Article
Ophthalmology
Kristina Voss, Cindi Kao Yim, Annie Nguyen, Mehdi Roozbahani, Martin Heur
Summary: The study evaluated the safety and efficacy of Bowman's membrane electrocautery in managing blind painful eyes with bullous keratopathy not suitable for corneal transplantation. The procedure effectively resolved bullae in all eyes up to 6 months postoperatively, with some recurrence by 1 year. Pain reduction was achieved in all eyes at 1 month, but some subjects experienced recurrence by 6 months to 1 year. Overall, Bowman's membrane electrocautery appeared to be a safe and minimally invasive option for these cases.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Veterinary Sciences
Jessica B. B. Burn
Summary: This study aimed to describe the use of a nictitating membrane flap as a treatment for corneal ulceration and bullous keratopathy in horses. The results showed that aggressive medical therapy combined with nictitating membrane flap placement can effectively treat bullous keratopathy in horses.
VETERINARY OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Tim Berger, Berthold Seitz, Elias Flockerzi, Shady Suffo, Fidelis A. Flockerzi, Maximilian Berger, Nora Szentmary, Loay Daas
Summary: This study retrospectively analyzed 18 eyes with complicated Descemet's membrane detachment (DMD) and reported clinical outcomes after surgical intervention. The results showed that in eyes with previous penetrating keratoplasty (PKP), AS-OCT demonstrated rupture of Descemet's membrane (DM) in some cases, but spontaneous reattachment occurred in most cases within 8 weeks. Visual acuity significantly improved after surgical treatments such as PKP. In conclusion, PKP is an effective treatment option for complicated DMD.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Medicine, General & Internal
Fan Li, Zhe Zhu, Lubo Fan, Gengrong Yi, Xiaowei Zhu, Naiyang Li
Summary: The study aims to investigate a simple repair algorithm for DMD using Pentacam and AS-OCT. The findings suggest that this algorithm can be safely performed as an outpatient procedure, with accurate delineation using Pentacam and AS-OCT.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Ya-Bin Ma, Ya-Long Dang
Summary: Background: Malignant glaucoma is a challenging postsurgical complication caused by aqueous misdirection, characterized by normal/high intraocular pressure and shallowing of the anterior chambers. Its incidence is about 0.6%-4.0% and can be secondary to various surgeries. Short axial length and a history of angle closure glaucoma are the main risk factors.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Article
Veterinary Sciences
William Irving, Cameron Whittaker, Kelly Caruso, Benjamin Reynolds, Paul Mccarthy, Jeff Smith
Summary: A case of naturally occurring bullous keratopathy in a 2-year-old female neutered dwarf rabbit was successfully treated with temporary tarsorrhaphy and extended medical therapy.
JOURNAL OF EXOTIC PET MEDICINE
(2023)
Review
Medicine, General & Internal
Hon Shing Ong, Hla M. Htoon, Marcus Ang, Jodhbir S. Mehta
Summary: This study evaluated the visual outcomes and complications of endothelium-out and endothelium-in Descemet membrane endothelial keratoplasty (DMEK) graft insertion techniques. The results showed that the endothelium-in technique had lower endothelial cell loss compared to the endothelium-out technique at 6 months, while other outcomes were comparable between the two techniques.
FRONTIERS IN MEDICINE
(2022)
Article
Ophthalmology
Ozlem Dikmetas, Yasemin Kapucu, Ali Buelent Cankaya, Sibel Kocabeyoglu
Summary: The study concluded that AMT is a safe, valuable, and fast treatment technique for corneal epithelial defects from different etiologies that are refractory to conventional treatment.
CUTANEOUS AND OCULAR TOXICOLOGY
(2023)
Article
Ophthalmology
Gillian D. J. Y. Siu, Macy M. S. Wu, Amy L. Wong
Summary: This study describes a novel technique for unfolding an endothelium-in Descemet membrane graft, which was successful in 5 DMEK patients. The side press-and-release technique is essential when the graft does not unfold spontaneously. Overall, this controlled and simple manoeuvre is an efficient and safe method for unfolding such grafts.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Surgery
Alejandro Ontiveros-Holguin, Jorge Pacheco-Padron
Summary: A retained Descemet membrane is a rare but well-known complication of penetrating keratoplasty. We presented a case where a retained Descemet membrane was successfully treated with Descemetorhexis.
JOURNAL OF SURGICAL CASE REPORTS
(2022)
Article
Ophthalmology
Niveditha Narayanan
Summary: To overcome tissue shortage during the pandemic, we switched to using 100% glycerol preservation of the donor cornea, providing longer duration of storage and facing challenges of Descemet's detachments resistant to air tamponade during therapeutic penetrating keratoplasty. Reverse graft suturing was successfully used to reinforce Descemet's attachment, showing promising results for the corneal fraternity.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Veterinary Sciences
L. M. O'Leary, L. Sebbag, L. M. Moody, K. A. Diehl, R. A. Allbaugh
Summary: This case series describes acute corneal hydrops in three young horses, suspected to be caused by traumatic Descemet's membrane rupture. Treatment strategies included medical approaches such as topical antimicrobial therapy, anti-inflammatory therapy, targeted oedema therapy, corneal cross-linking, and temporary partial tarsorrhaphy. Overall, all cases had excellent outcomes with rapid resolution of ocular changes.
EQUINE VETERINARY EDUCATION
(2022)
Article
Ophthalmology
Onur Furundaoturan, Melis Palamar, Ozlem Barut Selver
Summary: The study showed that intrastromal amniotic membrane surgery can be an effective alternative for pain palliation in patients with limited visual prognosis after corneal transplantation when donor tissue is scarce.
TURK OFTALMOLOJI DERGISI-TURKISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Amr Galal, Moumen Seleet, Mohamed Kabeel, Ayman Swar
Summary: This study evaluated the success and outcome of Descemet membrane endothelial keratoplasty (DMEK) with secondary intraocular lens (IOL) implantation using the modified Yamane technique in cases of aphakic bullous keratopathy with insufficient capsular support. The results showed that this method is feasible in managing aphakic bullous keratopathy with inadequate capsular support and is comparable to DMEK alone.
JOURNAL OF THE EGYPTIAN OPHTHALMOLOGICAL SOCIETY
(2023)
Article
Ophthalmology
Abdulrahman AlDarrab
Summary: The study found that about one in three eyes required escalation of glaucoma therapy after DSAEK in an eye-care hospital in Saudi Arabia. Glaucoma and PK patients have a higher risk of GTE post-DSAEK.
OPEN OPHTHALMOLOGY JOURNAL
(2022)
Article
Ophthalmology
Ratnesh K. Singh, Francois Binette, Magdalene Seiler, Simon M. Petersen-Jones, Igor O. Nasonkin
Summary: Blindness caused by retinal degeneration is currently incurable, but regenerative medicine approaches have made groundbreaking discoveries in animal studies. However, the commercialization and standardization of these methods for human treatment are progressing slowly. This review outlines the potential of regenerative medicine approaches for treating blindness caused by retinal cell death.
JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
(2021)
Article
Veterinary Sciences
Katelin Quantz, Amanda L. Anderson, Christine D. Harman, Erica L. Noland, Jacquelyn M. Del Valle, Laurence M. Occelli, Jessica B. Burn, Simon M. Petersen-Jones, Daniel K. Langlois, Chris G. Pirie, Annette D. Petersen, Andras M. Komaromy
Summary: Long-term use of difluprednate ophthalmic emulsion in dogs results in HPA axis suppression and in some cases iatrogenic hyperadrenocorticism. A novel pattern of localized alopecia is suspected to be related to dermal absorption and local action due to superior potency and penetration compared to other commonly utilized ophthalmic corticosteroids.
BMC VETERINARY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Laurence M. Occelli, Anahita Daruwalla, Samantha R. De Silva, Paige A. Winkler, Kelian Sun, Nathaniel Pasmanter, Andrea Minella, Janice Querubin, Leslie A. Lyons, Anthony G. Robson, Elise Heon, Michel Michaelides, Andrew R. Webster, Krzysztof Palczewski, Ajoy Vincent, Omar A. Mahroo, Philip D. Kiser, Simon M. Petersen-Jones
Summary: This article introduces a novel cat model associated with RDH5 gene mutation, which replicates the development of macular atrophy in patients, and has the potential to improve molecular understanding and test therapeutic interventions.
HUMAN MOLECULAR GENETICS
(2022)
Article
Veterinary Sciences
Luis Felipe L. P. Marinho, Laurence M. Occelli, Mariza Bortolini, Kelian Sun, Paige A. Winkler, Fabiano Montiani-Ferreira, Simon M. Petersen-Jones
Summary: Focal bullous retinal detachments were observed in dogs with three distinct forms of progressive retinal atrophy. These lesions develop prior to retinal thinning and should be monitored in dogs with PRA. Gene augmentation therapy in CNGB1-mutant dogs may prevent formation of bullae.
VETERINARY OPHTHALMOLOGY
(2022)
Article
Veterinary Sciences
Laurence M. Occelli, Chris G. Pirie, Simon M. Petersen-Jones
Summary: Optical coherence tomography angiography (OCT-A) is a new non-invasive technique for evaluating retinal vasculature, providing more detailed information compared to traditional dye-based angiography. OCT-A can clearly demonstrate the anatomical depth of the imaged vessels. However, there are limitations and potential errors/artifacts associated with this technique that need to be considered.
VETERINARY OPHTHALMOLOGY
(2022)
Article
Veterinary Sciences
Shin Ae Park, Dodd Sledge, Colleen F. Monahan, Leandro Teixeira, Ryan Boyd, Katie Freeman, Kristin Koehl, Christine Harman, Kirk Munoz, Laurence M. Occelli, Chris G. Pirie, Harriet Davidson, Simon Petersen-Jones, Andras M. Komaromy
Summary: This is a case series describing atypical chorioretinal lesions in dogs with primary angle-closure glaucoma (PACG), suggesting a possible association between the two.
BMC VETERINARY RESEARCH
(2022)
Article
Ophthalmology
Nate Pasmanter, Laurence M. Occelli, Andras M. Komaromy, Simon M. Petersen-Jones
Summary: This study assessed different extended electroretinographic protocols to evaluate the contribution of retinal cells and characterize dogs with inherited retinal disease. The results showed that different stimuli could separate rod and cone responses, and the amplitudes varied with increasing background luminance. Extended flicker protocols were well fit with mathematical models in normal dogs. These protocols provide additional information on the health and function of retinal cells and allow quantifiable comparison between normal dogs and those with retinal disease.
DOCUMENTA OPHTHALMOLOGICA
(2022)
Article
Veterinary Sciences
Simon M. Petersen-Jones, Nate Pasmanter, Laurence M. Occelli, Kristen J. Gervais, Freya M. Mowat, Janice Querubin, Paige A. Winkler
Summary: The study describes an inherited abnormal negative response electroretinogram (NRE) in Papillon dogs that affects both dark- and light-adapted ERG responses.
VETERINARY OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Simon M. Petersen-Jones, Nathaniel Pasmanter, Laurence M. Occelli, Janice R. Querubin, Paige A. Winkler
Summary: This study reports the persistence of small, desensitized rod ERG responses in CNGB1 mutant dogs, which may be due to low levels of CNGA1 in outer segments.
DOCUMENTA OPHTHALMOLOGICA
(2022)
Article
Veterinary Sciences
Nate Pasmanter, Simon M. M. Petersen-Jones
Summary: This study investigates the changes in rod pathways under different lighting conditions in dogs using a long flash protocol with varying background luminance and stimulus strength. The results show that the b-wave of rod response is significantly reduced in mesopic conditions, resulting in a predominantly negative waveform. Rod bipolar cells saturate with dimmer backgrounds than rod photoreceptors, contributing to a large underlying negativity in mesopic backgrounds. These findings highlight the changes in signaling pathway of rod-driven responses that extend the range of lighting conditions over which the retina functions.
BMC VETERINARY RESEARCH
(2022)
Article
Multidisciplinary Sciences
Laurence M. Occelli, Kelian Sun, Paige A. Winkler, Brandy J. Morgan, Simon M. Petersen-Jones
Summary: The purpose of this study was to investigate whether raised levels of retinal cyclic guanosine monophosphate (cGMP) in PDE6A(-/-) dogs was reflected in plasma levels. The results showed that cGMP levels were significantly elevated in retinal samples of 2-month-old PDE6A(-/-) dogs, but there was no significant difference in plasma cGMP levels. Therefore, plasma cGMP levels may not be a useful biomarker for the disease at the 2-month timepoint.
Article
Veterinary Sciences
Andrea L. Minella, Kristina Narfstrom Wiechel, Simon M. Petersen-Jones
Summary: Mutations in the CEP290 gene in rdAc cats lead to a truncation of the protein by 157 amino acids, resulting in a milder phenotype compared to human patients with CEP290 mutations. The retention of some full-length CEP290 protein in mutant cats may contribute to the less severe phenotype.
VETERINARY OPHTHALMOLOGY
(2023)
Article
Veterinary Sciences
Mariza Bortolini, Paige A. Winkler, Juan Carlos Duque Moreno, Mario Teruo Sato, Bianca Luiza Valduga Guareschi, Simon M. Petersen-Jones, Fabiano Montiani-Ferreira
Summary: In this study, we identified a newly identified form of progressive retinal atrophy (PRA) in German Spitzes associated with a mutation in the GUCY2D gene. The initial clinical features included pale papilla and mild vascular attenuation, and the affected dogs showed impaired vision under both scotopic and photopic conditions. Fundus photography and optical coherence tomography revealed multiple small retinal bullae and retinal thinning. Pedigree analysis supported an autosomal recessive inheritance. A mutation was identified in the GUCY2D gene, which was found to be associated with the disease.
VETERINARY OPHTHALMOLOGY
(2023)
Meeting Abstract
Ophthalmology
Billie Beckwith-Cohen, Paige A. Winkler, Laurence M. Occelli, Kelian Sun, Fabiano Montiani-Ferreira, Luis Felipe Marinho, Amy Lee, Maciej Parys, Vilma Yuzbasiyan-Gurkan, William W. Hauswirth, Simon Petersen-Jones
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Meeting Abstract
Biotechnology & Applied Microbiology
Lena Zobel, Laurence M. Occelli, Pavel Kielkowski, Martin Biel, Simon Petersen-Jones, Stylianos Michalakis