Review
Medicine, General & Internal
Ilona Jaszczuk, Dorota Koczkodaj, Adrianna Kondracka, Anna Kwasniewska, Izabela Winkler, Agata Filip
Summary: miR-210 plays an important role in the development of pre-eclampsia and is a promising biomarker for monitoring this disease. Overexpression of miR-210 has a negative impact on cell migration and trophoblast invasion.
ANNALS OF MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jean Michell Santoyo, Jose Antonio Noguera, Francisco Aviles, Juan Luis Delgado, Catalina de Paco-Matallana, Virginia Perez, Isabel Hernandez
Summary: Pre-eclampsia is related to future cardiovascular disease risk, and this study aims to investigate factors and biomarkers related to endothelial dysfunction in women at high risk of pre-eclampsia who do not develop the disease. The study found that arterial pressure and oxidative stress biomarkers were significantly increased in the high-risk pre-eclampsia group, while biomarkers of inflammation and endothelial function were also significantly elevated.
Article
Obstetrics & Gynecology
Astha Sharma, Jyotsna Suri, Zeba Khanam, Divya Pandey, Sumitra Bachani, Anuradha Sharma
Summary: This study aimed to predict the probability of complications in women with pre-eclampsia within 24 hours of admission using the fullPIERS model and evaluate its predictive value. The results showed that the fullPIERS model had good discriminating ability in predicting complications between 48 hours and 7 days after admission.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Transplantation
Luca Valsecchi, Alessandro Galdini, Daniela Gabellini, Giacomo Dell'Antonio, Silvia Galbiati, Andrea Fanecco, Ilaria Vigano', Maddalena Smid, Rosa Bernardi, Silvia Maestroni, Hans J. Baelde, Gianpaolo Zerbini
Summary: Pre-eclampsia leads to inhibition of vascular endothelial growth factor (VEGF), which may cause an increase in VEGF synthesis in the kidney, leading to renal dysfunction. This non-canonical VEGF inhibition mechanism is possibly involved in podocyturia and the development of pre-eclampsia.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Environmental Sciences
Paola Mozzoni, Simona Iodice, Nicola Persico, Luca Ferrari, Silvana Pinelli, Massimo Corradi, Stefano Rossi, Michele Miragoli, Enrico Bergamaschi, Valentina Bollati
Summary: This study found that exposure to air pollutants is associated with changes in circulating levels of biomarkers in pregnant women, indicating systemic inflammation and endothelial dysfunction/activation. These findings support the hypothesis that inflammation and endothelial dysfunction play a central role in modulating the detrimental effects of air pollution exposure during pregnancy.
ENVIRONMENTAL RESEARCH
(2022)
Article
Immunology
Kamini Dangat, Nisha Wadhwani, Karuna Randhir, Anupam Poddar, Sanjay Gupte, Girija Wagh, Sanjay Lalwani, Sadhana Joshi
Summary: This study investigates the levels of high-sensitivity C-reactive protein (hs-CRP) in women with pre-eclampsia (PE) and found that hs-CRP levels were higher in PE group in early pregnancy, but they are not associated with an increased risk of PE.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Obstetrics & Gynecology
K. K. Venkatesh, J. E. Jelovsek, M. Hoffman, A. J. Beckham, G. Bitar, A. M. Friedman, K. A. Boggess, D. M. Stamilio
Summary: A prediction model for postpartum readmission for hypertension and pre-eclampsia was developed and validated using data from two clinical sites. The final model included six variables and showed improved net benefit in preventing readmission. Further validation using data from multiple sites is needed.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Acoustics
J. Binder, E. Kalafat, P. Palmrich, P. Pateisky, A. Khalil
Summary: This study aimed to investigate the value of angiogenic marker assessment in women with chronic hypertension and suspected superimposed PE. The study found that adding angiogenic markers to the traditional diagnostic criteria significantly improved the prediction of adverse outcomes for both mothers and infants. Therefore, the assessment of angiogenic markers should be considered when evaluating pregnant women with chronic hypertension.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Cell Biology
Maria Fernanda Garces, Julieth Daniela Buell-Acosta, Haiver Antonio Rodriguez-Navarro, Maria Carolina Paez-Leal, Luis Miguel Maldonado-Acosta, Jhon Jairo Peralta-Franco, alvaro Javier Burgos-Cardenas, Edith Angel-Muller, Arturo Jose Parada-Banos, Mario Orlando Parra-Pineda, Javier Eslava-Schmalbach, Camilo Andres Escobar-Sarmiento, Ezequiel Lacunza, Sofia Alexandra Caminos-Cepeda, Justo P. Castano, Ruben Nogueiras, Carlos Dieguez, Ariel Ivan Ruiz-Parra, Jorge Eduardo Caminos
Summary: The circulating levels of leptin and soluble leptin receptor (sOB-R) rise significantly during pregnancy, and the ratio of these two markers, called the free leptin index (FLI), is used as an indicator of leptin resistance. In mild pre-eclamptic pregnancies, FLI is significantly higher compared to healthy pregnancies, suggesting an alteration in leptin bioavailability and bioactivity. Leptin and FLI also show potential as reliable predictors for mild pre-eclampsia during the second trimester of pregnancy.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Michelle Broekhuizen, Rene de Vries, Marja A. W. Smits, Willem A. Dik, Sam Schoenmakers, Birgit C. P. Koch, Daphne Merkus, Irwin K. M. Reiss, A. H. Jan Danser, Sinno H. P. Simons, Emilie Hitzerd
Summary: This study investigated the placental transfer, vascular effects, and anti-inflammatory actions of pentoxifylline in healthy and pre-eclamptic human placentas. The results showed that while pentoxifylline had beneficial effects on vasodilation and inflammation in healthy placentas, these effects were not retained in pre-eclamptic placentas. This limits the application of pentoxifylline in the treatment of pre-eclampsia, but it may still have value for other placenta-related disorders.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Kartik Gupta, Rajat Kalra, Mike Pate, Shivaraj Nagalli, Sameer Ather, Indranee Rajapreyar, Pankaj Arora, Ankur Gupta, Wunan Zhou, Raul San Jose Estepar, Marcelo Di Carli, Sumanth D. Prabhu, Navkaranbir S. Bajaj
Summary: This study investigated the predictive value of circulating immune cell markers for cardiovascular mortality in ambulatory adults without cardiovascular disease, finding that MLR had the best predictive value. Adding MLR to the 10-year ASCVD risk score significantly improved risk classification for participants.
MAYO CLINIC PROCEEDINGS
(2021)
Article
Immunology
Chiara Agostinis, Gabriella Zito, Miriam Toffoli, Isabel Peterlunger, Livia Simoni, Andrea Balduit, Erica Curtolo, Alessandro Mangogna, Beatrice Belmonte, Davide Vacca, Federico Romano, Tamara Stampalija, Tiziana Salviato, Federica Defendi, Nicoletta Di Simone, Uday Kishore, Giuseppe Ricci, Roberta Bulla
Summary: C1q is essential in pregnancy, and its deficiency can lead to pregnancy failure. Anti-C1q autoantibodies are present in various diseases and in the general population. Recent evidence suggests an increased risk of PE in women undergoing ART. This study found that PE patients have lower levels of anti-C1q, and ART pregnancies showed similar levels of C1q and anti-C1q compared to PE patients. The findings suggest an immunological dysfunction at the fetal-maternal interface in ART pregnancies, with C1q deposition in placentae. Anti-C1q may have a physiological role in pregnancy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Hamideh Parhiz, Jacob S. Brenner, Priyal N. Patel, Tyler E. Papp, Hamna Shahnawaz, Qin Li, Ruiqi Shi, Marco E. Zamora, Amir Yadegari, Oscar A. Marcos-Contreras, Ambika Natesan, Norbert Pardi, Vladimir V. Shuvaev, Raisa Kiseleva, Jacob W. Myerson, Thomas Uhler, Rachel S. Riley, Xuexiang Han, Michael J. Mitchell, Kieu Lam, James Heyes, Drew Weissman, Vladimir R. Muzykantov
Summary: This study investigates the effects of nucleoside-modified RNA lipid nanoparticles (modmRNA-LNPs) on inflammation and immune response in mice. The results show that modmRNA-LNPs enhance inflammatory cytokine responses after lipopolysaccharide (LPS) immune stimulation, and macrophages play a key role in mediating this phenomenon. Additionally, pretreatment with anti-inflammatory drugs can partially alleviate the inflammatory response.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Cell Biology
Madeleine Crawford, Eliza H. Johnson, Kelly Y. P. Liu, Catherine Poh, Robert Y. L. Tsai
Summary: Early identification and management of precancerous lesions at high risk of developing cancers is crucial for reducing cancer incidence, mortality, and morbidity. Reliable cancer-risk-predictive markers play a significant role in decision making and understanding the malignant conversion of precancerous lesions.
Article
Peripheral Vascular Disease
Virginia A. Dines, Andrea G. Kattah, Amy L. Weaver, Lisa E. Vaughan, Alanna M. Chamberlain, Suzette J. Bielinski, Michelle M. Mielke, Vesna D. Garovic
Summary: This study found that both in utero exposure to HDP and maternal chronic hypertension are independently associated with an increased risk of chronic hypertension in offspring. When both risk factors are present, there is a 2.4-fold increase in the risk of hypertension in offspring.
Review
Obstetrics & Gynecology
Paolo Ivo Cavoretto, Veronica Giorgione, Alexandros Sotiriadis, Paola Vigano, Enrico Papaleo, Alessandro Galdini, Gerarda Gaeta, Massimo Candiani
Summary: The risk of IPTB before 37 weeks in singleton pregnancies achieved through IVF/ICSI is more than double that of natural conception.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Medical Laboratory Technology
Ronda F. Greaves, Larry Kricka, Damien Gruson, Helen Martin, Maurizio Ferrari, Sergio Bernardini
Summary: This study examines the key aspects of emerging technology in the field of laboratory medicine and proposes a practical definition. It defines emerging technology as an analytical method or device that, at the stage of development, translation into routine clinical practice, or adoption and implementation globally, has the potential to enhance clinical diagnostics.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Review
Medical Laboratory Technology
Chiara Zecca, Rosanna Tortelli, Paola Carrera, Maria Teresa Dell'Abate, Giancarlo Logroscino, Maurizio Ferrari
Summary: Frontotemporal dementia (FTD) is a progressive neurodegenerative disorder characterized by atrophy of the frontal and anterior temporal lobes. There are different clinical syndromes based on clinical presentation, and there is often an overlap between cognitive and motor phenotypes. FTD-related genes are genetically diverse, and some variants seem to be associated with specific clinical syndromes.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Silvia Galbiati, Daniela Gabellini, Alessandro Ambrosi, Nadia Soriani, Federica Pasi, Massimo Locatelli, Roberta Luciano, Massimo Candiani, Luca Valsecchi, Gianpaolo Zerbini, Maddalena Smid
Summary: Preeclampsia is a severe complication of pregnancy, and finding predictive biomarkers is crucial for prevention. This study compared the diagnostic accuracy of carbonic anhydrase IX (CAIX) and sFlt1/PlGF ratio as biomarkers for predicting preeclampsia. CAIX levels significantly increased before the onset of preeclampsia, and it performed better than sFlt1/PlGF ratio in predicting the disease. CAIX could be an effective predictive biomarker for preeclampsia, but further studies are needed to confirm this finding.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Medical Laboratory Technology
Ronda Greaves, Larry Kricka, Damien Gruson, Maurizio Ferrari, Helen Martin, Tze Ping Loh, Sergio Bernardini
Summary: An emerging technology in laboratory medicine is defined as an analytical method or device that has the potential to add value to clinical diagnostics. This document explores eight tools used throughout the life cycle of implementing emerging technologies, which cover clinical, analytical, operational, and financial aspects. These tools help support the overall quality and sustainability of implementation by providing a systematic approach, including identifying needs, forecasting, assessments, change management, and evaluation checklists.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Oncology
Laura Cristina Gironi, Elia Esposto, Francesca Zottarelli, Roberto Giorgione, Pamela Farinelli, Elisa Zavattaro, Edoardo Cammarata, Nunzia Di Cristo, Paola Ogliara, Lara Camillo, Mara Giordano, Simona Mellone, Barbara Pasini, Alessandro Ambrosi, Paola Savoia
Summary: We investigated the correlation between the occurrence of cutaneous melanoma and noncutaneous tumors in CDKN2A mutation carriers and wild-type melanoma patients. The study found that mutation carriers had a significantly higher number of cutaneous melanoma cases compared to the wild-type patients. Additionally, both groups had a similar rate of diagnosis for malignant NCTs. The onset of cutaneous melanoma generally preceded the occurrence of NCTs, emphasizing the importance of comprehensive surveillance for melanoma patients.
Article
Clinical Neurology
Pietro Panni, Lucia Riccio, Roberta Cao, Alessandro Pedicelli, Enrico Marchese, Anselmo Caricato, Alberto Feletti, Mattia Testa, Paolo Zanatta, Nicola Gitti, Simone Piva, Dikran Mardighian, Vittorio Semeraro, Giordano Nardin, Emilio Lozupone, Giafranco Paiano, Edoardo Picetti, Vito Montanaro, Massimo Petranca, Carlo Bortolotti, Antonino Scibilia, Luigi Cirillo, Andrea Luigi Lanterna, Alessandro Ambrosi, Pietro Mortini, Luigi Beretta, Andrea Falini
Summary: This study aimed to investigate predictors and clinical impact of rebleeding in poor-grade aneurysmal subarachnoid hemorrhage (aSAH). The study found that ultra-early vasospasm (UEV) and presence of dissecting aneurysm were the strongest predictors of aneurysmal rebleeding, while a history of hypertension reduced the chances of rebleeding. Additionally, rebleeding emerged as an independent predictor of intrahospital mortality.
Article
Medicine, General & Internal
Alice Bergamini, Giorgia Mangili, Alessandro Ambrosi, Gianluca Taccagni, Emanuela Rabaiotti, Luca Bocciolone, Giorgio Candotti, Raffaella Cioffi, Francesca Pella, Giulia Sabetta, Costanza Saponaro, Massimo Candiani
Summary: The study compares data from patients with endometrioid and clear cell ovarian tumors associated with endometriosis to investigate the hypothesis of a dichotomy in their histogenesis. It found that the occurrence of endometriosis is more frequent in patients with clear cell ovarian cancer. The EAOEC group showed higher bilateral occurrences and a higher solid/cystic rate at gross pathology. ECC patients had a more advanced disease stage and a synchronous endometrial carcinoma was found in 38% of EAEOC patients.
Article
Medicine, General & Internal
Cinzia Giacometti, Kathrin Ludwig, Monica Guidi, Elvira Colantuono, Anna Coracina, Marcello Rigano, Mauro Cassaro, Alessandro Ambrosi
Summary: Gestational diabetes mellitus (GDM) can affect placental villous maturation and vascularity. The expression of hENT1 and the formation of vasculo-syncytial membranes (VSM) are reduced in GDM placentas, while the proliferative pattern of trophoblasts is increased.
Article
Chemistry, Analytical
Francesco Damin, Silvia Galbiati, Nicola Clementi, Roberto Ferrarese, Nicasio Mancini, Laura Sola, Marcella Chiari
Summary: Since the emergence of the COVID-19 pandemic, monitoring and tracking the distribution of SARS-CoV-2 variants is crucial for adjusting public health interventions. However, genome sequencing is not cost-effective and rapid. We have developed a microarray-based assay that can accurately detect known viral variants present in clinical samples by detecting mutations in the Spike protein gene. This assay can genotype the WHO-reported variants of concern (VOCs) in patient samples.
Article
Clinical Neurology
Claudia Godi, Francesco Destro, Paolo Garofalo, Enrico Tombetti, Alessandro Ambrosi, Antonella Iadanza, Caterina Michelozzi, Andrea Falini, Nicoletta Anzalone
Summary: Vessel wall imaging (VWI) with black-blood (BB) technique can reveal aneurysmal enhancement prior to growth/rupture in treatment-naive cerebral aneurysms. Recent studies suggest that BB enhancement may also occur in endovascularly treated aneurysms, but its significance is debatable. This study explores the relationship between BB enhancement and incomplete occlusion status and coil packing density, hypothesizing a flow-related mechanism.
Article
Neurosciences
Alessandra Pisciottani, Laura Croci, Fabio Lauria, Chiara Marullo, Elisa Savino, Alessandro Ambrosi, Paola Podini, Marta Marchioretto, Filippo Casoni, Ottavio Cremona, Stefano Taverna, Angelo Quattrini, Jean-Michel Cioni, Gabriella Viero, Franca Codazzi, G. Giacomo Consalez
Summary: Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disease primarily affecting individuals between 50-60 years old. The presence of TDP-43 proteinopathy, characterized by cytoplasmic aggregates formed by TDP-43 protein, disrupts mRNA transport and localization. This study generated and analyzed cellular models of TDP-43 proteinopathy, showing that neurons expressing TDP-43 fusion proteins have impaired axonal protein synthesis, increased oxidative stress, and defects in presynaptic function and electrical activity. These changes are correlated with deregulation of axonal mRNA levels involved in the same processes.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Review
Endocrinology & Metabolism
Giovanna Laura Di Domenico, Margherita Minoli, Nicola Discepoli, Alessandro Ambrosi, Massimo de Sanctis
Summary: This study aimed to assess the effect of non-surgical periodontal therapy on glycemic control in patients with type 2 diabetes and periodontitis. The findings showed that non-surgical periodontal therapy was effective in improving glycemic control in these patients.
ACTA DIABETOLOGICA
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Francesco Giganti, Alexander P. Cole, Fiona M. Fennessy, Timothy Clinton, Pedro Lopes Da Frota Moreira, Mariana Costa Bernardes, Carl-Fredrik Westin, Deepa Krishnaswamy, Andriy Fedorov, Daniel A. Wollin, Bjoern Langbein, Nicola Frego, Muhieddine Labban, Joy S. Badaoui, Steven L. Chang, Logan G. Briggs, Junichi Tokuda, Alessandro Ambrosi, Alex Kirkham, Mark Emberton, Veeru Kasivisvanathan, Caroline M. Moore, Clare Allen, Clare M. Tempany
Summary: This study assessed the impact of a prostate MRI quality training lecture on the participants' ability to apply the PI-QUAL scoring system. The results showed that the teaching course significantly improved the participants' ability to evaluate the quality of prostate MRI examinations using the PI-QUAL score.
EUROPEAN RADIOLOGY
(2023)
Article
Nursing
Laura Apadula, Gabriele Capurso, Alessandro Ambrosi, Paolo Giorgio Arcidiacono
Summary: This study aims to develop a questionnaire to evaluate the experience of patients undergoing endoscopic ultrasound (EUS), identifying and prioritizing the factors related to the patient's experience. The questionnaire creation and validity testing phase will contribute to optimizing the evaluation of the quality of care provided to patients undergoing EUS.