Article
Medicine, General & Internal
Eric Anderson, Alexis LeVee, Sungjin Kim, Katelyn Atkins, Michelle Guan, Veronica Placencio-Hickok, Natalie Moshayedi, Andrew Hendifar, Arsen Osipov, Alexandra Gangi, Miguel Burch, Kevin Waters, May Cho, Samuel Klempner, Joseph Chao, Mitchell Kamrava, Jun Gong
Summary: The study reveals that neoadjuvant chemoradiation (nCRT) is associated with the highest rate of pathologic complete response, while neoadjuvant and adjuvant chemotherapy (CTTU) is associated with the best overall survival.
Article
Multidisciplinary Sciences
Chunmei Zhang, Ruiyi Tang, Hanlong Zhu, Xianxiu Ge, Yue Wang, Xue Wang, Lin Miao
Summary: This study investigated the treatment patterns and survival impact on early-onset gastric cancer (EOGC) patients. It found that patients who received nonsurgical treatment had the highest risk of overall death, and additional radiotherapy, chemotherapy or chemoradiotherapy did not provide a coordinated survival benefit to EOGC patients.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Jacopo Desiderio, Andrea Sagnotta, Irene Terrenato, Bruno Annibale, Stefano Trastulli, Federico Tozzi, Vito D'Andrea, Sergio Bracarda, Eleonora Garofoli, Yuman Fong, Yanghee Woo, Amilcare Parisi
Summary: In Western gastric cancer patients, postoperative gastrectomy has shown better survival benefits, improving management for stage IV diseases.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Marco Mariani, Roberta Pastorino, Denise Pires Marafon, Ken C. Johnson, Jinfu Hu, Antonio Jose Molina de la Torre, Guillermo Fernandez-Tardon, David Zaridze, Dmitry Maximovich, Eva Negri, Carlo La Vecchia, Zuo-Feng Zhang, Robert C. Kurtz, Claudio Pelucchi, Matteo Rota, Stefania Boccia
Summary: This study aimed to estimate the association between leisure-time physical activity (PA) and gastric cancer (GC) through a pooled analysis of case-control studies. The results showed no significant relationship between leisure-time PA and GC, except for a slight decreased risk below age 55 and in control population-based studies.
Article
Oncology
Lauren M. Janczewski, Charles D. Logan, Dominic J. Vitello, Joanna T. Buchheit, John D. Abad, David J. Bentrem, Akhil Chawla
Summary: This study evaluated perioperative and histopathologic outcomes among patients with locoregional gastric cancer who received neoadjuvant chemotherapy and neoadjuvant chemoradiation treatments. NCRT was associated with better histologic tumor response, while NAC was associated with improved overall survival.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Review
Oncology
Mohan Hingorani, Rebecca Goody, Georgios Bozas, Khwaja Zahid, David James Mitton, Prashant Jain, Vincent Wong, Rajarshi Roy
Summary: Neoadjuvant chemotherapy (nCT) and chemoradiotherapy (nCRT) have been shown to improve survival compared to surgery alone for adenocarcinoma of esophagus and gastro-esophageal junction (GOJ). We conducted a comprehensive review to define the optimal treatment algorithm and identify specific patient sub-groups who may benefit from these neoadjuvant options.
Article
Oncology
Smita S. Joshi, Brian D. Badgwell
Summary: Gastric cancer is a common cause of cancer death worldwide, with treatment options including systemic chemotherapy, radiotherapy, surgery, immunotherapy, and targeted therapy. Classification and biomarkers for gastric cancer help in personalized therapy and identifying populations most likely to benefit from immunotherapy and targeted therapy.
CA-A CANCER JOURNAL FOR CLINICIANS
(2021)
Article
Genetics & Heredity
Zhang-Hua Chen, Shu-Mei Yan, Xi-Xi Chen, Qi Zhang, Shang-Xin Liu, Yang Liu, Yi-Ling Luo, Chao Zhang, Miao Xu, Yi-Fan Zhao, Li-Yun Huang, Bin-Liu Liu, Tian-Liang Xia, Da-Zhi Xu, Yao Liang, Yong-Ming Chen, Wei Wang, Shu-Qiang Yuan, Hui-Zhong Zhang, Jing-Ping Yun, Wei-Wei Zhai, Mu-Sheng Zeng, Fan Bai, Qian Zhong
Summary: This study depicted the (epi) genomic evolution process of EBVaGCs, revealed extensive genomic diversity of EBV between tumors and normal tissue sites, and demonstrated the synergistic activation of the PI3K and Wnt pathways in EBVaGCs, offering a new potential treatment strategy for this disease.
Article
Surgery
U. G. Lange, Y. Moulla, M. Mehdorn, J. Tuennemann, A. Zabel-Langhennig, A. Ouaid, A. Dietrich
Summary: This article reports a case of bile reflux and development of Barrett's metaplasia after mini-gastric bypass surgery. The authors emphasize the potential significance of bile reflux in the development of Barrett's metaplasia and call for long-term prospective studies to further understand this issue.
Review
Oncology
George Pappas-Gogos, Kostas Tepelenis, Fotis Fousekis, Konstantinos Katsanos, Michail Pitiakoudis, Konstantinos Vlachos
Summary: Gastric cancer is the fifth most common cancer globally, with Helicobacter pylori identified as a risk factor. The intestinal microbiota plays a role in carcinogenesis, cancer prevention, and chemotherapy effectiveness. Recent studies suggest that certain bacteria may enhance the effects of traditional anticancer drugs and immunotherapies.
Review
Surgery
Caroline E. Hall, Felipe Maegawa, Ankit D. Patel, Edward Lin
Summary: Gastric adenocarcinoma is a complex disease that requires a thorough multidisciplinary approach for appropriate management. Different regions have different management strategies, but overall survival remains low despite improvements in chemotherapy and surgical techniques. Early detection, preoperative reduction of tumor burden, consistent surgical technique, and postoperative eradication of tumor cells are likely to lead to the best outcomes. This review aims to describe the management of gastric cancer, including staging, imaging workup, surgical resection and reconstruction, and adjuvant treatment strategies.
Article
Surgery
Jae Ho Cho, Cheol Min Shin, Hyuk Yoon, Young Soo Park, Nayoung Kim, Dong Ho Lee
Summary: This study evaluated and compared the efficacy of ESD and EMR-P in treating small gastric adenomas, finding no significant differences in en bloc resection rate, complete resection rate, bleeding rate, and local recurrence rate between the two methods. However, ESD had a significantly longer procedure time, and EMR-P showed lower efficacy for adenomas in the proximal stomach.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Multidisciplinary Sciences
Bettina Kunze, Moritz Middelhoff, H. Carlo Maurer, Tatiana Agibalova, Akanksha Anand, Anne-Marie Buhrer, Hsin-Yu Fang, Theresa Baumeister, Katja Steiger, Julia Strangmann, Roland M. Schmid, Timothy C. Wang, Michael Quante
Summary: Activation of the Notch signaling pathway in Dclk1-positive tuft cells accelerates the development of BE, while genetic ablation of Notch receptor 2 in Dclk1-positive cells delays BE progression and leads to increased secretory cell differentiation. This suggests that Notch activation plays a role in BE development.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Kenichi Kishimoto, Kotaro Shibagaki, Saya Nonomura, Shohei Sumi, Naoki Fukuda, Yusuke Takahashi, Satoshi Kotani, Eiko Okimoto, Naoki Oshima, Kousaku Kawashima, Norihisa Ishimura, Shunji Ishihara
Summary: Heterotopic gastric mucosa of esophagus, primarily occurring in cervical esophagus, is usually asymptomatic. In this case, a middle-aged woman with postprandial heartburn was diagnosed with middle esophageal HGM and esophageal ulcers, with treatment including oral vonoprazan based on findings from 8-channel pH monitoring and histology.
Review
Microbiology
Jinpu Yang, Xinxin Zhou, Xiaosun Liu, Zongxin Ling, Feng Ji
Summary: The gastric microbiome plays a critical role in maintaining homeostasis and promoting gastric carcinogenesis, with both H. pylori and non-H. pylori bacteria contributing to the development of gastric cancer. Understanding the contribution of the gastric microbiome to GC can lead to improvements in prevention, diagnosis, and treatment.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Sajiv Sethi, Jade Edwards, Alexander Webb, Saritza Mendoza, Ambuj Kumar, Soojong Chae
Summary: Women are underrepresented in the field of gastroenterology at all levels of leadership in fellowship programs, and increasing the number of women in leadership positions is associated with an increase in female program directors and trainees.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Cell Biology
Mei Sun, Devon Cogswell, Sheila Adams, Yasmin Ayoubi, Ambuj Kumar, Tea Reljic, Marcel Y. Avila, Curtis E. Margo, Edgar M. Espana
Summary: Collagen XI plays a vital role in corneal fibrillogenesis by nucleating collagen fibrils and regulating their diameter. It is expressed during development and after injury, and is involved in the formation of new fibrils during regeneration.
JOURNAL OF CELL SCIENCE
(2022)
Article
Surgery
Sara E. Soni, Nicole K. Le, Mitchell Buller, Ashley D. Modica, Ambuj Kumar, Paul D. Smith, Christine Laronga
Summary: This study compared the safety profile of prepectoral breast reconstruction with total submuscular tissue expander reconstruction. The results showed that prepectoral reconstruction had a higher incidence of infection, but a low rate of reconstructive loss, comparable to total submuscular reconstruction.
ANNALS OF PLASTIC SURGERY
(2022)
Article
Oncology
Abdelhafeez H. Abdelhafeez, Tea Reljic, Ambuj Kumar, Tahmina Banu, Sharon Cox, Andrew M. Davidoff, Ahmed Elgendy, Khalil Ghandour, J. Ted Gerstle, Jonathan Karpelowsky, Sue C. Kaste, Nahla Kechiche, Natia Esiashvili, Abdulrasheed Nasir, Amon Ngongola, Jin Marollano, Amabelle A. Moreno, Arlene Muzira, Jeannette Parkes, Lily J. Saldana, Jaime Shalkow, Gordan M. Vujanic, Thelma Velasquez, Kokila Lakhoo, Sheena Mukkada, Simone Abib
Summary: This study provides resource-sensitive recommendations for the surgical management of Wilms tumor. The recommendations include expediting treatment initiation, performing surgery in high-volume settings, optimizing preoperative planning with cross-sectional imaging, and more.
PEDIATRIC BLOOD & CANCER
(2022)
Review
Oncology
Aileen Xu, Pilar Suz, Tea Reljic, Abhirup C. Are, Ambuj Kumar, Benjamin Powers, Jonathan Strosberg, Jason W. Denbo, Jason B. Fleming, Daniel A. Anaya
Summary: Intraoperative carcinoid crisis is a common complication in patients undergoing surgery for midgut NET and/or liver metastasis, occurring in up to 20% of cases. Prophylactic octreotide may not be effective in reducing the risk of CC.
Review
Oncology
Narendranath Epperla, Tea Reljic, Sayan Mullick Chowdhury, Andres J. M. Ferreri, Ambuj Kumar, Mehdi Hamadani
Summary: The optimal consolidation strategy for newly diagnosed primary central nervous system lymphoma (PCNSL) remains controversial between autologous hematopoietic cell transplant (auto-HCT) and whole-brain radiotherapy (WBRT). A systematic review and meta-analysis of randomized controlled trials was conducted, revealing no significant differences in survival outcomes between auto-HCT and WBRT consolidation, but a higher degree of neurocognitive decline associated with WBRT. Individualized decision-making based on age, frailty, and co-morbidities is recommended.
HEMATOLOGICAL ONCOLOGY
(2023)
Review
Education, Scientific Disciplines
Andrew Sephien, Tea Reljic, Jeffrey Jordan, Xavier Prida, Ambuj Kumar
Summary: The study found that shorter resident duty hours may be associated with improvement in resident-based outcomes, specifically emotional exhaustion, overall well-being, sleep duration, and sleepiness, without adverse impact on patient hospital length of stay and serious medical errors.
Article
Medicine, General & Internal
Andrew Sephien, Ambuj Kumar, Kira Zwygart, Antoneyous R. Mellek, Jeffrey Orr, Charles Nofsinger, Danielle Gulick
Summary: This study aimed to investigate whether participation in an orthopedic interest group (OIG) improves the chances of matching into an orthopedic surgery residency. The results showed that applicants who were members of the OIG had a significantly higher match rate compared to non-OIG applicants.
SOUTHERN MEDICAL JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Andrew Sephien, Mike Ghobrial, Tea Reljic, Xavier Prida, Nishant Nerella, Ambuj Kumar
Summary: This study provides an overview of systematic reviews and meta-analyses on the efficacy of SGLT2i in the management of heart failure. The results suggest that SGLT2i may be beneficial in patients with heart failure, but further research is needed to compare the efficacy of different types of SGLT2i.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Review
Immunology
Jacob R. Albers, Jeffrey B. Brown, Shaun V. Charkowick, Natasha Ram, Farina A. Klocksieben, Ambuj Kumar
Summary: This article systematically assesses the efficacy, risks, and methodological quality of evidence from five major publicly available vaccine trials. The results indicate that all five vaccines are effective and safe, but there is room for improvement in the conduct of large-scale vaccine trials.
Article
Multidisciplinary Sciences
Sheon Baby, Tea Reljic, Nuria Villalba, Ambuj Kumar, Sarah Y. Yuan
Summary: The concentration of plasma glycocalyx-associated molecules is higher in patients with sepsis-associated encephalopathy (SAE), indicating their potential use in early identification of cognitive decline in sepsis patients.
Article
Rheumatology
Patricia Teran-Wodzinski, Ambuj Kumar
Summary: In order to improve the lives of individuals with Hypermobile Ehlers-Danlos Syndrome (hEDS) and Generalized Hypermobility Spectrum Disorder (G-HSD), a study was conducted to identify their priorities. An online survey was conducted, with 483 responses analyzed out of 396 participants. The survey revealed the prevalence of pain, fatigue, joint hypermobility, joint instability, and other physical and emotional issues in hEDS and G-HSD individuals. The findings underline the urgent need for better treatment options, diagnostic processes, and healthcare provider education.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Hematology
Narendranath Epperla, Ambuj Kumar, Syed A. Abutalib, Farrukh T. Awan, Yi-Bin Chen, Ajay K. Gopal, Jennifer Holter-Chakrabarty, Natasha Kekre, Catherine J. Lee, Lazaros Lekakis, Yi Lin, Matthew Mei, Sunita Nathan, Loretta Nastoupil, Olalekan Oluwole, Adrienne A. Phillips, Erin Reid, Andrew R. Rezvani, Judith Trotman, Joanna Zurko, Mohamed A. Kharfan-Dabaja, Craig S. Sauter, Miguel-Angel Perales, Frederick L. Locke, Paul A. Carpenter, Mehdi Hamadani
Summary: Autologous hematopoietic cell transplantation has been the standard approach for patients with relapsed/refractory diffuse large B cell lymphoma. However, the introduction of CAR T cell therapy has changed the management of these patients, especially with the approval of CD19-directed CAR-T therapy in the second-line setting for high-risk groups. The American Society of Transplantation and Cellular Therapy has formulated consensus recommendations to address the lack of consensus on the role and sequencing of HCT and cellular therapies in DLBCL.
TRANSPLANTATION AND CELLULAR THERAPY
(2023)
Article
Hematology
Abu-Sayeef Mirza, Ankita Tandon, Dakota Jenneman, Shu Cao, Thomas Brimer, Ambuj Kumar, Michelle Kidd, Farhad Khimani, Rawan Faramand, Asmita Mishra, Hien Liu, Taiga Nishihori, Lia Perez, Aleksandr Lazaryan, Nelli Bejanyan, Michael Nieder, Claudio Anasetti, Joseph Pidala, Hany Elmariah
Summary: This study retrospectively analyzed the outcomes and subsequent management of patients with intolerance to the TAC/SIR regimen following allogeneic hematopoietic cell transplantation. The results showed that TAC/SIR intolerance was associated with poorer outcomes, with early intolerance contributing to a higher risk of acute graft-versus-host disease, increased nonrelapse mortality, and inferior survival. Most patients who developed intolerance were switched to alternative two-drug regimens, while those with late intolerance tended to be continued on single-drug therapy.
TRANSPLANTATION AND CELLULAR THERAPY
(2022)
Review
Gastroenterology & Hepatology
Shreya Narayanan, Ambuj Kumar, Tea Reljic, Wojciech Blonski
Summary: This study found that there is no significant difference in the incidence of colon cancer or colon polyps between patients with inguinal hernias compared to those without. However, larger prospective studies are needed to further investigate the relationship between the risk of colon cancer or polyps and the presence of inguinal hernia.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2022)