Intratumoural interleukin 12 gene therapy stimulates the immune system and decreases angiogenesis in dogs with spontaneous cancer

The promising alliance of anti-cancer electrochemotherapy with immunotherapy

(2016) Christophe Y. Calvet et al.   CANCER AND METASTASIS REVIEWS

Reducing tumor growth and angiogenesis using a triple therapy measured with Contrast-enhanced ultrasound (CEUS)

(2015) Philipp Marius Paprottka et al.   BMC CANCER

Electrochemotherapy of tumors as in situ vaccination boosted by immunogene electrotransfer

(2015) Gregor Sersa et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Cytokine-Enhanced Vaccine andInterferon-βplus Suicide Gene Therapy as Surgery Adjuvant Treatments for Spontaneous Canine Melanoma

(2015) Liliana M.E. Finocchiaro et al.   HUMAN GENE THERAPY

Defining the Pharmacodynamic Profile and Therapeutic Index of NHS-IL12 Immunocytokine in Dogs with Malignant Melanoma

(2015) Melissa Paoloni et al.   PLoS One

New insights into IL-12-mediated tumor suppression

(2014) S Tugues et al.   CELL DEATH AND DIFFERENTIATION

Safety and Efficacy of Tumor-Targeted Interleukin 12 Gene Therapy in Treated and Non-Treated, Metastatic Lesions

(2014) Jeffry Cutrera et al.   CURRENT GENE THERAPY

Validation of Dynamic Contrast-Enhanced Ultrasound in Predicting Outcomes of Antiangiogenic Therapy for Solid Tumors

(2014) Nathalie Lassau et al.   INVESTIGATIVE RADIOLOGY

Combination of interleukin-12 gene therapy, metronomic cyclophosphamide and DNA cancer vaccination directs all arms of the immune system towards tumor eradication

(2014) Sofie Denies et al.   JOURNAL OF CONTROLLED RELEASE

Efficient Electrotransfection into Canine Muscle

(2014) Darja Pavlin et al.   TECHNOLOGY IN CANCER RESEARCH & TREATMENT

Clinical Trials of Immunogene Therapy for Spontaneous Tumors in Companion Animals

(2014) Gerardo Claudio Glikin et al.   TheScientificWorldJOURNAL

The effect of anesthesia with propofol and sedation with butorphanol on quantitative contrast-enhanced ultrasonography of the healthy feline kidney

(2014) Emmelie Stock et al.   VETERINARY JOURNAL

Intracellular Tracking of Single-plasmid DNA Particles After Delivery by Electroporation

(2013) Christelle Rosazza et al.   MOLECULAR THERAPY

Electroporation mediated DNA vaccination directly to a mucosal surface results in improved immune responses

(2013) Gleb Kichaev et al.   Human Vaccines & Immunotherapeutics

Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning

(2012) H. J. Pegram et al.   BLOOD

Involvement of eosinophils in the anti-tumor response

(2012) Solène Gatault et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

IL-12 based gene therapy in veterinary medicine

(2012) Darja Pavlin et al.   Journal of Translational Medicine

Clinical and Immunomodulatory Effects of Toceranib Combined with Low-Dose Cyclophosphamide in Dogs with Cancer

(2012) L. Mitchell et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Etiology of Paraneoplastic Autoimmunity

(2011) Emanual Maverakis et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

IL-12 inhibits the TGF-β-dependent T cell developmental programs and skews the TGF-β-induced differentiation into a Th1-like direction

(2011) Jana Prochazkova et al.   IMMUNOBIOLOGY

The role of interleukin-12 on modulating myeloid-derived suppressor cells, increasing overall survival and reducing metastasis

(2011) Catherine E. Steding et al.   IMMUNOLOGY

Metabolic Considerations in Management of Surgical Patients

(2011) George L. Blackburn   SURGICAL CLINICS OF NORTH AMERICA

Bleomycin/interleukin-12 electrochemogenetherapy for treating naturally occurring spontaneous neoplasms in dogs

(2010) S D Reed et al.   CANCER GENE THERAPY

Cancer Electrogene Therapy with Interleukin-12

(2010) Maja Cemazar et al.   CURRENT GENE THERAPY

Targeting inhibitory pathways in cancer immunotherapy

(2010) Marcio O Lasaro et al.   CURRENT OPINION IN IMMUNOLOGY

Double-blind Placebo-controlled Study With Interleukin-18 and Interleukin-12-encoding Plasmid DNA Shows Antitumor Effect in Metastatic Melanoma in Gray Horses

(2010) Jessika- M.V. Müller et al.   JOURNAL OF IMMUNOTHERAPY

Electrogene therapy with interleukin-12 in canine mast cell tumors

(2010) Darja Pavlin et al.   Radiology and Oncology

Central Role of IFN -Indoleamine 2,3-Dioxygenase Axis in Regulation of Interleukin-12-Mediated Antitumor Immunity

(2009) T. Gu et al.   CANCER RESEARCH

Interleukin 12 Stimulates IFN- -Mediated Inhibition of Tumor-Induced Regulatory T-Cell Proliferation and Enhances Tumor Clearance

(2009) X. Cao et al.   CANCER RESEARCH

Electroporation-mediatedIL-12gene therapy in a transplantable canine cancer model

(2009) Tien-Fu Chuang et al.   INTERNATIONAL JOURNAL OF CANCER

Interferon-γ enhances human eosinophil effector functions induced by granulocyte-macrophage colony-stimulating factor or interleukin-5

(2008) Takafumi Yamaguchi et al.   IMMUNOLOGY LETTERS

IL-24: a classic cytokine and/or a potential cure for cancer?

(2008) S. Kreis et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Phase I Trial of Interleukin-12 Plasmid Electroporation in Patients With Metastatic Melanoma

(2008) Adil I. Daud et al.   JOURNAL OF CLINICAL ONCOLOGY