Journal
VETERINARY AND COMPARATIVE ONCOLOGY
Volume 15, Issue 2, Pages 481-492Publisher
WILEY
DOI: 10.1111/vco.12192
Keywords
canine cancer; cell line panel; comparative oncology; doxorubicin; drug sensitivity; gene expression; microRNA
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Funding
- Morris Animal Foundation [D13CA-058]
- CSU Cancer Supercluster
- Colorado State University College of Veterinary Medicine and Biomedical Sciences Foundation Funds
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Mammalian cell tissue culture has been a critical tool leading to our current understanding of cancer including many aspects of cellular transformation, growth and response to therapies. The current use of large panels of cell lines with associated phenotypic and genotypic information now allows for informatics approaches and in silico screens to rapidly test hypotheses based on simple as well as complex relationships. Current cell line panels with large amounts of associated drug sensitivity and genomics data are comprised of human cancer cell lines (i.e. NCI60 and GDSC). There is increased recognition of the contribution of canine cancer to comparative cancer research as a spontaneous large animal model with application in basic and translational studies. We have assembled a panel of canine cancer cell lines to facilitate studies in canine cancer and report here phenotypic and genotypic data associated with these cells.
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