Article
Medicine, General & Internal
Eran Ashwal, Jasmine Ali-Gami, Amir Aviram, Stefania Ronzoni, Elad Mei-Dan, John Kingdom, Nir Melamed
Summary: This study aimed to investigate the association of second-trimester sonographic placental morphology markers with placenta-mediated complications and determine whether these markers are predictive of placental dysfunction independent of uterine artery Doppler. The results showed that placental area is independently associated with the risk of placenta-mediated complications, but when combined with uterine artery Doppler, it did not significantly improve the prediction of such complications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Graham W. Aberdeen, Jeffery S. Babischkin, Jonathan R. Lindner, Gerald J. Pepe, Eugene D. Albrecht
Summary: Uterine spiral artery remodeling (SAR) is crucial for placental perfusion and fetal development. This study found that prematurely elevating estradiol levels or delivering the sFlt-1 gene increases placental sFlt-1 protein expression and suppresses SAR in early baboon pregnancy.
Article
Acoustics
G. Ashoor, A. Syngelaki, I Papastefanou, K. H. Nicolaides, R. Akolekar
Summary: The study demonstrates that a model combining maternal risk factors, UtA-PI, and EFW at 19-24 weeks' gestation can effectively predict antepartum stillbirths due to impaired placentation, especially those occurring preterm.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Medicine, General & Internal
Lindsay S. Cahilla, Greg Stortzc, Anjana Ravi Chandrand, Natasha Milligane, Shiri Shinard, Clare L. Whiteheadd, Sebastian R. Hobsond, Viji Ayyathuraid, Anum Rahmana, Rojan Saghiana, Karl J. Jobstb, Cyrethia McShaneh, Dana Block-Abrahamh, Viola Seravallih, Melissa Laurieh, Sarah Millardh, Cassandra Delph, Denise Wolfsonh, Ahmet A. Baschath, Kellie E. Murphyd, Lena Serghidesk, Eric Morgenn, Christopher K. Macgowanc, W. Tony Parksn, John C. Kingdom, John G. Sted
Summary: The study examined whether wave reflections in the umbilical artery can predict placental vascular pathology, with results showing significantly elevated wave reflections in women with MVM or FVM pathology, while umbilical and uterine artery pulsatility indices were only elevated in the MVM group.
Article
Pharmacology & Pharmacy
Z. Avul, C. M. Guven, B. S. Feyzioglu, S. O. Sancar
Summary: This study aimed at evaluating the hypothesis that 6-14 months pregnant women diagnosed with COVID-19 may have abnormal placental function detectable by increased uterine artery Doppler indices in the second trimester and whether these women could benefit from treatment; it was observed that uterine artery Doppler indices were significantly increased in second trimester women with COVID-19 infection compared to those without COVID-19, suggesting that Doppler Ultrasound measurement may be a potential method for the management of high-risk pregnancies after asymptomatic/mild COVID-19 infection.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Z. Avul, C. M. Guven, B. S. Feyzioglu, S. O. Sancar
Summary: This study aimed to evaluate whether 6-14 months pregnant women diagnosed with COVID-19 may have abnormal placental function detectable by increased uterine artery Doppler indices in the second trimester and whether these women could benefit from treatment. A total of 63 women diagnosed with COVID-19 during the first trimester of their pregnancy and 68 healthy women were involved in the study. The results showed that uterine artery Doppler indices were significantly increased in second trimester women with COVID-19 compared to those without COVID-19, indicating potential high-risk pregnancies.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Developmental Biology
Sara L. Jones, Amir Aviram, Ludmila Porto, Tianhua Huang, Abheha Satkunaratnam, Jon F. R. Barrett, Nir Melamed, Elad Mei-Dan
Summary: The study found that in women with abnormal FTS analytes, those with elevated UtA-PI are at increased risk of FGR. However, the predictability of FGR based on UtA-PI is moderate-to-poor.
Review
Medicine, General & Internal
Serena Resta, Gaia Scandella, Ilenia Mappa, Maria Elena Pietrolucci, Pavjola Maqina, Giuseppe Rizzo
Summary: The number of pregnancies achieved through IVF is increasing globally, with improved chances of success due to technological advances. However, pregnancies conceived through IVF have a higher risk of adverse maternal and perinatal outcomes, mainly related to hypertensive diseases, pre-eclampsia, and fetal growth restriction. Advances in ultrasound technology allow for the evaluation of placental volume and hemodynamics, with differences observed between fresh and frozen-thawed embryos.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Suchada Erjongmanee, Vorapong Phupong
Summary: This study aimed to determine the predictive value of first-trimester serum SHARP1 level and second-trimester uterine artery Doppler in singleton pregnancy for the prediction of preeclampsia. The study demonstrated that combining the first-trimester serum SHARP1 level with the second-trimester uterine artery PI had good sensitivity to predict preeclampsia.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Article
Medicine, General & Internal
Stephanie Springer, Katharina Worda, Marie Franz, Eva Karner, Elisabeth Krampl-Bettelheim, Christof Worda
Summary: Early prediction of fetal growth restriction is important for treatment options and neonatal outcomes. This study assessed the association of parameters used in first-trimester screening and the development of fetal growth restriction. The findings showed that PAPP-A levels and uterine artery Doppler pulsatility index weresignificantly associated with fetal growth restriction.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Leah Paranavitana, Melissa Walker, Anjana Ravi Chandran, Natasha Milligan, Shiri Shinar, Clare L. Whitehead, Sebastian R. Hobson, Lena Serghides, W. Tony Parks, Ahmet A. Baschat, Christopher K. Macgowan, John G. Sled, John C. Kingdom, Lindsay S. Cahill
Summary: The study found that there is no difference in uterine artery pulsatility index (PI) between female and male fetuses in normal pregnancies, but in complicated pregnancies (preeclampsia, preterm birth, or fetal growth restriction), the trajectory of PI varies by fetal sex, with male fetuses showing a more progressive deterioration in uteroplacental perfusion over gestation. This highlights the importance of considering fetal sex when interpreting hemodynamic markers of placental maturation, as observed through changes in uterine artery PI.
BIOLOGY OF SEX DIFFERENCES
(2021)
Article
Acoustics
Angelo Sirico, Anke Diemert, Peter Glosemeyer, Kurt Hecher
Summary: This study found a correlation between umbilical artery pulsatility index and estimated fetal weight percentile and birthweight percentile, with low UA-PI independently associated with neonatal LGA. The results suggest that the higher the EFW and BW percentiles, the lower the UA-PI.
ULTRASCHALL IN DER MEDIZIN
(2021)
Article
Obstetrics & Gynecology
Adjima Soongsatitanon, Vorapong Phupong
Summary: This study demonstrated that the combination of serum PP13 level and uterine artery Doppler in the first trimester increased the sensitivity for predicting preeclampsia.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Erika Bonacina, Pablo Garcia-Manau, Monica Lopez, Sara Caamina, Angels Vives, Eva Lopez-Quesada, Marta Ricart, Anna Maroto, Laura de Mingo, Elena Pintado, Laura Castillo-Ribelles, Lourdes Martin, Alicia Rodriguez-Zurita, Esperanza Garcia, Mar Pallarols, Laia Vidal-Sagnier, Mireia Teixidor, Carmen Orizales-Lago, Adela Perez-Gomez, Vanesa Ocana, Linda Puerto, Pilar Millan, Merce Alsius, Sonia Diaz, Nerea Maiz, Elena Carreras, Anna Suy, Manel Mendoza
Summary: The study aimed to assess whether aspirin treatment could be discontinued in pregnancies with a normal uterine artery pulsatility index (≤90th percentile) at 24-28 weeks. The results showed that discontinuing aspirin treatment was non-inferior to continuing aspirin treatment for preventing preterm pre-eclampsia in women with a uterine artery pulsatility index ≥90th percentile at 24-28 weeks.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Luiza Meelhuysen Sousa Aguiar, Lumena Goncalves Machado Zanotto, Carlos Henrique Mascarenhas Silva, Marianna Amaral Pedroso
Summary: A retrospective study showed that using both transverse and longitudinal Doppler techniques during the first trimester morphological examination can reliably measure the pulsatility index of uterine arteries in pregnant women, without affecting the final outcome of preeclampsia screening.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Acoustics
N. Khan, W. Andrade, H. De Castro, A. Wright, D. Wright, K. H. Nicolaides
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2020)
Article
Obstetrics & Gynecology
Diane Nzelu, Dan Biris, Theodoros Karampitsakos, Kypros K. Nicolaides, Nikos A. Kametas
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2020)
Article
Obstetrics & Gynecology
Trisha V. Vigneswaran, Salma Jabak, Argyro Syngelaki, Marietta Charakida, John M. Simpson, Kypros H. Nicolaides, Vita Zidere
Summary: The study found that the incidence of isolated right aortic arch (RAA) and double aortic arch (DAA) in fetuses undergoing routine first-trimester ultrasound examination in a local population is 2-3 times higher than that reported in postnatal studies. Additionally, the risk for these abnormalities is substantially increased in fetuses conceived by in vitro fertilization (IVF), with a significantly higher median maternal age in the group with isolated RAA or DAA.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Acoustics
B. Cimpoca, A. Syngelaki, A. Chi Mu, E. Savvoulidou, K. H. Nicolaides
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2020)
Article
Acoustics
B. Cimpoca, A. Syngelakbd, E. Litwinska, A. Muzaferovic, K. H. Nicolaides
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2020)
Article
Acoustics
D. Wright, A. Wright, E. Smith, K. H. Nicolaides
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2020)
Article
Acoustics
H. Z. Ling, P. G. Jara, A. Bisquera, L. C. Poon, K. H. Nicolaides, N. A. Kametas
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2020)
Article
Acoustics
A. Frick, V. Kostiv, D. Vojtassakova, R. Akolekar, K. H. Nicolaides
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2020)
Article
Acoustics
P. Chaveeva, A. Wright, A. Syngelaki, L. Konstantinidou, D. Wright, K. H. Nicolaides
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2020)
Article
Acoustics
E. Litwinska, A. Syngelaki, B. Cimpoca, I. Sapantzoglou, K. H. Nicolaides
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2020)
Article
Acoustics
H. De Castro, A. Ciobanu, C. Formuso, R. Akolekar, K. H. Nicolaides
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2020)
Article
Obstetrics & Gynecology
Joshua A. Copel, Lawrence D. Platt, John C. Hobbins, Yalda Afshar, Olga Grechukhina, Divya Mallampati, Bryann Bromley, Aaron B. Caughey, William Grobman, Christina S. Han, Kypros Nicolaides, Christian Pettker, George Saade, Baha Sibai, Hygrav Simhan, Jiri Sonek, Erika Werner, Nancy Chescheir
OBSTETRICS AND GYNECOLOGY
(2020)
Article
Acoustics
W. Zhang, S. Geris, J. Beta, G. Ramadan, K. H. Nicolaides, R. Akolekar
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2020)
Editorial Material
Acoustics
J. C. Jani, M. M. Gil, A. Benachi, F. Prefumo, K. O. Kagan, A. Tabor, C. M. Bilardo, G. C. Di Renzo, K. H. Nicolaides
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2020)
Article
Acoustics
G. P. Minnella, F. M. Crupano, A. Syngelaki, V. Zidere, R. Akolekar, K. H. Nicolaides
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2020)