Article
Veterinary Sciences
Satoshi Gondaira, Koji Nishi, Jumpei Fujiki, Hidetomo Iwano, Reina Watanabe, Ayako Eguchi, Yuki Hirano, Hidetoshi Higuchi, Hajime Nagahata
Summary: Mycoplasma bovis is a significant worldwide pathogen of cattle, and neutrophils play an important role in the immune response during infection. Stimulation of bovine neutrophils with M. bovis results in increased proinflammatory cytokines and potential induction of neutrophil extracellular traps (NETs). Both live and killed M. bovis induce innate immune responses in neutrophils, with live M. bovis escaping NETs formation.
VETERINARY RESEARCH
(2021)
Review
Immunology
Cecilia Righi, Giulia Franzoni, Francesco Feliziani, Clinton Jones, Stefano Petrini
Summary: Bovine Alphaherpesvirus 1 (BoHV-1) is a significant respiratory pathogen in cattle worldwide, causing bovine respiratory disease. Immunosuppression initially occurs after infection but is followed by the development of innate and adaptive immune responses. Vaccines targeting both humoral and cell-mediated immunity have been developed. This review summarizes the current understanding of cell-mediated immune responses against BoHV-1 infection and vaccination.
Article
Biochemistry & Molecular Biology
Elena L. Bolkhovitina, Julia D. Vavilova, Andrey O. Bogorodskiy, Yuliya A. Zagryadskaya, Ivan S. Okhrimenko, Alexander M. Sapozhnikov, Valentin Borshchevskiy, Marina A. Shevchenko
Summary: In this study, it was found that induction of RBD-specific antibodies stimulates the activation of mature neutrophils in response to RBD-coated particles without triggering excessive inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Vasilios Aris Morikis, Szu Jung Chen, Julianna Madigan, Myung Hyun Jo, Lisette Caroline Werba, Taekjip Ha, Scott Irwin Simon
Summary: A cluster of high affinity β(2)-integrin bonds under tension on arrested neutrophils can trigger Ca2+ flux in response to shear stress. Neutrophils sense the fluid drag force transduced through individual β(2)-integrin bonds to modulate inflammatory response.
Article
Cell Biology
Claudia Alexandra Dumitru, Hannah Schroeder, Frederik Till Alexander Schaefer, Jan Friedrich Aust, Nina Kresse, Carl Ludwig Raven Siebert, Klaus-Peter Stein, Aiden Haghikia, Ludwig Wilkens, Christian Mawrin, Ibrahim Erol Sandalcioglu
Summary: Progesterone Receptor Membrane Component 1 (PGRMC1) is found to promote tumour growth and progression in glioblastoma (GBM). PGRMC1 is associated with the expression of ITGB1 and TCF 1/7 and enhances Interleukin-8 production in GBM cells. Additionally, high expression of PGRMC1 alters the sensitivity of GBM cells to specific drugs.
Article
Multidisciplinary Sciences
Weicai Huang, Yuming Jiang, Wenjun Xiong, Zepang Sun, Chuanli Chen, Qingyu Yuan, Kangneng Zhou, Zhen Han, Hao Feng, Hao Chen, Xiaokun Liang, Shitong Yu, Yanfeng Hu, Jiang Yu, Yan Chen, Liying Zhao, Hao Liu, Zhiwei Zhou, Wei Wang, Yikai Xu, Guoxin Li
Summary: In this study, the authors used CT-based radiomics to predict the response to immunotherapy in gastric cancer patients, and found that radiomics imaging biomarker is closely associated with tumor immune microenvironment and may correlate with prognosis and response to anti PD-1 immunotherapy.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Fatih Yergoz, Julian Friebel, Nicolle Kraenkel, Ursula Rauch-Kroehnert, Heinz-Peter Schultheiss, Ulf Landmesser, Andrea Doerner
Summary: ANT1 in ischemic heart tissue promotes an anti-inflammatory immune response by increasing the infiltration of anti-inflammatory cells and reducing the activity of pro-inflammatory cells, resulting in improved cardiac function.
Article
Dentistry, Oral Surgery & Medicine
N. Fine, J. W. Chadwick, C. Sun, K. K. Parbhakar, N. Khoury, A. Barbour, M. Goldberg, H. C. Tenenbaum, M. Glogauer
Summary: The presence of periodontal diseases is closely related to other chronic inflammatory conditions such as cardiovascular disease, diabetes, and arthritis. Studies show that periodontal tissue inflammation affects the production and activation of polymorphonuclear neutrophils (PMNs), contributing to a hyperinflammatory response in the body. This systemic effect of PD on immune response can exacerbate inflammatory reactions when faced with secondary infections, highlighting the complex interactions between PD and other inflammatory diseases.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Aoife B. Kilgallen, Frederieke van den Akker, Dries A. M. Feyen, Sandra Crnko, Christian J. B. Snijders Blok, Hendrik Gremmels, Bastiaan C. du Pre, Robin Reijers, Pieter A. Doevendans, Saskia C. A. de Jager, Joost P. G. Sluijter, Vasco Sampaio-Pinto, Linda W. van Laake
Summary: Circadian rhythms play a crucial role in the hyperacute immune response after a myocardial infarction (MI). The levels of immune cells and cardiac damage vary throughout the day, indicating the circadian influence on the immune response. These findings align with the clinical observation that patients who experience an MI early in the morning have worse outcomes.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Arun K. Mankan, Paulina Czajka-Francuz, Maria Prendes, Sriram Ramanan, Marcin Koziej, Laura Vidal, Kamal S. Saini
Summary: As the first responders, neutrophils lead the innate immune response by employing strategies such as phagocytosis, microbicide granules, ROS production, and NETs secretion. More recently, their ability to sense and respond to pathogen-associated molecular patterns is being recognized. This review summarizes current information about intracellular DNA recognition by neutrophils and proposes models of signal amplification in immune response. The clinical relevance of DNA sensing by neutrophils in infectious and non-infectious diseases including malignancy is also discussed.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yu Wai Chen, Shah Kamranur Rahman
Summary: The study analyzes the stable intrinsically disordered proteins (IDPs) related to the Renpenning syndrome, which are mutants of the polyglutamine tract-binding protein 1 (PQBP-1). These mutants exhibit higher thermal stabilities and more folded contents compared to the wild-type protein, forming stable soluble dimers. Unlike other conformational disease proteins that lead to aggregation, the toxicity of PQBP-1 mutant dimers lies in compromising their native functions rather than proceeding to aggregation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Ioannis Mitroulis, Akrivi Chrysanthopoulou, Georgios Divolis, Charalampos Ioannidis, Maria Ntinopoulou, Athanasios Tasis, Theocharis Konstantinidis, Christina Antoniadou, Natalia Soteriou, George Lallas, Stella Mitka, Mathias Lesche, Andreas Dahl, Stephanie Gembardt, Maria Panopoulou, Paschalis Sideras, Ben Wielockx, Uenal Coskun, Konstantinos Ritis, Panagiotis Skendros
Summary: This study provides an in-depth analysis of the transcriptomic alterations that occur in human phagocytes upon infection and in peripheral blood immune populations during active brucellosis. It reveals molecular changes related to the disease progression and treatment response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Magdalena P. Crossley, Chenlin Song, Michael J. Bocek, Jun-Hyuk Choi, Joseph Kousorous, Ataya Sathirachinda, Cindy Lin, Joshua R. Brickner, Gongshi Bai, Hannes Lans, Wim Vermeulen, Monther Abu-Remaileh, Karlene A. Cimprich
Summary: R-loops are RNA-DNA hybrids with important cellular roles, but their deregulation can lead to DNA damage. This study identifies a new population of cytoplasmic RNA-DNA hybrids that are processed from nuclear R-loops. These cytoplasmic hybrids activate innate immune response and induce cell death. Aberrant R-loop processing and innate immune activation may contribute to various diseases.
Article
Chemistry, Medicinal
Malkeet Singh Bahia, Netaly Khazanov, Qingxian Zhou, Zhengrong Yang, Chi Wang, Jeong S. Hong, Andras Rab, Eric J. Sorscher, Christie G. Brouillette, John F. Hunt, Hanoch Senderowitz
Summary: The study predicted the impact of mutations on the stability of CFTR's domains using different algorithms, with FoldX and Rosetta showing the best performance. This helps in understanding the mechanisms of CF and could potentially be applied to predict the effects of disease-causing mutations in other proteins as well.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2021)
Article
Engineering, Biomedical
Derek Avery, Lais Morandini, Natalie Celt, Leah Bergey, Jamelle Simmons, Rebecca K. Martin, Henry J. Donahue, Rene Olivares-Navarrete
Summary: This study evaluates the response of inflammatory and immune cells to four common orthopedic materials (pure titanium, titanium alloy, 316L stainless steel, PEEK). The results show that PEEK and stainless steel induce a stronger inflammatory response compared to titanium or titanium alloy, characterized by high infiltration of neutrophils and T cells. The chemical composition of the biomaterials plays a crucial role in the immune cell response.
ACTA BIOMATERIALIA
(2023)
Article
Veterinary Sciences
L. Alibrandi, R. Tognetti, O. Domenech, M. Croce, M. Giuntoli, G. Grosso, T. Vezzosi
Summary: This study assessed the feasibility and diagnostic reliability of a new smartphone-based ECG device in dogs, and found no significant differences compared to a traditional ECG device. The results suggest that the smartphone-based device is clinically reliable for assessing heart rate and rhythm in dogs.
VETERINARY JOURNAL
(2024)