Regulation of Stress Responses and Translational Control by Coronavirus

Suppression of type I interferon production by porcine epidemic diarrhea virus and degradation of CREB-binding protein by nsp1

(2016) Qingzhan Zhang et al.   VIROLOGY

Middle East Respiratory Syndrome Coronavirus nsp1 Inhibits Host Gene Expression by Selectively Targeting mRNAs Transcribed in the Nucleus while Sparing mRNAs of Cytoplasmic Origin

(2015) Kumari G. Lokugamage et al.   JOURNAL OF VIROLOGY

The nsp1, nsp13, and M Proteins Contribute to the Hepatotropism of Murine Coronavirus JHM.WU

(2015) Rong Zhang et al.   JOURNAL OF VIROLOGY

An eIF2α-binding motif in protein phosphatase 1 subunit GADD34 and its viral orthologs is required to promote dephosphorylation of eIF2α

(2015) Margarito Rojas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C5a/C5aR pathway is essential for the pathogenesis of murine viral fulminant hepatitis by way of potentiating Fgl2/fibroleukin expression

(2014) Gui-lian Xu et al.   HEPATOLOGY

The Endoplasmic Reticulum Stress Sensor IRE1  Protects Cells from Apoptosis Induced by the Coronavirus Infectious Bronchitis Virus

(2014) T. S. Fung et al.   JOURNAL OF VIROLOGY

Protein Disulfide Isomerase A6 Controls the Decay of IRE1α Signaling via Disulfide-Dependent Association

(2014) Davide Eletto et al.   MOLECULAR CELL

Coronavirus-induced ER stress response and its involvement in regulation of coronavirus–host interactions

(2014) To Sing Fung et al.   VIRUS RESEARCH

The PDZ-Binding Motif of Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Is a Determinant of Viral Pathogenesis

(2014) Jose M. Jimenez-Guardeño et al.   PLoS Pathogens

RETRACTED: The Unfolded Protein Response Element IRE1α Senses Bacterial Proteins Invading the ER to Activate RIG-I and Innate Immune Signaling

(2013) Jin A. Cho et al.   Cell Host & Microbe

Transmissible gastroenteritis virus infection induces cell apoptosis via activation of p53 signalling

(2013) Y. Huang et al.   JOURNAL OF GENERAL VIROLOGY

Upregulation of CHOP/GADD153 during Coronavirus Infectious Bronchitis Virus Infection Modulates Apoptosis by Restricting Activation of the Extracellular Signal-Regulated Kinase Pathway

(2013) Y. Liao et al.   JOURNAL OF VIROLOGY

Attenuation of Mouse Hepatitis Virus by Deletion of the LLRKxGxKG Region of Nsp1

(2013) Lin Lei et al.   PLoS One

Infectious Bronchitis Virus Generates Spherules from Zippered Endoplasmic Reticulum Membranes

(2013) H. J. Maier et al.   mBio

Severe Acute Respiratory Syndrome Coronavirus Nonstructural Proteins 3, 4, and 6 Induce Double-Membrane Vesicles

(2013) M. M. Angelini et al.   mBio

Protein disulfide isomerase-associated 6 is an ATF6-inducible ER stress response protein that protects cardiac myocytes from ischemia/reperfusion-mediated cell death

(2012) John A. Vekich et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Monitoring of S Protein Maturation in the Endoplasmic Reticulum by Calnexin Is Important for the Infectivity of Severe Acute Respiratory Syndrome Coronavirus

(2012) M. Fukushi et al.   JOURNAL OF VIROLOGY

Severe Acute Respiratory Syndrome Coronavirus Protein nsp1 Is a Novel Eukaryotic Translation Inhibitor That Represses Multiple Steps of Translation Initiation

(2012) K. G. Lokugamage et al.   JOURNAL OF VIROLOGY

Severe Acute Respiratory Syndrome Coronavirus nsp1 Facilitates Efficient Propagation in Cells through a Specific Translational Shutoff of Host mRNA

(2012) T. Tanaka et al.   JOURNAL OF VIROLOGY

Structure of Alphacoronavirus Transmissible Gastroenteritis Virus nsp1 Has Implications for Coronavirus nsp1 Function and Evolution

(2012) A. M. Jansson   JOURNAL OF VIROLOGY

ER Stress Activates NF-κB by Integrating Functions of Basal IKK Activity, IRE1 and PERK

(2012) Arvin B. Tam et al.   PLoS One

SARS-CoV Accessory Protein 3b Induces AP-1 Transcriptional Activity through Activation of JNK and ERK Pathways

(2011) Bhavna Varshney et al.   BIOCHEMISTRY

ER stress and its regulator X-box-binding protein-1 enhance polyIC-induced innate immune response in dendritic cells

(2011) Fanlei Hu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress

(2011) Brian F. Teske et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of the p38 mitogen-activated protein kinase and dual-specificity phosphatase 1 feedback loop modulates the induction of interleukin 6 and 8 in cells infected with coronavirus infectious bronchitis virus

(2011) Ying Liao et al.   VIROLOGY

Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Regulates Cell Stress Response and Apoptosis

(2011) Marta L. DeDiego et al.   PLoS Pathogens

SARS Coronavirus nsp1 Protein Induces Template-Dependent Endonucleolytic Cleavage of mRNAs: Viral mRNAs Are Resistant to nsp1-Induced RNA Cleavage

(2011) Cheng Huang et al.   PLoS Pathogens

Coronavirus Gene 7 Counteracts Host Defenses and Modulates Virus Virulence

(2011) Jazmina L. G. Cruz et al.   PLoS Pathogens

Coronaviruses Hijack the LC3-I-Positive EDEMosomes, ER-Derived Vesicles Exporting Short-Lived ERAD Regulators, for Replication

(2010) Fulvio Reggiori et al.   Cell Host & Microbe

Nsp1 proteins of group I and SARS coronaviruses share structural and functional similarities

(2010) Yongjin Wang et al.   INFECTION GENETICS AND EVOLUTION

XBP-1 Couples Endoplasmic Reticulum Stress to Augmented IFN-  Induction via a cis-Acting Enhancer in Macrophages

(2010) L. Zeng et al.   JOURNAL OF IMMUNOLOGY

Alphacoronavirus Transmissible Gastroenteritis Virus nsp1 Protein Suppresses Protein Translation in Mammalian Cells and in Cell-Free HeLa Cell Extracts but Not in Rabbit Reticulocyte Lysate

(2010) C. Huang et al.   JOURNAL OF VIROLOGY

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages

(2010) Fabio Martinon et al.   NATURE IMMUNOLOGY

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

(2009) Julie Hollien et al.   JOURNAL OF CELL BIOLOGY

Depletion of phosphatidylcholine affects endoplasmic reticulum morphology and protein traffic at the Golgi complex

(2009) Nicole Testerink et al.   JOURNAL OF LIPID RESEARCH

Inhibition of Protein Kinase R Activation and Upregulation of GADD34 Expression Play a Synergistic Role in Facilitating Coronavirus Replication by Maintaining De Novo Protein Synthesis in Virus-Infected Cells

(2009) X. Wang et al.   JOURNAL OF VIROLOGY

Regulation of Proinflammatory Cytokine Expression in Primary Mouse Astrocytes by Coronavirus Infection

(2009) D. Yu et al.   JOURNAL OF VIROLOGY

Suppression of Host Gene Expression by nsp1 Proteins of Group 2 Bat Coronaviruses

(2009) Y. Tohya et al.   JOURNAL OF VIROLOGY

A two-pronged strategy to suppress host protein synthesis by SARS coronavirus Nsp1 protein

(2009) Wataru Kamitani et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The SARS Coronavirus 3a Protein Causes Endoplasmic Reticulum Stress and Induces Ligand-Independent Downregulation of the Type 1 Interferon Receptor

(2009) Rinki Minakshi et al.   PLoS One

The 8ab protein of SARS-CoV is a luminal ER membrane-associated protein and induces the activation of ATF6

(2009) Shu-Chiun Sung et al.   VIROLOGY

A SARS-CoV protein, ORF-6, induces caspase-3 mediated, ER stress and JNK-dependent apoptosis

(2008) Zhongde Ye et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

ATF6 Is a Transcription Factor Specializing in the Regulation of Quality Control Proteins in the Endoplasmic Reticulum

(2008) Yusuke Adachi et al.   CELL STRUCTURE AND FUNCTION

Severe acute respiratory syndrome coronavirus 3a protein activates the mitochondrial death pathway through p38 MAP kinase activation

(2008) K. Padhan et al.   JOURNAL OF GENERAL VIROLOGY

Coronavirus Infection Modulates the Unfolded Protein Response and Mediates Sustained Translational Repression

(2008) J. Bechill et al.   JOURNAL OF VIROLOGY

Severe Acute Respiratory Syndrome Coronavirus Triggers Apoptosis via Protein Kinase R but Is Resistant to Its Antiviral Activity

(2008) V. Krahling et al.   JOURNAL OF VIROLOGY

Severe Acute Respiratory Syndrome Coronavirus nsp1 Suppresses Host Gene Expression, Including That of Type I Interferon, in Infected Cells

(2008) K. Narayanan et al.   JOURNAL OF VIROLOGY

Activation of p38 MAPK by feline infectious peritonitis virus regulates pro-inflammatory cytokine production in primary blood-derived feline mononuclear cells

(2008) Andrew D. Regan et al.   VIROLOGY

SARS-Coronavirus Replication Is Supported by a Reticulovesicular Network of Modified Endoplasmic Reticulum

(2008) Kèvin Knoops et al.   PLOS BIOLOGY

Transcriptional profiling of Vero E6 cells over-expressing SARS-CoV S2 subunit: Insights on viral regulation of apoptosis and proliferation

(2007) Yin-Shan Yeung et al.   VIROLOGY