Journal
VIROLOGY
Volume 499, Issue -, Pages 278-287Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2016.07.008
Keywords
PRRSV; NSP1 alpha; Type I IFN; Nuclear export signal (NES)
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Funding
- National Natural Science Foundation of China [31170146, 31602076, 31370189, 31572550]
- Research Award Fund for Outstanding Young Scientist of Shandong Province [BS2014NY009, ZR2013CM023, ZR2015YL076]
- Funds for Distinguished Young Scientists of Shandong Province [JQ201411]
- Special Fund for Agro-scientific Research in the Public Interest [201303046, 2014CGPY04]
- Shandong Provincial Technology System of Modern Agricultural Industry [SDAIT-06-022-06]
- Taishan Scholars Project
- Agriculture and Food Research Initiative (AFRI) Competitive Grant of the US Department of Agriculture National Institute of Food and Agriculture (USDA-NIFA) [2013-67015-21243]
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The nonstructural protein 1 alpha (NSP1 alpha) of porcine reproductive and respiratory syndrome virus (PRRSV) is a nucleo-cytoplasmic protein that suppresses the production of type I interferon (IFN). In this study, we investigated the relationship between the subcellular distribution of NSP1 alpha and its inhibition of type I IFN. NSP1 alpha was found to contain the classical nuclear export signal (NES) and NSP1 alpha nuclear export was CRM-1-mediated. NSP1 alpha was shuttling between the nucleus and cytoplasm. We also showed that the nuclear export of NSP1 alpha was necessary for its ability for type I IFN inhibition. NSP1 alpha was also found to interact with CBP, which implies a possible mechanism of CBP degradation by NSP1 alpha. Taken together, our results describe a novel mechanism of PRRSV NSP1 alpha for type I IFN inhibition and suppression of the host innate antiviral response. (C) 2016 Published by Elsevier Inc.
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