Article
Gastroenterology & Hepatology
Lina Li, Jie Liu, Wei Huang
Summary: This study confirmed for the first time the upregulation of E2F5 in gastric cancer and discovered that E2F5 can directly upregulate UBE2T transcription, thereby promoting malignant progression.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Cell Biology
Li-Li Ren, Zhi-Wen Wang, Ren Sen, Zhou-Tong Dai, Xing-Hua Liao, Li-Juan Shen
Summary: GRB10 and its family members GRB7 and GRB14 are important adaptor proteins that regulate cellular functions by interacting with tyrosine kinase receptors and other phosphorus-containing amino acid proteins. Abnormal expression of GRB10 is closely related to cancer occurrence and development. In gastric cancer, high expression of GRB10 is associated with poorer overall survival. Knockdown of GRB10 inhibits proliferation and migration ability in gastric cancer, and miR-379-5p can downregulate GRB10 expression to suppress gastric cancer development. Therefore, miR-379-5p and GRB10 are potential targets for gastric cancer treatment.
Article
Oncology
Keiji Nishibeppu, Shuhei Komatsu, Jun Kiuchi, Takuma Kishimoto, Yusuke Takashima, Katsutoshi Shoda, Tomohiro Arita, Toshiyuki Kosuga, Hirotaka Konishi, Atsushi Shiozaki, Takeshi Kubota, Kazuma Okamoto, Hitoshi Fujiwara, Hitoshi Tsuda, Eigo Otsuji
Summary: The study revealed that overexpression of TRIM37 in gastric cancer is significantly correlated with tumor invasion, T/N staging, histology, and recurrence rate, predicting worse outcomes. Knockdown of TRIM37 increased apoptosis and suppressed migration and invasion in TRIM37-overexpressing gastric cancer cells.
Article
Oncology
Min Luo, Yuqian Zhou
Summary: Colorectal cancer is one of the most common malignancies worldwide. This study identified 1,835 genes differentially expressed in CRC, including those associated with modulating various pathways in CRC progression. Furthermore, UBE2T was identified as a potential key regulator in CRC.
Article
Oncology
Zehua Wang, Chenyi Wang, Bing-Hua Jiang, Litong Shi, Shan Lin, Lei Wang, Ling-Zhi Liu, Jian-Ge Qiu, Yanru Qin, Yongxu Jia
Summary: The overexpression of STK17A significantly promotes the proliferation and migration of gastric cancer cells, and is associated with the prognosis of patients with gastric cancer. STK17A may be a valuable biomarker for the prognosis of patients with gastric cancer.
Article
Biochemistry & Molecular Biology
Linfeng Mao, Weijie Yuan, Kaimei Cai, Chen Lai, Changhao Huang, Yi Xu, Shangwei Zhong, Chen Yang, Ran Wang, Pengwei Zeng, Heyuan Huang, Zhikang Chen, Zihua Chen
Summary: EphA2, YES1, and ANXA2 form a signaling axis that promotes gastric cancer invasion and metastasis. Overexpression of YES1 increases invasion and migration of gastric cancer cells, while knockdown of ANXA2 decreases these processes.
Article
Oncology
Xiangliu Chen, Yingying Huang, Jin Liu, Wu Lin, Chuanzhi Chen, Yiran Chen, Yongfeng Ding, Yan Yang, Yanyan Chen, Haiyong Wang, Lisong Teng
Summary: In this study, we found that EXOSC5 is upregulated in GC tissues and cell lines and is associated with poor prognosis. It promotes GC proliferation and tumorigenesis, possibly through activation of the AKT and STAT3 signaling pathways.
Article
Biochemistry & Molecular Biology
Zeyuan Yu, Xiangyan Jiang, Long Qin, Haixiao Deng, Jianli Wang, Wen Ren, Hongbin Li, Lei Zhao, Huanxiang Liu, Hong Yan, Wengui Shi, Qi Wang, Changjiang Luo, Bo Long, Huinian Zhou, Hui Sun, Zuoyi Jiao
Summary: In this study, dysregulation of the Wnt/β-catenin signaling pathway was found to be critically involved in gastric cancer progression. The scaffold protein RACK1 deficiency, promoted by UBE2T, was identified as a significant factor in GC progression. A novel UBE2T inhibitor, M435-1279, was discovered to effectively inhibit the hyperactivation of the Wnt/β-catenin pathway, providing a promising therapeutic option for GC patients.
Article
Mathematical & Computational Biology
Yuan Yang, Yuwei Ye, Min Liu, Ya Zheng, Guozhi Wu, Zhaofeng Chen, Yuping Wang, Qinghong Guo, Rui Ji, Yongning Zhou
Summary: This study discovers that FAM153B is downregulated in gastric cancer tissues and positively associated with unfavorable survival. Enrichment pathways of FAM153B involve regulation of signaling receptor activity, DNA replication, cell cycle transition, and chromosomal regulation. Additionally, the protein expression level of FAM153B is related to the degree of immune cell infiltration.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2022)
Article
Cell Biology
Lingjun Ge, Gaichao Zhao, Chao Lan, Houji Song, Dan Qi, Pan Huang, Xiaoxue Ke, Hongjuan Cui
Summary: Gastric cancer is a deadly disease with high incidence and mortality rates. MESP2, a transcription factor, is found to be decreased in gastric cancer tissue and cell lines. Overexpression of MESP2 can suppress the growth, migration, and invasion of gastric cancer cells, and it achieves this by regulating the SKP2/p27 axis.
CELL DEATH DISCOVERY
(2023)
Article
Anatomy & Morphology
Yu Chen, Biling Wang, Zihao Zhao, Ming Li, Fei Wang
Summary: Overexpression of PRSS2 in gastric cancer is associated with poor prognosis and can serve as a potential biomarker for assessing the prognosis of gastric cancer. Knockdown of PRSS2 reduces the proliferation, migration, and invasion of GC cells.
Article
Oncology
Jing-jing Teng, Wen-jing Zhao, Xun-lei Zhang, Da-Kun Zhao, Xin-Yue Qiu, Xu-dong Chen, Lei Yang
Summary: PRDM5 is downregulated in gastric cancer and associated with poor survival and tumor progression. Methylation of PRDM5 promoter is closely related to histological types and tumor progression in gastric cancer.
Article
Cell Biology
Wangkai Xie, Zheng Han, Ziyi Zuo, Dong Xin, Hua Chen, Juanjuan Huang, Siyu Zhu, Han Lou, Zhiqiang Yu, Chenbin Chen, Sian Chen, Yuanbo Hu, Jingjing Huang, Fabiao Zhang, Zhonglin Ni, Xian Shen, Xiangyang Xue, Kezhi Lin
Summary: This study analyzed the relationship between differential expression of cytoskeleton genes and prognosis in gastric cancer (GC). ASAP1 was found to play a key role in cytoskeletal remodeling and prognosis in GC patients, and its overexpression can be used as a predictor of poor prognosis.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Shidong Wang, Chen Qiao, Jun Li, Si Liu, Peng Li
Summary: CASC19 exerts an oncogenic effect in gastric cancer by interacting with CREB1 and enhancing its stability. These findings highlight CASC19 as a potential biomarker and therapeutic target for advanced gastric cancer.
Article
Oncology
Hai Zhu, Gang Wang, Haixing Zhu, Aman Xu
Summary: The study demonstrated that MTFR2 is up-regulated in gastric cancer, and its overexpression is associated with poor prognosis. Downregulation of MTFR2 inhibited proliferation, migration, and invasion of gastric cancer cells both in vitro and in vivo. Bioinformatics analysis identified potential factors contributing to MTFR2 overexpression. Function and pathway enrichment analyses revealed involvement of MTFR2 in chromosome segregation, catalytic activity, cell cycle, and ribonucleic acid transport.
