Review
Oncology
Deepika Kumar, Adebowale J. Adeniran
Summary: This review focuses on micropapillary urothelial carcinoma, discussing its biology, histopathologic characteristics, genetic and molecular features, diagnosis, clinical management, and future research directions. Recent studies have shown moderate interobserver reproducibility in the diagnostic criteria, with the most reproducible criteria being the presence of multiple nests in the same lacunar spaces. There have also been reports of high rates of intratumoral heterogeneity of ERBB2 amplification in tumors containing both micropapillary and classic urothelial components. Accurate recognition and reporting of this pattern is crucial for optimal management, and further exploration of therapeutic strategies based on molecular and genetic findings is needed.
CURRENT ONCOLOGY REPORTS
(2022)
Article
Medical Laboratory Technology
Marjorie Perron, Hannah Y. Wen, Matthew G. Hanna, Edi Brogi, Dara S. Ross
Summary: This study conducted a detailed assessment of HER2 immunohistochemical staining patterns in 187 cases of invasive micropapillary carcinoma (IMPC), finding that the most common staining pattern was basolateral, with many cases being HER2 IHC positive or equivocal/FISH amplified. If a basolateral pattern and weak to moderate staining is observed in IMPC, alternative testing should be done to confirm the HER2 status.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2021)
Article
Oncology
Lien-Ping Chou, Che-Wei Hsu, Sheau-Fang Yang, Chung-Ta Lee, Yin-Chien Ou, Kun-Che Lin, Che-Yuan Hu, Yeong-Chin Jou, Yuh-Shyan Tsai, Nan-Haw Chow
Summary: The clinical significance of micropapillary urothelial carcinoma (MPUC) of the upper urinary tract (UTUC) was examined in this retrospective cohort study. MPUC was found to be an aggressive variant of UTUC, presenting as a small locally advanced disease. HER2 immunohistochemistry may identify candidates for targeted therapy among MPUC patients.
CLINICAL GENITOURINARY CANCER
(2023)
Review
Oncology
Emilie Scherrer, Ashley Kang, Lisa M. Bloudek, Vadim S. Koshkin
Summary: This study sheds light on HER2 expression in UC through a systematic literature review, providing insights into a potentially clinically relevant biomarker-driven subpopulation for emerging HER2-directed regimens. The results reveal variability in the assessment of HER2+ status expression levels, highlighting the importance of consensus on standardized HER2 testing and scoring criteria for a better understanding of clinical relevance in patients with UC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yu Fan, Qinhan Li, Qi Shen, Zhifu Liu, Zhenan Zhang, Shuai Hu, Wei Yu, Zhisong He, Qun He, Qian Zhang
Summary: This study identified the expression characteristics of the corresponding targets of ADCs EV, SG, and RC-48 in muscle-invasive UC and its histologic variants through immunohistochemistry.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jae-Hoon Chung, Chung-Un Lee, Dong-Hyeon Lee, Wan Song
Summary: This study found that positive PD-L1 expression in tumor-infiltrating immune cells (TICs) is significantly associated with poorer recurrence-free survival in urothelial carcinoma (UC) patients with variant histology.
Article
Oncology
Li Zhou, Zhiting Shao, Yiqiang Liu, Xieqiao Yan, Juan Li, Xiaowen Wu, Bixia Tang, Siming Li, Chuanliang Cui, Zhihong Chi, Lu Si, Yan Kong, Lili Mao, Bin Lian, Xuan Wang, Xue Bai, Jie Dai, Jun Guo, Xinan Sheng
Summary: This study reports on the expression of HER2 in patients with urothelial carcinoma, analyzes its association with clinical characteristics and prognosis, and explores the efficacy of disitamab vedotin in a real-world setting. The results show that HER2 positivity is associated with survival in urothelial carcinoma patients and receiving disitamab vedotin treatment improves prognosis. This study suggests that the new-generation anti-HER2 ADC treatment has improved the survival of patients with urothelial carcinoma, and HER2 expression is no longer a poor prognostic factor.
Article
Pathology
Alessandro Rizzo, Veronica Mollica, Francesca Giunchi, Filippo Gustavo Dall'Olio, Matteo Rosellini, Andrea Marchetti, Tania Franceschini, Riccardo Schiavina, Eugenio Brunocilla, Michelangelo Fiorentino, Andrea Ardizzoni, Francesco Massari
Summary: This study investigated the prognostic role of HER2 amplification in UC patients. It found that HER2 amplification was present in a portion of patients and may be associated with shorter survival, although the difference did not reach statistical significance.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Medicine, General & Internal
Takafumi Kitazono, Kazuya Tsubouchi, Ritsu Ibusuki, Katsuhiro Inoue, Kimitaka Miyajima, Junichi Motoshita, Yuki Okamatsu, Taishi Harada
Summary: A 70-year-old woman was hospitalized for dyspnea, and examination revealed high-signal-intensity lesions in the urinary bladder, which were confirmed as micropapillary urothelial carcinoma. This case represents the first autopsy case of pulmonary tumor thrombotic microangiopathy (PTTM) associated with this rare variant of urothelial carcinoma.
Article
Oncology
Thomas van Doeveren, Jose A. Nakauma-Gonzalez, Andrew S. Mason, Geert J. L. H. van Leenders, Tahlita C. M. Zuiverloon, Ellen C. Zwarthoff, Isabelle C. Meijssen, Angelique C. van der Made, Antoine G. van Der Heijden, Kees Hendricksen, Bas W. G. van Rhijn, Charlotte S. Voskuilen, Job van Riet, Winand N. M. Dinjens, Hendrikus J. Dubbink, Harmen J. G. van de Werken, Joost L. Boormans
Summary: By sequencing genes in 15 UTUC patients treated by RNU, it was found that the majority of patients had a clonal relationship between UTUC and subsequent UCB, supporting the idea that UCBs following UTUC surgery are primarily clonally derived recurrences.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Editorial Material
Multidisciplinary Sciences
Luke M. M. Evans, Pamela N. Romero N. Villela
Summary: An analysis of rare genetic variants shows their impact on human traits is mediated through similar biological pathways as common variants, enhancing our understanding of their influence on complex traits.
Article
Oncology
Jian Wang, Xiepeng Zuo, Yu Zhang, Weiwei Wang, Diansheng Zhou, Wenbo Liu, Guoqiang Han, Changli Wu, Dawei Tian
Summary: This study investigated the impact of histological variants (HV) in patients with upper tract urothelial carcinoma (UTUC) and analyzed the potential association between HV and postoperative bladder recurrence. The results showed that UTUC patients with HV were associated with biologically aggressive disease and recurrent MIBC after surgery. Therefore, bladder recurrence following surgery needs to be given more attention in advanced UTUC patients with HV.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Wu Zhou, Yong-Zhong Li, Li-Min Gao, Di-Ming Cai
Summary: By retrospectively evaluating the sonographic features and clinical characteristics of 133 cases of breast cancer and conducting bivariable analyses, it was found that MUMPC showed more frequent non-circumscribed margins and invasive growth compared to cPMBC, with lymphatic metastasis more likely to occur in MUMPC than cPMBC. Sonography is helpful in distinguishing MUMPC from cPMBC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Yunfeng Huang, Dora Bodnar, Chia-Yen Chen, Gabriela Sanchez-Andrade, Mark Sanderson, Jun E. Shi, Katherine S. Meilleur, Matthew A. Hurles, Sebastian Gerety, Ellen Tsai, Heiko Runz
Summary: The authors conducted an exome study on hand grip strength, which serves as a proxy for overall muscle strength. They discovered six significant genes, associated with diseases, and found that rare and common genetic variants both contribute to muscle strength. Muscle strength has a strong genetic basis and is a predictor of various negative health outcomes, including mortality.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Samia Kada Mohammed, Oumar Billa, Sylvain Ladoire, Clementine Jankowski, Isabelle Desmoulins, Marie-Laure Poillot, Charles Coutant, Francoise Beltjens, Sandrine Dabakuyo, Laurent Arnould
Summary: This study analysed the data from a registry database in France to compare outcomes of patients with HER2+ invasive lobular cancer (ILC), HER2+ invasive ductal cancer (IDC), and HER2- ILC. The results showed that the survival rates of HER2+ ILC were similar to HER2+ IDC and did not differ significantly from HER2- ILC.
Article
Radiology, Nuclear Medicine & Medical Imaging
Daniel Lohmann, Marga Lang-Welzenbach, Lorenz Feldberger, Ellen Sommer, Stefan Buecken, Michael Lotter, Oliver J. Ott, Rainer Fietkau, Christoph Bert
Summary: Risk analysis is required by laws and regulations in Germany, impacting every department of a large clinic. The method introduced successfully improved the overall workflow of the radiation oncology department by efficiently and continuously identifying and addressing risks. It takes time and effort, but the interdisciplinary team's regular meetings have proven effective in managing risks.
ZEITSCHRIFT FUR MEDIZINISCHE PHYSIK
(2022)
Correction
Immunology
Anna-Jasmina Donaubauer, Ina Becker, Thomas Weissmann, Birgitta M. Froehlich, Luis E. Munoz, Thomas Gryc, Manuel Denzler, Oliver J. Ott, Rainer Fietkau, Udo S. Gaipl, Benjamin Frey
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Thomas Weissmann, Michael Rueckert, Jian-Guo Zhou, Michaela Seeling, Sebastian Lettmaier, Anna-Jasmina Donaubauer, Falk Nimmerjahn, Oliver J. Ott, Markus Hecht, Florian Putz, Rainer Fietkau, Benjamin Frey, Udo S. Gaipl, Lisa Deloch
Summary: Osteoarthritis is a common degenerative joint disease, particularly affecting the ankle and foot. Low-dose radiotherapy has been shown to be highly effective in treating osteoarthritis, with analgesic effects mediated by an interplay of cellular and immune factors, especially in younger patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Adela Ademaj, Danai P. Veltsista, Pirus Ghadjar, Dietmar Marder, Eva Oberacker, Oliver J. Ott, Peter Wust, Emsad Puric, Roger A. Haelg, Susanne Rogers, Stephan Bodis, Rainer Fietkau, Hans Crezee, Oliver Riesterer
Summary: This review examines the existing clinical evidence regarding the correlation between thermometric parameters and cancer response in patients treated with hyperthermia (HT) in combination with radiotherapy (RT) and/or chemotherapy (CT). Some studies indicate that thermometric parameters correlate with treatment response, suggesting their potential significance for treatment guidance.
Article
Oncology
Azzaya Sengedorj, Michael Hader, Lukas Heger, Benjamin Frey, Diana Dudziak, Rainer Fietkau, Oliver J. Ott, Stephan Scheidegger, Sergio Mingo Barba, Udo S. Gaipl, Michael Rueckert
Summary: Hyperthermia (HT) is a cancer treatment that locally heats the tumor to supraphysiological temperature, and it is an effective sensitizer for radiotherapy (RT) and chemotherapy. This study found that the sequence of HT and RT does not strongly affect the immune phenotype of breast cancer cells, but the combination of HT and RT upregulates immune suppressive immune checkpoint molecules. Therefore, the addition of immune checkpoint inhibitors should be considered in multimodal tumor treatments with RT and HT.
Article
Oncology
Tim-Oliver Sauer, Oliver J. Ott, Godehard Lahmer, Rainer Fietkau, Christoph Bert
Summary: A markerless workflow for breast cancer patients has been introduced and evaluated retrospectively. The results show that this workflow can save time and dose while ensuring appropriate positioning accuracy.
STRAHLENTHERAPIE UND ONKOLOGIE
(2023)
Article
Oncology
Oliver J. Ott, Wilhelm Stillkrieg, Ulrike Lambrecht, Tim-Oliver Sauer, Claudia Schweizer, Allison Lamrani, Vratislav Strnad, Carolin C. Hack, Matthias W. Beckmann, Michael Uder, Rainer Fietkau, Luitpold Distel
Summary: Accelerated partial breast irradiation is a safe and effective treatment option for selected patients with early stage breast cancer. A prospective trial found that the risk of radiogenic pneumonitis was very low with this treatment, and it may be limited to exceptional cases with increased radiation susceptibility.
Article
Oncology
Adela Ademaj, Paraskevi D. Veltsista, Dietmar Marder, Roger A. Haelg, Emsad Puric, Thomas B. Brunner, Hans Crezee, Dorota Gabrys, Martine Franckena, Cihan Gani, Michael R. Horsman, Robert Krempien, Lars H. Lindner, Sergio Maluta, Markus Notter, Griseldis Petzold, Sultan Abdel-Rahman, Antonella Richetti, Andreas R. Thomsen, Pelagia Tsoutsou, Rainer Fietkau, Oliver J. Ott, Pirus Ghadjar, Oliver Riesterer
Summary: There is significant heterogeneity among European clinical centers in the practice of hyperthermia, including the indications treated and the recording of thermometric parameters. More evidence from clinical studies is needed to standardize hyperthermia practice.
STRAHLENTHERAPIE UND ONKOLOGIE
(2023)
Article
Oncology
Oliver J. Ott, Udo S. Gaipl, Allison Lamrani, Rainer Fietkau
Summary: For decades, the antineoplastic potential of hyperthermia alone or in combination with radiotherapy and/or chemotherapy has been extensively researched in various tumor entities. This article summarizes the clinical evidence on the beneficial effects of additional hyperthermia in combination with intravesical Mitomycin C for superficial non-muscle-invasive bladder cancer, as well as deep regional microwave hyperthermia techniques used during external beam radiotherapy or chemoradiation for more advanced tumors. The presented data justifies further prospective trials on multimodality treatment for bladder preservation, including mild regional hyperthermia.
SEMINARS IN RADIATION ONCOLOGY
(2023)
Review
Oncology
Thomas Weissmann, Michael Rueckert, Florian Putz, Anna-Jasmina Donaubauer, Markus Hecht, Soren Schnellhardt, Philipp Schubert, Johannes Roesch, Daniel Hoefler, Oliver J. Ott, Marlen Haderlein, Sebastian Lettmaier, Rainer Fietkau, Benjamin Frey, Udo S. Gaipl, Lisa Deloch
Summary: Osteoarthritis is a common and economically relevant disease, especially in an ageing population. Despite numerous conventional treatment options, many patients are still refractory to treatment. Low-dose radiotherapy has shown potential in treating patients with inflammatory and degenerative diseases, but its effectiveness has not been proven in randomized trials. Further research is needed to investigate the underlying mechanisms and optimize patient stratification and treatment procedures.
STRAHLENTHERAPIE UND ONKOLOGIE
(2023)
Article
Cell Biology
Mareike F. Bauer, Laura S. Hildebrand, Marie-Charlotte Rosahl, Ramona Erber, Soren Schnellhardt, Maike Buettner-Herold, Florian Putz, Oliver J. Ott, Carolin C. Hack, Rainer Fietkau, Luitpold Distel
Summary: Cell-in-cell (CIC) structures in early hormone-sensitive breast cancer were studied. In vitro experiments showed that breast cancer cell lines had higher phagocytic capacity compared to primary human fibroblasts. Tissue analysis from 147 patients in a clinical trial revealed that CIC structures were associated with favorable local recurrence-free survival and disease-free survival, but unfavorable for metastasis-free survival. CIC had the highest prognostic value in young breast cancer patients.
Article
Oncology
Oliver J. Ott, Wilhelm Stillkrieg, Ulrike Lambrecht, Claudia Schweizer, Allison Lamrani, Tim-Oliver Sauer, Vratislav Strnad, Christoph Bert, Carolin C. Hack, Rainer W. Fietkau, Matthias W. Beckmann
Summary: Compared to whole-breast irradiation, partial-breast irradiation reduces radiation doses to healthy tissues and should be recommended to suitable patients to minimize risks of secondary tumors and major cardiac events.
Meeting Abstract
Oncology
Marlen Haderlein, Jens Von der Grun, Claus Roedel, Matthias Hautmann, Christopher Bohr, Thomas Hehr, Carmen Stromberger, Volker Budach, Markus Michael Schymalla, Rita Engenhart-Cabillic, Lukas Kocik, Ursula Nestle, Gunther Klautke, Christine Gall, Markus Hecht, Oliver Ott, Marco Kesting, Heinrich Iro, Sarina Mueller, Rainer Fietkau
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Cell & Tissue Engineering
Azzaya Sengedorj, Michael Hader, Benjamin Frey, Rainer Fietkau, Oliver J. Ott, Udo S. Gaipl, Michael Rueckert
Summary: Radiotherapy is a crucial standard cancer therapy that not only achieves local tumor control but also induces systemic anti-tumor immunity. However, the effects of radiotherapy on the immune system can be both immunostimulatory and immunosuppressive. Combining radiotherapy with additional therapies such as hyperthermia and immune checkpoint inhibitors shows promising approaches to effectively induce anti-tumor immunity.
CURRENT STEM CELL REPORTS
(2022)
Meeting Abstract
Oncology
A. Sengedorj, M. Hader, M. Rueckert, B. Frey, R. Fietkau, O. J. Ott, S. Scheidegger, S. M. Barba, U. S. Gaipl
STRAHLENTHERAPIE UND ONKOLOGIE
(2022)