Article
Nanoscience & Nanotechnology
Xiajun Liu, Wenbin Ma, Defu Song, Saeed Rohani
Summary: A nanocomposite delivery system was developed for the delivery of curcumin and resveratrol to treat spinal cord injury in a rat model. The system showed sustained release of both drugs and was non-toxic to PC-12 cells. In vivo studies demonstrated that co-administration of curcumin and resveratrol had significantly higher healing activity compared to other groups, and the delivery system downregulated the expression profile of NF-kB and TNF-a genes.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Wenjing Wang, Shang Li, Haiyan Li, Peilin Guo, Chengliang Lyu, Peng Ye, Weiqiang Yang, Jinghui Wang, Dingle Yu, Guihong Lu, Hui Tan
Summary: A drug delivery system that readily penetrates the blood spinal cord barrier and targets spinal cord injury (SCI) is developed by using microglia-derived cell membranes to construct biomimetic polylactic-co-glycolic acid and resveratrol (PLGA-RSV) nanoparticles (PR@MM). In SCI, the PR@MM has the ability to scavenge reactive oxygen species and exerts anti-inflammatory effects, which ultimately promotes the recovery of locomotory function after SCI.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Neurosciences
Ruihua Fan, Yong Zhang, Benson O. A. Botchway, Xuehong Liu
Summary: The pathophysiological mechanisms of spinal cord injury are not well-defined, with neuroinflammation and astrocyte alterations playing key roles. Resveratrol has the potential to modulate neuroinflammatory factors and enhance injury recovery in spinal cord injury.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Nutrition & Dietetics
Jonas Campos, Nuno A. Silva, Antonio J. Salgado
Summary: Spinal cord injury is a condition that leads to motor, sensory, and autonomic impairments, and nutritional interventions have been proposed as a way to circumvent these issues. Published data have shown that nutritional interventions can improve various relevant pathophysiological processes of SCI, ultimately leading to neuroprotection and neuroplasticity.
Review
Biology
Sajad Fakhri, Mohammad Mehdi Gravandi, Sadaf Abdian, Seyed Zachariah Moradi, Javier Echeverria
Summary: Spinal cord injury (SCI) is a complex disease with no FDA-approved treatment. Flavonoids, especially quercetin, found in plant secondary metabolites, have the potential to combat SCI and have been extensively studied.
Article
Pharmacology & Pharmacy
Ning He, Gerong Shen, Xiaoqin Jin, Heyangzi Li, Jingyu Wang, Lintao Xu, Jun Chen, Xi Cao, Chunyan Fu, Dongling Shi, Xinghui Song, Shuangshuang Liu, Yanwei Li, Tengfei Zhao, Jun Li, Jinjie Zhong, Yueliang Shen, Mingzhi Zheng, Ying-ying Chen, Lin-lin Wang
Summary: Spinal cord injury can alter the gut microbiota and metabolites, affecting the prognosis of the injury. Resveratrol, with its anti-inflammatory properties, can restore the disrupted gut microbiota and increase the concentration of butyrate, promoting functional recovery after spinal cord injury.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Li Deng, Jun Qiao Lv, Lin Sun
Summary: This study systematically analyzed the experimental treatments and their mechanisms for reducing blood spinal cord barrier (BSCB) injury in the early stage of traumatic spinal cord injury (t-SCI). BMSC-Exos, which inhibit matrix metalloproteinases (MMPs) expression, are currently the most effective therapeutic modality for alleviating BSCB damage. In addition, the regulation of MMPs, the Akt pathway, and the ER stress pathway play important roles in alleviating BSCB injury.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Emma Adriana Ozon, Izabela Dana Maria Iuga, Magdalena Mititelu, Adina Magdalena Musuc, Bogdan Nicolae Manolescu, Simona Petrescu, Jeanina Pandele Cusu, Adriana Rusu, Vasile-Adrian Surdu, Eliza Oprea, Sorinel Marius Neacsu, Oana Karampelas, Viviana Elian
Summary: The excess of free radicals leads to various imbalances in the body, causing premature aging, degradation of internal structures, and the development of pathologies that increase the risk of premature death. This study evaluates the physical, chemical, pharmacotechnical, and antioxidant activity of newly achieved capsule formulations. Two formulations, F1(a.i)(.) and F2(a.i.), containing different active ingredients in specific ratios, were tested. The results showed that the F2(c.c)(.) formulation had the strongest antioxidant capacity, confirming the suitable formulation and selection of active ingredients and excipients for developing effective antioxidant supplements for the human body.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Giovanni Schepici, Serena Silvestro, Emanuela Mazzon
Summary: Spinal cord injury (SCI) is a devastating condition that causes permanent motor and sensory deficits. Researchers have been studying potential therapeutic strategies to mitigate the neuro-inflammatory response following injury. Recent studies have shown that exosomes-derived MSCs (MSC-EXOs) have promising effects as an innovative therapy for SCI patients.
Article
Biochemistry & Molecular Biology
Pauline Michel-Flutot, Laurie Efthimiadi, Lynda Djerbal, Therese B. Deramaudt, Marcel Bonay, Stephane Vinit
Summary: This study evaluated the antioxidant response in phrenic motoneurons following C2 spinal cord lateral hemi-section in rats, and found that the AMPK-Nrf2 signaling pathway plays a significant role in the oxidative stress response after high SCI. Harnessing this pathway could improve the antioxidant response and help in improving diaphragm activity in patients with high SCI.
Article
Cell & Tissue Engineering
Song Zhang, Qifeng Li, Song Zhang
Summary: Spinal cord injury is a major clinical problem in young patients. This study developed an electrical conductive composite related to spinal cord injury regeneration. Experimental tests showed that the composite had good regeneration and differentiation ability, better biocompatibility, and suitable mechanical and conductivity properties.
REGENERATIVE THERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Hannu-Pekka Honkanen, Caius Mustonen, Johanna Herajarvi, Hannu Tuominen, Tuomo Starck, Mika Kallio, Kai Kiviluoma, Vesa Anttila, Tatu Juvonen
Summary: This study aimed to assess the efficacy of thoracic segmental artery occlusion as a method of spinal cord protection during aortic aneurysm surgery. The results showed that acute priming of the spinal cord by occluding the segmental arteries before aortic crossclamp significantly reduced the risk of paraplegia and improved neurological outcomes. Histopathology and motor-evoked potentials also supported the protective effect of priming. These findings suggest that modifying the spinal cord vasculature through priming can effectively protect against ischemic injury in aortic aneurysm surgery.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Engineering, Biomedical
Xue Jiang, Xiaoyao Liu, Qi Yu, Wenwen Shen, Xifan Mei, He Tian, Chao Wu
Summary: This study aimed to design plasma complex component functionalized manganese-doped silica nanoparticles as a targeted drug carrier for resveratrol. The results showed that this drug delivery system effectively reduced oxidative stress, inflammation, and neuronal apoptosis in spinal cord tissue after spinal cord injury, promoting motor function recovery in mice.
MATERIALS TODAY BIO
(2022)
Article
Neurosciences
Alireza Masoudi, Masoumeh Jorjani, Morteza Alizadeh, Solmaz Mirzamohammadi, Mola Mohammadi
Summary: The study demonstrates that astaxanthin offers significant protective effects on SCI rat models by reducing tissue damage and mechanical pain through its anti-inflammatory and antioxidant properties.
BRAIN RESEARCH BULLETIN
(2021)
Article
Neurosciences
Fei-xiang Lin, Qi-lin Pan, Hou-yun Gu, Fang-jun Zeng, Zhi-jun Lu
Summary: Spinal cord injury (SCI) is a severe and disabling injury that affects the central nervous system, leading to impaired sensory and motor function. Pathological processes, such as oxidative stress, inflammation, apoptosis, and glial scarring, worsen the condition. Resveratrol, a natural polyphenol, has anti-inflammatory and antioxidant properties and has shown potential as a therapeutic drug for various diseases, including nerve damage. Preclinical studies have suggested that resveratrol activates signaling pathways related to SCI pathology, making it a potential treatment for SCI. This review summarizes the role of resveratrol in promoting nerve function recovery by regulating oxidative stress, inflammation, apoptosis, and glial scar formation in SCI, as well as the current research trends and limitations in resveratrol studies. It provides a foundation for further understanding the molecular mechanisms of SCI and the development of therapeutic options.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Clinical Neurology
Turan Kandemir, Fulya Buge Ergen, Didem Turgut Cosan, Fezan Mutlu, Zuhtu Ozbek, Tevfik Erhan Cosan
TURKISH NEUROSURGERY
(2019)
Article
Environmental Sciences
P. K. Cevik, A. B. Eroglu, G. Yildizli, D. Cosan, C. Kantar, G. Coral
JOURNAL OF ENVIRONMENTAL BIOLOGY
(2019)
Article
Toxicology
A. Soyocak, H. Kurt, D. Turgut Cosan, F. Saydam, I. U. Calis, U. K. Kolac, Z. Ozdemir Koroglu, I Degirmenci, F. Sahin Mutlu, H. Gunes
HUMAN & EXPERIMENTAL TOXICOLOGY
(2019)
Article
Ophthalmology
Deniz Marangoz, Cagri Oner, Martin Schicht, Didem Turgut Cosan, Friedrich Paulsen, Erdost Yildiz, Noushin Zibandeh, Afsun Sahin
Summary: This study investigated the effects of DHT on LPS-induced proinflammatory cytokine release in human ocular surface epithelial cells. The results showed that LPS + LBP stimulated the secretion of certain cytokines, while DHT suppressed the secretion of some of those cytokines, demonstrating its anti-inflammatory activity.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2021)
Article
Biochemistry & Molecular Biology
Ahu Soyocak, Merih Ozgen, Didem Turgut Cosan, Hulyam Kurt, Fulya Doganer, Onur Armagan, Irfan Degirmenci, Fezan Sahin Mutlu
BIOSCIENCE REPORTS
(2020)
Article
Chemistry, Multidisciplinary
Aysegul Oglakci-Ilhan, Kevser Kusat-Ol, Kubilay Uzuner, Onur Uysal, Ibrahim Sogut, Ferruh Yucel, Gungor Kanbak
Summary: The study found that long-term high dose alcohol consumption led to increased myocardial apoptosis, while calpain inhibitor 1 could reduce myocardial apoptosis and prevent myocardial tissue injury, especially in cases of myocardial injury after alcohol consumption.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Article
Oncology
Sibel Gunes, Merve Nur Soykan, Ayla Eker Sariboyaci, Onur Uysal, Tugba Semerci Sevimli
Summary: The study demonstrated that overexpression of the human Klotho gene via CRISPR/Cas9 in resistant human colon cancer cells sensitized TRAIL death receptor DR4, leading to suppression of cell proliferation through apoptosis. This research sheds new light on the role of the Klotho gene in colon cancer.
Article
Genetics & Heredity
Tugba Semerci Sevimli, Murat Sevimli, Emilia Qomi Ekenel, Burcugul Altug Tasa, Merve Nur Soykan, Zilif Demir Gucluer, Ulukan Inan, Onur Uysal, Sibel Gunes Bagis, Fatih Cemrek, Ayla Eker Sariboyaci
Summary: This study investigated the differences in exosomal microRNA-127-5p expression profiles between hAT-MSCs and hSF-MSCs during chondrogenesis for cartilage regeneration treatment. Differentiation of hAT-MSCs, hSF-MSCs, and hfCCs was induced, and staining was performed to detect chondrogenic differentiation. Exosomes from differentiated cells were isolated, and expression of microRNA-127-5p was measured by qRT-PCR. Higher levels of microRNA-127-5p expression were found in hAT-MSCs exosomes compared to hSF-MSCs, suggesting hAT-MSCs are better sources for stimulating chondrogenesis and regenerative therapy of cartilage-related pathologies. hAT-MSCs exosomes are rich in microRNA-127-5p and can be a significant candidate for cartilage regeneration treatments.
Article
Biochemistry & Molecular Biology
Merve Nur Soykan, Burcugul Altug, Harun Bas, Hamed Ghorbanpoor, Huseyin Avci, Sertac Eroglu, Sultan Butun Sengel, Ayla Eker Sariboyaci, Sibel Gunes Bagis, Onur Uysal, Eray Atalay
Summary: A PRP-laden GelMA hydrogel contact lens is developed to support and protect limbal stem cells after ocular surface injuries.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Oncology
Ayla Eker Sariboyaci, Onur Uysal, Merve Nur Soykan, Sibel Gunes
Summary: This study demonstrated the anti-tumor and apoptotic effects of exogenous Klotho protein in colorectal adenocarcinoma cells. The results showed that Klotho induced cytotoxicity and apoptosis in a dose-dependent manner, specifically targeting cancer cells without affecting healthy colon cells. These findings suggest the potential therapeutic application of Klotho in adjuvant therapy for colorectal adenocarcinoma.
Article
Medicine, General & Internal
Mehmet Caner Ozer, Mehmet Kaya, Ahmet Berkiz Turp, Cengiz Bal, Nilufer Erkasap, Didem Turgut Cosan, Hikmet Hassa
ANNALS OF CLINICAL AND ANALYTICAL MEDICINE
(2020)
Article
Medicine, General & Internal
Turgut D. Cosan, A. Soyocak, C. Oner
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
(2020)
Meeting Abstract
Biochemistry & Molecular Biology
F. B. Ergen, D. Turgut Cosan, T. Kandemir, F. Mutlu, T. E. Cosan
EUROPEAN JOURNAL OF HUMAN GENETICS
(2019)
Article
Medicine, General & Internal
Merih Ozgen, Didem Turgut Cosan, Fulya Doganer, Ahu Soyocak, Onur Armagan, Selen Kuzgun, Ayse Merve Aydogan, Hasan Veysi Gunes, Irfan Degirmenci, Fezan Mutlu
Meeting Abstract
Biochemistry & Molecular Biology
D. Turgut Cosan, A. Soyocak, C. Oner
EUROPEAN JOURNAL OF HUMAN GENETICS
(2018)
