Article
Biochemistry & Molecular Biology
Zhan Chen, Yan Lv, Lu He, Shunli Wu, Zhuang Wu
Summary: The study showed that decreased CDKL2 expression in ccRCC patients is closely associated with poor prognosis, suggesting it as a potential prognostic biomarker related to immune infiltrates.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Oncology
Zijian Zhou, Jiajin Wu, Yuanyuan Yang, Peng Gao, Lujia Wang, Zhong Wu
Summary: This study found that hepcidin expression is upregulated in clear cell renal cell carcinoma (ccRCC) and is correlated with patient age, T stage, and pathologic stage. Hepcidin promoter methylation is significantly associated with poor clinical parameters and hepcidin may serve as an independent prognostic factor. Mechanistically, hepcidin is involved in immune-related and metabolism-related pathways.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Review
Oncology
Haixiang Shen, Jin Liu, Shiming Chen, Xueyou Ma, Yufan Ying, Jiangfeng Li, Weiyu Wang, Xiao Wang, Liping Xie
Summary: High expression of CD68+ TAMs and M2-TAMs are risk factors for poor prognosis in ccRCC patients. TAMs' high density is associated with advanced clinicopathological features in ccRCC. TAMs could be potential biomarkers for prognosis and novel targets for immunotherapy in ccRCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Chunxiu Yang, Jingjing Pang, Jian Xu, He Pan, Yueying Li, Huainian Zhang, Huan Liu, Shu-Yuan Xiao
Summary: Our study revealed that LRRK2 plays a crucial role in the tumorigenesis and progression of ccRCC, and may serve as a potential predictor and therapeutic target for this type of cancer. The up-regulation of LRRK2 in ccRCC was found to be correlated with DNA methylation and associated with a better prognosis in patients with ccRCC.
CANCER CELL INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Qian Long, Chunyu Huang, Jinsheng Huang, Qi Meng, Yanjun Cheng, Yilin Li, Liru He, Miao Chen, Changlin Zhang, Xiaonan Wang, Wancui Zhu, Jin Peng, Dingbo Shi, Fufu Zheng, Pei Dong, Wuguo Deng
Summary: This study investigates the biological and clinical significance of JAK3 promoter methylation in clear cell renal cell carcinoma (ccRCC). The results show that JAK3 promoter is significantly hypomethylated in ccRCC tumor tissues and is strongly correlated with high JAK3 mRNA expression. JAK3 promoter hypomethylation predicts advanced clinicopathological characteristics and shorter overall survival. Furthermore, JAK3 promoter methylation is associated with immune cell infiltration and expression of immune checkpoint molecules. The findings suggest that JAK3 promoter methylation may serve as a molecular biomarker for predicting responses to immune checkpoint inhibitors in ccRCC.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Zhenfei Xiang, Erdong Shen, Mingyao Li, Danfei Hu, Zhanchun Zhang, Senquan Yu
Summary: The study identified potential prognostic biomarkers for ccRCC patients and immune cells fraction. Analysis revealed 4 lncRNAs and 7 genes that showed independent prognostic values in patients with ccRCC.
Article
Oncology
Hui Meng, Xuewen Jiang, Huangwei Huang, Neng Shen, Changsheng Guo, Chunxiao Yu, Gang Yin, Yu Wang
Summary: The study analyzed the correlation between genetic alterations and expression levels of MUCIN genes and the prognosis of ccRCC patients, identifying two major clusters with distinct tumor microenvironment features affecting survival outcomes.
Article
Immunology
Chengdong Qin, Siyuan Liu, Shiqi Zhou, Qibo Wang, Xianghou Xia, Jiejie Hu, Xiaohong Yuan, Zongping Wang, Yang Yu, Dening Ma
Summary: PIK3C2A expression is decreased in various tumors, particularly in renal clear cell carcinoma (KIRC). It is significantly correlated with tumor stage, grade, and other clinicopathological features in KIRC. PIK3C2A serves as a potential biomarker for tumor progression and is associated with immune infiltration in KIRC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Qiu Zhengqi, Guo Zezhi, Jiang Lei, Qiu He, Pan Jinyao, Ao Ying
Summary: This study evaluated the prognostic role of PHYH in clear cell renal cell carcinoma (ccRCC) using TCGA data, finding that high expression of PHYH is associated with better prognosis in ccRCC and related to high grade, high stage, and high level of stage_T. PHYH may serve as an independent prognostic factor, with gene set enrichment analysis revealing enrichment of different metabolic pathways in tissues with high PHYH expression.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2021)
Article
Immunology
Li Cheng, Zicheng Wang, Liang Nie, Chenglin Yang, Houbao Huang, Jian Lin, Dong Zhuo
Summary: In this study, the researchers investigated the functional role and prognostic significance of MFN2 in kidney renal clear cell carcinoma (KIRC). They found that downregulation of MFN2 was associated with inferior survival outcomes in KIRC patients. MFN2 was also shown to be involved in energy metabolism and autophagy, and associated with immune cell infiltration and immune checkpoints in KIRC tissues. Moreover, overexpression of MFN2 inhibited cell proliferation and migration in KIRC cell lines. These findings suggest that MFN2 may serve as a potential prognostic biomarker and therapeutic target in KIRC.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Oncology
Genyi Qu, Hao Wang, Huiqin Yan, Genlin Liu, Min Wu
Summary: The study identified 1,855 DEGs associated with ccRCC, including 1,207 upregulated genes and 648 downregulated genes. Functional and pathway enrichment analyses revealed key genes and pathways related to ccRCC. Oncomine confirmed the top six hub genes from the PPI network, with high expression of CXCL10 linked to poor prognosis in ccRCC patients.Survival analysis showed that CXCL10 expression level was significantly correlated with the prognosis of ccRCC patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Xiaomei Sun, Pengfei Liu
Summary: This study investigated the expression and prognostic significance of NEIL3 in KIRC. The results showed that NEIL3 was overexpressed in KIRC and associated with worse outcomes. Functional and immune infiltration analysis revealed that NEIL3 may be involved in multiple signaling pathways and immune cell regulation. Therefore, NEIL3 may serve as a potential independent biomarker for KIRC.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Kai Liu, Yingxue Gao, Quanwu Zhang
Summary: This study reveals the high expression of MALAT1 in ccRCC and its association with poor prognosis. MALAT1 expression is correlated with clinicopathological features, overall survival, and immune cell infiltration. Prognostic models are also established to predict survival.
Article
Cell Biology
Fan Zhang, Junyu Lin, Dechao Feng, Jiayu Liang, Yiping Lu, Zhihong Liu, Xianding Wang
Summary: This study explored the correlation between cuprotosis and clear cell renal cell carcinoma (ccRCC) and developed a cuprotosis-related signature to predict the prognosis of patients with ccRCC. The signature risk score was significantly associated with tumor stage, histological grade, and immune cell infiltrates in ccRCC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Oncology
Kalle E. Mattila, Paula Vainio, Panu M. Jaakkola
Summary: Approximately one fifth of newly diagnosed renal cell carcinoma patients have metastatic disease, and over one third of localized patients will develop distant metastases after surgery. Tumor size, grade, and extension into blood vessels are valid factors for predicting disease recurrence after surgery. Ongoing adjuvant therapy trials may reveal prognostic features for high-risk patients.
