Article
Immunology
Jialing Bao, Biying Mo, Guozhen An, Jian Luo, Mortimer Poncz, Guoqing Pan, Tian Li, Zeyang Zhou
Summary: VWF has been shown to bind microsporidia in circulation and modulate its pathogenicity, including promoting infection and germination. VWF facilitates the intravascular spreading and systemic infection of microsporidia.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Sergio Vazquez, Raquel Vallejo, Jose Espinosa, Noive Arteche, Jose A. Vega, Valentin Perez
Summary: This study investigated the relationship between macrophage infiltrates and histological grade and immunophenotype in cases of canine lymphoma. Results showed that high-grade and B-cell lymphomas had the highest number of macrophages, with a predominant M2 phenotype. The findings suggest a complex interaction between macrophages, tumor behavior, and immune response in canine lymphoma.
Article
Chemistry, Medicinal
Shaymaa Ramzy Senousy, Al-Shaimaa F. Ahmed, Dalia A. Abdelhafeez, Mohamed Montaser A. Khalifa, Mohammed A. S. Abourehab, Mahmoud El-Daly
Summary: Alpha-chymotrypsin has protective potential against sepsis by inhibiting oxidative stress and inflammatory responses, reducing lung, liver, and kidney injuries, and improving survival rates.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Agriculture, Dairy & Animal Science
Wan-Ching Cheng, Lois Wilkie, Tsumugi Anne Kurosawa, Melanie Dobromylskyj, Simon Lawrence Priestnall, Virginia Luis Fuentes, David J. Connolly
Summary: Cardiomyopathy is common in domestic cats and can result in severe outcomes like aortic thromboembolism. Research has shown increased expression of von Willebrand Factor in the left atrium of cats with cardiomyopathy, potentially aiding in preventing thrombus formation.
Article
Pathology
Gregory A. Krane, Carly A. O'Dea, David E. Malarkey, Andrew D. Miller, C. Ryan Miller, Debra A. Tokarz, Heather L. Jensen, Kyathanahalli S. Janardhan, Keith R. Shockley, Norris Flagler, Brittani A. Rainess, Christopher L. Mariani
Summary: Immune evasion is crucial in the pathogenesis of glioma, with canine glioma showing a robust immune cell infiltrate. Different numbers of specific cells were found in low-grade and high-grade gliomas, suggesting potential therapeutic targets for repolarization of macrophages or Treg interference in canine glioma.
VETERINARY PATHOLOGY
(2021)
Article
Obstetrics & Gynecology
Alexander Schwickert, Wolfgang Henrich, Martin Vogel, Kerstin Melchior, Loreen Ehrlich, Matthias Ochs, Thorsten Braun
Summary: The study examined the histological structure of large vessels in cases of placenta percreta, revealing a potential association between VWF-negative vessel endothelia and increased vascularization induced by PAS. The immature vessel architecture and Ephrin B2 and EPH receptor B4 negativity in the artery-like vessels may suggest an underlying pathomechanism that needs further evaluation in a larger patient cohort.
REPRODUCTIVE SCIENCES
(2022)
Article
Hematology
Dalia A. Bashir, Qi Da, Subhashree Pradhan, Nitin Sekhar, Christian Valladolid, Fong Lam, Danielle Guffey, Jordana Goldman, Moreshwar S. Desai, Miguel A. Cruz, Carl Allen, Trung C. Nguyen, K. Vinod Vijayan
Summary: Hyperferritinemia is associated with poor outcomes in critically ill patients, potentially promoting thrombosis and organ injury by inducing endothelial VWF secretion and reducing ADAMTS-13 activity. The study provides new insights into the role of hyperferritinemia in sepsis, HLH, MAS, and COVID-19 patients.
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2021)
Article
Anatomy & Morphology
Andre Costa Teixeira, Fabio Tavora, Ester Almeida Mourao, Gabriel Bezerra Castaldelli, Thiago Belmino Almeida Bernardo Evangelista, Ronaldo de Matos Esmeraldo, Taina Veras de Sandes-Freitas
Summary: This study evaluated the expression of Caveolin-1, Vwf, and T-Cadherin in kidney allograft biopsies and found that Vwf had good accuracy in predicting graft failure. A Vwf positivity of more than 10% in the microvasculature was associated with reduced graft survival, especially in patients with mild interstitial fibrosis.
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
(2022)
Article
Veterinary Sciences
Filipe Krasinski Cestari, Monica Regina de Matos, Jessica Goncalves dos Santos, Giovane Franchesco de Carvalho, Karim Cristhine Pase Montagnini, Marcio Hamamura, Olicies da Cunha, Aline de Marco Viott
Summary: Intravascular lymphoma (IL) is a rare disease characterized by the presence of neoplastic lymphocytes in the lumen of blood vessels, leading to blockage and inflammation. Diagnosing IL can be challenging due to the lack of solid tumors and the need for a combination of histopathological and immunohistochemical examinations, along with laboratory tests and clinical presentation.
ACTA SCIENTIAE VETERINARIAE
(2021)
Article
Urology & Nephrology
Andre Costa Teixeira, Fabio Tavora, Melissa Lou Fagundes de Deus e Silva, Renan Martins Gomes Prado, Ronaldo de Matos Esmeraldo, Taina Veras de Sandes-Freitas
Summary: The study found that the expression of Vwf, Cad, and Cav is associated with antibody-mediated injury, potentially aiding in the diagnosis of AMR. Vwf showed significant associations with various markers of injury, while Cad was more expressed in chronic AMR cases compared to acute cases. Cav expression was also linked to MVI and AMR, with higher levels in chronic AMR cases. A combined score of Vwf and Cad was significantly higher in AMR cases compared to other groups, suggesting their potential as diagnostic markers.
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2021)
Article
Hematology
Jana van den Berg, Jasmin D. Haslbauer, Anna K. Stalder, Anna Romanens, Kirsten D. Mertz, Jan -Dirk Studt, Martin Siegemund, Andreas Buser, Andreas Holbro, Alexandar Tzankov
Summary: In this study, autopsy samples from COVID-19 patients were compared to controls, and it was found that VWF is a key component of COVID-19-related thrombi. It is suggested that VWF may be a potential therapeutic target for severe COVID-19.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Immunology
Yassien Badr, Ahmed E. Noreldin, Yaser Hosny Ali Elewa, Mohamed S. Ahmed, Yasuo Inoshima, Nabil M. Baker, Waleed Nabih Aamer, Osama M. Abas, Mohamed Nayel, Md. Matiur Rahman, Emad Elgendy, Asmaa G. Saleh, Mahmoud S. El-neweshy
Summary: This study investigated the immunopathological changes in the skin nodules of cattle infected with lumpy skin disease. The findings showed that early infection is characterized by hyperkeratosis, vasculitis, and early cellules claveleuses of Borrel, while late-stage infection exhibited epidermal hyperkeratosis and dermal lymphocytic and histiocytic infiltrations. IFN-gamma+ cells, CD4+ T lymphocytes, and macrophages were found to play a key role in immunity against the virus. These results contribute to our understanding of the pathogenesis of lumpy skin disease.
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
(2022)
Article
Pathology
Ha-Young Lim, Byung-Joon Seung, Seung-Hee Cho, Soo-Hyeon Kim, Min-Kyung Bae, Jung-Hyang Sur
Summary: This study suggests that obesity may influence the development and progression of canine mammary cancer, associated with higher histologic grade, greater infiltration of TAMs, and increased tumor angiogenesis.
VETERINARY PATHOLOGY
(2022)
Article
Medicine, Legal
Takeshi Kondo, Motonori Takahashi, Gentaro Yamasaki, Marie Sugimoto, Azumi Kuse, Mai Morichika, Kanako Nakagawa, Makoto Sakurada, Migiwa Asano, Yasuhiro Ueno
Summary: Von Willebrand factor (VWF) plays a crucial role in hemostasis and thrombosis, and its expression is elevated around myocardial cells undergoing remodeling. Immunohistochemistry analysis revealed that VWF can serve as an endothelial marker in diagnosing ischemic heart disease, providing valuable insights into myocardial remodeling processes.
Article
Hematology
A. Koloskov, Yu. Divakova, E. L. Belyaeva, I. P. Tokareva, S. A. Karalevich, E. Chernova, O. Philippova, T. Avdeeva
Summary: This study evaluated the quantitative and qualitative changes in von Willebrand factor (vWF), ADAMTS13 metalloprotease, and P-selectin in patients with sepsis. The results showed that the levels of vWF, P-selectin, and ADAMTS13 were significantly different between patients with sepsis, healthy individuals, and patients with idiopathic thrombocytopenic purpura (ITP).
GEMATOLOGIYA I TRANSFUZIOLOGIYA
(2023)
Editorial Material
Cell Biology
D. K. Meyerholz, A. P. Beck, B. Singh
CELL AND TISSUE RESEARCH
(2020)
Review
Cell Biology
Vanessa Vrolyk, Baljit Singh
CELL AND TISSUE RESEARCH
(2020)
Article
Cell Biology
Jasmine Hui, Gurpreet Kaur Aulakh, Suraj Unniappan, Baljit Singh
Summary: Deletion of the NUCB2/nesfatin-1 gene led to an increase in accumulation of adherent neutrophils in the lungs of NKO mice, suggesting an anti-inflammatory role of NUCB2/nesfatin-1 in acute lung inflammation.
CELL AND TISSUE RESEARCH
(2021)
Article
Environmental Sciences
Upkardeep Pandher, Shelley Kirychuk, David Schneberger, Brooke Thompson, Gurpreet Aulakh, R. S. Sethi, Baljit Singh
Summary: The combined exposure of LPS and glyphosate resulted in more severe inflammatory responses in the respiratory system of mice compared to individual exposure, but the inflammation decreased after 10 days, with leukocyte infiltration persisting. Glyphosate exposure modified LPS-induced inflammatory responses, and TLR-2 might play a crucial role in modulating the inflammatory response.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Veterinary Sciences
Fernando P. Freitas, Niels K. Koehncke, Cheryl L. Waldner, Brian A. Scansen, Alexandra F. Belotta, Kursten Pierce, Elissa Randall, Anthony Carr, Koji Aoki, Monique N. Mayer
Summary: The study found that while over 95% of respondents believed that radiation can cause cancer, around 60% never wore hand or eye protection during fluoroscopic procedures, and 28% never adjusted the operating parameters of the fluoroscopy machine to reduce radiation dose. Respondents who had received training on machine operating parameters were more likely to adjust these parameters to reduce their radiation exposure.
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
(2021)
Article
Immunology
Michelle Townsend, Baljit Singh
Summary: The study found a significant increase in the expression of PTX3 in infected calf lungs and a change in PTX3 staining pattern in neutrophils stimulated with LPS. Research on PTX3 in cattle lungs and neutrophils may contribute to our understanding of innate immunity in cattle lungs.
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
(2021)
Article
Anatomy & Morphology
Jasmine Hui, Gurpreet K. Aulakh, Suraj Unniappan, Baljit Singh
Summary: The study reveals the localization of NUCB2/nesfatin-1 in human lungs and neutrophils, indicating its potential role in neutrophilic lung inflammation. The nuclear localization of NUCB2/nesfatin-1 also suggests its potential involvement in transcriptional regulation.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2022)
Article
Anatomy & Morphology
Shankaramurthy Channabasappa, Sarah Caldwell, Rani Kanthan, Baljit Singh
Summary: In this study, the expression of retinoid receptors in normal and inflamed lungs was investigated using immunohistochemistry and Western blot analysis. The results showed that all six retinoid receptor subtypes were expressed in both mouse and human lungs, with differential expression patterns in different lung cells. These findings suggest the potential roles of retinoid receptors in lung pathophysiology.
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2022)
Article
Immunology
Yadu Balachandran, Sarah Caldwell, Gurpreet Kaur Aulakh, Baljit Singh
Summary: TLR10 expression in neutrophils is regulated by ROS production and NF-κB regulation, and TLR10 knockdown reduces neutrophil chemotaxis.
JOURNAL OF INNATE IMMUNITY
(2022)
Editorial Material
Veterinary Sciences
Sheena W. Wong, Nicole J. Fernandez, Kevin Cosford, Anthony P. Carr
VETERINARY CLINICAL PATHOLOGY
(2022)
Article
Cell Biology
Yadu Balachandran, Baljit Singh
Summary: TLR10 plays a significant role in the innate immune response to Streptococcus pneumoniae infection, with knockdown affecting the expression of various inflammatory cytokines and NF-κB nuclear translocation.
CELL AND TISSUE RESEARCH
(2022)
Article
Respiratory System
Nguyen Phuong Khanh Le, Amanda Florentina do Nascimento, David Schneberger, Chi Cuong Quach, Xiaobei Zhang, Gurpreet K. Aulakh, Wojciech Dawicki, Lixin Liu, John R. Gordon, Baljit Singh
Summary: This study found that deficiency of LSP1 reduces airway hyper-responsiveness and lung inflammation in a mouse model of asthma. The levels of LSP1 were increased in the lungs of asthmatic mice and were associated with leukocyte recruitment. These findings suggest that LSP1 is involved in the pathogenesis of asthma.
RESPIRATORY RESEARCH
(2022)
Article
Veterinary Sciences
Samuel J. Hornsey, Anthony P. Carr, Jennifer M. Loewen
Summary: A 12-year-old spayed female German shorthaired pointer dog presented with extensive bite wounds around the neck and developed atrial fibrillation, which spontaneously converted to sinus rhythm without the need for antiarrhythmic therapy. Imbalances in autonomic tone due to trauma may have contributed to the development of atrial fibrillation in this case.
CANADIAN VETERINARY JOURNAL-REVUE VETERINAIRE CANADIENNE
(2021)
Article
Veterinary Sciences
Harpreet Dhingra, Kamaljit Kaur, Baljit Singh
Summary: AMPs have been shown to be effective against M. haemolytica while minimizing the risk of drug residues. HBD3, 28AA, and 20AA analogues exhibited intermediate bactericidal activity against M. haemolytica, with the 10AA analogue showing higher activity likely due to lower final inoculum size. Neutrophils showed chemotaxis towards HBD3 and 20AA peptides in vitro.
VETERINARY RESEARCH
(2021)
Article
Respiratory System
Gurpreet K. Aulakh, Sushmita Maltare, Baljit Singh
Summary: The study explored the role of CD34 in lung neutrophil migration during acute lung inflammation, finding delays in recruitment kinetics in CD34 knock-out mice. The knock-out mice maintained lung vascular barrier properties and had lower levels of pro-inflammatory cytokines and chemokines compared to the wild-type mice. However, CD34 expression in the bronchiolar epithelium and alveolar septa suggests a role in lung neutrophil recruitment but not alveolar migration, cytokine expression, and lung inflammation.
RESPIRATORY RESEARCH
(2021)