Glucocorticoid receptor function in health and disease

Mapracorat, a selective glucocorticoid receptor agonist, upregulates RelB, an anti-inflammatory nuclear factor-kappaB protein, in human ocular cells

(2014) Sherry L. Spinelli et al.   EXPERIMENTAL EYE RESEARCH

The Methyltransferase WBSCR22/Merm1 Enhances Glucocorticoid Receptor Function and Is Regulated in Lung Inflammation and Cancer

(2014) Maryam Jangani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serum cholesterol selectively regulates glucocorticoid sensitivity through activation of JNK

(2014) Nan Yang et al.   JOURNAL OF ENDOCRINOLOGY

Respiratory Infections Cause the Release of Extracellular Vesicles: Implications in Exacerbation of Asthma/COPD

(2014) Suffwan Eltom et al.   PLoS One

Discovery of GW870086: a potent anti-inflammatory steroid with a unique pharmacological profile

(2013) I J Uings et al.   BRITISH JOURNAL OF PHARMACOLOGY

A novel macrolide/fluoroketolide, solithromycin (CEM-101), reverses corticosteroid insensitivity via phosphoinositide 3-kinase pathway inhibition

(2013) Y Kobayashi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease

(2013) Peter J. Barnes   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Efficacy and safety of once-daily GW870086 a novel selective glucocorticoid in mild-moderate asthmatics: a randomised, two-way crossover, controlled clinical trial

(2013) Philippe Bareille et al.   JOURNAL OF ASTHMA

A ligand-specific kinetic switch regulates glucocorticoid receptor trafficking and function

(2013) P. J. Trebble et al.   JOURNAL OF CELL SCIENCE

The glucocorticoid receptor dimer interface allosterically transmits sequence-specific DNA signals

(2013) Lisa C Watson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Chromatin remodeling during glucocorticoid receptor regulated transactivation

(2012) Heather A. King et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Anti-inflammatory Effects of Mapracorat, a Novel Selective Glucocorticoid Receptor Agonist, Is Partially Mediated by MAP Kinase Phosphatase-1 (MKP-1)

(2012) Thomas R. Vollmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucocorticoid Receptor-Beta Up-Regulation and Steroid Resistance Induction by IL-17 and IL-23 Cytokine Stimulation in Peripheral Mononuclear Cells

(2012) Alejandro Vazquez-Tello et al.   JOURNAL OF CLINICAL IMMUNOLOGY

How glucocorticoid receptors modulate the activity of other transcription factors: A scope beyond tethering

(2012) Dariusz Ratman et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Insights into Negative Regulation by the Glucocorticoid Receptor from Genome-wide Profiling of Inflammatory Cistromes

(2012) N. Henriette Uhlenhaut et al.   MOLECULAR CELL

The structural basis of direct glucocorticoid-mediated transrepression

(2012) William H Hudson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Nortriptyline Reverses Corticosteroid Insensitivity by Inhibition of Phosphoinositide-3-Kinase- 

(2011) N. Mercado et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Chromatin accessibility pre-determines glucocorticoid receptor binding patterns

(2011) Sam John et al.   NATURE GENETICS

Temperature-Responsive Release of Cortisol from Its Binding Globulin: A Protein Thermocouple

(2010) Angus Cameron et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Inhibition of PI3Kδ Restores Glucocorticoid Function in Smoking-induced Airway Inflammation in Mice

(2009) John A. Marwick et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Characterization of ZK 245186, a novel, selective glucocorticoid receptor agonist for the topical treatment of inflammatory skin diseases

(2009) H Schäcke et al.   BRITISH JOURNAL OF PHARMACOLOGY

Drug Insight: selective agonists and antagonists of the glucocorticoid receptor

(2008) Andrew McMaster et al.   Nature clinical practice. Endocrinology & metabolism