Journal
TUMOR BIOLOGY
Volume 37, Issue 12, Pages 15383-15397Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1007/s13277-016-5436-9
Keywords
microRNA; EMT; EMT-TFs; Cancer; Metastasis; Progression
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Funding
- National Natural Science Foundation of China [81172351, 81372856]
- Taishan Scholars Programme of Shandong Province [ts201511096]
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Metastasis is an important factor in predicting the prognosis of the patients with cancers and contributes to high cancer-related mortality. Recent studies indicated that microRNAs (miRNAs) played a functional role in the initiation and progression of human malignancies. MicroRNAs are small non-coding RNAs of about 22 nucleotides in length that can induce messenger RNA (mRNA) degradation or repress mRNA translation by binding to the 3' untranslated region (3'-UTR) of their target genes. Overwhelming reports indicated that miRNAs could regulate cancer invasion and metastasis via epithelial-to-mesenchymal transition (EMT)-related and/or non-EMT-related mechanisms. In this review, we concentrate on the underlying mechanisms of miRNAs in regulating cancer progression and metastasis.
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