Journal
VIRUSES-BASEL
Volume 8, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/v8040095
Keywords
natural killer cells; viral evasion; activating receptor; ligands; herpesvirus
Categories
Funding
- Doctoral Program Foundation of Institutions of Higher Education of China [20130171120059]
- Science and Technology Program of Guangzhou [2014J4100164]
- Natural Science Foundation of Guangdong Province [2015A030313050]
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Natural killer (NK) cells play a key role in antiviral innate defenses because of their abilities to kill infected cells and secrete regulatory cytokines. Additionally, NK cells exhibit adaptive memory-like antigen-specific responses, which represent a novel antiviral NK cell defense mechanism. Viruses have evolved various strategies to evade the recognition and destruction by NK cells through the downregulation of the NK cell activating receptors. Here, we review the recent findings on viral evasion of NK cells via the impairment of NK cell-activating receptors and ligands, which provide new insights on the relationship between NK cells and viral actions during persistent viral infections.
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