First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes-Chapter 2b: genetically modified source pigs

Control of IBMIR in Neonatal Porcine Islet Xenotransplantation in Baboons

(2014) W. J. Hawthorne et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Pig-to-Monkey Islet Xenotransplantation Using Multi-Transgenic Pigs

(2014) R. Bottino et al.   AMERICAN JOURNAL OF TRANSPLANTATION

One-step generation of knockout pigs by zygote injection of CRISPR/Cas system

(2014) Tang Hai et al.   CELL RESEARCH

Parallel evolution of a self-signal: humans and new world monkeys independently lost the cell surface sugar Neu5Gc

(2014) Stevan A. Springer et al.   IMMUNOGENETICS

Creating Class I MHC–Null Pigs Using Guide RNA and the Cas9 Endonuclease

(2014) Luz M. Reyes et al.   JOURNAL OF IMMUNOLOGY

Genetically engineered pigs and target-specific immunomodulation provide significant graft survival and hope for clinical cardiac xenotransplantation

(2014) Muhammad M. Mohiuddin et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Dual Fluorescent Reporter Pig for Cre Recombination: Transgene Placement at the ROSA26 Locus

(2014) Shun Li et al.   PLoS One

The new CRISPR–Cas system: RNA-guided genome engineering to efficiently produce any desired genetic alteration in animals

(2014) Davide Seruggia et al.   TRANSGENIC RESEARCH

Meta-analysis of the independent and cumulative effects of multiple genetic modifications on pig lung xenograft performance during ex vivo perfusion with human blood

(2014) Donald G. Harris et al.   XENOTRANSPLANTATION

Glucose metabolism in pigs expressing human genes under an insulin promoter

(2014) Martin Wijkstrom et al.   XENOTRANSPLANTATION

Efficient generation of genetically distinct pigs in a single pregnancy using multiplexed single-guide RNA and carbohydrate selection

(2014) Ping Li et al.   XENOTRANSPLANTATION

COSMID: A Web-based Tool for Identifying and Validating CRISPR/Cas Off-target Sites

(2014) Thomas J Cradick et al.   Molecular Therapy-Nucleic Acids

One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering

(2013) Haoyi Wang et al.   CELL

The Protective Effects of CD39 Overexpression in Multiple Low-Dose Streptozotocin-Induced Diabetes in Mice

(2013) J. S. J. Chia et al.   DIABETES

Kidney xenotransplantation

(2013) Peter J. Cowan et al.   KIDNEY INTERNATIONAL

Double knockout pigs deficient in N-glycolylneuraminic acid and Galactose α-1,3-Galactose reduce the humoral barrier to xenotransplantation

(2013) Andrew J. Lutz et al.   XENOTRANSPLANTATION

Early Islet Damage after Direct Exposure of Pig Islets to Blood: Has Humoral Immunity Been Underestimated?

(2012) Dirk J. Van Der Windt et al.   CELL TRANSPLANTATION

Xenografted Islet Cell Clusters From INSLEA29Y Transgenic Pigs Rescue Diabetes and Prevent Immune Rejection in Humanized Mice

(2012) N. Klymiuk et al.   DIABETES

Generation and Characterization of Human Heme Oxygenase-1 Transgenic Pigs

(2012) Hye-Jung Yeom et al.   PLoS One

Efficient TALEN-mediated gene knockout in livestock

(2012) D. F. Carlson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Islet Xenotransplantation Using Gal-Deficient Neonatal Donors Improves Engraftment and Function

(2011) P. Thompson et al.   AMERICAN JOURNAL OF TRANSPLANTATION

CRISPR-Cas Systems in Bacteria and Archaea: Versatile Small RNAs for Adaptive Defense and Regulation

(2011) Devaki Bhaya et al.   Annual Review of Genetics

Control of instant blood-mediated inflammatory reaction to improve islets of Langerhans engraftment

(2011) Bo Nilsson et al.   Current Opinion in Organ Transplantation

Clinical xenotransplantation: the next medical revolution?

(2011) Burcin Ekser et al.   LANCET

Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases

(2011) J. Hauschild et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transgenic expression of human heme oxygenase-1 in pigs confers resistance against xenograft rejection during ex vivo perfusion of porcine kidneys

(2011) Björn Petersen et al.   XENOTRANSPLANTATION

Long-Term Controlled Normoglycemia in Diabetic Non-Human Primates After Transplantation with hCD46 Transgenic Porcine Islets

(2009) D. J. van der Windt et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Chapter 2: Source pigs

(2009) Henk-Jan Schuurman   XENOTRANSPLANTATION

Transgenic expression of the human A20 gene in cloned pigs provides protection against apoptotic and inflammatory stimuli

(2009) Marianne Oropeza et al.   XENOTRANSPLANTATION