Article
Oncology
Yizhen Fu, Xia Li, Zhenyun Yang, Shaoqiang Li, Yangxun Pan, Jinbin Chen, Juncheng Wang, Dandan Hu, Zhongguo Zhou, Li Xu, Minshan Chen, Yaojun Zhang
Summary: This study aimed to establish a risk-based post-resection follow-up strategy for hepatocellular carcinoma (HCC) patients. The results showed that this strategy could detect tumor relapse earlier and reduce the number of follow-ups without compromising on survival.
Review
Oncology
Jack Horan, Conor Reid, Michael R. Boland, Gordon R. Daly, Stephen Keelan, Angus J. Lloyd, Eithne Downey, Adam Walmsley, Marie Staunton, Colm Power, Abeeda Butt, Deirdre Duke, Arnold D. K. Hill
Summary: This study evaluated diagnostic modalities for recurrent breast cancer, with a focus on the role of annual clinical examination. The results showed that clinical examination provides little value in diagnosing recurrence, suggesting that surveillance programs should reduce focus on this modality and instead prioritize regular radiological assessment and ensuring easy access to breast clinics for patients with new symptoms/signs.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Algirdas Zalimas, Raimonda Kubiliute, Kristina Zukauskaite, Rasa Sabaliauskaite, Mantas Trakymas, Simona Letautiene, Edita Miseikyte Kaubriene, Jurgita Usinskiene, Albertas Ulys, Sonata Jarmalaite
Summary: Active surveillance is the best strategy for managing small renal masses, but reliable methods for early detection and disease aggressiveness prediction are urgently needed. This study validates DNA methylation biomarkers for non-invasive detection and prognosis of small renal masses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
M. C. Rulanda, O. Mogensen, P. T. Jensen, D. G. Hansen, C. Wu, M. M. Jeppesen
Summary: This study compares the effects of patient initiated follow up (PIFU) versus hospital based follow up (HBFU) on fear of cancer recurrence (FCR), quality of life (QoL), and healthcare use after 34 months of follow up. The results indicate that patient initiated follow up is a valid alternative to hospital based follow up for low-intermediate risk endometrial carcinoma patients.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Review
Oncology
Begona Campos-Balea, Ovidio Fernandez-Calvo, Roberto Garcia-Figueiras, Carlos Neira, Carmen Pena-Penabad, Carmela Rodriguez-Lopez, Rocio Vilchez-Simo, Maria Quindos-Varela
Summary: In this article, a consensus- and experience-based follow-up strategy for melanoma patients is recommended, considering prognostic factors and biomarkers, as well as high-risk periods and patterns of recurrence in each (sub)stage of the disease.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2022)
Article
Oncology
Marco Baia, Samuel J. Ford, Sinziana Dumitra, Laura Sama, David N. Naumann, Gaya Spolverato, Dario Callegaro
Summary: Retroperitoneal sarcomas (RPS) are rare malignancies that can be cured by surgical resection. After surgery, regular surveillance is recommended due to the risk of local recurrence (LR) and distant metastasis (DM). Despite the lack of definitive evidence, dynamic nomograms can predict recurrence patterns to tailor surveillance and relieve patient anxiety. A proposed randomized controlled study aims to provide clarity on the optimal follow-up protocol for RPS patients.
Article
Surgery
Michael J. Pflueger, James F. Griffin, Wenzel M. Hackeng, Satomi Kawamoto, Jun Yu, Peter Chianchiano, Eunice Shin, Gemma Lionheart, Hua-Ling Tsai, Hao Wang, Neda Rezaee, Richard A. Burkhart, John L. Cameron, Elizabeth D. Thompson, Christopher L. Wolfgang, Jin He, Lodewijk A. A. Brosens, Laura D. Wood
Summary: This study aimed to identify risk factors for recurrence after surgical resection for intraductal papillary mucinous neoplasm (IPMN). The results showed that family history of pancreatic cancer and high-grade IPMN are risk factors for recurrence. In addition, the size and grade of the dysplastic focus at the margin were significantly correlated with recurrence in margin-positive patients. The majority of recurrences occurred after 3 years of surgery.
Review
Oncology
Fiorenza De Rose, Bruno Meduri, Maria Carmen De Santis, Antonella Ferro, Lorenza Marino, Riccardo Ray Colciago, Fabiana Gregucci, Valentina Vanoni, Giovanni Apolone, Serena Di Cosimo, Suzette Delaloge, Javier Cortes, Giuseppe Curigliano
Summary: Current follow-up strategies for breast cancer need to be re-evaluated to consider individual differences. New strategies should take into account subtypes, prognosis, and treatments. Advanced prediction models, imaging techniques, and biomarker assessment can help in anticipating diseases. Patient education and involvement of general practitioners are also important in personalized surveillance programs.
CANCER TREATMENT REVIEWS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mi Hye Yu, Jung Hoon Kim, Hyo-Jin Kang, Seo-Youn Choi, Yang Shin Park, Eun Sun Lee, Hyun Jeong Park
Summary: The detection rate of transabdominal ultrasound (TAUS) for low-risk pancreatic cysts incidentally detected on CT or MRI is influenced by factors such as cyst size, location, and multiplicity. Larger cysts (>10 mm), cysts located outside the tail of the pancreas, and single cysts have higher detection rates than smaller cysts, cysts in the tail, and multiple cysts. Interobserver agreement is excellent for the size of detected cysts and the diameter of the main pancreatic duct, indicating the reliability of TAUS for surveillance of low-risk pancreatic cysts.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2021)
Article
Surgery
Sin Hye Park, Woo Jin Hyung, Han-Kwang Yang, Young-Kyu Park, Hyuk-Joon Lee, Ji Yeong An, Wook Kim, Hyoung-Il Kim, Hyung-Ho Kim, Seung Wan Ryu, Hoon Hur, Min-Chan Kim, Seong-Ho Kong, Gyu Seok Cho, Jin-Jo Kim, Do Joong Park, Young-Woo Kim, Jong Won Kim, Joo-Ho Lee, Sang-Uk Han, Keun Won Ryu
Summary: The study did not find any survival benefit from regular follow-up after radical gastrectomy for gastric cancer, and it suggests the need for a prospective randomized controlled trial to determine the survival benefit.
BRITISH JOURNAL OF SURGERY
(2023)
Article
Oncology
Virginie Westeel, Pascal Foucher, Arnaud Scherpereel, Jean Domas, Philippe Girard, Jean Tredaniel, Marie Wislez, Patrick Dumont, Elisabeth Quoix, Olivier Raffy, Denis Braun, Marc Derollez, Francois Goupil, Jacques Hermann, Etienne Devin, Hubert Barbieux, Eric Pichon, Didier Debieuvre, Gervais Ozenne, Jean-Francois Muir, Stephanie Dehette, Jerome Virally, Michel Grivaux, Francois Lebargy, Pierre-Jean Souquet, Faraj Al Freijat, Nicolas Girard, Emmanuel Courau, Reza Azarian, Michel Farny, Jean-Paul Duhamel, Alexandra Langlais, Franck Morin, Bernard Milleron, Gerard Zalcman, Fabrice Barlesi
Summary: This study evaluates the efficacy of postoperative follow-up methods for patients with resectable NSCLC. The results show that there is no significant difference in survival and disease-free survival between the follow-up group and the minimal follow-up group in the intention-to-treat population. However, CT-based follow-up enables earlier detection of recurrence and second primary lung cancer, which can be treated with curative intent.
Article
Otorhinolaryngology
Maria T. T. Brands, Iris J. J. Swinkels, Anne M. W. M. Aarts, Andre L. M. Verbeek, Matthias A. W. Merkx, Henri A. M. Marres, Johannes H. A. M. Kaanders, Willem J. G. Melchers, Ilse van Engen-van Grunsven, Robert P. P. Takes, Sandra M. E. Geurts
Summary: Routine follow-up does not improve overall survival in OPSCC patients. The focus should be on providing psychosocial care and rehabilitation.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Obstetrics & Gynecology
Feng Sun, Jin Yu, YiLian Pan, XiaoNa Huo, YePing Yang, Hong Xu
Summary: A retrospective study with a three-year follow-up was conducted to identify the clinical risk factors for symptomatic recurrence of adenomyosis after laparoscopic adeno-myomectomy. The study found that concomitant ovarian endometrioma, postoperative hormonal suppression, and older age at surgery were associated with lower risk of recurrence.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2023)
Review
Oncology
Francesca De Felice, Mary Lei, Richard Oakley, Andrew Lyons, Alastair Fry, Jean-Pierre Jeannon, Ricard Simo, Teresa Guerrero Urbano
Summary: Follow-up is essential for patients with head and neck squamous cell carcinoma (HNSCC) after treatment, and risk stratified follow-up interventions can help prevent and detect recurrences, manage treatment toxicities, and improve patients' quality of life.
Article
Gastroenterology & Hepatology
Yanis Dahel, Vanessa Cottet, Cyril Boisson, Sylvain Manfredi, Thibault Degand
Summary: This study aimed to evaluate compliance with French follow-up recommendations after high-risk colorectal adenoma removal and assess the impact of how information was given and if patients actually underwent their control colonoscopy according to the instructions. The results showed poor compliance with follow-up guidelines, with inappropriate intervals often being longer than recommended.
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Urology & Nephrology
Anke Richters, Joost L. Boormans, Michiel S. van der Heijden, Antoine G. van der Heijden, Richard P. Meijer, Niven Mehra, Lambertus A. L. M. Kiemeney, Katja K. H. Aben
Summary: The study found no significant survival benefit of cisplatin over carboplatin as first-line chemotherapy in patients with mUCB.
EUROPEAN UROLOGY FOCUS
(2022)
Article
Psychology, Developmental
Martina Arenella, Gemma Cadby, Ward De Witte, Rachel M. Jones, Andrew J. O. Whitehouse, Eric K. Moses, Alex Fornito, Mark A. Bellgrove, Ziarih Hawi, Beth Johnson, Jeggan Tiego, Jan K. Buitelaar, Lambertus A. Kiemeney, Geert Poelmans, Janita Bralten
Summary: Autism spectrum disorders present clinical heterogeneity, posing challenges for genetic studies. Investigating individual autistic-like traits can enhance understanding of autism spectrum disorders, revealing genetic relationships and highlighting the potential role of immune-related genes in specific dimensions of the disorder.
Article
Urology & Nephrology
Janneke E. W. Walraven, Theodora M. Ripping, Jorg R. Oddens, Bas W. G. van Rhijn, Catharina A. Goossens-Laan, Maarten C. C. M. Hulshof, Lambertus A. Kiemeney, J. A. Witjes, Valery E. P. P. Lemmens, Jacobus J. M. van der Hoeven, Ingrid M. E. Desar, Katja K. H. Aben, Rob H. A. Verhoeven
Summary: This study investigated the role of specialised genitourinary multidisciplinary team meetings (MDTMs) in decision-making and identified factors that influenced the probability of receiving treatment with curative intent for patients with muscle invasive bladder cancer (MIBC). The study found that age, performance status, and the type of hospital were associated with the likelihood of being discussed in an MDTM and receiving curative treatment. Patient preference was the main reason for non-adherence to treatment advice.
Article
Oncology
Chiara Grasso, Maja Popovic, Elena Isaevska, Fulvio Lazzarato, Valentina Fiano, Daniela Zugna, John Pluta, Benita Weathers, Kurt D'Andrea, Kristian Almstrup, Lynn Anson-Cartwright, D. Timothy Bishop, Stephen J. Chanock, Chu Chen, Victoria K. Cortessis, Marlene D. Dalgaard, Siamak Daneshmand, Alberto Ferlin, Carlo Foresta, Megan N. Frone, Marija Gamulin, Jourik A. Gietema, Mark H. Greene, Tom Grotmol, Robert J. Hamilton, Trine B. Haugen, Russ Hauser, Robert Karlsson, Lambertus A. Kiemeney, Davor Lessel, Patrizia Lista, Ragnhild A. Lothe, Chey Loveday, Coby Meijer, Kevin T. Nead, Jeremie Nsengimana, Rolf I. Skotheim, Clare Turnbull, David J. Vaughn, Fredrik Wiklund, Tongzhang Zheng, Andrea Zitella, Stephen M. Schwartz, Katherine A. McGlynn, Peter A. Kanetsky, Katherine L. Nathanson, Lorenzo Richiardi
Summary: This study found that genetic variants within the MTHFR gene are associated with the risk of testicular germ cell tumors (TGCT), potentially affecting the establishment of DNA methylation patterns. This finding suggests that the pathogenesis of TGCT may be related to the status of the folate cycle, and this relation could be partly due to hereditary factors.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Genetics & Heredity
Jinyoung Byun, Younghun Han, Yafang Li, Jun Xia, Erping Long, Jiyeon Choi, Xiangjun Xiao, Meng Zhu, Wen Zhou, Ryan Sun, Yohan Bosse, Zhuoyi Song, Ann Schwartz, Christine Lusk, Thorunn Rafnar, Kari Stefansson, Tongwu Zhang, Wei Zhao, Rowland W. Pettit, Yanhong Liu, Xihao Li, Hufeng Zhou, Kyle M. Walsh, Ivan Gorlov, Olga Gorlova, Dakai Zhu, Susan M. Rosenberg, Susan Pinney, Joan E. Bailey-Wilson, Diptasri Mandal, Mariza de Andrade, Colette Gaba, James C. Willey, Ming You, Marshall Anderson, John K. Wiencke, Demetrius Albanes, Stephan Lam, Adonina Tardon, Chu Chen, Gary Goodman, Stig Bojeson, Hermann Brenner, Maria Teresa Landi, Stephen J. Chanock, Mattias Johansson, Thomas Muley, Angela Risch, H-Erich Wichmann, Heike Bickeboeller, David C. Christiani, Gad Rennert, Susanne Arnold, John K. Field, Sanjay Shete, Loic Le Marchand, Olle Melander, Hans Brunnstrom, Geoffrey Liu, Angeline S. Andrew, Lambertus A. Kiemeney, Hongbing Shen, Shanbeh Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil Caporaso, Angela Cox, Yun-Chul Hong, Jian-Min Yuan, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Alpa Patel, Qing Lan, Nathaniel Rothman, Fiona Taylor, Linda Kachuri, John S. Witte, Lori C. Sakoda, Margaret Spitz, Paul Brennan, Xihong Lin, James McKay, Rayjean J. Hung, Christopher Amos
Summary: A genome-wide association meta-analysis of lung cancer among different populations reveals five new susceptibility loci and identifies population-specific effects of common and rare variants. The study also highlights the potential role of genes such as IRF4 and FUBP1 in promoting DNA damage in lung fibroblasts.
Article
Oncology
S. G. Creemers, B. Van Santvoort, F. W. P. J. van den Berkmortel, L. A. Kiemeney, I. M. van Oort, K. K. H. Aben, P. Hamberg
Summary: Participation in multidisciplinary team meetings is associated with a higher likelihood of receiving chemohormonal therapy in patients with metastatic prostate cancer, suggesting that the organizational structure of MDTs aids in the implementation of innovative treatment options.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Article
Medicine, General & Internal
Katja Schlichtig, Lisa Cuba, Pauline Duerr, Laura Bellut, Norbert Meidenbauer, Frank Kunath, Peter J. Goebell, Andreas Mackensen, Frank Doerje, Martin F. Fromm, Bernd Wullich
Summary: Oral antitumor therapeutics (OAT) carry a high risk of medication errors, particularly for uro-oncological patients. This study investigates the frequency and relevance of medication errors in patients with prostate cancer or renal cell carcinoma treated with OAT and provides recommendations for clinical practice. Tailored strategies should be implemented to improve medication safety.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Meta H. M. Diekstra, Jesse J. Swen, Loes F. M. van der Zanden, Sita H. Vermeulen, Epie Boven, Ron H. J. Mathijssen, Koya Fukunaga, Taisei Mushiroda, Fumiya Hongo, Egbert Oosterwijk, Anne Cambon-Thomsen, Daniel Castellano, Achim Fritsch, Jesus Garcia Donas, Cristina Rodriguez-Antona, Rob Ruijtenbeek, Marius T. Radu, Tim Eisen, Kerstin Junker, Max Roessler, Ulrich Jaehde, Tsuneharu Miki, Stefan Bohringer, Michiaki Kubo, Lambertus A. L. M. Kiemeney, Henk-Jan Guchelaar
Summary: This study identified novel genetic variants in PDLIM3 and DSCAM that are associated with progression-free survival and overall survival in metastatic renal cell carcinoma patients receiving sunitinib.
Article
Nutrition & Dietetics
Bernd J. Schmitz-Draeger, Ekkehardt Bismarck, Dorothee Grammenos, Thomas Ebert, Roland Starlinger, Bertram Ottillinger, Peter J. Goebell, Stephan Muehlich, Natalya Benderska-Soder, Oliver Hakenberg
Summary: The management of side effects caused by androgen deprivation therapy (ADT) in prostate cancer (PCa) patients has become increasingly important. This study examines the impact of written patient information on physical activity and dietary habits of PCa patients receiving ADT. The results suggest that although information regarding nutrition and physical activity is lacking, most patients would make use of this information if provided.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Oncology
Nikoletta Vidra, Ivy Beeren, Moniek van Zutphen, Katja K. Aben, Ellen Kampman, J. Alfred Witjes, Antoine G. van Der Heijden, Lambertus A. Kiemeney, Alina Vrieling
Summary: Although the evidence is limited, adherence to the WCRF/AICR lifestyle recommendations is associated with improved health-related quality of life in patients with NMIBC.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Clinical Neurology
Sarah R. Vreijling, Marije van Haeringen, Yuri Milaneschi, Floris Huider, Mariska Bot, Najaf Bot, Joline W. Beulens, Marijke A. Bremmer, Petra J. Elders, Tessel E. Galesloot, Lambertus A. Kiemeney, Hanna M. van Loo, H. Susan J. Picavet, Femke Rutters, Ashley van der Spek, Anne M. van de Wiel, Cornelia van Duijn, Edith J. M. Feskens, Catharina A. Hartman, Albertine J. Oldehinkel, Jan H. Smit, W. M. Monique Verschuren, Gonneke Willemsen, Eco J. C. de Geus, Dorret I. Boomsma, Brenda W. J. H. Penninx, Femke Lamers, Rick Jansen
Summary: In a subgroup of depressed patients, energy-related symptoms are associated with immuno-metabolic dysregulations. This study examines the associations between energy-related symptoms and sociodemographic, lifestyle, and clinical characteristics.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Oncology
Christian Doehn, Martin Boegemann, Viktor Gruenwald, Manfred Welslau, Jens Bedke, Martin Schostak, Thomas Wolf, Rainer Ehness, Elisa Degenkolbe, Stefanie Witecy, Peter J. Goebell
Summary: The PAZOREAL study provides valuable real-world data for the primary treatment of metastatic renal cell carcinoma (mRCC) with pazopanib. The study shows that pazopanib as a first-line treatment for mRCC has good efficacy and safety.
Review
Oncology
Lisa M. C. van Hoogstraten, Alina Vrieling, Antoine G. van der Heijden, Manolis Kogevinas, Anke Richters, Lambertus A. Kiemeney
Summary: Bladder cancer is a significant burden for healthcare systems worldwide due to its high incidence and mortality. The occurrence of bladder cancer is influenced by factors such as population growth, aging, and exposure to risk factors like tobacco smoking. Primary prevention efforts are crucial in reducing the burden of bladder cancer, and less-invasive diagnostic approaches using urinary biomarkers show promise. Increasing awareness of risk factors and symptoms among healthcare professionals and high-risk groups is also important. Further research on the relationship between lifestyle factors and bladder cancer outcomes should be prioritized.
NATURE REVIEWS CLINICAL ONCOLOGY
(2023)
Article
Urology & Nephrology
Christine G. J. I. van Straten, Max H. Bruins, Siebren Dijkstra, Erik B. Cornel, Michael D. H. Kortleve, Thijn F. de Vocht, Lambertus A. L. M. Kiemeney, Antoine G. van der Heijden
Summary: The prognosis of muscle-invasive bladder cancer (MIBC) has not improved for three decades. The standard procedure, transurethral resection of the bladder tumor (TURBT), has limitations in tumor staging. Recent studies have shown that mpMRI is accurate in staging bladder tumors. This study compares the diagnostic efficacy of urethrocystoscopy (UCS) with pathology.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Medicine, Research & Experimental
Albert Rosenberger, Nils Muttray, Rayjean J. Hung, David C. Christiani, Neil E. Caporaso, Geoffrey Liu, Stig E. Bojesen, Loic Le Marchand, Demetrios Albanes, Melinda C. Aldrich, Adonina Tardon, Guillermo Fernandez-Tardon, Gad Rennert, John K. Field, Michael P. A. Davies, Triantafillos Liloglou, Lambertus A. Kiemeney, Philip Lazarus, Bernadette Wendel, Aage Haugen, Shanbeh Zienolddiny, Stephen Lam, Matthew B. Schabath, Angeline S. Andrew, Eric J. Duell, Susanne M. Arnold, Gary E. Goodman, Chu Chen, Jennifer A. Doherty, Fiona Taylor, Angela Cox, Penella J. Woll, Angela Risch, Thomas R. Muley, Mikael Johansson, Paul Brennan, Maria Teresa Landi, Sanjay S. Shete, Christopher Amos, Heike Bickeboeller
Summary: This study assessed the association and predictive ability of AhR/Wnt genes with lung cancer in individuals of European descent. The results showed no genome-wide significant association with overall lung cancer, but significant associations were observed in subgroups of ever smokers and never smokers. Although the predictability is poor, AhR/Wnt variants are overrepresented in optimized prediction scores for lung cancer.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)