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Medicine, Research & Experimental
Xiaoting Huang, Leyang Xiang, Baiyao Wang, Jijie Hu, Chunshan Liu, Anbang Ren, Kunpeng Du, Gengtai Ye, Yingying Liang, Yunqiang Tang, Dinghua Yang, Yawei Yuan
Summary: This study demonstrates that CMTM6 plays a critical role in promoting proliferation, migration, and invasion in HCC through interacting with and stabilizing vimentin. The overexpression of CMTM6 is significantly associated with poor prognosis in HCC, suggesting its potential as a biomarker and therapeutic target for treating HCC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
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Oncology
Chun-Ming Li, Jie Zhang, Wu Wu, Zhu Zhu, Feng Li, Di Wu, Xiao-Jun Wang, Chuan-Ming Xie, Jian-Ping Gong
Summary: This study investigated the biological function and potential mechanism of FBXO43 in hepatocellular carcinoma (HCC). The results showed that FBXO43 was upregulated in HCC patient tissues and correlated with poor clinicopathological features. Knockdown of FBXO43 inhibited HCC cell proliferation, migration, and epithelial-mesenchymal transition (EMT), which was mediated by its interaction with cyclin D1 (CCND1) and promotion of CCND1 stability. Targeting the FBXO43-CCND1 axis may provide a new potential strategy for HCC treatment.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell Biology
Fei Cao, Anguo Luo, Chaowen Yang
Summary: Ferroptosis is a significant form of cell death in cancer research, with G6PD and POR being associated with both HCC progression and prognosis. G6PD promotes HCC development by inhibiting ferroptosis, while downregulation of POR is correlated with better prognosis in HCC.
CELLULAR SIGNALLING
(2021)
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Cell Biology
Xiao-Wei Dang, Qi Pan, Zhen-Hai Lin, Hao-Hao Wang, Lu-Hao Li, Lin Li, Dong-Qi Shen, Pei-Ju Wang
Summary: This study confirmed that DEPDC1B knockdown restricts tumor growth in vitro and in vivo, and it interacts with CDK1, being a potential therapeutic target involved in HCC growth and progression. The results suggest that DEPDC1B plays a key role in HCC and may be a promising target for therapeutic interventions.
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Biochemistry & Molecular Biology
Luhao Li, Suxin Li, Haohao Wang, Lin Li, Peiju Wang, Dongqi Shen, Xiaowei Dang
Summary: The study revealed that GSG2 is overexpressed in HCC tissues, and knockdown of GSG2 can inhibit the progression of HCC, promote cell apoptosis, and potentially participate in the oncogenesis of HCC.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
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Oncology
Youlin Yu, Shuqing You, Rengen Fan, Xiangxiang Shan
Summary: This study reveals the correlation between high expression of UCK2 and the progression of HCC, suggesting UCK2 as a potential target for HCC therapy.
Article
Medicine, Research & Experimental
Xia-Hui Lin, Dan-Ying Zhang, Zhi-Yong Liu, Wen-qing Tang, Rong-Xin Chen, Dong-ping Li, Shuqiang Weng, Ling Dong
Summary: The lncRNA-AC079061.1/VIPR1 axis was identified as a novel biomarker that inhibited the proliferation and invasion of hepatocellular carcinoma, affecting the ultimate disease outcome.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
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Biochemistry & Molecular Biology
Yuanguang Liu, Qing Chang, Xiaotang Wu, Youlin Yu, Huizhong Zhang
Summary: The study aimed to investigate the effect of chemokine CXCL14 on the in vitro angiogenesis of human hepatocellular carcinoma (HCC) cells. The results showed that overexpression of CXCL14 could inhibit angiogenesis, proliferation, migration, and invasion abilities of HCC cells. These findings may contribute to further research on treatment methods for HCC.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
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Cell Biology
Libing Wang, Mingxin Cui, Daming Cheng, Fengzhi Qu, Jingkun Yu, Yanbin Wei, Ling Cheng, Xiaotang Wu, Xiaogang Liu
Summary: The study revealed that miR-9-5p is highly expressed in HCC cells while ESR1 is poorly expressed; overexpression of miR-9-5p can enhance cell proliferation, invasion, and migration; ESR1 is identified as a downstream target of miR-9-5p in HCC.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Minhua Wu, Hui Lan, Zhongwei Ye, Yonghui Wang
Summary: The study found that Pregnancy Zone Protein (PZP) is highly methylated and poorly expressed in hepatocellular carcinoma, and inhibits the proliferation, invasion, and migration of HCC cells. These findings may provide a basis for exploring novel therapeutic targets for HCC.
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Biochemistry & Molecular Biology
Lin Lyu, Tsung-Chin Lin, Nami McCarty
Summary: Autophagy plays a crucial role in cancer cell survival, while TRIM44 is a key element regulating DNA damage response, increasing DNA damage repair and serving as a potential therapeutic target for therapy-resistant tumor cells with intact autophagy.
Review
Biochemistry & Molecular Biology
Meijin Liu, Zhonghong Lai, Xiaoying Yuan, Qing Jin, Haibin Shen, Dingyu Rao, Defa Huang
Summary: This review explores the role of exosomes in hepatocellular carcinoma (HCC), including their involvement in cancer cell proliferation, invasion, and metastasis. Additionally, the potential applications of exosomes in HCC diagnosis and treatment are discussed, highlighting their versatility as both a diagnostic platform and drug delivery vehicle.
MOLECULAR MEDICINE
(2023)
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Oncology
Yan Lu, Qihua Dang, Yin Bo, Xuejin Su, Liping Wang, Jiaqi Sun, Junyuan Wei, Chengshi Quan, Yanru Li
Summary: CLDN6 was found to be highly expressed in human hepatocellular carcinoma (hHCC) and promoted the development of the cancer. Silencing of CLDN6 in hHCC cells inhibited proliferation, migration, and invasion abilities, upregulated E-cadherin expression, and downregulated N-cadherin and Vimentin expression, suggesting that CLDN6 could be a potential target for hHCC treatment.
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Cell Biology
Zhipeng Tang, Pei Zhao, Wanxing Zhang, Qian Zhang, Ming Zhao, He Tan
Summary: This study found that SALL4 activates the PI3K/AKT signaling pathway through targeting PTEN, thereby facilitating the migration, invasion, and proliferation of HCC cells.
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Biotechnology & Applied Microbiology
Qisheng Su, Zheng Yang, Xiaobin Guo, Wuning Mo, Xiaohong Li
Summary: The study revealed that TPPP3 is significantly down-regulated in NPC tissues and cells, and its overexpression can inhibit cell proliferation and invasion ability, while having no significant effect on migration ability. Overexpression of TPPP3 also decreases the expression of MMP-2 and MMP-9 mRNA.