Article
Infectious Diseases
Sainan Chen, Wenjing Gu, Min Wu, Chuangli Hao, Canhong Zhu, Xuejun Shao, Yuqing Wang
Summary: This study found that 22.2% of infants experience recurrent wheezing after bronchiolitis. A history of eczema was identified as the only independent risk factor for developing recurrent wheezing after bronchiolitis.
BMC INFECTIOUS DISEASES
(2021)
Article
Pediatrics
Yunlian Zhou, Lin Tong, Mengyao Li, Yingshuo Wang, Lanxin Li, Dehua Yang, Yuanyuan Zhang, Zhimin Chen
Summary: The study found that RSV bronchiolitis may increase the incidence of recurrent wheezing and asthma in children, with patients who develop asthma having higher birth weight and older age of onset.
FRONTIERS IN PEDIATRICS
(2021)
Article
Biochemistry & Molecular Biology
Silvia Carraro, Valentina Agnese Ferraro, Michela Maretti, Giuseppe Giordano, Paola Pirillo, Matteo Stocchero, Stefania Zanconato, Eugenio Baraldi
Summary: Despite no metabolic dysregulation at birth associated with acute bronchiolitis or recurrent wheezing post-bronchiolitis, a metabolic signature was discovered distinguishing children who develop wheezing not preceded by bronchiolitis.
Article
Pediatrics
Brooke Gustafson, Rodney D. Britt Jr, Mariah Eisner, Deepika Narayanan, Mitchell H. Grayson
Summary: This retrospective study identified risk factors associated with the development of wheezing in late preterm infants. Positive family history of asthma, receiving antibiotics during the neonatal period, requiring continuous positive airway pressure for less than 24 hours, and receiving supplemental oxygen during the newborn period were associated with the development of wheezing.
PEDIATRIC PULMONOLOGY
(2023)
Article
Immunology
Jason T. Patregnani, Michimasa Fujiogi, Carlos A. Camargo, Bonnie A. Brooks, Claire E. Hoptay, Jonathan M. Mansbach, Stephen J. Teach, Robert J. Freishtat, Kohei Hasegawa
Summary: Serum sRAGE levels are inversely associated with acute and chronic morbidities of bronchiolitis, including recurrent wheeze. Higher presenting sRAGE levels are associated with lower risk of intensive care and significantly lower rate of recurrent wheeze. The effect of sRAGE on development of recurrent wheeze is potentially driven through pathways other than acute severity of bronchiolitis.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Xiaoyan Zhang, Dan Peng, Xiang Zhang, Xinglan Wang, Ning Chen, Shunying Zhao, Qiushui He
Summary: This study used serum metabolomics to identify differential metabolic signatures during severe RSV bronchiolitis in infancy that were associated with the development of subsequent recurrent wheezing in childhood. High levels of L-lactic acid were found in infants who developed recurrent wheezing, and pathways related to pyrimidine metabolism, glycerophospholipid metabolism, and arginine biosynthesis were identified as significantly changed between the two groups. Additionally, L-lactic acid levels were positively correlated with serum CXCL8 levels.
Article
Pediatrics
Marja Ruotsalainen, Paula Heikkila, Katri Backman, Matti Korppi
Summary: This cohort study aimed to evaluate doctor-diagnosed and self-reported asthma in young adults after early-childhood hospitalisation for wheezing. Results showed that early-childhood hospitalisation for wheezing was an independently significant risk factor of asthma in young adults, with an increased risk of self-reported asthma that remained statistically significant in analyses adjusted for confounding factors. Previous asthma during early childhood was also identified as a strong risk factor for asthma in young adulthood.
Article
Allergy
Pekka Hurme, Kiara Homil, Pasi Lehtinen, Riitta Turunen, Tero Vahlberg, Tytti Vuorinen, Carlos A. Jr Jr Camargo, James E. Gern, Tuomas Jartti
Summary: The study aimed to investigate the interactions between high-dose inhaled salbutamol and oral corticosteroid in young hospitalized children with the first episode of acute rhinovirus-induced severe wheezing. The results indicated that the high-dose group had lower relapse rates and longer duration in the prednisolone arm, but no significant difference was detected in the placebo arm.
CLINICAL AND EXPERIMENTAL ALLERGY
(2021)
Article
Allergy
Beatriz Sastre, Maria Luz Garcia-Garcia, Jose Antonio Canas, Cristina Calvo, Jose Manuel Rodrigo-Munoz, Inmaculada Casas, Ignacio Mahillo-Fernandez, Victoria del Pozo
Summary: The study found that bronchiolitis patients have higher levels of innate lymphoid cells and related mRNA compared to recurrent wheezing patients. The levels of pro-inflammatory and immunomodulatory factors in the supernatant were similar between the two groups, but a significant difference was found in the ratio of prostaglandin E2 and cysteinyl leukotrienes C4.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Pediatrics
Franca Rusconi, Enrico Lombardi, Elena Spada, Sonia Brescianini, Martina Culasso, Francesca Di Toro, Antonella Frassanito, Lorenzo Richiardi, Luca Ronfani, Ileana Stella, Luigi Gagliardi
Summary: The study found that children who had wheezing and lower respiratory tract infections during infancy had reduced lung function in school age, whereas those with lower respiratory tract infections only did not show the same impact.
PEDIATRIC PULMONOLOGY
(2022)
Article
Immunology
Wei Tang, Lei Zhang, Tao Ai, Wanmin Xia, Cheng Xie, Yinghong Fan, Sisi Chen, Zijin Chen, Jiawei Yao, Yi Peng
Summary: This study analyzed the bronchial bacterial microbiome of infants with recurrent wheezing to understand the pathogenesis of atopic wheezing and identify diagnostic biomarkers. Significant differences in bacterial composition and community-level functions were observed between wheezing infants with and without atopy. A predictive model based on the airway microbiota showed potential diagnostic value for distinguishing atopic from non-atopic wheezing infants. Further investigation combining airway microbiome and metabolomics analysis is needed to confirm these findings.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Frederico Friedrich, Renata Ongaratto, Marcelo C. Scotta, Tiago N. Veras, Renato T. Stein, Magali Santos Lumertz, Marcus Herbert Jones, Talitha Comaru, Leonardo Araujo Pinto
Summary: The study found a significant reduction in hospital admissions for acute bronchiolitis in infants under 1 year old in Brazil due to the social distancing measures implemented during the COVID-19 pandemic. The reduction ranged from 58% to 93% across different regions of Brazil, indicating the important impact of social distancing on reducing the transmission of respiratory viruses.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Pekka Hurme, Miisa Komulainen, Marleena Tulkki, Annamari Leino, Beate Ruckert, Riitta Turunen, Tytti Vuorinen, Mubeccel Akdis, Cezmi A. Akdis, Tuomas Jartti
Summary: The cytokine profiles of Rhinovirus (RV) and respiratory syncytial virus (RSV)-induced first wheezing episode differ, with higher cytokine expression and longer hospitalization time in the RSV group. In the RV group, increased expression of I-309 (CCL1) and TARC is associated with fewer relapses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pediatrics
Pierluigi Marzuillo, Anna Di Sessa, Raffaella Golino, Paola Tirelli, Maeva De Lucia, Giulio Rivetti, Emanuele Miraglia del Giudice, Stefano Guarino, Felice Nunziata
Summary: We investigated the prevalence and associated factors of acute kidney injury (AKI) in hospitalized patients with viral bronchiolitis. Among the retrospective enrollment of 139 children, AKI was found in 15 patients. Respiratory syncytial virus (RSV) infection, preterm birth, low birth weight, and high hematocrit levels were significantly associated with AKI. This study highlights the importance of monitoring kidney function in viral bronchiolitis patients and identifying risk factors for AKI.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
Liting Geng, Xiaoyu Tang, Li Hua, Haipei Liu, Shaolong Ren, Wenwei Zhong, Jianhua Zhang
Summary: Through analyzing and discussing the risk factors and intervention measures of recurrent wheezing in infants, individualized treatment can be provided to reduce the occurrence of recurrent wheezing. The study found that male, history of eczema, history of rhinitis, history of wheezing before hospitalization, family smoke exposure, mycoplasma infection, and inhalation allergen sensitization were risk factors for recurrent wheezing in infants and young children. Long-term intervention and inhaled corticosteroids treatment after discharge can reduce the probability of recurrent wheezing.
TRANSLATIONAL PEDIATRICS
(2023)