Role of bile acids in carcinogenesis of pancreatic cancer: An old topic with new perspective

Cancer statistics, 2015

(2015) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Slc10a2-null mice uncover colon cancer-promoting actions of endogenous fecal bile acids

(2015) Jean-Pierre Raufman et al.   CARCINOGENESIS

Gut Microbiota, Cirrhosis, and Alcohol Regulate Bile Acid Metabolism in the Gut

(2015) Jason M. Ridlon et al.   DIGESTIVE DISEASES

The role of bile acids in reducing the metabolic complications of obesity after bariatric surgery: a systematic review

(2015) N C Penney et al.   INTERNATIONAL JOURNAL OF OBESITY

LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes

(2015) Pingping Li et al.   NATURE MEDICINE

Metabolic Mechanisms in Obesity and Type 2 Diabetes: Insights from Bariatric/Metabolic Surgery

(2015) Adriana Florinela Cătoi et al.   Obesity Facts

The role of pancreatic ducts in the pathogenesis of acute pancreatitis

(2015) Peter Hegyi et al.   PANCREATOLOGY

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

(2015) Changtao Jiang et al.   Nature Communications

Colonic inflammation and secondary bile acids in alcoholic cirrhosis

(2014) Genta Kakiyama et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Novel Mechanistic Insights into Ectodomain Shedding of EGFR Ligands Amphiregulin and TGF- : Impact on Gastrointestinal Cancers Driven by Secondary Bile Acids

(2014) N. S. Nagathihalli et al.   CANCER RESEARCH

Adipocyte Inflammation Is Essential for Healthy Adipose Tissue Expansion and Remodeling

(2014) Ingrid Wernstedt Asterholm et al.   Cell Metabolism

The role of the microbiota in inflammation, carcinogenesis, and cancer therapy

(2014) Amiran Dzutsev et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Nicotine Promotes Initiation and Progression of KRAS-Induced Pancreatic Cancer via Gata6-Dependent Dedifferentiation of Acinar Cells in Mice

(2014) Patrick C. Hermann et al.   GASTROENTEROLOGY

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

(2014) Changtao Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Interplay of host microbiota, genetic perturbations, and inflammation promotes local development of intestinal neoplasms in mice

(2014) Gerold Bongers et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Artificial sweeteners induce glucose intolerance by altering the gut microbiota

(2014) Jotham Suez et al.   NATURE

Increased Risk of Colorectal Cancer After Obesity Surgery

(2013) Maryam Derogar et al.   ANNALS OF SURGERY

Chronic pancreatitis: A path to pancreatic cancer

(2013) Andreia V. Pinho et al.   CANCER LETTERS

Immunobiology of mesenchymal stem cells

(2013) S Ma et al.   CELL DEATH AND DIFFERENTIATION

Human Insulin Resistance Is Associated With Increased Plasma Levels of 12 -Hydroxylated Bile Acids

(2013) R. A. Haeusler et al.   DIABETES

Models of Acute and Chronic Pancreatitis

(2013) Markus M. Lerch et al.   GASTROENTEROLOGY

The Epidemiology of Pancreatitis and Pancreatic Cancer

(2013) Dhiraj Yadav et al.   GASTROENTEROLOGY

Carcinogenesis of Pancreatic Adenocarcinoma: Precursor Lesions

(2013) Antonio Gnoni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pancreatic Acinar Cell Nuclear Factor κB Activation Because of Bile Acid Exposure Is Dependent on Calcineurin

(2013) Kamaldeen A. Muili et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diagnostic criteria for pancreaticobiliary maljunction 2013

(2013) Terumi Kamisawa et al.   Journal of Hepato-Biliary-Pancreatic Sciences

Impact of oral vancomycin on gut microbiota, bile acid metabolism, and insulin sensitivity

(2013) Anne Vrieze et al.   JOURNAL OF HEPATOLOGY

The role of insulin and IGF system in pancreatic cancer

(2013) Marija Trajkovic-Arsic et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Bile acid accelerates erbB2-induced pro-tumorigenic activities in biliary tract cancer

(2013) Takuya Kitamura et al.   MOLECULAR CARCINOGENESIS

Hepatic Cannabinoid Receptor Type 1 Mediates Alcohol-Induced Regulation of Bile Acid Enzyme Genes Expression Via CREBH

(2013) Dipanjan Chanda et al.   PLoS One

EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis

(2012) Christine M. Ardito et al.   CANCER CELL

Regulation of intestinal epithelial permeability by tight junctions

(2012) Takuya Suzuki   CELLULAR AND MOLECULAR LIFE SCIENCES

Diabetes: Have We Got It All Wrong?: Hyperinsulinism as the culprit: surgery provides the evidence

(2012) W. J. Pories et al.   DIABETES CARE

Nuclear Receptors HNF4α and LRH-1 Cooperate in RegulatingCyp7a1 in Vivo

(2012) Serkan Kir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

KRASG12D- and BRAFV600E-Induced Transformation of Murine Pancreatic Epithelial Cells Requires MEK/ERK-Stimulated IGF1R Signaling

(2012) V. A. Appleman et al.   MOLECULAR CANCER RESEARCH

Farnesoid X Receptor Deficiency Improves Glucose Homeostasis in Mouse Models of Obesity

(2011) J. Prawitt et al.   DIABETES

The Bile Acid Membrane Receptor TGR5: A Valuable Metabolic Target

(2011) Thijs W.H. Pols et al.   DIGESTIVE DISEASES

Insulin receptor and cancer

(2011) A. Belfiore et al.   ENDOCRINE-RELATED CANCER

Reactive Oxygen Species Induced by Bile Acid Induce Apoptosis and Protect Against Necrosis in Pancreatic Acinar Cells

(2011) David M. Booth et al.   GASTROENTEROLOGY

Bile Acid Is a Host Factor That Regulates the Composition of the Cecal Microbiota in Rats

(2011) K.B.M. Saiful Islam et al.   GASTROENTEROLOGY

Glucose and Insulin Induction of Bile Acid Synthesis

(2011) Tiangang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Toll-Like Receptor 2 Pathway Establishes Colonization by a Commensal of the Human Microbiota

(2011) J. L. Round et al.   SCIENCE

Experimental bariatric surgery in rats generates a cytotoxic chemical environment in the gut contents

(2011) Jia Li   Frontiers in Microbiology

Colesevelam improves insulin resistance in a diet-induced obesity (F-DIO) rat model by increasing the release of GLP-1

(2010) Quan Shang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbidities

(2010) Rohit Kohli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Risk of Obesity-Related Cancer After Obesity Surgery in a Population-Based Cohort Study

(2010) Magdalena Plecka Östlund et al.   ANNALS OF SURGERY

Regulation of FXR transcriptional activity in health and disease: Emerging roles of FXR cofactors and post-translational modifications

(2010) Jongsook Kim Kemper   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The membrane-bound bile acid receptor TGR5 (Gpbar-1) is localized in the primary cilium of cholangiocytes

(2010) Verena Keitel et al.   BIOLOGICAL CHEMISTRY

Targeting EGFR/HER2 pathways enhances the antiproliferative effect of gemcitabine in biliary tract and gallbladder carcinomas

(2010) Ymera Pignochino et al.   BMC CANCER

Crosstalk between Insulin/Insulin-like Growth Factor-1 Receptors and G Protein-Coupled Receptor Signaling Systems: A Novel Target for the Antidiabetic Drug Metformin in Pancreatic Cancer

(2010) E. Rozengurt et al.   CLINICAL CANCER RESEARCH

Adult pancreatic acinar cells dedifferentiate to an embryonic progenitor phenotype with concomitant activation of a senescence programme that is present in chronic pancreatitis

(2010) A. V. Pinho et al.   GUT

Gender-dependent effect of Gpbar1 genetic deletion on the metabolic profiles of diet-induced obese mice

(2010) Galya Vassileva et al.   JOURNAL OF ENDOCRINOLOGY

Hydrophobic bile salts inhibit gallbladder smooth muscle function via stimulation of GPBAR1 receptors and activation of KATPchannels

(2010) Brigitte Lavoie et al.   JOURNAL OF PHYSIOLOGY-LONDON

Experimental acute biliary pancreatitis induced by retrograde infusion of bile acids into the mouse pancreatic duct

(2010) George Perides et al.   Nature Protocols

Diabesity: an overview of a rising epidemic

(2010) Y. M. K. Farag et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Dietary fat and bile juice, but not obesity, are responsible for the increase in small intestinal permeability induced through the suppression of tight junction protein expression in LETO and OLETF rats

(2010) Takuya Suzuki et al.   Nutrition & Metabolism

Context-Dependent Transformation of Adult Pancreatic Cells by Oncogenic K-Ras

(2009) Sharon Y. Gidekel Friedlander et al.   CANCER CELL

Glycemic Index, Carbohydrates, Glycemic Load, and the Risk of Pancreatic Cancer in a Prospective Cohort Study

(2009) L. Jiao et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

HER2 overexpression correlates with survival after curative resection of pancreatic cancer

(2009) Masahiro Komoto et al.   CANCER SCIENCE

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

(2009) Charles Thomas et al.   Cell Metabolism

Biliary Acute Pancreatitis in Mice is Mediated by the G-Protein−Coupled Cell Surface Bile Acid Receptor Gpbar1

(2009) George Perides et al.   GASTROENTEROLOGY

The Role of Bile Acids in Gallstone-Induced Pancreatitis

(2009) Markus M. Lerch et al.   GASTROENTEROLOGY

Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation

(2009) G. Solinas et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Bile acid-activated receptors in the treatment of dyslipidemia and related disorders

(2009) Stefano Fiorucci et al.   PROGRESS IN LIPID RESEARCH

Insulin, insulin-like growth factors and neoplasia

(2008) Michael Pollak   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Matrilysin (MMP-7) Is a Novel Broadly Expressed Tumor Antigen Recognized by Antigen-Specific T Cells

(2008) Y. Yokoyama et al.   CLINICAL CANCER RESEARCH

Novel Potent and Selective Bile Acid Derivatives as TGR5 Agonists: Biological Screening, Structure−Activity Relationships, and Molecular Modeling Studies

(2008) Hiroyuki Sato et al.   JOURNAL OF MEDICINAL CHEMISTRY