Review
Food Science & Technology
Felipe Mendes Delpino, Lilian Munhoz Figueiredo
Summary: The systematic review with meta-analysis showed that resveratrol supplementation has protective effects on diabetes parameters. The analysis revealed significant reduction in insulin resistance and glycated hemoglobin, and a significant impact on fasting blood glucose in individuals with diabetes.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Beatriz Isabel Garcia-Martinez, Mirna Ruiz-Ramos, Jose Pedraza-Chaverri, Edelmiro Santiago-Osorio, Victor Manuel Mendoza-Nunez
Summary: The findings of the study indicate that resveratrol has a significant dose-response effect on glucose concentrations, HbA1c, and insulin levels. However, there is currently no established therapeutic dose.
Article
Endocrinology & Metabolism
Samuel Dagogo-Jack, Robert Frederich, Jie Liu, Christopher P. Cannon, Harry Shi, David Z. Cherney, Francesco Cosentino, Urszula Masiukiewicz, Ira Gantz, Richard E. Pratley
Summary: In the VERTIS CV trial, ertugliflozin treatment decreased the likelihood of insulin initiation, delayed the time to insulin initiation by up to approximately 1.8 years, and reduced insulin dose requirements without increasing the incidence of hypoglycemia events.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Wanying Su, Meiyi Tao, Lin Ma, Ke Tang, Fang Xiong, Xuan Dai, Yuelan Qin
Summary: This meta-analysis confirms the beneficial impact of resistance training (RT) on glycated hemoglobin (HbA1c) and fasting blood glucose (FBG) levels in patients with type 2 diabetes mellitus (T2DM). Additionally, the study identifies critical training parameters that are important for enhancing HbA1c and FBG reductions.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Shi Tai, Liyao Fu, Ningjie Zhang, Ying Zhou, Zhenhua Xing, Yongjun Wang
Summary: The triglyceride-glucose (TyG) index is associated with the occurrence of cardiovascular events in patients with type 2 diabetes mellitus (T2DM). High and very high TyG index trajectories are associated with a greater risk of future cardiovascular events.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Food Science & Technology
Felipe Mendes Delpino, Lilian Munhoz Figueiredo, Bruna Goncalves Cordeiro da Silva, Taiciane Goncalves da Silva, Gicele Costa Mintem, Renata Moraes Bielemann, Denise Petrucci Gigante
Summary: The study found that omega-3 supplementation has significant effects in reducing fasting blood glucose and insulin resistance, but not on glycated hemoglobin levels in diabetes.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Medicine, General & Internal
Trinitat Cambras, Odile Romero, Antoni Diez-Noguera, Albert Lecube, Gabriel Sampol
Summary: The study revealed a high prevalence of sleep apnea and circadian rhythm abnormalities in patients with diabetes, which were associated with poor glycemic control.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Mohammed Ewid, Abdullah Saleh Algoblan, Elzaki M. Elzaki, Mohamad Ayham Muqresh, Ahmad Riad Al Khalifa, Albaraa Muad Alshargabi, Shahad Abdullah Alotaibi, Abdullah Saleh Alfayez, Mervat Naguib
Summary: This study assessed the prevalence and factors related to suboptimal glycemic control and complications in a group of patients with type 2 diabetes. The results showed that longer disease duration was significantly associated with poor glycemic control, while age was independently associated with macrovascular complications. Hyperlipidemia was significantly associated with neuropathy and retinopathy. Lower physical activity was independently associated with neuropathy.
Review
Nutrition & Dietetics
Felipe Mendes Delpino, Lilian Munhoz Figueiredo, Bruno Pereira Nunes
Summary: This study reviewed randomized clinical trials on the effects of melatonin supplementation in diabetes and found that melatonin can help reduce diabetes parameters such as fasting blood glucose, glycated hemoglobin, and insulin resistance compared to placebo.
CLINICAL NUTRITION
(2021)
Article
Endocrinology & Metabolism
Katherine A. Sauder, Jeanette M. Stafford, Shelley Ehrlich, Jean M. Lawrence, Angela D. Liese, Santica Marcovina, Amy K. Mottl, Catherine Pihoker, Sharon Saydah, Amy S. Shah, Ralph B. D'Agostino, Dana Dabelea
Summary: Disparities in HbA(1c) testing frequency were observed primarily based on health care-related factors, which were associated with diabetes outcomes in type 1 diabetes. Higher frequency of HbA(1c) testing was linked to lower HbA(1c) levels and decreased odds of microvascular complications over time. However, these associations were attenuated after adjusting for HbA(1c) testing correlates.
Article
Nutrition & Dietetics
Arpita Basu, Andrew Hooyman, Leigh Ann Richardson, Amy C. Alman, Janet K. Snell-Bergeon
Summary: This study found an inverse association between dietary fiber intake and glycemic control in adults with prediabetes, but not in those with type 1 diabetes. This suggests that dietary fiber may have a protective effect on glycemic control in individuals at risk of developing diabetes.
Article
Medicine, General & Internal
You-Ting Lin, Wei-Lun Huang, Hung-Pin Wu, Man-Ping Chang, Ching-Chu Chen
Summary: This study found that mean HbA1c was consistently associated with HF in patients with T2DM, while the association with HbA1c variability disappeared. Patients with HbA1c-Mean <7% and high variability in HbA1c showed comparable risk of HF to those with HbA1c-Mean>=8%. In addition to absolute HbA1c level, stability of HbA1c was also important for preventing HF in patients with T2DM.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Hye Soon Kim, Jae Myung Yu, Hak Chul Jang, Eui Kwang Choi, Jeong Hyun Park, Ho Sang Shon, Choon Hee Chung, Keun-Gyu Park, Jae Hyoung Cho, Won Kim, Kyoung Hwa Lee, Jee Hyun Lee, Soon Jib Yoo
Summary: This study explored the pattern and clinical effectiveness of the use of rapid-acting insulins (RAIs) in Korean patients with type 2 diabetes mellitus (T2DM). The results showed that the use of insulin glulisine significantly reduced glycated hemoglobin, fasting plasma glucose, and post prandial blood glucose levels, but led to an increase in body weight. Additionally, the intensive regimen (basal insulin+>= 2 RAI injections/day) was more effective in achieving glycemic targets.
DIABETES METABOLIC SYNDROME AND OBESITY
(2022)
Review
Endocrinology & Metabolism
Anders L. Carlson, Timothy Dilon Daniel, Andrea DeSantis, Serge Jabbour, Esra Karslioglu French, Davida Kruger, Eden Miller, Kerem Ozer, Tom Elliott
Summary: This real-world study and meta-analysis showed that the use of flash glucose monitoring technology led to a significant reduction in HbA1c levels in adults with type 2 diabetes managed with basal insulin. The improvement in HbA1c was observed across different demographics and durations of insulin use.
BMJ OPEN DIABETES RESEARCH & CARE
(2022)
Article
Endocrinology & Metabolism
Abrar M. Al-Mutairi, Mohammad A. Alshabeeb, Salah Abohelaika, Fadhel A. Alomar, Keshore R. Bidasee
Summary: This study investigated the impact of telemedicine on glycemic control in patients with type 2 diabetes during the COVID-19 lockdown in Saudi Arabia. The results showed that 63.1% of patients maintained good glycemic control and some patients showed improvement through telemedicine. Male patients had better glycemic control compared to female patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Cristina Morelli, Vincenzo Formica, Silvia Riondino, Antonio Russo, Patrizia Ferroni, Fiorella Guadagni, Mario Roselli
Summary: The study discusses the potential link between RAS, BRAF, and microsatellite instability with the efficacy of oxaliplatin and irinotecan in chemotherapy. KRAS mutation increases sensitivity to oxaliplatin, while limited data is available on the efficacy of BRAF mutations. Irinotecan shows enhanced cytotoxicity to MSI cell lines due to the involvement of mismatch repair components in DNA repair processes.
CURRENT MEDICINAL CHEMISTRY
(2021)
Review
Oncology
V. Formica, C. Morelli, A. Patrikidou, KK. Shiu, A. Nardecchia, J. Lucchetti, M. Roselli, HT. Arkenau
Summary: PD-L1 positive patients derive significant survival benefit from immune checkpoint inhibitors in gastro-oesophageal junction/gastric cancer, with other predictors needed for further refining patient selection.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Medicine, General & Internal
Vincenzo Formica, Jessica Lucchetti, Elena Doldo, Silvia Riondino, Cristina Morelli, Renato Argiro, Nicola Renzi, Daniele Nitti, Antonella Nardecchia, Emanuela Dell'Aquila, Patrizia Ferroni, Fiorella Guadagni, Giampiero Palmieri, Augusto Orlandi, Mario Roselli
Summary: This study demonstrates that mutational analysis through plasma can better predict survival outcomes for colorectal cancer patients, compared to relying solely on tumor tissue analysis. Plasma mutations further refine prognosis and can help guide clinical management.
JOURNAL OF CLINICAL MEDICINE
(2021)
Meeting Abstract
Oncology
C. Morelli, V. Formica, E. Doldo, S. Riondino, M. Rofei, G. Palmieri, A. Orlandi, M. Roselli
ANNALS OF ONCOLOGY
(2021)
Article
Cell Biology
David Della-Morte, Francesca Pacifici, Camillo Ricordi, Renato Massoud, Valentina Rovella, Stefania Proietti, Mariannina Iozzo, Davide Lauro, Sergio Bernardini, Stefano Bonassi, Nicola Di Daniele
Summary: This study found a significant association between low plasminogen levels and inflammatory markers, coagulation markers, and organ dysfunction markers in COVID-19 patients. Plasminogen may play a vital role in controlling the complex mechanisms behind the complications of COVID-19, serving as both a biomarker for prognosis and a potential therapeutic target.
CELL DEATH & DISEASE
(2021)
Review
Nutrition & Dietetics
Francesca Pacifici, Valentina Rovella, Donatella Pastore, Alfonso Bellia, Pasquale Abete, Giulia Donadel, Silvia Santini, Heinz Beck, Camillo Ricordi, Nicola Di Daniele, Davide Lauro, David Della-Morte
Summary: This article reviewed the association between polyphenols and stroke protection, including prevention, acute phase effects, and rehabilitation. These compounds have clinical relevance in reducing vascular risk factors for stroke.
Review
Biochemistry & Molecular Biology
Giovanni Maria Iannantuono, Francesco Torino, Roberto Rosenfeld, Simona Guerriero, Manuela Carlucci, Stefano Sganga, Barbara Capotondi, Silvia Riondino, Mario Roselli
Summary: Precision medicine has ushered in a new era in anti-cancer drug development by focusing on biomarkers predictive of treatment response regardless of tumor histology. Although there have been histology-agnostic drugs approved by the FDA in recent years, the efficacy data for metastatic castration-resistant prostate cancer patients is still limited. Therefore, large multi-institutional registries are needed to collect real-world data.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Health Care Sciences & Services
Roberto Rosenfeld, Silvia Riondino, Vincenzo Formica, Francesco Torino, Eugenio Martuscelli, Mario Roselli
Summary: Breast cancer is the most common type of cancer in women, and the chemotherapy drug doxorubicin can cause heart toxicity. Early diagnosis of heart toxicity is important to prevent complications. Non-coding RNA, specifically microRNA and circular RNA, are being researched as potential biomarkers for early detection. Further studies are needed to understand the mechanisms and develop reliable detection methods.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Oncology
Valentina Russo, Eleonora Lallo, Armelle Munnia, Miriana Spedicato, Luca Messerini, Romina D'Aurizio, Elia Giuseppe Ceroni, Giulia Brunelli, Antonio Galvano, Antonio Russo, Ida Landini, Stefania Nobili, Marcello Ceppi, Marco Bruzzone, Fabio Cianchi, Fabio Staderini, Mario Roselli, Silvia Riondino, Patrizia Ferroni, Fiorella Guadagni, Enrico Mini, Marco Peluso
Summary: Metastatic colorectal cancer (mCRC) has a high incidence and mortality rate. Innovative biomarkers have been developed for predicting treatment response. By analyzing specific narrative publications, this study examines the ability of learning methods to build predictive models for mCRC patients, either for chemotherapy alone or combined with targeted therapy. The results show promising outcomes in predicting treatment response or toxic side-effects. Radiomics and molecular biomarkers are able to accurately identify responders and non-responders in the majority of patients.
Article
Biochemistry & Molecular Biology
Patrizia Ferroni, Raffaele Palmirotta, Gabriella Egeo, Cinzia Aurilia, Maria Giovanna Valente, Antonella Spila, Alberto Pierallini, Piero Barbanti, Fiorella Guadagni
Summary: The study investigates the association between white matter hyperintensities (WMHs) and genetic pro-inflammatory/pro-oxidative status in migraine patients. The results show no significant difference in gene polymorphisms between patients and controls. However, specific alleles of the lymphotoxin alpha (LTA) and superoxide dismutase 1 (SOD1) genes are associated with WMHs. This suggests that an imbalance between pro-inflammatory/pro-oxidative and antioxidant events may contribute to the development of WMHs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Marco Infante, Massimo Pieri, Santina Lupisella, Ali Mohamad, Sergio Bernardini, David Della-Morte, Andrea Fabbri, Alberto De Stefano, Marco Iannetta, Lorenzo Ansaldo, Angela Crea, Massimo Andreoni, Maria Morello
Summary: Type 2 diabetes mellitus and impaired kidney function are linked to a higher risk of adverse outcomes in COVID-19. This study found that admission estimated glomerular filtration rate and white blood cell count were significantly associated with in-hospital mortality among patients with diabetes and COVID-19.
CURRENT MEDICAL RESEARCH AND OPINION
(2023)
Article
Immunology
Marco Infante, Laura Vitiello, Andrea Fabbri, Camillo Ricordi, Nathalia Padilla, Francesca Pacifici, Pasquale Di Perna, Marina Passeri, David Della-Morte, Massimiliano Caprio, Luigi Uccioli
Summary: We describe a case of a 22-year-old Italian man with new-onset type 1 diabetes who experienced an unusually prolonged clinical remission phase (31 months). The patient was treated with calcifediol and low-dose insulin, resulting in the maintenance of residual beta-cell function and clinical remission. This may be attributed to the immunoregulatory properties of calcifediol.
Article
Oncology
Silvia Riondino, Vincenzo Formica, Elena Valenzi, Cristina Morelli, Valeria Flaminio, Ilaria Portarena, Francesco Torino, Mario Roselli
Summary: This study aimed to identify a cut-off point of body mass index (BMI) that would have a significant prognostic impact on stage I-II BC patients receiving AI treatment. The results showed that a BMI cut-off >29 was associated with a deteriorating disease-free survival (DFS) in AI-treated BC patients, indicating that obesity is a risk factor for recurrence in breast cancer.
