Journal
VACCINE
Volume 34, Issue 6, Pages 744-749Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2015.12.062
Keywords
A/H7N9 influenza vaccine; Adenoviral vector vaccine; H7HA, cell-mediated immunity; Antibody responses; Protective immunity; Mouse model
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Funding
- Influenza Division of Centers for Disease Control and Prevention
- Public Health Service grant from the National Institute of Allergy and Infectious Diseases [AI059374]
- Hatch fund at Purdue University
- Juvaris Bio-Therapeutics
- GlaxoSmithKline
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Since the first case of human infection in March 2013, continued reports of H7N9 cases highlight a potential pandemic threat. Highly immunogenic vaccines to this virus are urgently needed to protect vulnerable populations who lack protective immunity. In this study, an egg- and adjuvant-independent adenoviral vector-based, hemagglutinin H7 subtype influenza vaccine (HAd-H7HA) demonstrated enhanced cell mediated immunity as well as serum antibody responses in a mouse model. Most importantly, this vaccine provided complete protection against homologous A/H7N9 viral challenge suggesting its potential utility as a pandemic vaccine. Published by Elsevier Ltd.
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