Jacqueline van de Wetering, Jan N. M. Ijzermans, Frank J. M. F. Dor
Summary: This study assessed the informed consent practice for live kidney donation and found that the knowledge score of donors is generally low, especially regarding long-term complications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
History & Philosophy Of Science
Anji E. Wall, Giuliano Testa
Summary: This article conducts an in-depth ethical analysis of living donor uterus transplantation by integrating clinical, psychological, and qualitative study data. The concept of living organ donors as patients in their own right is applied to living uterus donation, grounded in the principles of research ethics and considering eight potential vulnerabilities of living donors. It also emphasizes the importance of special responsibilities in the relationship between living donor advocates and potential donors. Additionally, ethical analyses need to be conducted separately for directed and non-directed uterus donors due to their different relationships with recipients.
PERSPECTIVES IN BIOLOGY AND MEDICINE
(2023)
Article
Surgery
Nicole DePasquale, Matthew J. Ellis, Debra L. Sudan, Patti L. Ephraim, Lisa M. McElroy, Dinushika Mohottige, Clemontina A. Davenport, Xiyuan Zhang, Sarah B. Peskoe, Tara S. Strigo, Ashley N. Cabacungan, Iris Pounds, Jennie A. Riley, Margaret Falkovic, L. Ebony Boulware
Summary: The study found that family functioning affected the likelihood of discussing living-donor kidney transplantation, and family functioning, discussion occurrence, and discussion characteristics were significantly associated with donor activation.
CLINICAL TRANSPLANTATION
(2021)
Article
Urology & Nephrology
Siah Kim, Anita van Zwieten, Melanie Wyld, Maleeka Ladhani, Chandana Guha, Amanda Dominello, Kylie-Ann Mallitt, Anna Francis, Roslyn B. Mannon, Germaine Wong
Summary: Based on data from Australia and New Zealand, females constitute a larger proportion of kidney donors to male recipients. The relationship between recipient and donor is a factor that modifies the association between recipient gender and donor gender. Older recipients residing in remote areas are more likely to receive kidneys from female donors.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Surgery
Mathilde C. Pronk, Lisa Burnapp, Marlies E. J. Reinders, Emma K. Massey
Summary: This study investigated the experiences and attitudes towards anonymity among kidney donors and recipients participating in non-directed altruistic kidney donation and the UK living kidney sharing scheme. The results showed that some participants broke anonymity after transplantation and were satisfied with contact or meeting with the other party. Another group of participants remained anonymous, but a portion of them also expressed a desire to meet post-transplant. The study supports the expansion of conditional anonymity to other countries that allow anonymous kidney transplantation.
TRANSPLANT INTERNATIONAL
(2022)
Article
Gastroenterology & Hepatology
Desley A. H. Neil, Marta Minervini, Maxwell L. Smith, Stefan G. Hubscher, Elizabeth M. Brunt, A. Jake Demetris
Summary: There is a lack of consensus on how to assess steatosis in potential donor livers for transplantation, leading to wide variations in definitions and approaches used by pathologists. A study by the Banff Working Group on Liver Allograft Pathology aimed to address this issue by establishing criteria for defining large droplet fat (LDF) and developing an algorithm for determining fat droplet size and percentage of hepatocytes involved. The proposed guidelines intend to improve standardization in steatosis assessment of donor liver biopsies, with the calculated percentage of LDF to be provided to the surgeon.
Article
Surgery
Al-Faraaz Kassam, Ahmad Mirza, Young Kim, Dennis Hanseman, E. Steve Woodle, Ralph C. Quillin, Bobby L. Johnson, Amit Govil, Michael Cardi, Daniel P. Schauer, Eric P. Smith, Tayyab S. Diwan
AMERICAN JOURNAL OF TRANSPLANTATION
(2020)
Article
Surgery
E. Steve Woodle, Dixon B. Kaufman, Adele R. Shields, John Leone, Arthur Matas, Alexander Wiseman, Patricia West-Thielke, Ting Sa, Eileen C. King, Rita R. Alloway
AMERICAN JOURNAL OF TRANSPLANTATION
(2020)
Review
Surgery
David P. Al-Adra, Laura Hammel, John Roberts, E. Steve Woodle, Deborah Levine, Didier Mandelbrot, Elizabeth Verna, Jayme Locke, Jonathan D'Cunha, Maryjane Farr, Deirdre Sawinski, Piyush K. Agarwal, Jennifer Plichta, Sandhya Pruthi, Deborah Farr, Richard Carvajal, John Walker, Fiona Zwald, Thomas Habermann, Morie Gertz, Philip Bierman, Don S. Dizon, Carrie Langstraat, Talal Al-Qaoud, Scott Eggener, John P. Richgels, George J. Chang, Cristina Geltzeiler, Gonzalo Sapisochin, Rocco Ricciardi, Alexander S. Krupnick, Cassie Kennedy, Nisha Mohindra, David P. Foley, Kymberly D. Watt
Summary: This article discusses the evaluation of solid organ transplantation for patients with a history of malignancy, emphasizing the need to balance the benefits of transplantation and the risk of tumor recurrence. It also points out that previous guidelines do not fully consider current staging, disease biology, and advances in cancer treatments.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Review
Surgery
David P. Al-Adra, Laura Hammel, John Roberts, E. Steve Woodle, Deborah Levine, Didier Mandelbrot, Elizabeth Verna, Jayme Locke, Jonathan D'Cunha, Maryjane Farr, Deirdre Sawinski, Piyush K. Agarwal, Jennifer Plichta, Sandhya Pruthi, Deborah Farr, Richard Carvajal, John Walker, Fiona Zwald, Thomas Habermann, Morie Gertz, Philip Bierman, Don S. Dizon, Carrie Langstraat, Talal Al-Qaoud, Scott Eggener, John P. Richgels, George J. Chang, Cristina Geltzeiler, Gonzalo Sapisochin, Rocco Ricciardi, Alexander S. Krupnick, Cassie Kennedy, Nisha Mohindra, David P. Foley, Kymberly D. Watt
Summary: This document reviews prognosis, treatment, and transplant recommendations for patients with a history of malignancy undergoing solid organ transplantation. It also addresses the potential effects of immunosuppression on cancer-specific outcomes.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Allan D. Kirk, Andrew B. Adams, Antoine Durrbach, Mandy L. Ford, David A. Hildeman, Christian P. Larsen, Flavio Vincenti, David Wojciechowski, E. Steve Woodle
Summary: Kidney transplant recipients administered belatacept-based maintenance immunosuppression show a more favorable metabolic profile, but have higher rates of early cellular rejection. Further clinical trials are needed to determine the optimal alternative belatacept-based regimen.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
E. Steve Woodle, John S. Gill, Stephanie Clark, Darren Stewart, Rita Alloway, Roy First
Summary: This study compared the long-term outcomes of kidney transplant patients randomized to continue or withdraw corticosteroids, and found that long-term corticosteroids may not be necessary for low- to moderate-immune risk kidney transplant recipients as part of an immunosuppressive regimen.
Article
Urology & Nephrology
Dixon B. Kaufman, E. Steve Woodle, Adele Rike Shields, John Leone, Arthur Matas, Alexander Wiseman, Patricia West-Thielke, Ting Sa, Eileen C. King, Rita R. Alloway
Summary: The study compared the outcomes of kidney transplant patients receiving belatacept versus tacrolimus for maintenance immunosuppression with rapid steroid withdrawal over a period of 2 years. The results showed similar patient and graft survival rates between the groups, but a significantly lower incidence of eGFR <45 ml/min per 1.73 m(2) in the belatacept group and a significantly higher incidence of biopsy-proven acute rejection.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Review
Immunology
Amy P. Rossi, Rita R. Alloway, David Hildeman, E. Steve Woodle
Summary: Solid organ transplantation is a life-saving procedure that has made significant progress in the past 70 years, particularly in T-cell-targeted immunosuppression and organ allocation systems. However, humoral alloimmune responses remain a major challenge, especially for patients with preexisting anti-HLA antibodies. Therapies to target plasma cells, the source of antibody production, have had limited effectiveness in reducing antibody levels.
IMMUNOLOGICAL REVIEWS
(2021)
Article
Urology & Nephrology
Rajasree Menon, Andrew S. Bomback, Blue B. Lake, Christy Stutzke, Stephanie M. Grewenow, Steven Menez, Vivette D. D'Agati, Sanjay Jain
KIDNEY INTERNATIONAL
(2022)
Article
Transplantation
Bassam G. Abu Jawdeh, Begona Campos-Naciff, Karthikeyan Meganathan, E. Steve Woodle, Bradley P. Dixon
Summary: This study investigates the potential of complement split-products (CSP) as biomarkers for acute antibody-mediated rejection (AMR). The results did not support the utility of CSP as surrogate biomarkers for AMR. However, larger studies are needed to confirm these findings.
TRANSPLANTATION DIRECT
(2022)
Article
Immunology
Alin L. Girnita, Lin Wang, Adriana Colovai, Patrick Ahearn, Yorg Azzi, Madhav C. Menon, Marcelo Fernandez-Vina, Howard M. Gebel, E. Steve Woodle, Paolo Cravedi, Jonathan S. Maltzman, Enver Akalin
Summary: This study investigated the changes in anti-HLA antibodies in kidney transplant recipients after COVID-19 and compared them with anti-SARS-CoV-2 antibodies. The results showed that anti-HLA antibodies were mainly IgG, while anti-SARS-CoV-2 antibodies had a high IgA/IgM profile.
Article
Pediatrics
Ellen M. Cody, Charles Varnell Jr, Danielle Lazear, Katherine VandenHeuvel, Francisco X. Flores, E. Steve Woodle, David K. Hooper
Summary: Two pediatric patients with kidney transplant who experienced rejection due to antibodies were treated with the second generation proteasome inhibitor carfilzomib. One patient, a two-year-old female, recovered after completing three cycles of treatment, while the other patient, a 17-year-old female, showed improvement after two cycles of treatment.
PEDIATRIC TRANSPLANTATION
(2023)
Meeting Abstract
Surgery
B. G. Abu Jawdeh, B. Campos-Naciff, K. Harrison, K. Meganathan, A. Kumar, M. Anand, A. Govil, E. S. Woodle, B. P. Dixon
AMERICAN JOURNAL OF TRANSPLANTATION
(2020)
Meeting Abstract
Surgery
P. West-Thielke, A. Shields, D. Kaufman, J. Leone, A. Wiseman, A. Matas, T. Sa, E. King, R. Alloway, S. Woodle
AMERICAN JOURNAL OF TRANSPLANTATION
(2020)
Meeting Abstract
Surgery
N. Wilson, A. R. Shields, A. Wiseman, A. L. Christianson, S. Tremblay, D. Kaufman, J. P. Leone, A. J. Matas, P. West-Thielke, R. R. Alloway, E. S. Woodle
AMERICAN JOURNAL OF TRANSPLANTATION
(2020)
