Review
Radiology, Nuclear Medicine & Medical Imaging
Akitoshi Inoue, Shannon P. Sheedy, Jay P. Heiken, Payam Mohammadinejad, Rondell P. Graham, Hee Eun Lee, Scott R. Kelley, Stephanie L. Hansel, David H. Bruining, Jeff L. Fidler, Joel G. Fletcher
Summary: MRI is commonly used for staging rectal cancer and detecting EMVI, a predictor for worse prognosis. T2-weighted and diffusion-weighted images can help identify EMVI, while contrast enhanced T1-weighted images show tumor signal intensity.
INSIGHTS INTO IMAGING
(2021)
Article
Surgery
Osman Serhat Guner, Latif Volkan Tumay
Summary: In rectal cancer patients, persistent EMVI positivity after neoadjuvant therapy may serve as an independent predictor of poor overall survival and disease-free survival, along with mesorectal fascia involvement and poor differentiation as significant independent predictors of worse disease-free survival.
ASIAN JOURNAL OF SURGERY
(2021)
Article
Oncology
Lianfen Tian, Ningqin Li, Dong Xie, Qiang Li, Chuanji Zhou, Shilai Zhang, Lijuan Liu, Caiyun Huang, Lu Liu, Shaolu Lai, Zheng Wang
Summary: This study verified the value of MRI to construct a nomogram for preoperatively predicting EMVI in rectal cancer. The nomogram including MRI characteristics showed good predictive ability for EMVI in both the internal training and external validation groups.
FRONTIERS IN ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Weicui Chen, Qiurong Wei, Weikang Huang, Jialiang Chen, Shaowei Hu, Xia Lv, Liting Mao, Bo Liu, Wu Zhou, Xian Liu
Summary: This study investigates the diagnostic ability of diffusion kurtosis imaging (DKI) in combination with clinical data as risk factors for EMVI's involvement status in rectal adenocarcinoma. The results show that the K-mean values derived from DKI are positively correlated with EMVI scores, while ADC(mean) values are negatively correlated. Multivariate analysis identifies Kmean values, lymph node involvement, and advanced tumor stage as independent risk factors for EMVI. These findings highlight the potential of DKI as a biomarker for evaluating EMVI.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Weicui Chen, Guoqing Liu, Jialiang Chen, Qiurong Wei, Yongsong Ye, Xiaohua Du, Jiepin Feng, Zhaoxian Yan, Kan Deng, Xian Liu
Summary: Whole-tumor histogram analysis of APTw images combined with clinical factors showed better diagnostic efficiency in predicting pEMVI involvement in rectal adenocarcinoma compared to conventional MRI assessment.
EUROPEAN RADIOLOGY
(2023)
Article
Oncology
Siye Liu, Xiaoping Yu, Songhua Yang, Pingsheng Hu, Yingbin Hu, Xiaoyan Chen, Yilin Li, Zhe Zhang, Cheng Li, Qiang Lu
Summary: A radiomics nomogram based on primary tumor features was established and validated to predict preoperative pathological extramural venous invasion (EMVI) in rectal cancer using machine learning. The nomogram showed high efficiency in predicting EMVI, helping patients choose optimal treatment strategies.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Mo Chen, Yan Ma, Yi-wen Song, Jinhua Huang, Yuan-hong Gao, Jian Zheng, Fang He
Summary: In this retrospective study, we found that most LARC patients with mrEMVI converted to EMVI-negative after neoadjuvant treatment, resulting in improved overall survival and disease-free survival. Patients receiving neoadjuvant chemoradiotherapy had better survival outcomes compared to those receiving neoadjuvant chemotherapy alone, suggesting the importance of including radiotherapy in the treatment. Patients receiving neoadjuvant chemotherapy in addition to chemoradiotherapy had higher rates of pathological complete response and downstaging, but their survival rates were not improved.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ke-xin Wang, Jing Yu, Qing Xu
Summary: Histogram analysis of DCE-MRI K-trans maps can be used for the identification of extramural venous invasion (EMVI) in rectal cancer patients. The mean values of K-trans and V-e were significantly higher in the EMVI-positive group compared to the EMVI-negative group. Parameters such as kurtosis and entropy of K-trans were identified as independent predictors for EMVI.
BMC MEDICAL IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhenyu Shu, Dewang Mao, Qiaowei Song, Yuyun Xu, Peipei Pang, Yang Zhang
Summary: In patients with rectal cancer, a radiomics signature based on the Bayes algorithm performed well in both the training and test sets, while the joint model showed the best performance in predicting EMVI, serving as a key tool for clinical individualized EMVI prediction.
EUROPEAN RADIOLOGY
(2022)
Article
Oncology
Fei Gao, Bin Shi, Peipei Wang, Chuanbin Wang, Xin Fang, Jiangning Dong, Tingting Lin
Summary: This study aimed to evaluate the value of 3.0T MRI IVIM-DWI parameters combined with texture analysis in evaluating extramural vascular invasion (EMVI) of rectal adenocarcinoma. Results showed statistically significant differences in the measured parameters between EMVI positive and negative patients. A prediction model was established, and the AUC of the model was higher than that of other single parameters.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Jessica Juliana Tan, Rachel V. Carten, Amna Babiker, Muti Abulafi, Amy C. Lord, Gina Brown
Summary: mrEMVI is significantly associated with worsened survival outcomes in rectal cancer, both at baseline and after neoadjuvant treatment. Regression of mrEMVI after neoadjuvant treatment is associated with improved survival outcomes. Accurate and consistent reporting of mrEMVI status is essential.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Cui Tang, Gaixia Lu, Jinming Xu, Jie Kuang, Jinlei Xu, Peijun Wang
Summary: This study investigated the prognostic value of DKI-derived parameters, conventional ADC values, and mrEMVI in rectal cancer patients. The results showed that these parameters were associated with different histopathological prognostic factors and could be used to distinguish mucinous adenocarcinoma from common adenocarcinoma. They also showed potential for discriminating KRAS mutation.
ABDOMINAL RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuxi Ge, Yanlong Jia, Yunzhi Li, Jiankun Dai, Rongping Guan, Shudong Hu
Summary: This study evaluated the imaging quality of a synthetic phase-sensitive inversion recovery (SyPSIR) vessel and its value in detecting extramural venous invasion (EMVI) in patients with rectal cancer using T2-weighted imaging (T2WI). The results showed that combining T2WI and SyPSIR vessels improved the diagnostic performance for EMVI, with increased sensitivity and area under the curve.
EUROPEAN RADIOLOGY
(2023)
Article
Oncology
Hannah M. M. Thompson, David D. B. Bates, Jennifer Golia Pernicka, Sun Jin Park, Mahra Nourbakhsh, James L. L. Fuqua, Megan Fiasconaro, Jessica A. A. Lavery, Iris H. H. Wei, Emmanouil P. P. Pappou, J. Joshua Smith, Garrett M. M. Nash, Martin R. R. Weiser, Philip B. B. Paty, Julio Garcia-Aguilar, Maria Widmar
Summary: This study investigated the association of persistent extramural venous invasion (EMVI) after total neoadjuvant therapy (TNT) with survival in patients with locally advanced rectal cancer. The results showed that EMVI regression on surgical pathology was associated with improved disease-free survival and overall survival. However, the impact of persistent EMVI on post-TNT MRI on decision-making and prognosis remains unclear.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Taru M. Lehtonen, Laura E. Koskenvuo, Toni T. Seppala, Anna H. Lepisto
Summary: This study found that extramural venous invasion observed in preoperative MRI is a significant prognostic factor for poorer survival and recurrences in rectal cancer patients. A circumferential margin <= 1 mm is associated with local recurrence, but this risk can be controlled with chemoradiotherapy and extended surgery.
COLORECTAL DISEASE
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Ingrid M. White, Erica Scurr, Andreas Wetscherek, Gina Brown, Aslam Sohaib, Simeon Nill, Uwe Oelfke, David Dearnaley, Susan Lalondrelle, Shreerang Bhide
BRITISH JOURNAL OF RADIOLOGY
(2019)
Article
Oncology
A. E. Vallance, D. Harji, N. S. Fearnhead
Article
Oncology
Erin D. Kennedy, Marko Simunovic, Kartik Jhaveri, Richard Kirsch, Jim Brierley, Sebastien Drolet, Carl Brown, Patrick M. Vos, Wei Xiong, Tony MacLean, Selliah Kanthan, Peter Stotland, Simon Raphael, Gil Chow, Catherine A. O'Brien, Charles Cho, Cathy Streutker, Raimond Wong, Selina Schmocker, Sender Liberman, Caroline Reinhold, Neil Kopek, Victoria Marcus, Alexandre Bouchard, Caroline Lavoie, Stanislas Morin, Martine Perigny, Ann Wright, Katerina Neumann, Sharon Clarke, Nikhilesh G. Patil, Thomas Arnason, Lara Williams, Robin McLeod, Gina Brown, Alex Mathieson, Amandeep Pooni, Nancy N. Baxter
Article
Oncology
Francesco Sclafani, Sanna Hulkki Wilson, David Cunningham, David Gonzalez De Castro, Eleftheria Kalaitzaki, Ruwaida Begum, Andrew Wotherspoon, Jaume Capdevila, Bengt Glimelius, Susana Rosello, Janet Thomas, Daina Tait, Gina Brown, Jacqui Oates, Ian Chau
INTERNATIONAL JOURNAL OF CANCER
(2020)
Article
Gastroenterology & Hepatology
N. D'Souza, A. C. Lord, A. Shaw, A. Patel, S. Balyasnikova, V. Tudyka, M. Abulafi, B. Moran, S. Rasheed, P. Tekkis, J. C. Coffey, M. Terlizzo, N. P. West, P. Quirke, G. Brown
COLORECTAL DISEASE
(2020)
Article
Oncology
Shelize Khakoo, Paul David Carter, Gina Brown, Nicola Valeri, Simona Picchia, Maria Antonietta Bali, Ridwan Shaikh, Thomas Jones, Ruwaida Begum, Isma Rana, Andrew Wotherspoon, Monica Terlizzo, Katharina von Loga, Eleftheria Kalaitzaki, Claire Saffery, David Watkins, Diana Tait, Ian Chau, Naureen Starling, Michael Hubank, David Cunningham
CLINICAL CANCER RESEARCH
(2020)
Article
Oncology
Nigel D'Souza, Amy Lord, Annabel Shaw, Anisha Patel, Svetlana Balyasnikova, Vera Tudyka, Muti Abulafi, Brendan Moran, Shahnawaz Rasheed, Paris Tekkis, Monica Terlizzo, Nick West, Philip Quirke, Gina Brown
Article
Oncology
Amy C. Lord, Nikki Knijn, Gina Brown, Iris D. Nagtegaal
EUROPEAN JOURNAL OF CANCER
(2020)
Article
Surgery
Deborah S. Keller, Mariana Berho, Gina Brown, Tracy Hull, Gabriela Moeslein, Steven D. Wexner
Letter
Gastroenterology & Hepatology
Jeremy Richard Huddy, Shahnawaz Rasheed, Gina Brown, Henry S. Tilney
JOURNAL OF GASTROINTESTINAL SURGERY
(2020)
Article
Medicine, General & Internal
Amy C. Lord, Brendan Moran, Muti Abulafi, Shahnawaz Rasheed, Iris D. Nagtegaal, Monica Terlizzo, Gina Brown
Article
Cell Biology
Amy Lord, Gina Brown, Muti Abulafi, Adrian Bateman, Wendy Frankel, Robert Goldin, Purva Gopal, Richard Kirsch, Maurice B. Loughrey, Bruno Maerkl, Brendan Moran, Giacomo Puppa, Shahnawaz Rasheed, Yoshifumi Shimada, Petur Snaebjornsson, Magali Svrcek, Kay Washington, Nicholas West, Newton Wong, Iris Nagtegaal
Summary: Tumour deposits (TDs) are an important prognostic marker in colorectal cancer, but their classification and inclusion in staging are controversial. Expert consensus suggests a need for a clearer, more reproducible definition of TDs, and the recommendation to record the number of TDs and not exclude nodules with evidence of origin.
Article
Gastroenterology & Hepatology
Simon P. Bach, Alexandra Gilbert, Kristian Brock, Stephan Korsgen, Ian Geh, James Hill, Talvinder Gill, Paul Hainsworth, Matthew G. Tutton, Jim Khan, Jonathan Robinson, Mark Steward, Christopher Cunningham, Bruce Levy, Alan Beveridge, Kelly Handley, Manjinder Kaur, Natalie Marchevsky, Laura Magill, Ann Russell, Philip Quirke, Nicholas P. West, David Sebag-Montefiore
Summary: An organ-preserving strategy with selective total mesorectal excision could be a feasible treatment option for early-stage rectal cancer, achieving high levels of organ preservation with relatively low morbidity and indications of improved quality of life. Further evaluation is needed to assess the long-term oncological outcomes of organ preservation in comparison to radical surgery.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2021)
Letter
Surgery
Jeremy Richard Huddy, Shahnawaz Rasheed, Gina Brown, Henry S. Tilney
Meeting Abstract
Oncology
David Sebag-Montefiore, Richard Adams, Simon Gollins, Leslie M. Samuel, Robert Glynne-Jones, Robert Harte, Nicholas West, Philip Quirke, Arthur Sun Myint, Simon P. Bach, Philip Parsons, Stephen Falk, Amandeep Singh Dhadda, Vivek Misra, Nick Brown, Gina Brown, Mark Harrison, Laura White, Marian Duggan, Andre Lopes
JOURNAL OF CLINICAL ONCOLOGY
(2020)