Review
Urology & Nephrology
Tobias Klatte, Alessandro Berni, Sergio Serni, Riccardo Campi
Summary: This study evaluated the intermediate- and long-term oncological outcomes of active surveillance for localized renal masses. The findings suggest that active surveillance is a safe management option for patients with small renal masses, while data for non-small renal masses are limited.
Review
Radiology, Nuclear Medicine & Medical Imaging
Pratik Adusumilli, Nishant Ravikumar, Geoff Hall, Sarah Swift, Nicolas Orsi, Andrew Scarsbrook
Summary: Radiomics has the potential to be a clinical diagnostic tool in patients with ovarian lesions, improving lesion stratification, treatment selection, and outcome prediction. However, standardization of feature extraction methods, larger and more diverse patient cohorts, and real-world evaluation are needed before clinical translation.
INSIGHTS INTO IMAGING
(2023)
Review
Microbiology
Imane Allali, Regina E. Abotsi, Lemese Ah. Tow, Lehana Thabane, Heather J. Zar, Nicola M. Mulder, Mark P. Nicol
Summary: There are significant gaps in microbiome research in Africa, especially those focusing on diseases of public health importance. Local leadership, capacity building, intra-continental collaboration, and national government investment are needed in microbiome research within Africa.
Review
Radiology, Nuclear Medicine & Medical Imaging
Robert A. Frank, Haben Dawit, Patrick M. M. Bossuyt, Mariska Leeflang, Trevor A. Flood, Rodney H. Breau, Matthew D. F. McInnes, Nicola Schieda
Summary: This article provides a systematic review of the available evidence on the diagnostic accuracy of biparametric (bp)-MRI and multiparametric (mp)-MRI for solid renal masses in differentiating malignant from benign, aggressive from indolent, and clear cell renal cell carcinoma (ccRCC) from other histology. The review reveals deficits in the available evidence, with limited studies and high risk of bias, as well as heterogeneity in definitions, imaging techniques, diagnostic criteria, and outcome measures for solid masses.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Review
Medicine, General & Internal
Antonio Tufano, Luca Antonelli, Giovanni Battista Di Pierro, Rocco Simone Flammia, Rocco Minelli, Umberto Anceschi, Costantino Leonardo, Giorgio Franco, Francesco Maria Drudi, Vito Cantisani
Summary: Contrast-enhanced ultrasound (CEUS) is a promising diagnostic tool for the characterization of small renal masses, with high accuracy in detecting malignant lesions. This systematic review and meta-analysis provide evidence for the diagnostic performance of CEUS in the evaluation of small renal masses.
Review
Medicine, General & Internal
Carmen M. Galvez-Sanchez, Gustavo A. Reyes del Paso, Stefan Duschek, Casandra I. Montoro
Summary: Anger is associated with increased pain perception, and its specific connection with Fibromyalgia Syndrome (FMS) has not been established. Studies have shown that FMS patients have higher levels of anger-in and anger-out compared to healthy participants and other chronic pain patients. Anger seems to amplify pain, especially in women. Only two studies have proposed intervention programs focusing on anger treatment, which have observed positive reductions in anger levels.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Oncology
Wenwen Shang, Guohui Hong, Wei Li
Summary: This study aimed to review the diagnostic performance of magnetic resonance imaging in differentiating small malignant renal masses from benign ones. The results showed that MRI had moderate diagnostic performance with significant heterogeneity in both sensitivity and specificity.
FRONTIERS IN ONCOLOGY
(2023)
Review
Surgery
Vinson Wai-Shun Chan, Ahmad Abul, Filzah Hanis Osman, Helen Hoi-Lam Ng, Kaiwen Wang, Yuhong Yuan, Jon Cartledge, Tze Min Wah
Summary: This review compared the oncological outcomes of ablative therapies (AT) and partial nephrectomy (PN) in patients with small renal masses (SRM). It found that while AT patients in the T1a group had worse overall survival, they experienced fewer post-operative complications, better kidney function preservation, and similar cancer-specific survival compared to PN patients. Further long-term high-quality studies are needed to confirm the potential benefits of AT, especially in T1b patients.
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Review
Environmental Sciences
A. B. Cundy, F. M. Rowlands, G. Lu, W-X Wang
Summary: The development of the Greater Bay area in China has led to significant pressures on the ecosystems in the Pearl River Delta. This systematic review of published papers examines the trends, sampling focus, and concentrations of emerging contaminants in the area. The study finds that while there is an increasing number of publications on emerging contaminants, they are understudied compared to traditional contaminants. The review also identifies data coverage issues and significant variations in reported contaminant concentrations.
ENVIRONMENTAL SCIENCE & POLICY
(2022)
Review
Education & Educational Research
Melanie S. S. Meyer, Yuyang Shen, Jonathan A. A. Plucker
Summary: Unequal access to advanced learning opportunities is a complex issue in American K-12 schools. This systematic review identified 80 empirical research studies that focused on strategies for reducing excellence gaps. The analysis suggests a revised approach to equitable, advanced education.
REVIEW OF EDUCATIONAL RESEARCH
(2023)
Review
Chemistry, Multidisciplinary
Luigi Napolitano, Luca Orecchia, Carlo Giulioni, Umberto Carbonara, Giovanni Tavella, Leonardo Lizzio, Deborah Fimognari, Antonio De Palma, Alberto Gheza, Antonio Andrea Grosso, Ugo Falagario, Stefano Parodi, Vittorio Fasulo, Federico Romantini, Giuseppe Rosiello, Silvia Vigano, Salvatore Rabito, Tommaso Ceccato, Mirko Pinelli, Graziano Felici, Francesco De Vita, Francesco Prata, Francesco Dibitetto, Matteo Tedde, Federico Piramide, Fabio Traunero, Mario De Michele, Michele Morelli, Pietro Piazza, Rocco Simone Flammia
Summary: Renal cell carcinoma (RCC), the most common form of kidney cancer, has high mortality rates in advanced-stage disease despite current treatments. MicroRNAs (miRNAs) have emerged as important players in cancer, including RCC, and show potential as biomarkers and therapeutic targets. This study analyzes recent data on the application of miRNAs in diagnosing, treating, and predicting response to treatment in RCC patients.
APPLIED SCIENCES-BASEL
(2023)
Review
Environmental Sciences
Enrico Lucca, Jerome El Jeitany, Giulio Castelli, Tommaso Pacetti, Elena Bresci, Fernando Nardi, Enrica Caporali
Summary: The water-energy-food-ecosystems (WEFE) Nexus approach is crucial in the Mediterranean region due to water scarcity, climate change, and ecosystem degradation. Most research in the region focuses on water-energy interdependences, while the expansion to other components is limited. The research is primarily conducted in isolated case studies, lacking large-scale assessments and representation from certain countries. Further research is needed to understand the economic implications of WEFE Nexus interactions and harmonization in design objectives to achieve comprehensive sustainability.
ENVIRONMENTAL RESEARCH LETTERS
(2023)
Review
Green & Sustainable Science & Technology
Wenkai Luo, Malindu Sandanayake, Lei Hou, Yongtao Tan, Guomin Zhang
Summary: This study investigates the latest trends in green construction research over the past decade using scientometrics methods, identifying both advancements in the field and research gaps. It also offers a list of suggestions for future research directions to bridge major knowledge gaps.
JOURNAL OF CLEANER PRODUCTION
(2022)
Review
Green & Sustainable Science & Technology
Wenkai Luo, Malindu Sandanayake, Lei Hou, Yongtao Tan, Guomin Zhang
Summary: Construction activities can have significant negative impacts on the environment, but green construction research can help mitigate these effects. This study utilized scientometrics methods to analyze the state-of-the-art green construction research over the past decade and identify knowledge gaps.
JOURNAL OF CLEANER PRODUCTION
(2022)
Review
Oncology
Alessio Pecoraro, Riccardo Campi, Riccardo Bertolo, Maria Carmen Mir, Michele Marchioni, Sergio Serni, Steven Joniau, Hendrik Van Poppel, Maarten Albersen, Eduard Roussel
Summary: This study reviewed the prediction models for postoperative renal function after surgery for nonmetastatic renal tumors. Most of the models are not ready for routine clinical practice, but a few have been externally validated and may be valuable for patients and clinicians.
EUROPEAN UROLOGY ONCOLOGY
(2023)
Article
Oncology
Hiten D. Patel, Elizabeth L. Koehne, Steven M. Shea, Yasin Bhanji, Marielia Gerena, Alex Gorbonos, Marcus L. Quek, Robert C. Flanigan, Ari Goldberg, Gopal N. Gupta
Summary: Men with prior negative prostate biopsies have a lower risk of being diagnosed with prostate cancer, and decision curve analyses suggest that many unnecessary biopsies can be avoided by using the PLUM models or a PI-RADS 4 cutoff.
Article
Urology & Nephrology
Hiten D. Patel, Sunil H. Patel, Enrique Blanco-Martinez, Jake Kuzbel, Victor S. Chen, Aleksander Druck, Elizabeth L. Koehne, Parth M. Patel, Chirag P. Doshi, Noah M. Hahn, Jean H. Hoffman-Censits, Stephanie Berg, Trinity J. Bivalacqua, Max Kates, Marcus L. Quek
Summary: Patients with muscle-invasive bladder cancer who completed 3 cycles of cisplatin-based neoadjuvant chemotherapy showed similar pathological response and short-term survival compared to those who completed 4 cycles.
JOURNAL OF UROLOGY
(2022)
Article
Urology & Nephrology
Hiten D. Patel, Elizabeth L. Koehne, Steven M. Shea, Andrew M. Fang, Marielia Gerena, Alex Gorbonos, Marcus L. Quek, Robert C. Flanigan, Ari Goldberg, Soroush Rais-Bahrami, Gopal N. Gupta
Summary: A prostate cancer risk calculator incorporating multiparametric magnetic resonance imaging (mpMRI) has been developed and validated, outperforming other risk calculators in diagnosing high-risk prostate cancer and potentially reducing unnecessary biopsies.
Review
Urology & Nephrology
Duvuru Geetha, Andreas Kronbichler, Megan Rutter, Divya Bajpai, Steven Menez, Annemarie Weissenbacher, Shuchi Anand, Eugene Lin, Nicholas Carlson, Stephen Sozio, Kevin Fowler, Ray Bignall, Kathryn Ducharlet, Elliot K. Tannor, Eranga Wijewickrama, Muhammad I. A. Hafiz, Vladimir Tesar, Robert Hoover, Deidra Crews, Charles Varnell, Lara Danziger-Isakov, Vivekanand Jha, Sumit Mohan, Chirag Parikh, Valerie Luyckx
Summary: This review summarizes the challenges and missed opportunities in caring for patients with kidney disease during the COVID-19 pandemic. It discusses the impact on patients and clinicians, including increased infection risk and resource shortages, and provides a framework for management and support.
NATURE REVIEWS NEPHROLOGY
(2022)
Correction
Urology & Nephrology
Duvuru Geetha, Andreas Kronbichler, Megan Rutter, Divya Bajpai, Steven Menez, Annemarie Weissenbacher, Shuchi Anand, Eugene Lin, Nicholas Carlson, Stephen Sozio, Kevin Fowler, Ray Bignall, Kathryn Ducharlet, Elliot K. Tannor, Eranga Wijewickrama, Muhammad I. A. Hafidz, Vladimir Tesar, Robert Hoover, Deidra Crews, Charles Varnell, Lara Danziger-Isakov, Vivekanand Jha, Sumit Mohan, Chirag Parikh, Valerie Luyckx
NATURE REVIEWS NEPHROLOGY
(2022)
Review
Public, Environmental & Occupational Health
Anna Russell, J. Lee Jenkins, Allen Zhang, Lisa M. Wilson, Eric B. Bass, Edbert B. Hsu
Summary: This review examined the prevalence, incidence, and severity of infections among the emergency medical service (EMS) workforce. The majority of studies focused on SARS-CoV-2 infection, with varying prevalence rates. MRSA and Hepatitis C infections were also reported. Limited studies reported incidence rates. Differences in infection rates were observed between EMS clinicians and firefighters, with higher hospitalization or death rates for SAR-CoV-2 and higher prevalence of Hepatitis C among EMS clinicians. More research is needed to understand the incidence and severity of occupationally-acquired infections in the EMS workforce.
AMERICAN JOURNAL OF INFECTION CONTROL
(2023)
Article
Oncology
Hiten D. Patel, Yudai Okabe, Goran Rac, Gaurav Pahouja, Shalin Desai, Steven M. Shea, Alex Gorbonos, Marcus L. Quek, Robert C. Flanigan, Ari Goldberg, Gopal N. Gupta
Summary: This study compared the impact of MRI vs. non-MRI diagnostic pathways on surgical outcomes for patients undergoing radical prostatectomy (RP). The results showed that MRI-based diagnostic approach was associated with lower positive surgical margin rates, higher utilization of bilateral nerve-sparing, and improved cancer control by biochemical recurrence.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2023)
Article
Oncology
Charles D. Logan, Ashorne K. Mahenthiran, Mohammad R. Siddiqui, Dustin D. French, Matthew T. Hudnall, Hiten D. Patel, Adam B. Murphy, Joshua A. Halpern, David J. Bentrem
Summary: Most radical prostatectomies are done with robotic assistance. This study examined disparities in access and outcomes of robot-assisted radical prostatectomy (RARP) and found that non-Hispanic Black and Hispanic patients were less likely to receive RARP, and underinsured patients had lower rates of RARP. RARP was associated with decreased perioperative mortality and improved overall survival compared to open radical prostatectomy (ORP).
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Anas Elgenidy, Ahmed K. Awad, Huzaifa Ahmad Cheema, Abia Shahid, Salah Eddine Oussama Kacimi, Mostafa G. Aly, Nirmish Singla, Ahmed M. Afifi, Hiten D. Patel
Summary: This study aimed to assess the frequency and risk of different causes of death in patients with renal cell carcinoma (RCC) in the United States. The majority of deaths were due to kidney cancer, but a significant proportion was caused by non-cancerous reasons. The proportion of deaths attributed to RCC decreased with increasing follow-up, and cardiovascular diseases and cerebrovascular diseases were the most common non-RCC-related causes of death. Coordination of multidisciplinary care is needed to prevent death from non-cancerous causes, depending on the stage of the disease.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2023)
Article
Medicine, Research & Experimental
Kyungho Lee, Elizabeth A. Thompson, Sepideh Gharaie, Chirag H. Patel, Johanna T. Kurzhagen, Phillip M. Pierorazio, Lois J. Arend, Ajit G. Thomas, Sanjeev Noel, Barbara S. Slusher, Hamid Rabb
Summary: T cells in acute kidney injury (AKI) undergo metabolic reprogramming, and targeting the T cell glutamine pathway could be a promising therapeutic approach. Ischemic AKI in mice showed the presence of a distinct T cell subset with altered expression of certain metabolic proteins. Similarly, human nonischemic and ischemic kidney tissue exhibited similar findings. Inhibition of glutamine with JHU083 attenuated renal injury and reduced T cell activation and proliferation in AKI.
Article
Urology & Nephrology
Suzanne M. Boyle, James Martindale, Andrew S. Parsons, Stephen M. Sozio, Rachel Hilburg, Jehan Bahrainwala, Lili Chan, Lauren D. Stern, Karen M. Warburton
Summary: This study developed and validated an instrument to assess clinical reasoning in nephrology fellows. The results showed that the majority of fellows met the criteria for coaching in at least one reasoning domain, highlighting the need for learner assessment and instruction in clinical reasoning.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Education & Educational Research
Hosam H. Alkhatib, Mary Catherine Beach, Kelly A. Gebo, Eric B. Bass, Jenny R. Park, Meredith A. Atkinson, Sapna R. Kudchadkar, Stephen M. Sozio
Summary: This study examined the association between medical school Scholarly Concentrations (SC) programs and students' specialty choices. The results showed that students' interest in a specialty at baseline and their research productivity with SC mentors were associated with increased odds of entering a related specialty. However, completing an SC project did not increase the odds of matching into that specialty or a higher ranked program.
MEDICAL EDUCATION ONLINE
(2023)
Article
Oncology
Michael A. Gorin, Hiten D. Patel, Steven P. Rowe, Noah M. Hahn, Hans J. Hammers, Alice Pons, Bruce J. Trock, Phillip M. Pierorazio, Thomas R. Nirschl, Daniela C. Salles, Julie E. Stein, Tamara L. Lotan, Janis M. Taube, Charles G. Drake, Mohamad E. Allaf
Summary: In this study, the safety and tolerability of preoperative administration of three doses of the immune checkpoint inhibitor nivolumab in patients with clinically localized high-risk renal cell carcinoma were evaluated. The study demonstrated the safety of this approach and found that a subset of patients may have features of an immune-related pathologic response.
EUROPEAN UROLOGY ONCOLOGY
(2022)
Article
Urology & Nephrology
Christian D. Fankhauser, Luca Afferi, Sean P. Stroup, Nicholas R. Rocco, Kathleen Olson, Aditya Bagrodia, Fady Baky, Walter Cazzaniga, Erik Mayer, David Nicol, Ekrem Islamoglu, Stephane de Vergie, Ragheed Saoud, Scott E. Eggener, Sebastiano Nazzani, Nicola Nicolai, Lee Hugar, Wade J. Sexton, Deliu-Victor Matei, Ottavio De Cobelli, Joseph Cheaib, Phillip M. Pierorazio, James Porter, Thomas Hermanns, Robert J. Hamilton, Andreas Hiester, Peter Albers, Noel Clarke, Agostino Mattei
Summary: The study aims to describe the perioperative safety, functional, and immediate post-operative oncological outcomes of minimally invasive RPLND (miRPLND) for testis cancer. The results show that miRPLND has a positive impact on postoperative ejaculatory function and a low proportion of complications and peritoneal recurrences, supporting further studies on miRPLND.
WORLD JOURNAL OF UROLOGY
(2022)
