Article
Gastroenterology & Hepatology
Julien Kirchgesner, Rishi J. Desai, Maria C. Schneeweiss, Laurent Beaugerie, Sebastian Schneeweiss, Seoyoung C. Kim
Summary: Combination therapy with vedolizumab and thiopurines is associated with a lower risk of treatment failure compared to vedolizumab monotherapy in patients with CD, but the effect is less pronounced in UC.
Article
Gastroenterology & Hepatology
Jurij Hanzel, Peter Bossuyt, Valerie Pittet, Mark Samaan, Monika Tripathi, Wladyslawa Czuber-Dochan, Johan Burisch, Salvatore Leone, Roberto Saldana, Filip Baert, Uri Kopylov, Susanna Jaghult, Michel Adamina, Naila Arebi, Krisztina Gecse
Summary: This study aimed to develop a core outcome set for real-world studies in adult patients with inflammatory bowel disease (IBD). Candidate outcomes and outcome measures were identified through a systematic review and a modified Delphi consensus process. The international panel agreed on the final core outcome set, which will facilitate the synthesis and generation of real-world evidence.
JOURNAL OF CROHNS & COLITIS
(2023)
Review
Immunology
Reza Yarani, Ali Shojaeian, Oana Palasca, Nadezhda T. Doncheva, Lars Juhl Jensen, Jan Gorodkin, Flemming Pociot
Summary: This review discusses the differential regulation of miRNAs in inflammatory bowel disease (IBD) and their potential diagnostic and therapeutic applications. Through literature curation and computational analysis, a consensus set of differentially expressed miRNAs in mucosal tissues was obtained. The role of these miRNAs and their potential targets in IBD are highlighted.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Tatsuki Noguchi, Soichiro Ishihara, Motoi Uchino, Hiroki Ikeuchi, Koji Okabayashi, Kitaro Futami, Shinji Tanaka, Hiroki Ohge, Hisashi Nagahara, Kazuhiro Watanabe, Michio Itabashi, Kinya Okamoto, Yoshiki Okita, Tsunekazu Mizushima, Yusuke Mizuuchi, Kazutaka Yamada, Yoshifumi Shimada, Yu Sato, Hideaki Kimura, Kenichi Takahashi, Koya Hida, Yusuke Kinugasa, Junji Okuda, Koji Daito, Fumikazu Koyama, Hideki Ueno, Takayuki Yamamoto, Tsunekazu Hanai, Atsuo Maemoto, Koji Oba, Yoichi Ajioka, Kenichi Sugihara
Summary: Patients with longstanding inflammatory bowel disease, such as ulcerative colitis and Crohn's disease, are at high risk of developing intestinal cancers. This study found significant differences between intestinal cancers associated with ulcerative colitis and Crohn's disease. Crohn's disease-associated cancers were diagnosed at more advanced stages, detected less frequently by surveillance, and had a poorer prognosis compared to those associated with ulcerative colitis.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Biochemical Research Methods
Florent Clerc, Karli R. Reiding, Noortje de Haan, Carolien A. M. Koeleman, Agnes L. Hipgrave Ederveen, Natalia Manetti, Viktoria Dotz, Vito Annese, Manfred Wuhrer
Summary: This study investigates the associations of immunoglobulin A1 and A2 glycosylation with inflammatory bowel diseases (IBD). Differences in IgA O- and N-glycosylation between patient groups were found to be associated with the diseases, and a statistical model was constructed to predict the disease group of the patients. These findings contribute to the development of noninvasive biomarkers for IBD and improvement in patient care.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Amy L. Lightner, Sarah Vogler, John McMichael, Xue Jia, Miguel Regueiro, Taha Qazi, Scott R. Steele
Summary: While UC patients were more likely to have neoplasia detected during colonoscopy, the rates of progression from LGD and HGD to adenocarcinoma were equivalent in UC and CD, suggesting consistent endoscopic surveillance strategies for all IBD patients.
JOURNAL OF CROHNS & COLITIS
(2021)
Review
Genetics & Heredity
Sara Jarmakiewicz-Czaja, Magdalena Zielinska, Aneta Sokal, Rafal Filip
Summary: This review examines the genetic factors associated with inflammatory bowel disease (IBD), including disease predisposition and pharmacogenetics.
Article
Public, Environmental & Occupational Health
Kasper Monsted Pedersen, Yunus Colak, Signe Vedel-Krogh, Camilla Jannie Kobylecki, Stig Egil Bojesen, Borge Gronne Nordestgaard
Summary: The study found that smoking was associated with an increased risk of ulcerative colitis, while offering potential protection against Crohn's disease. However, genetic evidence did not support a causal relationship between smoking intensity and the development of these inflammatory bowel diseases.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Clement Bresteau, Aurelien Amiot, Julien Kirchgesner, Nicola De'Angelis, Jeremie H. Lefevre, Yoram Bouhnik, Yves Panis, Laurent Beaugerie, Matthieu Allez, Antoine Brouquet, Franck Carbonnel, Antoine Meyer
Summary: A retrospective study of 247 patients who underwent IPAA surgery between 2011 and 2019 found a 5-year cumulative incidence of CP or CDP of 35.3%. Risk factors included IBDU diagnosis, age less than 35 at surgery, articular manifestations, and other extra-intestinal manifestations.
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Gastroenterology & Hepatology
Antoine Meyer, Catherine Dong, Corinne Casagrande, Simon S. M. Chan, Inge Huybrechts, Genevieve Nicolas, Fernanda Rauber, Renata Bertazzi Levy, Christopher Millett, Bas Oldenburg, Elisabete Weiderpass, Alicia K. Heath, Tammy Y. N. Tong, Anne Tjonneland, Cecilie Kyro, Rudolf Kaaks, Verena A. Katzke, Manuela M. Bergman, Domenico Palli, Giovanna Masala, Rosario Tumino, Carlotta Sacerdote, Sandra M. Colorado-Yohar, Maria-Jose Sanchez, Olof Grip, Stefan Lindgren, Robert Luben, Marc J. Gunter, Yahya Mahamat-Saleh, Marie-Christine Boutron-Ruault, Franck Carbonnel
Summary: The study found that consuming unprocessed/minimally processed foods is associated with a lower risk of Crohn's disease, but not with the risk of ulcerative colitis.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Julian Hercun, Justin Cote-Daigneault, Raymond G. Lahaie, Carole Richard, Ramses Wassef, Pierre Poitras
Summary: The study found that Crohn's disease can develop postoperatively with an increasing cumulative incidence over time. Preoperative predictive factors are limited and should not determine candidacy for surgery. Most patients have favorable outcomes with medical therapy, while 16% of Crohn's disease patients require pouch removal.
DISEASES OF THE COLON & RECTUM
(2021)
Article
Gastroenterology & Hepatology
Anika Varma, Jennifer Weinstein, Jamison Seabury, Spencer Rosero, Ellen Wagner, Christine Zizzi, Elizabeth Luebbe, Nuran Dilek, Michael McDermott, John Heatwole, Lawrence Saubermann, Larissa Temple, Scott Rogoff, Chad Heatwole
Summary: This study aimed to identify the most prevalent and impactful symptoms in patients with Crohn's disease (CD) and to determine the modifying factors associated with a higher disease burden in CD.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Scott Friedberg, David Choi, Thomas Hunold, Natalie K. Choi, Nicole M. Garcia, Emma A. Picker, Nathaniel A. Cohen, Russell D. Cohen, Sushila R. Dalal, Joel Pekow, Atsushi Sakuraba, Noa Krugliak Cleveland, David T. Rubin
Summary: In this study, the authors reported a large real-world experience with the use of upadacitinib in patients with ulcerative colitis and Crohn's disease. They found that upadacitinib was rapidly effective and safe, even in patients who had prior exposure to tofacitinib.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Michael Due Larsen, Bente Mertz Norgard, Jens Kjeldsen
Summary: This study aimed to evaluate the prognostic impact of disease activity after 14 weeks of biologic therapy on surgery and steroid-free remission in patients with Crohn's disease and ulcerative colitis. The study found that a positive treatment response to biologic therapy predicted a better short-term outcome in CD and UC patients.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Gastroenterology & Hepatology
Hamed Khalili, Niclas Hakansson, Kevin Casey, Emily Lopes, Jonas F. Ludvigsson, Andrew T. Chan, Simon S. M. Chan, Ola Olen, Alicja Wolk
Summary: This study found that certain healthy eating patterns were associated with a lower risk of older-onset Crohn's disease, but not with the risk of ulcerative colitis.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Balakrishnan Vijayalekshmi, Anand Sharma, Savit B. Prabhu, Sukesh C. Nair, Joy Mammen, Ashish Goel, Uday George Zachariah, Amit Kumar Dutta, Kunissery A. Balasubramanian, Elwyn Elias, Chundamannil E. Eapen
Summary: The study aimed to assess reticuloendothelial activation in patients with severe alcoholic hepatitis, finding that the reticuloendothelial system was markedly activated and correlated with disease severity in these patients, with von Willebrand factor independently predicting short-term mortality.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Rajesh Sanjeevi, Kapil Dev Jamwal, Sudipta Dhar Howdhury, Balamurugan Ramadass, R. Gayathri, Amit Kumar Dutta, Anjilivelil Joseph Joseph, Balakrishnan S. Ramakrishna, Ashok Chacko
Summary: SIBO is not uncommon in chronic pancreatitis patients, with GHBT showing high specificity in its diagnosis.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Public, Environmental & Occupational Health
Amol Prabhakar Patil, Ebby George Simon, Amit Kumar Dutta, Anjilivelil Joseph Joseph, Reuben Thomas Kurien, Sudipta Dhar Chowdhury
Summary: Patients with inflammatory bowel disease are at risk of hepatitis B infection. There is a need to raise awareness among physicians regarding the importance of screening and vaccination for hepatitis B in these patients. Risk factors for positive viral markers include age, non-inflammatory bowel disease-related surgery, and hospital admission.
Article
Gastroenterology & Hepatology
Shivaram Prasad Singh, Vineet Ahuja, Uday C. Ghoshal, Govind Makharia, Usha Dutta, Showkat Ali Zargar, Jayanthi Venkataraman, Amit Kumar Dutta, Asish K. Mukhopadhyay, Ayaskanta Singh, Babu Ram Thapa, Kim Vaiphei, Malathi Sathiyasekaran, Manoj K. Sahu, Niranjan Rout, Philip Abraham, Prakash Chandra Dalai, Pravin Rathi, Saroj K. Sinha, Shobna Bhatia, Susama Patra, Ujjala Ghoshal, Ujjal Poddar, Venigalla Pratap Mouli, Vikram Kate
Summary: The Indian Society of Gastroenterology formed a Task Force on Helicobacter pylori to produce consensus statements on the infection. Twenty-five experts from various fields participated in the process, reviewing literature and developing statements through a modified Delphi process. The resulting consensus serves as a guide for the diagnosis and management of H. pylori infection and future research in the field.
INDIAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Amit K. Dutta, Rosalind Mitchell-Hay, Gabriella Baio, Perminder S. Phull
Summary: Incidental colorectal abnormalities detected on PET-CT scans are often clinically significant, but careful selection for colonoscopy is important due to poor survival in these patients related to the underlying primary malignancy.
JOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY
(2022)
Review
Gastroenterology & Hepatology
Amit Kumar Dutta, Perminder Singh Phull
Summary: Treatment options for H.pylori infection in patients with penicillin allergy include first-line Bismuth-based quadruple therapy for 10-14 days, and second-line Levoflaxacin-based triple therapy for 10 days. Patients with persistent infection after 2 treatment courses should be tested for penicillin allergy, and treatment should be guided by H.pylori culture and sensitivity testing results.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Susanna K. Jose, Betty Simon, Ebby George Simon, Anu Eapen, Reetu A. John, Tharani Putta, Amit Kumar Dutta, Anna B. Pulimood
Summary: The study found a modest correlation between MEGS and faecal calprotectin, CRP level, and Harvey Bradshaw index in patients with Crohn's disease. In patients with terminal ileal disease, there was a strong correlation between segmental MEGS and Simple Endoscopic Score. Mural thickness was found to be the only MRE parameter correlated with active disease.
ABDOMINAL RADIOLOGY
(2022)
Review
Gastroenterology & Hepatology
Arshdeep Singh, Ramit Mahajan, Saurabh Kedia, Amit Kumar Dutta, Abhinav Anand, Charles N. Bernstein, Devendra Desai, C. Ganesh Pai, Govind Makharia, Harsh Vardhan Tevethia, Joyce W. Y. Mak, Kirandeep Kaur, Kiran Peddi, Mukesh Kumar Ranjan, Perttu Arkkila, Rakesh Kochhar, Rupa Banerjee, Saroj Kant Sinha, Siew Chien Ng, Stephen Hanauer, Suhang Verma, Usha Dutta, Vandana Midha, Varun Mehta, Vineet Ahuja, Ajit Sood
Summary: Inflammatory bowel disease (IBD) is now a global disease, with treatment mainly involving biologics and thiopurines, although their use is limited in developing countries. Thiopurines are critical for IBD patients in these regions, but face restrictions in usage.
INTESTINAL RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Rohan Yewale, Kartik Natarajan, Jeyaraj Ubal Dhus, Sarojini Ashok Parameswaran, Kallipatti Palaniswamy, Doraisamy Babu Vinish, Aravindh Somasundaram, Arulraj Ramakrishnan, Sibithooran Karmegam, Ramaswamy Saraswathy Arun, Ujjani Shankaraiah Manmohan, Balakrishnan Mahadevan, Baskkaran Harri Prasad, Toguluva Seshadri Chandrasekar, Bollu Janakan Gokul, Amit Dutta, Anjilivelil Joseph Joseph, Jayanthi Venkatraman, Panchapakesan Ganesh, Subramanyam Shanmuganathan, Palaniappan L. Alagammai, Ramalingam Ramasubramanian, Leelakrishnan Venkatakrishnan, Ramamoorthi Ganesan, Arunachalam Arun, Sankaranarayanan Srinivas, Mariappan Kannan, M. Shanmugam Revathy, Malathi Sathiyasekaran, Arulprakash Sarangapani, Natrajan Rajesh, Velusamy Arulselvan, Arumugam Aravind, Karunakaran Premkumar, Sampath Kavitha, Hema Vijayalakshmi Varadarajulu, Murugesan Manimaran, Pandurangan Basumani, Ananthavadivelu Murali, Balakrishnan Siddartha Ramakrishna
Summary: This study provides detailed information on the characteristics of IBD patients in Tamil Nadu, India, including disease types, clinical manifestations, treatment options, etc., which serves as an important reference for further understanding the situation of IBD in the region.
Article
Gastroenterology & Hepatology
Yogesh Kumar Gupta, Arshdeep Singh, Vikram Narang, Vandana Midha, Ramit Mahajan, Varun Mehta, Dharmatma Singh, Namita Bansal, Madeline Vithya Barnaba Durairaj, Amit Kumar Dutta, Ajit Sood
Summary: Inflammatory bowel disease (IBD) is increasingly recognized in elderly patients, and elderly-onset IBD in India has similar clinical characteristics to adult-onset IBD, although the disease is milder.
INTESTINAL RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Amit Kumar Dutta, Noriya Uedo, Deepu David, Jagan Chandramohan, Abhishek Jain, Itish Patnayak, Piyush Gupta, Bharath K. Ayapati, Kaushik Chatterjee, Rajeeb Jaleel, Reuben T. Kurien, Sudipta D. Chowdhury, Ebby G. Simon, Anjilivelil J. Joseph, Anna B. Pulimood
Summary: This study investigated the role of image-enhanced endoscopy in differentiating fundic gland polyps (FGP) from hyperplastic polyps (HP). The results showed that magnification narrow band imaging (mNBI) performed very well in distinguishing FGP from HP, with higher accuracy than conventional white light endoscopy (WLE).
INDIAN JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Gastroenterology & Hepatology
Arup Choudhury, Anuraag Jena, Vaneet Jearth, Amit K. Dutta, Govind Makharia, Usha Dutta, Mahesh Goenka, Rakesh Kochhar, Vishal Sharma
Summary: This systematic review examines the impact of proton pump inhibitors (PPI) on the absorption of vitamin B12 and finds that PPI use may increase the risk of vitamin B12 deficiency. Although some studies suggest a slightly higher risk of vitamin B12 deficiency in PPI users, the pooled analysis results are not clear enough, and better-designed prospective studies are needed to further clarify this issue.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Amit Kumar Dutta, Abhinav Jain, Vaneet Jearth, Ramit Mahajan, Manas Kumar Panigrahi, Vishal Sharma, Mahesh Kumar Goenka, Rakesh Kochhar, Govind Makharia, Duvvur Nageshwar Reddy, Richard Kirubakaran, Vineet Ahuja, Neha Berry, Naresh Bhat, Usha Dutta, Uday Chand Ghoshal, Ajay Jain, Umesh Jalihal, V. Jayanthi, Ajay Kumar, Sandeep Nijhawan, Ujjal Poddar, G. N. Ramesh, Shivram P. Singh, Showkat Zargar, Shobna Bhatia
Summary: Proton pump inhibitors (PPIs), commonly prescribed medications for gastric acid-related disorders, have raised safety concerns due to their association with adverse effects. Inappropriate use of PPIs is common, highlighting the need for PPI stewardship to ensure their appropriate use. The Indian Society of Gastroenterology has formulated guidelines based on a modified Delphi process to promote rational use of PPIs, providing clinicians with evidence-based recommendations for optimizing their use and promoting PPI stewardship.
INDIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Medicine, General & Internal
Royson Dsouza, Gigi Varghese, Deepa Rebecca Korula, Amit Kumar Dutta
Review
Medicine, General & Internal
Amit Kumar Dutta, Ashish Goel, Richard Kirubakaran, Ashok Chacko, Prathap Tharyan
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2020)
