Article
Multidisciplinary Sciences
Kaoru Suzuki, Hiroshi Sunaga, Kentaro Yamakawa, Yoshifumi Suga, Ichiro Kondo, Tsunehisa Tsubokawa, Shoichi Uezono
Summary: The intravenous infusion of rocuronium bromide dose-dependently delays the emergence from propofol anesthesia in a rat model. Although neuromuscular blockade induced by rocuronium bromide can be rapidly antagonized by sugammadex, its effects on circulatory and respiratory parameters were not significant. Further studies are needed to determine the mechanism of this effect.
Article
Neurosciences
Arjun Bharioke, Martin Munz, Alexandra Brignall, Georg Kosche, Max Ferdinand Eizinger, Nicole Ledergerber, Daniel Hillier, Brigitte Gross-Scherf, Karl-Klaus Conzelmann, Emilie Mace, Botond Roska
Summary: General anesthetics induce synchronized activity in mouse layer 5 pyramidal neurons, which coincides with the loss and recovery of consciousness. This suggests that brain-wide synchrony in layer 5 pyramidal neurons may play a key role in anesthesia.
Article
Medicine, Research & Experimental
Rui-zhi Yang, Min Liang, Song Lin, Jing Weng, Jia-min Hu, Shi-zhu Lin, Xiao-dan Wu, Kai Zeng
Summary: This study investigated the effect of general anesthetics on the lung microbiome and found that continuous inhalation of isoflurane altered the diversity and composition of the lung microbiota in rats, resulting in post-anesthesia depression.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Alessandro Mirra, Claudia Spadavecchia, Olivier Levionnois
Summary: This study aimed to investigate the relationship between propofol dose and variables generated by the EEG-based depth of anaesthesia monitor Sedline in pigs. The results showed that the Patient state index and suppression ratio fitted specific pharmacodynamic models, while the relationship between spectral edge frequency 95% and propofol administration was not significant. Additionally, commonly used clinical outcomes did not provide a reliable assessment of propofol dose.
Article
Anesthesiology
Soo Yeon Kim, Ji-Yoon Kim, Jonghae Kim, Seungcheol Yu, Kwang Hyun Lee, Hyeon Seok Lee, Min Seok Oh, Eugene Kim
Summary: The study compared the antinociceptive properties of sevoflurane and desflurane by measuring the pupillary dilation reflex (PDR). The results showed that there was no difference in the change of PDR amplitude, mean arterial pressure (MAP), and heart rate (HR) between the two anesthetics after a noxious stimulation. This suggests that sevoflurane and desflurane may have similar antinociceptive properties.
ANESTHESIA AND ANALGESIA
(2022)
Article
Behavioral Sciences
Xiao-Fang Yue, Ai-Zhong Wang, Yi-Ping Hou, Kun Fan
Summary: In rat experiments, it was found that a high dose of propofol can increase deep slow-wave sleep, producing high-quality sleep; while a medium dose of propofol can lead to fragmented and low-quality sleep by disrupting the continuity of wakefulness. The sleep-promoting effects of propofol are correlated with activation of the ventrolateral preoptic nucleus cluster and inhibition of wake-related systems such as the tuberomammillary nucleus, perifornical nucleus, lateral hypothalamic nucleus, ventrolateral periaqueductal gray, and supramammillary region.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Anesthesiology
David P. Obert, Frederick Schneider, Gerhard Schneider, Falk von Dincklage, Pablo Sepulveda, Paul S. Garcia, Stephan Kratzer, Matthias Kreuzer
Summary: This study evaluated the influence of patient's age and time delay on the patient state index (PSI) of the SEDLine monitor. The results showed that PSI and spectral edge frequency (SEF) increase with age, and the time delays vary depending on the type of transition.
ANESTHESIA AND ANALGESIA
(2023)
Article
Anesthesiology
Thomas W. Schnider, Charles F. Minto
Summary: Variability is high in predicted propofol concentrations during clinical anesthesia, and improving pharmacokinetic models is unlikely to reduce variability in target anesthetic concentrations across patients in clinical practice.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Neurosciences
Xuewei Qin, Xuanling Chen, Bo Wang, Xin Zhao, Yi Tang, Lan Yao, Zhenhu Liang, Jianghong He, Xiaoli Li
Summary: This study compared the EEG changes in vegetative state (VS) patients and non-craniotomy, non-vegetative state (NVS) patients during general anesthesia with low-dose propofol and investigated if it affects the arousal rate of VS patients. The results showed that low doses of propofol caused significant differences in the EEG of different types of VS patients, indicating unique responses of damaged nerve cell residual function to propofol. These weak responses may be the basis of brain recovery.
Article
Behavioral Sciences
Yawen Ao, Bo Yang, Caiju Zhang, Sirui Li, Haibo Xu
Summary: The activity of PVT neurons is enhanced after emergence from anesthesia, and the dopaminergic signaling in the PVT may facilitate emergence from isoflurane anesthesia.
BRAIN AND BEHAVIOR
(2021)
Article
Neurosciences
Zhenhu Liang, Na Ren, Xin Wen, Haiwen Li, Hang Guo, Yaqun Ma, Zheng Li, Xiaoli Li
Summary: The study analyzed EEG signals from 131 patients across different age groups, showing that EEG power and cross frequency coupling characteristics vary with age during anesthesia. The Diag_En index performed the best in distinguishing different states for patients under 6 years old.
Review
Clinical Neurology
Shyam Kumar Sudhakar
Summary: Traumatic brain injuries caused by physical impact can have negative effects on the well-being of individuals. This paper reviews the neuroprotective effects of drugs that increase GABAergic currents based on preclinical literature, and finds no evidence of neuroprotection from these drugs after a primary brain injury. In fact, they may even worsen outcomes. Therefore, caution should be exercised when using anesthetic agents that enhance GABAergic neurotransmission in TBI patients until their neuroprotective efficacy is confirmed in clinical literature.
FRONTIERS IN NEUROLOGY
(2023)
Article
Anesthesiology
Jiang-hua Shen, Min Ye, Qian Chen, Yan Chen, Hai-lin Zhao, Ameena Khan, Bin Yi, Jiao-lin Ning, Kai-zhi Lu, Jian-teng Gu
Summary: Circadian rhythms have a significant impact on the depth of anesthesia and propofol infusion concentrations during target-controlled infusion, with lower levels observed during night surgeries compared to daytime surgeries. Proper adjustment of propofol infusion concentrations is recommended for nighttime surgeries under general anesthesia.
BMC ANESTHESIOLOGY
(2021)
Article
Neurosciences
Shuang Cai, Ai-Chen Tang, Tian-Yuan Luo, Shao-Cheng Yang, Huanhuan Yang, Cheng-Xi Liu, Yue Shu, Yun-Chao Pan, Yu Zhang, Liang Zhou, Tian Yu, Shou-Yang Yu
Summary: The activation of BF GABA(SOM) neurons facilitates propofol and isoflurane anesthesia, leading to longer anesthesia durations and faster inductions. In contrast, manipulation of BF GABA(Parv) neurons has limited effects on anesthesia.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Clinical Neurology
Ryusuke Tanaka, Satoshi Tanaka, Kazuko Hayashi, Keisuke Iida, Teiji Sawa, Mikito Kawamata
Summary: The study found that hydroxyzine enhances the effects of sevoflurane and propofol anesthesia, likely by facilitating GABAergic neural circuit mechanisms. These findings provide a new insight into the role of histaminergic neurons during general anesthesia in humans.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Veterinary Sciences
L. Alibrandi, R. Tognetti, O. Domenech, M. Croce, M. Giuntoli, G. Grosso, T. Vezzosi
Summary: This study assessed the feasibility and diagnostic reliability of a new smartphone-based ECG device in dogs, and found no significant differences compared to a traditional ECG device. The results suggest that the smartphone-based device is clinically reliable for assessing heart rate and rhythm in dogs.
VETERINARY JOURNAL
(2024)
