Article
Acoustics
A. C. M. Kluivers, A. Biesbroek, W. Visser, L. Saleh, H. Russcher, A. H. J. Danser, R. I. Neuman
Summary: This study aims to evaluate the levels of placental growth factor (PlGF), soluble fms-like tyrosine kinase-1 (sFlt-1), and free PlGF in women with pre-eclampsia (PE) with or without a small-for-gestational-age (SGA) neonate. The findings suggest that diminished PlGF production is an important cause of low free PlGF levels, particularly in pregnancies with early-onset PE and SGA. The upregulation of sFlt-1 occurs synergistically in women with both PE and SGA.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xue-Fei Liu, Meng-Die Li, Jing-Jing Lu, Ying Li, An-Rong Zeng, Jin-Wei Qiang
Summary: This study investigates the use of MRI, MRS, and serum metabolomics to differentiate between pre-eclampsia (PE) and gestational hypertension (GH). Increased T1 signal intensity index (T1SI), lactate/creatine (Lac/Cr), and glutamine and glutamate (Glx)/Cr, as well as decreased apparent diffusion coefficient (ADC) value and myo-inositol (mI)/Cr, were found in PE patients. Combination of Lac/Cr, Glx/Cr, and mI/Cr showed the highest differentiating performance. Serum metabolomics analysis identified 12 differential metabolites associated with various metabolic pathways. MRS is expected to be a noninvasive and effective tool for monitoring GH patients to avoid the development of PE.
EUROPEAN RADIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Nataliia Sergeevna Karpova, Olga Pavlovna Dmitrenko, Tatyana Sergeevna Budykina
Summary: One of the main causes of maternal and neonatal morbidity and mortality is pre-eclampsia, characterized by a high sFlt1/PlGF ratio. Pregestational diseases in mothers may increase the risk, but few studies have looked at the connection between maternal comorbidities and the sFlt1/PlGF ratio. This review summarizes the latest information on the association between maternal pregestational diseases and the ratio of sFlt1/PlGF, as well as the link between changes in pregnancy hormones/metabolites and a high sFlt1/PlGF ratio. Debate remains on the association between the ratio and maternal disorders, calling for further research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Obstetrics & Gynecology
Pablo Garcia-Manau, Manel Mendoza, Erika Bonacina, Carmen Garrido-Gimenez, Antoni Fernandez-Oliva, Julia Zanini, Marina Catalan, Helena Tur, Berta Serrano, Elena Carreras
Summary: This study aimed to compare sFlt-1/PlGF values and pregnancy outcomes among early-onset SGA/FGR stages, with results showing higher sFlt-1/PlGF ratios and increased frequency of adverse outcomes in FGR patients. There was a significant correlation between sFlt-1/PlGF values and gestational age at delivery, adverse pregnancy outcomes, etc.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Obstetrics & Gynecology
Katherine G. Y. Lau, Allan Wright, Emmanouil Kountouris, Kypros H. Nicolaides, Nikos A. Kametas
Summary: The study aimed to investigate the difference in OA PSV-ratio among women with PE, GH, and CH, and found that the OA PSV-ratio was significantly higher in PE patients compared to CH and GH patients, which may be a useful test for assessing women with hypertension.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Endocrinology & Metabolism
Xiujuan Su, Yang Liu, Guohua Li, Xiaosong Liu, Shijia Huang, Tao Duan, Qiaoling Du
Summary: This study found that hypothyroxinemia during pregnancy was associated with an increased risk of preeclampsia-eclampsia, especially in women with persistent hypothyroxinemia in early pregnancy. However, there was no significant association between hypothyroxinemia and gestational hypertension.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Clinical Neurology
Satu Kotikoski, Arttu Kurtelius, Heidi J. Nurmonen, Juho Paavola, Virve Karkkainen, Terhi J. Huuskonen, Jukka Huttunen, Timo Koivisto, Mikael von Und zu Fraunberg, Juha E. Jaaskelainen, Antti E. Lindgren
Summary: This study found a higher prevalence of pre-eclampsia in patients with saccular intracranial aneurysms (sIAs) compared to the general population, with sIA patients with pre-eclampsia more frequently having irregularly shaped aneurysms. Further research is needed to determine if a history of pre-eclampsia indicates an elevated risk for sIA formation or rupture.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Obstetrics & Gynecology
K. Hilden, A. Magnuson, S. Montgomery, E. Schwarcz, U. Hanson, D. Simmons, H. Backman
Summary: This study investigates the associations between pre-eclampsia, gestational diabetes mellitus (GDM), and cardiovascular disease (CVD). The results show that both pre-eclampsia and GDM are independent risk factors for later CVD. The association between pre-eclampsia and CVD is not modified by body mass index (BMI). Effective CVD preventive programs for high-risk women are urgently needed.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Acoustics
M. Reddy, K. Palmer, D. L. Rolnik, E. M. Wallace, B. W. Mol, F. Da Silva Costa
Summary: This study assessed the performance of placental, fetal, and maternal cardiovascular markers in predicting adverse perinatal and maternal outcomes in women with suspected or confirmed pre-eclampsia. The sFlt-1/PlGF ratio showed good performance in predicting adverse perinatal outcomes but had poor predictive ability for adverse maternal outcomes.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
A. Peguero, L. Fernandez-Blanco, E. Mazarico, L. Benitez, A. Gonzalez, L. Youssef, F. Crispi, S. Hernandez, F. Figueras
Summary: Longitudinal changes in sFlt-1 levels improve the prediction of complications and interval to delivery in women with early-onset severe pre-eclampsia.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Medicine, Research & Experimental
Alice Hurrell, Jenie Sparkes, Kate Duhig, Paul T. Seed, Jenny Myers, Cheryl Battersby, Katherine Clark, Marcus Green, Rachael M. Hunter, Andrew H. Shennan, Lucy C. Chappell, Louise Webster
Summary: The PARROT-2 trial is a multi-centre randomised controlled trial investigating the impact of repeat PIGF-based testing on women with suspected pre-eclampsia between 22-35 weeks of gestation. The primary objective of the trial is to determine whether repeat PIGF-based testing reduces severe adverse outcomes for both mother and baby. The clinical and cost-effectiveness of repeat PIGF-based testing has not yet been evaluated.
Article
Immunology
Chiara Tersigni, Donatella Lucchetti, Rita Franco, Filomena Colella, Caterina Neri, Laura Crispino, Alessandro Sgambato, Antonio Lanzone, Giovanni Scambia, Manu Vatish, Nicoletta Di Simone
Summary: PE is a common pregnancy disorder characterized by hypertension and proteinuria, with aberrant expression of HLA-DR in STBEVs specifically associated with PE. Further studies are needed to define the role of abnormal placental HLA-DR expression in PE pathogenesis and evaluate the potential application of detecting circulating HLA-DR positive STBEVs in diagnosing and predicting PE in early and mid-pregnancy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Neurosciences
Xue-Fei Liu, Jing-Jing Lu, Meng-Die Li, Ying Li, An-Rong Zeng, Jin-Wei Qiang
Summary: A radiomics nomogram based on diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) maps was established to predict pre-eclampsia (PE) from gestational hypertension (GH). The nomogram exhibited good performance in both the training and test cohorts for predicting PE from GH. It can be conveniently used to facilitate treatment decisions for clinicians and patients.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Nutrition & Dietetics
Huifeng Shi, Yuanhui Jiang, Pengbo Yuan, Lian Chen, Xiaoli Gong, Yike Yang, Yuanyuan Wang, Hai Jiang, You Li, Mengxing Sun, Yangyu Zhao, Yuan Wei
Summary: This study revealed a non-linear association between vitamin E concentrations in the first trimester and gestational vitamin E change with pre-eclampsia. The findings showed that vitamin E concentrations below 7.3 mg/L and gestational decrease were associated with increased risk of pre-eclampsia.
FRONTIERS IN NUTRITION
(2022)
Article
Biology
Jieun Kang, Sangwon Hwang, Taesic Lee, Kwangjin Ahn, Dong Min Seo, Seong Jin Choi, Young Uh
Summary: The prediction of pre-eclampsia is important, but current biomarkers face challenges in clinical settings. This study found that incorporating serum creatinine levels and considering renal hyperfiltration significantly improved PE prediction. The developed model is practical and can be easily applied in primary care settings.
Article
Acoustics
D. Di Mascio, G. Rizzo, A. Khalil, F. D'Antonio
Summary: This study aimed to investigate the role of fetal brain MRI in detecting associated anomalies in fetuses with congenital CMV infection and normal neurosonography. The results showed that fetal brain MRI can detect additional anomalies in fetuses with congenital CMV infection and negative neurosonography, and the viral load in the amniotic fluid is an independent predictor of the risk of associated anomalies in these fetuses.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Review
Pediatrics
Christine E. Jones, Heather Bailey, Alasdair Bamford, Anna Calvert, Robert B. Dorey, Simon B. Drysdale, Asma Khalil, Paul T. Heath, Hermione Lyall, Kate Monica Isabel Ralph, Shari Sapuan, Tushna Vandrevala, Simone Walter, Elizabeth Whittaker, Sharon Wood
Summary: Congenital human cytomegalovirus (CMV) infection is a common condition with long-term consequences for children. However, it is not well-known among pregnant women, families, and healthcare providers. Timely diagnosis and treatment are important for reducing transmission and improving outcomes for infants. Further research is needed to inform screening, outcomes, and treatment decisions.
ARCHIVES OF DISEASE IN CHILDHOOD
(2023)
Review
Acoustics
S. Sorrenti, D. Di Mascio, A. Khalil, N. Persico, F. D'antonio, F. Zullo, V. D'ambrosio, G. Greenberg, J. Hasson, F. Vena, L. Muzii, R. Brunelli, A. Giancotti
Summary: This study evaluated outcomes of dichorionic twin pregnancies undergoing early vs late selective termination of pregnancy. The results showed that the risk of pregnancy loss prior to 24 weeks was lower in the early-ST group, and the risks of preterm birth and low birth weight were also lower. Therefore, the importance of early diagnosis of fetal anomalies in twin pregnancies was highlighted.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Letter
Acoustics
F. D'Antonio, P. O'Brien, H. Blakeway, D. Buca, S. Prasad, A. Khalil
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Acoustics
B. Poljak, U. Agarwal, Z. Alfirevic, S. Allen, N. Canham, J. Higgs, A. Kaelin Agten, A. Khalil, D. Roberts, F. Mone, K. Navaratnam
Summary: This study examines the utilization and diagnostic yield of prenatal exome sequencing (pES) in a UK fetal medicine unit, as well as its impact on perinatal outcomes. The results show a diagnostic yield of 23.4% for pES, and the detection of causative variants significantly increases the rate of late termination of pregnancy (TOP).
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Review
Acoustics
F. D'Antonio, D. Marinceu, S. Prasad, A. Khalil
Summary: The objective of this systematic review and meta-analysis was to investigate the safety and effectiveness of prenatal valacyclovir therapy in pregnancies with maternal CMV infection. The findings suggest that valacyclovir therapy can reduce the risk of congenital CMV infection. However, further research is needed to determine the impact of valacyclovir on the course of infection in the fetus and the risk of symptomatic fetal or neonatal infection.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Berta Serrano, Erika Bonacina, Itziar Garcia-Ruiz, Manel Mendoza, Pablo Garcia-Manau, Paula Garcia-Aguilar, Judit Gil, Mireia Armengol-Alsina, Nuria Fernandez-Hidalgo, Elena Sulleiro, Laura Castillo-Ribelles, Nerea Maiz, Elena Carreras, Anna Suy
Summary: Since the outbreak of COVID-19, pregnant women with SARS-CoV-2 infection have shown an increased incidence of preeclampsia-like syndrome. This study aims to confirm this syndrome and its implications on pregnancy outcomes. The results suggest that more than 50% of pregnant women with severe COVID-19 and diagnostic criteria for preeclampsia may actually have a preeclampsia-like syndrome, which can affect up to 7.5% of women with severe COVID-19. The syndrome has similar perinatal outcomes to normotensive women with severe pneumonia caused by COVID-19. The study highlights the importance of using soluble fms-like tyrosine kinase 1-to-placental growth factor ratio in future research and clinical decisions.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Obstetrics & Gynecology
Jose Morales-Rosello, Rohan Bhate, Nashwa Eltaweel, Asma Khalil
Summary: This study compared the accuracy of the ductus venosus pulsatility index (DV PI) and cerebroplacental ratio (CPR) in predicting adverse perinatal outcomes. The results showed that CPR was a better predictor than DV PI for adverse perinatal outcomes.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Obstetrics & Gynecology
E. Kalafat, B. Liu, I. Barratt, R. Bhate, A. Papageorghiou, A. Khalil
Summary: This study investigated the perinatal outcomes of dichorionic twin pregnancies complicated by selective fetal growth restriction (sFGR). The umbilical artery Z-scores were found to be associated with both intrauterine death and adverse perinatal outcomes.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Cell Biology
Clara Apicella, Camino S. M. Ruano, Basky Thilaganathan, Asma Khalil, Veronica Giorgione, Geraldine Gascoin, Louis Marcellin, Cassandra Gaspar, Sebastien Jacques, Colin E. Murdoch, Francisco Miralles, Celine Mehats, Daniel Vaiman
Summary: In this study, we aimed to identify genetic variants affecting gene expression in the human placenta, specifically in normal and pathological situations. The analysis was constrained by the fact that placental tissue samples from diseased individuals are typically obtained at an earlier gestational age compared to control samples, leading to confounding factors in transcriptome regulation. To address this issue, we implemented a novel approach that accounted for gestational age and identified disease-specific cis-eQTLs. Through statistical correction and analysis, we identified a list of e-genes that significantly influenced expression levels, demonstrating the validity of our methodology for future research purposes.
Review
Obstetrics & Gynecology
Hiba J. Mustafa, Enaja Sambatur, Julie P. Barbera, Giorgio Pagani, Yuval Yaron, Caitlin D. Baptiste, Ronald J. Wapner, Asma Khalil
Summary: This study aimed to assess the diagnostic yield of prenatal exome sequencing after negative chromosomal microarray analysis in cases of prenatally diagnosed bilateral severe ventriculomegaly or hydrocephalus. The study identified relevant studies published until June 2022 and included studies in English reporting on the diagnostic yield of exome sequencing following negative chromosomal microarray analysis in cases of prenatally diagnosed bilateral severe ventriculomegaly. Meta-analysis was performed using a random-effects model to assess the incremental diagnostic yield of exome sequencing.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Review
Medicine, General & Internal
Francesco D'Antonio, Nashwa Eltaweel, Smriti C. Prasad, Maria Elena C. Flacco, Lamberto C. Manzoli, Asma C. Khalil
Summary: This systematic review and meta-analysis aimed to evaluate the role of cervical cerclage in preventing preterm birth and adverse outcomes in twin pregnancies. The findings suggest that cervical cerclage in twin pregnancies with short cervical length or cervical dilatation is associated with a reduced risk of preterm birth and improved neonatal outcomes. However, confirmation of these findings in large and well-designed randomized controlled trials is needed for stronger evidence.
Article
Medicine, General & Internal
Nawa Schirwani-Hartl, Pilar Palmrich, Christina Haberl, Nicole Perkmann-Nagele, Herbert Kiss, Angelika Berger, Judith Rittenschober-Bohm, Gregor Kasprian, Patric Kienast, Asma Khalil, Julia Binder
Summary: This retrospective analysis investigated the efficacy of administering hyperimmune globulin (HIG) therapy every 2 weeks compared to every 4 weeks in pregnant women with primary cytomegalovirus (CMV) infection. The study found no significant difference in congenital CMV rates or fetal ultrasound and magnetic resonance imaging (MRI) anomalies between the two groups. Larger studies are needed to evaluate the impact of administering HIG every 2 weeks on maternal-fetal transmission rates.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Ivan Hurtado, Erika Bonacina, Pablo Garcia-Manau, Berta Serrano, Mireia Armengol-Alsina, Manel Mendoza, Nerea Maiz, Elena Carreras
Summary: This study aims to create a predictive model involving biomarkers to evaluate its ability to predict adverse perinatal outcomes in patients with late-onset small fetuses, thus providing individualized counseling at the time of diagnosis.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Edgar Coello-Cahuao, Maria Angeles Sanchez-Duran, Ines Calero, Maria Teresa Higueras, Mayte Aviles Garcia, Carlota Rodo, Nerea Maiz, Alberto Plaja Rustein, Neus Castells-Sarret, Carmen Mediano-Vizuete, Elena Carreras
Summary: This study evaluates the performance of chromosomal microarray analysis in fetuses with nuchal translucency > 95th percentile, and identifies potential genetic variants.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)