Journal
VIRUS RESEARCH
Volume 222, Issue -, Pages 106-112Publisher
ELSEVIER
DOI: 10.1016/j.virusres.2016.06.007
Keywords
Bovine herpesvirus I (BoHV-1); Herpes simplex virus 1 (HSV-1); Serum and glucocorticoid-regulated; protein kinases; Productive infection
Categories
Funding
- USDA-NIFA Competitive Grants Program [13-01041]
- Sitlington endowment
- Oklahoma Center for Respiratory and Infectious Diseases (National Institutes of Health Centers for Biomedical Research Excellence Grant) [P20GM103648]
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Serum and glucocorticoid-regulated protein kinases (SGK) are serine/threonine protein kinases that contain a catalytic domain resembling other protein kinases: AKT/protein kinase B, protein kinase A, and protein kinase C-Zeta for example. Unlike these constitutively expressed protein kinases, SGK1 RNA and protein levels are increased by growth factors and corticosteroids. Stress can directly stimulate SGK1 levels as well as stimulate bovine herpesvirus 1 (BoHV-1) and herpes simplex virus 1 (HSV-1) productive infection and reactivation from latency suggesting SGK1 can stimulate productive infection. For the first time, we provide evidence that a specific SGK inhibitor (GSK650394) significantly reduced BoHV-1 and HSV-1 replication in cultured cells. Proteins encoded by the three BoHV-1 immediate early genes (bICP0, bICP4, and bICP22) and two late proteins (VP16 and gE) were consistently reduced by GSK650394 during early stages of productive infection. In summary, these studies suggest SGK may stimulate viral replication following stressful stimuli. (C) 2016 Elsevier B.V. All rights reserved.
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