Article
Microbiology
Jun Li, Rumeng Li, Qi Zhang, Peipei Peng, Xiaoquan Wang, Min Gu, Zenglei Hu, Xinan Jiao, Daxin Peng, Jiao Hu, Xiufan Liu
Summary: This study demonstrates that the H7N9 VLP vaccine provides complete clinical protection against HP H7N9 virus, significantly inhibits virus shedding, and abolishes viral replication in chickens. The VLP vaccine represents a promising alternative strategy for the development of novel H7N9 avian influenza vaccines for chickens.
VETERINARY MICROBIOLOGY
(2021)
Article
Fisheries
Thi Hao Vu, Jubi Heo, Suyeon Kang, Chaeeun Kim, Hyun S. Lillehoj, Yeong Ho Hong
Summary: This study investigates the role and mechanism of the chicken miRNA gga-miR-26a-5p in the immune response to HPAIV H5N1 infection. The results show that gga-miR-26a-5p acts as a translational repressor of MDA5 and negatively regulates the expression of signaling molecules and proinflammatory cytokines in the MDA5 signaling pathway. These findings contribute to a better understanding of the biological functions of gga-miR-26a-5p and the antiviral response in chickens.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Veterinary Sciences
Jiao Hu, Peipei Peng, Jun Li, Qi Zhang, Rumeng Li, Xiaoquan Wang, Min Gu, Zenglei Hu, Shunlin Hu, Xiaowen Liu, Xinan Jiao, Daxin Peng, Xiufan Liu
Summary: The bivalent H5+H7 VLP vaccine candidate shows promising results in protecting poultry against highly pathogenic H5N1 and H7N9 avian influenza viruses, and may serve as a critical alternative to traditional egg-based inactivated vaccines.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Review
Oncology
William J. Liu, Haixia Xiao, Lianpan Dai, Di Liu, Jianjun Chen, Xiaopeng Qi, Yuhai Bi, Yi Shi, George F. Gao, Yingxia Liu
Summary: Avian influenza A (H7N9) virus, closely associated with live poultry markets, has caused infections in humans in China since 2013. Five waves of the epidemic occurred between 2013 and 2017, with the emergence of highly pathogenic strains causing concern. Rapid response and control by specialists and officials utilized new technologies and surveillance tools. Characteristics of the virus were reviewed from multiple perspectives to provide tools for reducing future threats from H7N9 and other viruses.
FRONTIERS OF MEDICINE
(2021)
Article
Virology
Yu-Hsuan Yang, Ching-Hui Tai, Dayna Cheng, Ya-Fang Wang, Jen-Ren Wang
Summary: In this study, H5N6 virus-like particles (VLPs) were generated and tested for their potential as a broad-spectrum vaccine candidate against H5Nx avian influenza viruses. The results showed that H5N6 VLPs induced higher neutralizing antibody titers and increased production of immune-related cytokines compared to H5+N6 proteins, suggesting that H5N6 VLPs may be a potential vaccine candidate.
Article
Agriculture, Dairy & Animal Science
Ahmed Setta, Nahed Yehia, Amani Osman Shakak, Diana A. Al-Quwaie, Aljohara M. Al-Otaibi, Mohamed T. El-Saadony, Khaled A. El-Tarabily, Heba Salem
Summary: The study investigated the prevalence of highly pathogenic avian influenza (HPAI) virus in commercial broiler chicken flocks from 2019 to 2022. Samples were collected from 111 problematic flocks and analyzed using molecular tools. The results showed that 21.6% of the flocks tested positive for HPAI H5N8, with higher prevalence in vaccinated flocks and detection mainly in autumn and winter. Regular molecular monitoring, vaccine efficacy evaluation, and preventive strategies are recommended to control this serious threat.
Article
Multidisciplinary Sciences
Mariana Leguia, Alejandra Garcia-Glaessner, Breno Munoz-Saavedra, Diana Juarez, Patricia Barrera, Carlos Calvo-Mac, Javier Jara, Walter Silva, Karl Ploog, Lady Amaro, Paulo Colchao-Claux, Christine K. Johnson, Marcela M. Uhart, Martha I. Nelson, Jesus Lescano
Summary: Highly pathogenic avian influenza A/H5N1 viruses have invaded the Americas and pose a threat to wildlife, poultry, and humans. The HPAI/H5N1 viruses in Peru have genetic reassortment between Eurasian and American lineages, emphasizing the need for surveillance and control measures.
NATURE COMMUNICATIONS
(2023)
Editorial Material
Multidisciplinary Sciences
Younjung Kim, Guillaume Fournie, Raphalle Metras, Daesub Song, Christl A. Donnelly, Dirk U. Pfeiffer, Pierre Nouvellet
Summary: This article discusses recent outbreaks of highly pathogenic avian influenza in two cat shelters in South Korea and emphasizes the need to enhance surveillance for cross-species viral transmission from a One Health perspective.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Wendy Puryear, Kaitlin Sawatzki, Nichola Hill, Alexa Foss, Jonathon J. Stone, Lynda Doughty, Dominique Walk, Katie Gilbert, Maureen Murray, Elena Cox, Priya Patel, Zak Mertz, Stephanie Ellis, Jennifer Taylor, Deborah Fauquier, Ainsley Smith, Robert A. DiGiovanni Jr, Adriana van de Guchte, Ana Silvia Gonzalez-Reiche, Zain Khalil, Harm van Bakel, Mia K. Torchetti, Kristina Lantz, Julianna B. Lenoch, Jonathan Runstadler
Summary: We report the spread of highly pathogenic avian influenza A(H5N1) in marine mammals in the northeastern United States, which is concurrent with the presence of H5N1 in wild birds in the same area. Our findings highlight the importance of monitoring both wild coastal birds and marine mammals in assessing the potential for an influenza A virus pandemic.
EMERGING INFECTIOUS DISEASES
(2023)
Letter
Immunology
Ivan Sobolev, Kirill Sharshov, Nikita Dubovitskiy, Olga Kurskaya, Alexander Alekseev, Sergey Leonov, Yuriy Yushkov, Victor Irza, Andrey Komissarov, Artem Fadeev, Daria Danilenko, Junki Mine, Ryota Tsunekuni, Yuko Uchida, Takehiko Saito, Alexander Shestopalov
Summary: Two variants of highly pathogenic avian influenza A(H5N8) virus were detected in dead poultry in Western Siberia, Russia, during August and September 2020. One variant belonged to clade 2.3.4.4b and the other was a novel reassortant between clade 2.3.4.4b and Eurasian low pathogenicity avian influenza viruses circulating in wild birds.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Veterinary Sciences
Jiho Lee, Deok-hwan Kim, Jinyong Noh, Sungsu Youk, Jei-hyun Jeong, Joong-bok Lee, Seung-Yong Park, In-soo Choi, Sang-Won Lee, Chang-seon Song
Summary: This study developed a live recombinant vaccine that effectively prevents the transmission of H5 HPAIV in poultry and rapidly initiates an immune response.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Immunology
Nancy Beerens, Evelien A. Germeraad, Sandra Venema, Eline Verheij, Sylvia B. E. Pritz-Verschuren, Jose L. Gonzales
Summary: The study found that recent H5 clade 2.3.4.4 viruses were highly pathogenic for chickens, but had varying pathogenicity for different duck species, especially the most recent H5N6-2017 virus. On the other hand, the H5N8-2016 virus was efficiently transmitted to chickens through contaminated water sources.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Infectious Diseases
Debapriyo Chakraborty, Claire Guinat, Nicola F. Muller, Francois-Xavier Briand, Mathieu Andraud, Axelle Scoizec, Sophie Lebouquin, Eric Niqueux, Audrey Schmitz, Beatrice Grasland, Jean-Luc Guerin, Mathilde C. Paul, Timothee Vergne
Summary: This study analyzed the spatiotemporal dynamics of the highly pathogenic avian influenza epidemic in France in 2016-2017 and assessed the impact of control measures on viral spread. The results showed that large-scale culling of ducks significantly reduced viral spread between regions, while restrictions on duck transport within regions may not completely stop the viral spread.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Virology
Hae-Ji Kang, Ki-Back Chu, Keon-Woong Yoon, Gi-Deok Eom, Jie Mao, Min-Ju Kim, Su-Hwa Lee, Eun-Kyung Moon, Fu-Shi Quan
Summary: Research suggests that avian influenza VLP vaccines expressing multiple neuraminidases can provide both homologous and heterosubtypic protection against different subtypes, offering a promising approach for developing a universal influenza A vaccine against avian and human influenza virus infections.
Article
Biochemistry & Molecular Biology
Olivier Duriez, Yohan Sassi, Chloe Le Gall-Ladeveze, Lea Giraud, Robert Straughan, Lise Dauverne, Anna Terras, Thierry Boulinier, Remi Choquet, Anne van de Wiele, Julien Hirschinger, Jean-Luc Guerin, Guillaume Le Loc'h
Summary: A study found that terrestrial birds infected with highly pathogenic avian influenza (HPAI) virus exhibit immobility behavior during the breeding season, which may reduce the risk of virus transmission. However, these infections pose a threat to endangered vulture species, raising concerns about their resistance to the virus.