Journal
UROLOGIA INTERNATIONALIS
Volume 98, Issue 1, Pages 79-84Publisher
KARGER
DOI: 10.1159/000448691
Keywords
Prostate cancer; Metformin; Androgen deprivation therapy; C-peptide; Insulin; Body weight
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Funding
- National Natural Science Foundation of China [81272835]
- Outstanding Talents Cultivation Project of Shanghai Medical System [XBR2013092]
- Talents Development Foundation of Shanghai [201302]
- Scientific Research Innovation Project of Shanghai Education Committee [14ZZ010]
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Purpose: The study aimed to evaluate the effects of metformin on insulin, C-peptide and body weight in Chinese men undergoing androgen deprivation therapy (ADT). Methods: Between March 2013 and June 2014, 62 newly diagnosed patients of prostate cancer (PCa) due to receive ADT were recruited from 7 hospitals in Shanghai. Patients were randomized to respectively receive ADT (n = 31) and ADT + metformin (n = 31) for 6 months. Fasting and postprandial serum levels of insulin and C-peptide, blood glucose, prostate specific antigen, body mass index (BMI) and waist circumference (WC) were measured at the beginning and end of 6-month treatment. Results: Baseline characteristics were comparable between the 2 groups. Controlling for baseline levels, the ADT group had significantly higher levels of fasting glucose (p = 0.01) and higher WC (p = 0.04) than the ADT+ metformin group. The levels of insulin, C-peptide and BMI did not differ significantly. Conclusions: Metformin may be potentially efficient as a concomitant therapy on patients with PCa undergoing androgen deprivation treatment. 1:0 (C) 2016 S. Karger AG, Basel
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