Integration of next-generation sequencing in clinical diagnostic molecular pathology laboratories for analysis of solid tumours; an expert opinion on behalf of IQN Path ASBL

Cost-effectiveness of precision medicine in the fourth-line treatment of metastatic lung adenocarcinoma: An early decision analytic model of multiplex targeted sequencing

(2017) Brett Doble et al.   LUNG CANCER

Genotyping of colorectal cancer for cancer precision medicine: Results from the IPH Center for Molecular Pathology

(2016) Moritz Jesinghaus et al.   GENES CHROMOSOMES & CANCER

Clinical Validation and Implementation of a Targeted Next-Generation Sequencing Assay to Detect Somatic Variants in Non-Small Cell Lung, Melanoma, and Gastrointestinal Malignancies

(2016) Kevin E. Fisher et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

College of American Pathologists' Laboratory Standards for Next-Generation Sequencing Clinical Tests

(2015) Nazneen Aziz et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

Development of a semi-conductor sequencing-based panel for genotyping of colon and lung cancer by the Onconetwork consortium

(2015) Bastiaan BJ Tops et al.   BMC CANCER

Therapeutic Targeting of Anaplastic Lymphoma Kinase in Lung Cancer: A Paradigm for Precision Cancer Medicine

(2015) R. Katayama et al.   CLINICAL CANCER RESEARCH

Guidelines for diagnostic next-generation sequencing

(2015) Gert Matthijs et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology

(2015) Sue Richards et al.   GENETICS IN MEDICINE

A Decision Support Framework for Genomically Informed Investigational Cancer Therapy

(2015) Funda Meric-Bernstam et al.   JNCI-Journal of the National Cancer Institute

Molecularly targeted therapy based on tumour molecular profiling versus conventional therapy for advanced cancer (SHIVA): a multicentre, open-label, proof-of-concept, randomised, controlled phase 2 trial

(2015) Christophe Le Tourneau et al.   LANCET ONCOLOGY

Acquired EGFR C797S mutation mediates resistance to AZD9291 in non–small cell lung cancer harboring EGFR T790M

(2015) Kenneth S Thress et al.   NATURE MEDICINE

Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors

(2015) Jeanette E. Eckel-Passow et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Comparison of Variant Calling Pipelines Using Genome in a Bottle as a Reference

(2015) Adam Cornish et al.   Biomed Research International

A Decision Support Framework for Genomically Informed Investigational Cancer Therapy

(2015) Funda Meric-Bernstam et al.   JNCI-Journal of the National Cancer Institute

Next-Generation Sequencing in Clinical Molecular Diagnostics of Cancer: Advantages and Challenges

(2015) Rajyalakshmi Luthra et al.   Cancers

Dramatic reduction of sequence artefacts from DNA isolated from formalin-fixed cancer biopsies by treatment with uracil-DNA glycosylase.

(2015) Hongdo Do et al.   Oncotarget

Systematic comparison of variant calling pipelines using gold standard personal exome variants

(2015) Sohyun Hwang et al.   Scientific Reports

Prioritizing targets for precision cancer medicine

(2014) F. Andre et al.   ANNALS OF ONCOLOGY

Evaluation and optimisation of indel detection workflows for ion torrent sequencing of the BRCA1 and BRCA2 genes

(2014) Zhen Yeo et al.   BMC GENOMICS

Guidance for laboratories performing molecular pathology for cancer patients

(2014) Ian A Cree et al.   JOURNAL OF CLINICAL PATHOLOGY

Variation in pre-PCR processing of FFPE samples leads to discrepancies inBRAFandEGFRmutation detection: a diagnostic RING trial

(2014) Joshua R Kapp et al.   JOURNAL OF CLINICAL PATHOLOGY

Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine

(2014) Eliezer M Van Allen et al.   NATURE MEDICINE

An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge

(2014) Catherine A Brownstein et al.   GENOME BIOLOGY

Detection ofEGFRmutations andEML4-ALKrearrangements in lung adenocarcinomas using archived cytological slides

(2013) Natalia V. Mitiushkina et al.   CANCER CYTOPATHOLOGY

ACMG clinical laboratory standards for next-generation sequencing

(2013) Heidi L. Rehm et al.   GENETICS IN MEDICINE

Validation of Next Generation Sequencing Technologies in Comparison to Current Diagnostic Gold Standards for BRAF, EGFR and KRAS Mutational Analysis

(2013) Clare M. McCourt et al.   PLoS One

A SNP profiling panel for sample tracking in whole-exome sequencing studies

(2013) Reuben J Pengelly et al.   Genome Medicine

A tale of three next generation sequencing platforms: comparison of Ion torrent, pacific biosciences and illumina MiSeq sequencers

(2012) Michael Quail et al.   BMC GENOMICS

High concordance ofEGFRmutation status between histologic and corresponding cytologic specimens of lung adenocarcinomas

(2012) Ping-Li Sun et al.   CANCER CYTOPATHOLOGY

Effective Assessment of egfr Mutation Status in Bronchoalveolar Lavage and Pleural Fluids by Next-Generation Sequencing

(2012) F. Buttitta et al.   CLINICAL CANCER RESEARCH

Opportunities and Challenges Associated with Clinical Diagnostic Genome Sequencing

(2012) Iris Schrijver et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Assuring the quality of next-generation sequencing in clinical laboratory practice

(2012) Amy S Gargis et al.   NATURE BIOTECHNOLOGY

Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer

(2012) Clara Montagut et al.   NATURE MEDICINE

The challenge and importance of standardizing pre-analytical variables in surgical pathology specimens for clinical care and translational research

(2011) DG Hicks et al.   BIOTECHNIC & HISTOCHEMISTRY

Quantitative assessment shows loss of antigenic epitopes as a function of pre-analytic variables

(2011) Yalai Bai et al.   LABORATORY INVESTIGATION

Sequence variant classification and reporting: recommendations for improving the interpretation of cancer susceptibility genetic test results

(2008) Sharon E. Plon et al.   HUMAN MUTATION