Article
Medicine, General & Internal
Giulia Ciccarese, Astrid Herzum, Gaetano Serviddio, Corrado Occella, Aurora Parodi, Francesco Drago
Summary: HPV vaccines may have a therapeutic role in addition to standard treatments for anogenital warts and oral warts, especially for persistent lesions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Abbey B. Berenson, Jacqueline M. Hirth, Mihyun Chang
Summary: The study found variations in penile HPV infection prevalence among US males by race/ethnicity and age, with Black males and older age groups exhibiting higher prevalence. Even after controlling for confounders, certain populations still showed significantly elevated HPV infection prevalence.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Endocrinology & Metabolism
L. Di Bartolomeo, A. Motolese, M. Miraglia Del Giudice, C. Cuppari, G. Ceravolo, R. Chimenz, S. Sestito, M. Vaccaro, F. Borgia
Summary: This paper provides an overview of treatments available in children for HPV skin infections, including cryotherapy, medication therapy, and other therapies. The effectiveness of HPV vaccines in already infected patients is still being investigated.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Public, Environmental & Occupational Health
Pablo Daban-Lopez, Nicolas Francisco Fernandez-Martinez, Dafina Petrova, Miguel Rodriguez-Barranco, Jose Juan Jimenez-Moleon, Javier Gutierrez, Maria-Jose Sanchez
Summary: In this study, HPV infection was identified as a common risk factor for all anogenital cancers, with important epidemiological differences among specific cancer sites. Incidence of anogenital cancers showed a slight decrease over the past 30 years, except for vulvar cancer which saw a slight increase. Cervical cancer was found to be the main contributor to the burden of anogenital cancers, with significant improvements in all indicators compared to other cancer sites.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Dermatology
S. A. Braun, S. Silling, S. M. Schloer, S. C. Hofmann, B. Fritzen, F. Oellig, P. Lehmann, B. Homey, C. Assaf, S. Emmert, R. Foelster-Holst, C. Tigges, U. Wieland, A. Kreuter
Summary: In this study, it was found that anogenital warts in 5- to 12-year-old children are often associated with cutaneous HPV types, possibly due to horizontal transmission. HPV typing, in addition to comprehensive clinical and psychosocial evaluation, can potentially help in the assessment of these cases.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Immunology
Matthew Thomas Ferreira, Rossana Veronica Mendoza Lopez, Milena Giulia Goncalves, Silvaneide Ferreira, Bradley Sirak, Maria Luizai Baggio, Eduardo Lazcano-Ponce, Alan G. Nyitray, Anna R. Giuliano, Luisa L. Villa, Laura Sichero, Huiyi Lin, Jane Messina, Christine Pierce Campbell, Christine Gage, Donna J. Ingles, Kim Isaacs, Kayoko Kennedy, Andrea Bobanic, Shams Rahman, Matthew Schabath, Alan Nyitray, Julie Rathwell, Lenice Galan de Paula, Ricardo Cintra, Filomena Cernicchiaro, Graca Ribeiro, Rosaria Otero, Roberta Bocalon, Juliana Antunes, Fernanda Silva, Rossana Terreri, Aurelio Cruz Valdez, Rene de Jesus Alvear Vasquez, Oscar Rojas Juarez, Rossana del Carmen Gonzalez Sosa, Rosangel Rios Vences, Martha Huerta Segura, Alicia Rodriguez Galvan, Paula Roman Rodriguez, Ana Laura Landa Velez, Griselda Diaz Garcia, Veronica Chavez Abarca, Gisela Flores Quevedo, Maria del Pilar Hernandez Nevarez, Guillermina Sanchez Martinez, Adriana Ortiz Rojas, Carlos Omar Barrera Flores, Flavia Rotea Mangone, Ana Carolina Pavanelli
Summary: This study demonstrates the influence of HPV-16 nucleotide variability on the risk of persistent infection in the male genitalia for the first time. It suggests differences in the natural history of HPV-16 variants between men and women. The prevalence and persistence of HPV-16 variants in male external genitalia indicate unique characteristics compared to female infections.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Biotechnology & Applied Microbiology
Kandace L. Amend, Bruce Turnbull, Li Zhou, Morgan A. Marks, Christine Velicer, Patricia Saddier, John D. Seeger
Summary: This study assesses the safety of the 4-valent HPV vaccine in males and finds associations with same-day allergic reactions, ear infections, intracranial injury, cellulitis, and concussion. However, other adverse outcomes are determined to be more likely related to activities common in adolescent males rather than the vaccination itself.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Oncology
Gypsyamber D'Souza, Sakshi R. Tewari, Tanya Troy, Tim Waterboer, Linda Struijk, Rachel Castillo, Hannah Wright, Michael Shen, Brett Miles, Mattias Johansson, Hilary A. Robbins, Carole Fakhry
Summary: The study evaluated the selection of screening population for oropharyngeal cancer and found that using risk factors for oral HPV can enrich the population with high-risk HPV biomarkers. The results showed that compared to the general population, the prevalence of HPV16 biomarkers in the eligible screening population was significantly elevated.
Article
Immunology
Xinyi Zhou, Tian Tian, Zhen Lu, Yi-Fang Yu, Yuwei Li, Yiguo Zhou, Yi-Fan Lin, Carol Strong, Huachun Zou
Summary: This study aimed to assess the incidence, persistence, and clearance of anogenital HPV infections among MSM and the correlates. The results showed a high incidence and low clearance of anogenital HPV infection among MSM. Therefore, targeted HPV vaccination and promotion of safe sex are essential for this population.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Virology
Farideh Aghaeipour, Hamid Salehiniya, Hamid Abbaszadeh
Summary: The prevalence of HPV in oral lesions in Iran was found to be 21%, with the highest rates in Rasht (50%) and lip lesions (40%), and the lowest in normal mucosa (8%). The highest prevalence was observed in precancerous lesions (29%) and hairy leukoplakia (70%). Considering the fairly high prevalence of HPV, it is recommended to pay more attention to vaccination and treatment for HPV in Iran.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Otorhinolaryngology
Alyssa Larish, Linda Yin, Gretchen Glaser, Eric Moore, Jamie Bakkum-Gamez, David Routman, Daniel Ma, Daniel Price, Jeffrey Janus, Katharine Price, Ashish Chintakuntlawar, Michelle Neben-Wittich, Robert Foote, Kathryn Van Abel
Summary: The study found that 37.0% of women with HPV-positive oropharyngeal squamous cell carcinoma had a history of HPV-related anogenital disease, with the cervix being the most common site. Among those with a history, 94.1% required procedures to diagnose or treat HPV lesions.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Immunology
John D. Seeger, Kandace L. Amend, Bruce R. Turnbull, Li Zhou, Morgan A. Marks, Christine Velicer, Patricia Saddier
Summary: This study assessed the risk of new onset autoimmune conditions among males receiving the 4-valent human papillomavirus (HPV) vaccine (4vHPV), and the results showed that the incidence of autoimmune conditions among vaccinated males was similar to that among unvaccinated males.
Article
Infectious Diseases
Alexandra L. Hernandez, Rajiv Karthik, Murugesan Sivasubramanian, Anantharam Raghavendran, Shelly Lensing, Jeannette Y. Lee, Priya Abraham, Dilip Mathai, Joel M. Palefsky
Summary: This study found a high prevalence of oral HPV infection among HIV-positive Indian MSM, but oncogenic anogenital HPV types were relatively uncommon in this population. It is unknown what the impact of this distribution of oral HPV will be on oropharyngeal cancers.
BMC INFECTIOUS DISEASES
(2021)
Article
Virology
Lucijan Skubic, Lea Hosnjak, Jeannette P. Staheli, Michael R. Dyen, Rebecca M. Ducore, Lois M. A. Colgin, Anne D. Lewis, Mario Poljak
Summary: This study describes the first detection and characterization of papillomaviruses infecting Japanese macaques, with evidence of their etiological association with the development of original neoplasms. Molecular and phylogenetic analyses revealed distinct features of the two viruses, but additional experimental evidence is required for confirmation.
Article
Medicine, General & Internal
Massimo Giuliani, Tarik Gheit, Francesca Rollo, Massimo Tommasino, Alessandra Latini, Maria Benevolo, Barbara Pichi, Raul Pellini, Sandrine McKay-Chopin, Antonio Cristaudo, Eugenia Giuliani, Aldo Morrone, Maria Gabriella Dona
Summary: Predictors of oral infection differ between HIV-infected and uninfected men who have sex with men (MSM), as well as between alpha and beta/gamma HPVs.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Devyani Gholap, Sharayu Mhatre, Pankaj Chaturvedi, Sudhir Nair, Tarik Gheit, Massimo Tommasino, Rajesh Dikshit
Summary: This study examined the prevalence of HPV subtypes in different sub-sites of HNC in the western region of India. The prevalence of HPV was found to be 28.43%, 41.67%, 38.89%, and 15.79% in the oral cavity, oropharynx, hypopharynx, and larynx tumor tissues, respectively. HPV 16 genotype was the most common subtype in all HNC tumor tissues.
ECANCERMEDICALSCIENCE
(2022)
Article
Oncology
Jessica L. Castilho, Aihua Bian, Cathy A. Jenkins, Bryan E. Shepherd, Keith Sigel, M. John Gill, Mari M. Kitahata, Michael J. Silverberg, Angel M. Mayor, Sally B. Coburn, Dorothy Wiley, Chad J. Achenbach, Vincent C. Marconi, Ronald J. Bosch, Michael A. Horberg, Charles S. Rabkin, Sonia Napravnik, Richard M. Novak, W. Christopher Mathews, Jennifer E. Thorne, Jing Sun, Keri N. Althoff, Richard D. Moore, Timothy R. Sterling, Staci L. Sudenga
Summary: Low CD4/CD8 ratio is associated with increased cancer risk in PWH in the USA and Canada.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Immunology
Mariana Lopez-Filloy, Flor J. Cortez, Tarik Gheit, Omar Cruz y Cruz, Fernando Cruz-Talonia, Monserrat Chavez-Torres, Cristina Arteaga-Gomez, Ismael Mancilla-Herrera, Juan J. Montesinos, Victor Adrian Cortes-Morales, Cecilia Aguilar, Massimo Tommasino, Sandra Pinto-Cardoso, Leticia Rocha-Zavaleta
Summary: Cervical ectopy, a benign condition in the lower genital tract, is common among reproductive-age women. Although it is considered a physiological condition, some women experience symptoms that require medical intervention. While cervical ectopy is not linked to cervical cancer, it may facilitate the acquisition of sexually transmitted diseases. This study examined the presence of HPV and its impact on the cervicovaginal microenvironment in women with symptomatic cervical ectopy. The results showed that HPV infection and dysbiotic vaginal communities were associated with delayed recovery of the cervical epithelium and increased risk of STD acquisition.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Pediatrics
Luisa Lina Villa, Rosana Richtmann
Summary: Prophylactic HPV vaccines are recommended for the prevention of HPV-related infections, tumors, and genital warts. Two doses of the vaccine have been shown to be as effective as three doses, leading to reduced vaccination schedules in many countries. Single-dose HPV vaccination has also shown promise in reducing the incidence of pre-cancer and cervical cancer.
JORNAL DE PEDIATRIA
(2023)
Article
Oncology
Tarik Gheit, Richard Muwonge, Eric Lucas, Luisa Galati, Devasena Anantharaman, Sandrine McKay-Chopin, Sylla G. Malvi, Kasturi Jayant, Smita Joshi, Pulikkottil O. Esmy, M. Radhakrishna Pillai, Partha Basu, Rengaswamy Sankaranarayanan, Massimo Tommasino
Summary: This study compared the prevalence of oral HPV infections in women vaccinated with different doses of HPV vaccine and found that three doses of the vaccine were more effective in preventing oral HPV infection compared to a single dose.
Article
Public, Environmental & Occupational Health
Jean-Marc Kutz, Pia Rausche, Tarik Gheit, Dewi Ismajani Puradiredja, Daniela Fusco
Summary: This review synthesizes the factors influencing the successful implementation of HPV vaccination programs in sub-Saharan Africa in order to improve roll-out and coverage. The review provides an overview and contextualizes the barriers and facilitators of HPV vaccination implementation in 12 countries in sub-Saharan Africa. Lessons learned from past experiences of HPV vaccination in sub-Saharan Africa can contribute to more effective national HPV vaccination programs targeted at eliminating cervical cancer and implementing the WHO triple intervention strategy.
Article
Dermatology
Manuelle Viguier, Corine Perals, Beatrice Poirier, Maxime Battistella, Francois Aubin, Herve Bachelez, Jean-Luc Pretet, Tarik Gheit, Massimo Tommasino, Antoine Touze, Marie-Lise Gougeon, Nicolas Fazilleau
Summary: Lichen planus (LP) is a chronic inflammatory disease characterized by CD8(+) T-cell infiltrate, and HPV16-specific CD8(+) T-cells are involved in different clinical forms of LP. Lichen sclerosus et atrophicus (LSA) has a different immune response, with oligoclonal TCRVss6(+) CTL repertoire.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Virology
Luana Lorena Silva Rodrigues, Jose Henrique Pilotto, Katrini Guidolini Martinelli, Alcina F. Nicol, Vanessa Salete De Paula, Tarik Gheit, Nathalia Silva Carlos Oliveira, Carlos Silva-de-Jesus, Vikrant V. Sahasrabuddhe, Diane M. Da Silva, W. Martin Kast, Justin Hardick, Charlotte A. Gaydos, Mariza Goncalves Morgado
Summary: The aim of this study was to classify the diversity of anal HPV and non-HPV sexually transmitted infections (STIs) and compare the concordance between anal and genital infections in HIV-infected and uninfected women living in the Tapajos region, Amazon, Brazil. The overall prevalence of anal HPV infection was high, especially in HIV-infected women. The concordance analysis showed moderate to fair agreement between anal and genital HPV and non-HPV STIs.
Article
Microbiology
Amina Gihbid, Amal El Amrani, Fatima Zahra Mouh, Tarik Gheit, Mustapha Benhessou, Mariam Amrani, Sandrine McKay-Chopin, Selma Mohamed Brahim, Souha Sahraoui, Abdelouaheb Bennani, Mohammed El Mzibri, Meriem Khyatti
Summary: Breast cancer is the most common cancer in women worldwide, accounting for a significant percentage of new cancer cases and deaths. A study in Morocco explored the presence of viral DNA in breast cancer tissues and found a high prevalence of Epstein-Barr virus (EBV), suggesting its potential role in breast cancer development and progression.
Article
Immunology
Walid A. Al-Soneidar, Sam Harper, Francois Coutlee, Tarik Gheit, Massimo Tommasino, Belinda Nicolau
Summary: This study investigated the prevalence of alpha (α), beta (β), and gamma (γ) human papillomaviruses (HPVs) among head and neck cancer (HNC) cases and controls, and their relationship with sociodemographic, behavioral, and oral health factors. The findings showed that the prevalence of α- and γ-HPV was associated with sexual activity, smoking, and drinking habits, while the prevalence of β-HPV was not. Tumor samples mainly included α-HPV, with HPV-16 being the most common genotype.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Virology
Nilanjana Chatterjee, Farhin Sultana, Rituparna Roy, Samyadipta Dey, Sukanya Naskar, Aniruddha Dam, Anup K. Bhowmick, Rakiba Begum, Shyam S. Mandal, Ranajit K. Mandal, Jayanta Chakrabarti, Chinmay K. Panda, Massimo Tommasino, Tarik Gheit, Sankhadeep Dutta
Summary: This study investigated the prevalence of novel-HPV 223 and 225 in oral mucosa and keratinized skin epithelium. HPV 223 was found to be present only in the oral mucosal epithelium, while HPV 225 was found in both oral mucosa and skin epithelium.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Virology
Taja Lozar, Aysenur Keske, Racheal S. Dube Mandishora, Qiqi Yu, Adam Bailey, Jin Xu, Massimo Tommasino, Stephanie M. Mcgregor, Paul F. Lambert, Tarik Gheit, Megan B. Fitzpatrick
Summary: This study is the first to report the association between p16-negative vulvar squamous intraepithelial lesions and detection of beta-HPVs. These findings expand possible etiologic mechanisms that may contribute to p16-negative lesions of the vulva.
Article
Oncology
Abbas Karimi, Tohid Jafari-Koshki, Mojtaba Zehtabi, Farzaneh Kargar, Tarik Gheit
Summary: Liquid biopsy using HPV ctDNA can predict the rate of relapse or recurrence after treatment, with post-treatment measurement being more effective than baseline assessment. HPV ctDNA could be used as a surrogate or incorporated with other methods for detecting residual disease.
Article
Medicine, General & Internal
Lucas Rodrigues Boarini, Carlos Walter Sobrado, Giana Rabello Mota, Luisa Lina Villa, Idblan Carvalho de Albuquerque, Natalia Sousa Freitas Queiroz, Carolina Bortolozzo Graciolli Facanali, Sidney Roberto Nadal, Ivan Cecconello
Summary: The aim of the study was to evaluate the prevalence of HPV and high-risk HPV in patients with perianal Crohn's disease compared to a control group. The results showed that perianal fistulizing Crohn's disease patients had a higher frequency of HPV in the fistulous tract than those without Crohn's disease.
Article
Biology
G. A. Grazia, D. R. Bastos, L. L. Villa
Summary: CD40, a member of TNFR family, is expressed in different types of cells, including immune cells and cancer cells. The higher expression of CD40 is observed in squamous cell carcinomas compared to adenocarcinomas. Moreover, the expression of CD40 and CD40L in squamous cervical carcinomas is associated with better overall survival. These proteins could be explored as prognostic markers in cervical cancers.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2023)
Article
Virology
Naiqing Xu, Xinen Tang, Xin Wang, Miao Cai, Xiaowen Liu, Xiaolong Lu, Shunlin Hu, Min Gu, Jiao Hu, Ruyi Gao, Kaituo Liu, Yu Chen, Xiufan Liu, Xiaoquan Wang
Summary: This study found that the H9N2 subtype avian influenza virus has a high airborne transmissibility, while the H7N9 virus does not. The Hemagglutinin protein of the H9N2 virus was found to play a key role in replication, stability, and airborne transmission.
Article
Virology
Samar S. Ewies, Sabry M. Tamam, Ahmed S. Abdel-Moneim, Sherin R. Rouby
Summary: Contagious ecthyma (CE) is a highly contagious viral disease of sheep and goats worldwide. The study provided a clinical description of CE and screened for genetic variation in the B2L gene. Infected sheep exhibited anorexia and oral lesions, while inoculated chicken embryos showed pock lesions. The B2L gene was successfully amplified and found to be highly conserved.
Article
Virology
Yigal Farnoushi, Dan Heller, Avishai Lublin
Summary: In recent years, new variants of avian reovirus (ARV) have caused a variety of symptoms in chickens worldwide, including viral arthritis/tenosynovitis. This study analyzed emerging ARV variants in Israel and found significant genetic diversity. Most ARV isolates in Israel belonged to genotypic cluster 5 (GC5). The study suggests that Israel has not experienced the emergence of new ARV variants since the introduction of the live vaccine (ISR-7585), but ongoing monitoring is needed due to the continuous emergence of ARV variants.
Article
Virology
Shigeru Tajima, Michiyo Kataoka, Yuki Takamatsu, Hideki Ebihara, Chang-Kweng Lim
Summary: Yokose virus (YOKV), a bat-associated flavivirus, was found to replicate at a slower rate in mosquito cells compared to other mosquito-borne flaviviruses. Specific nucleotide mutations in the virus were identified to enhance its proliferation ability in mosquito cells.
Article
Virology
Alejandra Borjabad, Baojun Dong, Wei Chao, David J. Volsky, Mary Jane Potash
Summary: This study investigated HIV brain disease using a mouse model, and found that poly I:C can reverse associated cognitive impairment and reduce virus burden. The results also revealed transcriptional changes related to neuronal function and innate immune responses.
Article
Virology
Ching-Hung Lin, Feng-Cheng Hsieh, Meilin Wang, Chieh Hsu, Hsuan-Wei Hsu, Chun-Chun Yang, Cheng-Yao Yang, Hung-Yi Wu
Summary: This study demonstrates that the synthesis of coronavirus subgenomic mRNA is not solely determined by the sequence homology between the leader TRS and TRS-B, but also by the disassociation of the coronavirus polymerase from the viral genome. This finding provides a new insight into the transcription mechanism of coronaviruses.
Article
Virology
Nicholas S. Kron, Benjamin W. Neuman, Sathish Kumar, Patricia L. Blackwelder, Dayana Vidal, Delphina Z. Walker-Phelan, Patrick D. I. Gibbs, Lynne A. Fieber, Michael C. Schmale
Summary: Two recent studies documented the genome of a novel virus in marine animals, finding that the virus is widespread in apparently healthy animals but not highly expressed in neurons. The studies also identified viral replication factories and high levels of defective genomes in chronically infected animals.
Article
Virology
Andrew M. Ramey, Laura C. Scott, Christina A. Ahlstrom, Evan J. Buck, Alison R. Williams, Mia Kim Torchetti, David E. Stallknecht, Rebecca L. Poulson
Summary: We successfully detected and characterized highly pathogenic avian influenza viruses in hunter-harvested wild waterfowl samples from western Alaska. Genomic analysis revealed three independent viral introductions into Alaska. Our findings demonstrate the utility and potential limitations of using molecular processing approaches directly on original swab samples for viral research and monitoring.
Article
Virology
Ting Gong, Dongdong Wu, Yongzhi Feng, Xing Liu, Qi Gao, Xiaoyu Zheng, Zebu Song, Heng Wang, Guihong Zhang, Lang Gong
Summary: This study discovered that quercetin can inhibit PEDV replication both in vivo and in vitro, and alleviate the clinical symptoms and intestinal injury caused by the virus. This provides a new direction for the development of PED antiviral drugs.
Article
Virology
Min Zhu, Hao Zeng, Jianqiao He, Yaohui Zhu, Pingping Wang, Jianing Guo, Jinfan Guo, Huabo Zhou, Yifeng Qin, Kang Ouyang, Zuzhang Wei, Weijian Huang, Ying Chen
Summary: The reassortment between avian H9N2 and Eurasian avian-like (EA) H1N1 viruses may have potentially changed from avian-to-mammals adaptation. This study found that the introduction of EA H1N1 internal genes into H9N2 virus restored the replication capability and resulted in extreme virulence in some cases. This raises new concerns for public health due to the possible coexistence of H9N2 and EA H1N1 viruses in dogs.
