Journal
VIRUSES-BASEL
Volume 8, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/v8070192
Keywords
HIV-1; RNA; packaging; assembly
Categories
Funding
- United Kingdom Medical Research Council
- Biomedical Research Centre
- MRC [G0801709, MC_PC_13059, MR/N022939/1, G0800142] Funding Source: UKRI
- Medical Research Council [G0801709, MC_PC_13059, MR/N022939/1, 1366875, G0800142] Funding Source: researchfish
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The tremendous progress made in unraveling the complexities of human immunodeficiency virus (HIV) replication has resulted in a library of drugs to target key aspects of the replication cycle of the virus. Yet, despite this accumulated wealth of knowledge, we still have much to learn about certain viral processes. One of these is virus assembly, where the viral genome and proteins come together to form infectious progeny. Here we review this topic from the perspective of how the route to production of an infectious virion is orchestrated by the viral genome, and we compare and contrast aspects of the assembly mechanisms employed by HIV-1 with those of other RNA viruses.
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