Journal
CLINICAL IMMUNOLOGY
Volume 160, Issue 2, Pages 244-254Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2015.06.012
Keywords
Complement; Coagulation; Natural antibodies; B1 B cells; Pathogens; Cancer; SLE
Categories
Funding
- National Institutes of Health [R21 AI107005]
- National Bio and Agro-Defense Facility Fund
- Kansas State University
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The humoral innate immune system is composed of three major branches, complement, coagulation, and natural antibodies. To persist in the host, pathogens, such as bacteria, viruses, and cancers must evade parts of the innate humoral immune system. Disruptions in the humoral innate immune system also play a role in the development of autoimmune diseases. This review will examine how Gram positive bacteria, viruses, cancer, and the autoimmune conditions systemic lupus erythematosus and anti-phospholipid syndrome, interact with thee immune system components. Through examining evasion techniques it becomes clear that an interplay between these three systems exists. By exploring the interplay and the evasion/disruption of the humoral innate immune system, we can develop a better understanding of pathogenic infections, cancer, and autoimmune disease development. (C) 2015 Elsevier Inc. All rights reserved.
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