Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 22, Issue 3, Pages 1190-1201Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v22.i3.1190
Keywords
DNA methylation; Gastric cancer; Molecular subtype; Mutation; Next-generation sequencing
Categories
Funding
- genomics program of the National Research Foundation of Korea - the Ministry of Science, ICT, and Future Planning [NRF-2012M3A9D1054670, NRF-2014M3C9A3068554]
- Basic Science Research Program through the National Research Foundation of Korea - Ministry of Education [NRF-2013R1A1A2006621]
- Korea Research Institute of Bioscience and Biotechnology research initiative grant
- National Research Council of Science & Technology (NST), Republic of Korea [KGM4751612] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2014M3C9A3068554, 2012M3A9D1054670] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Gastric cancer is a complex disease that is affected by multiple genetic and environmental factors. For the precise diagnosis and effective treatment of gastric cancer, the heterogeneity of the disease must be simplified; one way to achieve this is by dividing the disease into subgroups. Toward this effort, recent advances in high-throughput sequencing technology have revealed four molecular subtypes of gastric cancer, which are classified as Epstein-Barr virus-positive, microsatellite instability, genomically stable, and chromosomal instability subtypes. We anticipate that this molecular subtyping will help to extend our knowledge for basic research purposes and will be valuable for clinical use. Here, we review the genomic and epigenomic heterogeneity of the four molecular subtypes of gastric cancer. We also describe a mutational meta-analysis and a reanalysis of DNA methylation that were performed using previously reported gastric cancer datasets.
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