Article
Immunology
Ruth Harbecke, Jeffrey Cohen, Michael N. Oxman
Summary: Herpes zoster is a common virus that affects many people, and vaccines for preventing HZ and PHN are important for older adults. Clinical trials and real-world studies have shown that the vaccines are safe and effective in preventing these conditions.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
C. S. van Dam, I Lede, J. Schaar, M. Al-Dulaimy, R. Rosken, M. Smits
Summary: COVID-19 can present with skin manifestations, including reactivation of herpes zoster. Vaccination may lead to transient lymphocytopenia, similar to that seen in COVID-19 disease. Further evaluation is needed to determine the relationship between COVID-19, COVID vaccines, and herpes zoster.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Biotechnology & Applied Microbiology
Lin Li, Andre Gorgens, Veronika Mussack, Elena Pepeldjiyska, Anne Sophie Hartz, Andreas Rank, Jorg Schmohl, Doris Kra''mer, Samir El Andaloussi, Michael W. Pfaffl, Helga Schmetzer
Summary: Extracellular Vesicles (EVs) play a crucial role in hematological malignancies, affecting bone marrow environment, immune system, drug resistance, and therapies. EVs collected from serum of leukemia samples have potential as biomarkers for disease pattern distinctions. This study aims to investigate the potential role and methodology of serum-derived EVs as biomarkers in leukemic versus healthy samples.
CANCER GENE THERAPY
(2022)
Article
Immunology
Sonya Krishnan, Artur T. L. Queiroz, Amita Gupta, Nikhil Gupte, Gregory P. Bisson, Johnstone Kumwenda, Kogieleum Naidoo, Lerato Mohapi, Vidya Mave, Rosie Mngqibisa, Javier R. Lama, Mina C. Hosseinipour, Bruno B. Andrade, Petros C. Karakousis
Summary: Novel high-throughput approaches may improve the recognition of tuberculosis in HIV-infected individuals, especially in those with severely suppressed immune systems.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Clinical Neurology
Han-Rui Fan, En-Ming Zhang, Yong Fei, Bing Huang, Ming Yao
Summary: Early intervention reduces the incidence of postherpetic neuralgia (PHN). Typical shingles are easy to diagnose, but there is no clear diagnostic method for neuralgia symptoms manifested before the onset of the rash, which can easily cause misdiagnosis and delay early treatment.
Review
Virology
Yasmin Marra, Fawziah Lalji
Summary: Infection with varicella zoster virus can cause either chickenpox or shingles. Two vaccines are available to prevent shingles, with the recombinant vaccine showing higher efficacy than the live vaccine. Safety data from both vaccines indicate mostly local and mild systemic reactions.
Article
Multidisciplinary Sciences
Chao-Yu Hsu, Der-Shin Ke, Cheng-Li Lin, Chia-Hung Kao
Summary: This study found that patients with plantar fascial fibromatosis have a higher risk of developing herpes zoster, especially older and male patients.
Review
Oncology
Jose D. Debes, Pablo A. Romagnoli, Jhon Prieto, Marco Arrese, Angelo Z. Mattos, Andre Boonstra
Summary: Hepatocellular carcinoma (HCC) is a major cause of cancer death worldwide. Late diagnosis and limited treatment options contribute to the low survival rate of patients with HCC. Currently, combining ultrasound with the biomarker AFP is a commonly used screening method, but its clinical utility and operator-dependence are controversial.
Article
Immunology
Ganapathi Iyer Parameswaran, Bethany A. Wattengel, Hubert C. Chua, Jessica Swiderek, Tom Fuchs, Michael T. Carter, Laura Goode, Kathleen Doyle, Kari A. Mergenhagen
Summary: This study found that there is an increased risk of stroke within 30 days following herpes zoster infection, but receiving zoster vaccination can mitigate this risk.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Virology
Tuba Oskay, Cem Keskin, Mehmet Ozen
Summary: The blood levels of major antioxidants are lower in patients with herpes zoster, while inflammatory markers are increased. These biomarkers are associated with postherpetic neuralgia and clinical severity, suggesting a potential link with virus reactivation, nerve damage, and persistent pain.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Health Care Sciences & Services
James F. Mbinta, Alex X. Wang, Binh P. Nguyen, Janine Paynter, Prosper Mandela A. Awuni, Russell Pine, Andrew A. Sporle, Colin R. Simpson
Summary: A study in New Zealand assessed the 'real-world' effectiveness of the zoster vaccine live (ZVL) against herpes zoster (HZ) and postherpetic neuralgia (PHN). The study found that the vaccine significantly reduced the risk of hospitalisation from HZ and PHN.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Review
Immunology
Desmond Curran, T. Mark Doherty, Nicolas Lecrenier, Thomas Breuer
Summary: Populations are ageing worldwide, putting pressure on healthcare budgets. Vaccination can help prevent diseases in older adults and promote healthy ageing. Herpes zoster (HZ) and its complications can cause severe pain and health problems. Vaccines to prevent HZ can reduce disease burden, maintain functioning and quality of life, supporting healthy ageing.
Article
Biotechnology & Applied Microbiology
Hongdong Li, Liyuan Ma, Fengyuan Luo, Wenkai Liu, Na Li, Tao Hu, Haijian Zhong, You Guo, Guini Hong
Summary: This study utilized a large miRNA-profiled serum samples repository to identify two miRNA pairs that can accurately diagnose glioma and differentiate it from other brain diseases. These findings provide potential population screening and cancer-specific biomarkers for glioma clinical practice.
Article
Biochemistry & Molecular Biology
Jaehoon Lee, Hee Seung Lee, Soo Been Park, Chanyang Kim, Kahee Kim, Dawoon E. Jung, Si Young Song
Summary: The study aimed to identify non-invasive miRNA markers for early pancreatic cancer diagnosis. A total of 39 miRNA markers were selected from blood serum samples to build a PC diagnosis model, which showed excellent performance in independent sample validation and differential expression in samples from PC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Maia Segura-Wang, Bertrand Grenier, Suzana Ilic, Ursula Ruczizka, Maximiliane Dippel, Moritz Buenger, Matthias Hackl, Veronika Nagl
Summary: This study investigated the changes in miRNA expression induced by DON in porcine liver, jejunum, and serum. The serum miRNA response to DON increased over time and declined after removal of contaminated diets. Receiver operating curve analyses for individual miRNAs were significant, and a combination of four miRNAs increased the predictive capacity for DON exposure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)