Cholesterol, Statins, and Dementia: What the Cardiologist Should Know

Does the evidence say a 4-point change in ADAS-cog score is clinically significant?

(2014) Mark Oremus   Alzheimers & Dementia

Effect of Evolocumab or Ezetimibe Added to Moderate- or High-Intensity Statin Therapy on LDL-C Lowering in Patients With Hypercholesterolemia

(2014) Jennifer G. Robinson et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Arterial Stiffness and β-Amyloid Progression in Nondemented Elderly Adults

(2014) Timothy M. Hughes et al.   JAMA Neurology

Midlife Hypertension and 20-Year Cognitive Change

(2014) Rebecca F. Gottesman et al.   JAMA Neurology

The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy

(2013) Patrick L. McGeer et al.   ACTA NEUROPATHOLOGICA

2013 Alzheimer's disease facts and figures

(2013)   Alzheimers & Dementia

Statins and Cognitive Function

(2013) Karl Richardson et al.   ANNALS OF INTERNAL MEDICINE

2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults

(2013) Neil J. Stone et al.   CIRCULATION

Association of statin use with risk of dementia: A meta-analysis of prospective cohort studies

(2013) Yu Song et al.   Geriatrics & Gerontology International

Cholesterol as a causative factor in Alzheimer's disease: a debatable hypothesis

(2013) W. Gibson Wood et al.   JOURNAL OF NEUROCHEMISTRY

2013 ACC/AHA Guideline on the Assessment of Cardiovascular Risk

(2013) David C. Goff et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Statins and Cognition: A Systematic Review and Meta-analysis of Short- and Long-term Cognitive Effects

(2013) Kristopher J. Swiger et al.   MAYO CLINIC PROCEEDINGS

Why Alzheimer trials fail: removing soluble oligomeric beta amyloid is essential, inconsistent, and difficult

(2013) William I. Rosenblum   NEUROBIOLOGY OF AGING

Twenty-year changes in dementia occurrence suggest decreasing incidence in central Stockholm, Sweden

(2013) C. Qiu et al.   NEUROLOGY

Alzheimer’s Disease, Cholesterol, and Statins: The Junctions of Important Metabolic Pathways

(2012) Tiago Silva et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cognitive impairment and outcomes in older adult survivors of acute myocardial infarction: Findings from the Translational Research Investigating Underlying disparities in acute Myocardial infarction Patients' Health Status registry

(2011) S. Michael Gharacholou et al.   AMERICAN HEART JOURNAL

Statins, Risk of Dementia, and Cognitive Function: Secondary Analysis of the Ginkgo Evaluation of Memory Study

(2011) Kerstin Bettermann et al.   Journal of Stroke & Cerebrovascular Diseases

Association of Alzheimer disease pathology with abnormal lipid metabolism: The Hisayama Study

(2011) T. Matsuzaki et al.   NEUROLOGY

A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease

(2011) M. Sano et al.   NEUROLOGY

Glucose tolerance status and risk of dementia in the community: The Hisayama Study

(2011) T. Ohara et al.   NEUROLOGY

Heavy Smoking in Midlife and Long-term Risk of Alzheimer Disease and Vascular Dementia

(2010) Minna Rusanen et al.   ARCHIVES OF INTERNAL MEDICINE

Reduction of Brain β-Amyloid (Aβ) by Fluvastatin, a Hydroxymethylglutaryl-CoA Reductase Inhibitor, through Increase in Degradation of Amyloid Precursor Protein C-terminal Fragments (APP-CTFs) and Aβ Clearance

(2010) Mitsuru Shinohara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Statins and serum cholesterol's associations with incident dementia and mild cognitive impairment

(2010) M. A. Beydoun et al.   JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH

Age-Varying Association Between Statin Use and Incident Alzheimer's Disease

(2010) Ge Li et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease: LEADe

(2010) H. H. Feldman et al.   NEUROLOGY

Diabetes, Alzheimer disease, and vascular dementia: A population-based neuropathologic study

(2010) S. Ahtiluoto et al.   NEUROLOGY

Long-term high-dose atorvastatin decreases brain oxidative and nitrosative stress in a preclinical model of Alzheimer disease: A novel mechanism of action

(2010) Eugenio Barone et al.   PHARMACOLOGICAL RESEARCH

Midlife Serum Cholesterol and Increased Risk of Alzheimer’s and Vascular Dementia Three Decades Later

(2009) Alina Solomon et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Cholesterol and statins in Alzheimer's disease: Current controversies

(2009) Ana Catarina R.G. Fonseca et al.   EXPERIMENTAL NEUROLOGY

Cholesterol metabolism and transport in the pathogenesis of Alzheimer’s disease

(2009) Ian J. Martins et al.   JOURNAL OF NEUROCHEMISTRY

Pravastatin and cognitive function in the elderly. Results of the PROSPER study

(2009) Stella Trompet et al.   JOURNAL OF NEUROLOGY

Why lipids are important for Alzheimer disease?

(2009) Veronica Hirsch-Reinshagen et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Cognitive functioning in Alzheimer’s and vascular dementia: A meta-analysis.

(2009) J. L. Mathias et al.   NEUROPSYCHOLOGY

Statin-Associated Adverse Cognitive Effects: Survey Results from 171 Patients

(2009) Marcella A Evans et al.   PHARMACOTHERAPY

The Atorvastatin/Donepezil in Alzheimer’s Disease Study (LEADe): Design and baseline characteristics

(2008) Roy W. Jones et al.   Alzheimers & Dementia

Effect of statins on a wide range of health outcomes: a cohort study validated by comparison with randomized trials

(2008) Liam Smeeth et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Reduced Risk of Incident AD with Elective Statin Use in a Clinical Trial Cohort

(2008) D. Sparks et al.   Current Alzheimer Research

Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study

(2008) M D M Haag et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Statins, incident Alzheimer disease, change in cognitive function, and neuropathology

(2008) Z. Arvanitakis et al.   NEUROLOGY

Use of statins and incidence of dementia and cognitive impairment without dementia in a cohort study

(2008) C. Cramer et al.   NEUROLOGY