Review
Immunology
Se-Hun Kim, Ramachandran Chelliah, Sudha Rani Ramakrishnan, Ayyappasamy Sudalaiyadum Perumal, Woo-Suk Bang, Momna Rubab, Eric Banan-Mwine Daliri, Kaliyan Barathikannan, Fazle Elahi, Eunji Park, Hyeon Yeong Jo, Su-Bin Hwang, Deog Hwan Oh
Summary: Campylobacter spp. are the leading cause of bacterial colon infections in humans globally, and their stress-adaptation mechanisms differ from other enteropathogenic bacteria, allowing them to survive in diverse environments and enhance their resistance mechanisms.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Microbiology
Harald Nothaft, Maria Elisa Perez-Munoz, Tianfu Yang, Abarna V. M. Murugan, Michelle Miller, Daniel Kolarich, Graham S. Plastow, Jens Walter, Christine M. Szymanski
Summary: The study shows that Campylobacter jejuni spreads through contaminated poultry products, and an attenuated Escherichia coli live vaccine strain expressing the C. jejuni N-glycan can reduce the Campylobacter load in poultry, with distinct responder and non-responder outcomes. Research indicates that antibodies from responder birds have higher Campylobacter-opsonophagocytic activity, and transplantation of cecal microbiota from responder birds can enhance vaccine-induced antigen-specific IgY responses.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Blake W. Stamps, Janelle Kuroiwa, Sandra D. Isidean, Megan A. Schilling, Clayton Harro, Kawsar R. Talaat, David A. Sack, David R. Tribble, Alexander C. Maue, Joanna E. Rimmer, Renee M. Laird, Chad K. Porter, Michael S. Goodson, Frederic Poly
Summary: The study showed that there were statistically significant but minor differences in beta diversity among study participants during the challenge period, and pre-challenge alpha diversity was higher in participants who did not develop campylobacteriosis compared to those who did. However, alpha diversity decreased in all participants after infection. Future studies could explore CHIM studies with inocula more closely resembling natural exposure and field studies involving naturally-occurring enteric infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Prerna Vohra, Cosmin Chintoan-Uta, Abi Bremner, Marta Mauri, Vanessa S. Terra, Jon Cuccui, Brendan W. Wren, Lonneke Vervelde, Mark P. Stevens
Summary: Campylobacter jejuni is a common bacterial cause of human gastroenteritis, primarily transmitted through contaminated poultry meat. Previous studies have shown that glycoconjugate vaccines with C. jejuni N-glycan provide partial protection in chickens, but subunit vaccines with FlpA or SodB proteins coupled with C. jejuni N-glycans did not show significant protection. A new vaccine strategy using glycoprotein G-ExoA with multiple C. jejuni N-glycans was evaluated in chickens, but did not result in reduced colonization by C. jejuni. The study suggests that protection against C. jejuni may be influenced by the amount of glycan presented and other study-specific variables.
Article
Multidisciplinary Sciences
Nikola Ondrikova, Helen E. Clough, Amy Douglas, Miren Iturriza-Gomara, Lesley Larkin, Roberto Vivancos, John P. Harris, Nigel A. Cunliffe
Summary: The COVID-19 pandemic had a more adverse impact on laboratory reporting of norovirus compared to Campylobacter in England. This may be explained by stronger behavioral interventions affecting norovirus transmission and a greater reduction in norovirus testing capacity. The study highlights the differential impact a pandemic can have on surveillance of gastrointestinal infectious diseases.
Article
Microbiology
Hengchun Cao, Hanxiao Xu, Chunhui Ning, Li Xiang, Qiufang Ren, Tiantian Zhang, Yusen Zhang, Rui Gao
Summary: This study investigated the pangenome of Campylobacter jejuni, analyzing its virulence genes and potential core vaccine targets. Through experiments and analysis, five core vaccine targets with high antigenicity were identified, which play important roles in the virulence of C. jejuni in different hosts. The findings contribute to the discovery of new vaccine targets and provide a method to prevent multidrug-resistant C. jejuni.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Galo Amaro Munoz, Maribel Denise Riveros-Ramirez, Elsa Chea-Woo, Theresa J. Ochoa
Summary: This study found that children with gastroenteritis caused by Campylobacter spp. had longer symptom duration, higher frequency of bowel movements, and higher rates of vomiting and fever when coinfected with other pathogens. Additionally, patients treated with macrolides may have faster recovery compared to those treated with nonmacrolides.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Multidisciplinary Sciences
Xiaofang Wu, Lei Ji, Yuehua Shen, Liping Chen, Deshun Xu, Fenfen Dong
Summary: Thirteen pathogenic Campylobacter strains were isolated from diarrhea cases and raw poultry meat products in Huzhou, including 11 Campylobacter jejuni and 2 Campylobacter coli strains. These strains contain multiple virulence-related genes and show high resistance to nalidixic acid, ciprofloxacin, and tetracycline. Genomic sequencing revealed the presence of tet(O) and blaOXA resistance genes in all C. jejuni strains and multiple drug resistance genes in 2 C. coli strains.
Article
Microbiology
Nicole Maier, Shannon L. Grahek, Jane Halpern, Suzanne Restrepo, Felipe Troncoso, Janet Shimko, Olga Torres, Jaime Belkind-Gerson, David A. Sack, Ann-Mari Svennerholm, Bjorn Gustafsson, Bjorn Sjostrand, Nils Carlin, A. Louis Bourgeois, Chad K. Porter
Summary: The efficacy of an oral whole cell ETEC vaccine against travelers' diarrhea was reevaluated using novel outcome and immunologic measures. The vaccine showed effectiveness against both severe and mild ETEC-associated diarrhea, and its efficacy was related to immunologic response and TD severity. These findings highlight the importance of improving vaccine formulation and suggest the inclusion of TD severity score as an endpoint in future studies.
Article
Microbiology
Myungseo Park, Jinshil Kim, Jill Feinstein, Kevin S. Lang, Sangryeol Ryu, Byeonghwa Jeon
Summary: Antibiotic tolerance in C. jejuni leads to the development of antibiotic resistance, particularly fluoroquinolone resistance. Exposure to ciprofloxacin or tetracycline induces antibiotic tolerance and promotes the emergence of fluoroquinolone-resistant C. jejuni clones. Alkyl hydroperoxide reductase plays a critical role in reducing the development of fluoroquinolone resistance after tolerance induction.
MICROBIOLOGY SPECTRUM
(2022)
Article
Multidisciplinary Sciences
Yuli Melisa Sierra-Arguello, Gustavo Perdoncini, Laura Beatriz Rodrigues, Luciana Ruschel dos Santos, Karen Apellanis Borges, Thales Quedi Furian, Carlos Tadeu Pippi Salle, Hamilton Luiz de Souza Moraes, Marcos Jose Pereira Gomes, Vladimir Pinheiro do Nascimento
Summary: Campylobacter jejuni is a common cause of foodborne illnesses worldwide, with limited research on strains isolated from Latin-American countries. This study in Southern Brazil identified 140 C. jejuni strains from various poultry sources and analyzed their virulence markers, providing insight into factors related to the occurrence of this pathogen and their epidemiology. The PCR analysis revealed 25 different virulence profiles, with certain combinations of virulence genes being more common among the strains.
SCIENTIFIC REPORTS
(2021)
Review
Immunology
Fang Liu, Seul A. A. Lee, Jessica Xue, Stephen M. Riordan, Li Zhang
Summary: Campylobacteriosis is a global health concern that requires increased research and improved strategies for prevention. This review provides comprehensive and updated information on the global epidemiology of campylobacteriosis, including reported incidence and outbreaks. The COVID-19 pandemic has impacted the reported incidence of campylobacteriosis, with a decrease observed in most countries where data were available.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Ruby Costigan, Emily Stoakes, R. Andres Floto, Julian Parkhill, Andrew J. Grant
Summary: This study reports the development of a CRISPRi-based tool in C. jejuni, which will be a valuable resource for the Campylobacter community. The tool was successfully validated through the repression of target genes and resulted in phenotypical changes.
Article
Environmental Sciences
Shuxin Zhang, Jiahua Shi, Xuan Li, Lachlan Coin, Jake W. O'Brien, Muttucumaru Sivakumar, Faisal Hai, Guangming Jiang
Summary: This study developed a triplex qPCR assay for the detection and quantification of Campylobacter species in wastewater samples, specifically targeting C. jejuni and C. coli. The assay demonstrated high sensitivity and reliability, and can be used for long-term monitoring of Campylobacter prevalence in communities and surrounding environments.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Multidisciplinary Sciences
S. Ghosh, M. Kumar, M. Santiana, A. Mishra, M. Zhang, H. Labayo, A. M. Chibly, H. Nakamura, T. Tanaka, W. Henderson, E. Lewis, O. Voss, Y. Su, Y. Belkaid, J. A. Chiorini, M. P. Hoffman, N. Altan-Bonnet
Summary: This study reveals a new transmission route for enteric viruses through salivary glands, finding that infected infants can transmit the viruses to their mothers' mammary glands through saliva, leading to an increase in secretory IgA antibodies in maternal milk.
Article
Public, Environmental & Occupational Health
Rebecca Sainato, Atef ElGendy, Frederic Poly, Janelle Kuroiwa, Patricia Guerry, Mark S. Riddle, Chad K. Porter
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2018)
Review
Infectious Diseases
M. S. Riddle, W. H. Chen, C. D. Kirkwood, C. A. MacLennan
CLINICAL MICROBIOLOGY AND INFECTION
(2018)
Article
Gastroenterology & Hepatology
Jordan E. Axelrad, Andrew Joelson, Yael Nobel, Susan Whittier, Garrett Lawlor, Mark S. Riddle, Peter H. R. Green, Benjamin Lebwohl
DIGESTIVE DISEASES AND SCIENCES
(2018)
Article
Medicine, Research & Experimental
Pardeep Kumar, F. Matthew Kuhlmann, Subhra Chakraborty, A. Louis Bourgeois, Jennifer Foulke-Abel, Brunda Tumala, Tim J. Vickers, David A. Sack, Barbara DeNearing, Clayton D. Harro, W. Shea Wright, Jeffrey C. Gildersleeve, Matthew A. Ciorba, Srikanth Santhanam, Chad K. Porter, Ramiro L. Gutierrez, Michael G. Prouty, Mark S. Riddle, Alexander Polino, Alaullah Sheikh, Mark Donowitz, James M. Fleckenstein
JOURNAL OF CLINICAL INVESTIGATION
(2018)
Editorial Material
Public, Environmental & Occupational Health
Mark S. Riddle
JOURNAL OF TRAVEL MEDICINE
(2018)
Review
Medicine, General & Internal
Karen L. Kotloff, Mark S. Riddle, James A. Platts-Mills, Patricia Pavlinac, Anita K. M. Zaidi
Article
Multidisciplinary Sciences
Chad K. Porter, Amanda Lynen, Mark S. Riddle, Kawsar Talaat, David Sack, Ramiro L. Gutierrez, Robin McKenzie, Barbara DeNearing, Brittany Feijoo, Robert W. Kaminski, David N. Taylor, Beth D. Kirkpatrick, A. Louis Bourgeois
Article
Multidisciplinary Sciences
Alexander A. Crofts, Simone M. Giovanetti, Erica J. Rubin, Frederic M. Poly, Ramiro L. Gutierrez, Kawsar R. Talaat, Chad K. Porter, Mark S. Riddle, Barbara DeNearing, Jessica Brubaker, Milton Maciel, Ashley N. Alcala, Subhra Chakraborty, Michael G. Prouty, Stephen J. Savarino, Bryan W. Davies, M. Stephen Trent
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Meeting Abstract
Gastroenterology & Hepatology
R. S. Choung, F. Petralia, J. Torres, T. Sato, X. -J. Li, P. Wang, S. Telesco, C. Porter, R. Laird, R. Gutierrez, F. Princen, S. Plevy, R. Strauss, M. Riddle, J. Murray, J. F. Colombel
JOURNAL OF CROHNS & COLITIS
(2019)
Article
Immunology
Egle Butkeviciute, Holly J. Prudden, Mark Jit, Peter G. Smith, Gagandeep Kang, Mark S. Riddle, Benjamin A. Lopman, Virginia E. Pitzer, Claudio F. Lanata, James A. Platts-Mills, Robert F. Breiman, Birgitte K. Giersing, Mateusz Hasso-Agopsowicz
Summary: This study compared the quality of studies used by IHME and MCEE to estimate mortality associated with enterotoxigenic Escherichia coli and Shigella in 2016. The results showed that the majority of studies used by both modeling groups were of high quality, with an overrepresentation of studies from certain regions. Recommendations were made for future estimates of mortality associated with enteric diseases.
Article
Immunology
Ryan C. Johnson, Joy D. Van Nostrand, Michele Tisdale, Brett Swierczewski, Mark P. Simons, Patrick Connor, Jamie Fraser, Angela R. Melton-Celsa, David R. Tribble, Mark S. Riddle
Summary: The study found that single-dose antibiotic regimens may not significantly alter the functional or antibiotic resistance composition of fecal microflora, which should inform clinical practice guidelines and antimicrobial stewardship.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Article
Immunology
Mark S. Riddle, A. Louis Bourgeois, Allison Clifford, Suhi Jeon, Birgitte K. Giersing, Mark Jit, Marta Tufet Bayona, Jared Ovitt, William P. Hausdorff
Summary: Shigella, a gram-negative bacterium, is a major cause of severe diarrhea and dysentery in children under five in low- and middle-income countries. Despite the development of promising Shigella vaccine candidates, the recommendation and adoption of such vaccines may face challenges due to declining disease rates, complex immunization programs, and availability of other vaccines.
Editorial Material
Public, Environmental & Occupational Health
Mark S. Riddle, Charles D. Ericsson, Robert Steffen
JOURNAL OF TRAVEL MEDICINE
(2023)
Article
Immunology
Christopher Duplessis, Kristen A. Clarkson, K. Ross Turbyfill, Ashley N. Alcala, Ramiro Gutierrez, Mark S. Riddle, Tida Lee, Kristopher Paolino, Hailey P. Weerts, Amanda Lynen, Edwin Oaks, Chad K. Porter, Robert Kaminski
Summary: Shigella species cause severe disease and an effective vaccine is urgently needed. InvaplexAR vaccine, a subunit vaccine approach, demonstrated increased immunogenicity in pre-clinical studies and was tested in a phase 1 trial, showing safety and potential for inducing immune responses.
Review
Medicine, General & Internal
Mark S. Riddle
POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ
(2018)
