Article
Oncology
Soazik P. Jamin, Feria Hikmet, Romain Mathieu, Bernard Jegou, Cecilia Lindskog, Frederic Chalmel, Michael Primig
Summary: CT genes are induced in germ cells and play a role in cancer progression. Identifying these genes is challenging due to the diverse sources and time periods of data. A study using RNA profiling analysis identified 478 candidate loci, including known CT genes and novel candidates that may serve as potential therapeutic targets or biomarkers.
MOLECULAR ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Hiromichi Sato, Kazuki Sasaki, Tomoaki Hara, Yoshiko Tsuji, Yasuko Arao, Chihiro Otsuka, Yumiko Hamano, Mirei Ogita, Shogo Kobayashi, Eric di Luccio, Takaaki Hirotsu, Yuichiro Doki, Hidetoshi Eguchi, Taroh Satoh, Shizuka Uchida, Hideshi Ishii
Summary: This article describes the causes and complexity of pancreatic ductal adenocarcinoma (PDAC), emphasizing the importance of early diagnosis and the multifaceted characteristics of PDAC in terms of cancer cell metabolism, mesenchymal cells, and metagenomics. The article also mentions various pathway alterations associated with PDAC treatment refractoriness and prospects for the application of new technologies.
Article
Biochemistry & Molecular Biology
Olivia M. Marx, Marc M. Mankarious, Melanie A. Eshelman, Wei Ding, Walter A. Koltun, Gregory S. Yochum
Summary: Despite a global decrease in colorectal cancer (CRC) incidence, the prevalence of early-onset colorectal cancer (EOCRC) has steadily increased. The understanding of genetic and molecular basis of EOCRC is limited. This study identified increased expression of c-MYC proto-oncogene (MYC) and its downstream targets in tumor samples. Elevated expression of the PVT1 long-non-coding RNA (lncRNA) was also detected. The findings suggest that deregulated MYC contributes to CRCs in younger patients.
Review
Chemistry, Physical
Yingwen Chen, Jia Song, Qingyu Ruan, Xi Zeng, Lingling Wu, Linfeng Cai, Xuanqun Wang, Chaoyong Yang
Summary: Cells are fundamental building blocks of biological systems, and studying single cells can provide insights into cell diversity and disease processes. Single-cell RNA sequencing technologies allow cellular heterogeneity to be dissected at unprecedented resolution.
Article
Genetics & Heredity
Konii Takenaka, Ellen M. Olzomer, Kyle L. Hoehn, Ashton Curry-Hyde, Bei Jun Chen, Rhonda Farrell, Frances L. Byrne, Michael Janitz
Summary: The present study investigated the circRNA transcriptome of twenty obese and post-menopausal women with endometrial cancer in Australia. This expands on previous findings from a similar cohort of six women in the United States. CircRNAs were found to be lower in abundance in endometrial cancer compared to adjacent non-cancerous tissue. Hotspot genes were also identified, which may act as diagnostic or prognostic biomarkers for endometrial cancer in obese women.
Article
Nutrition & Dietetics
Hun Hwan Kim, Sang Eun Ha, Min Yeong Park, Se Hyo Jeong, Pritam Bhagwan Bhosale, Abuyaseer Abusaliya, Chung Kil Won, Jeong Doo Heo, Meejung Ahn, Je Kyung Seong, Hyun Wook Kim, Gon Sup Kim
Summary: Using RNA sequencing, this study identified KYNA as a potential therapeutic target for gastric cancer. KYNA treatment inhibited cancer cell growth and proliferation, while inducing cell death. This research can provide valuable insights for the development of drugs targeting gastric cancer.
Article
Genetics & Heredity
Ruihuan Gu, Naidong Ge, Bin Huang, Jing Fu, Ying Zhang, Ningyi Wang, Yan Xu, Lu Li, Xiandong Peng, Yaoyu Zou, Yijuan Sun, Xiaoxi Sun
Summary: This study investigated the effects of vitrification/warming on the mRNA transcriptome of human ovarian tissues. The results showed that vitrification effectively preserved the ovarian tissues, but also led to significant changes in gene expression, which were mainly related to pathways such as systemic lupus erythematous, cytokine-cytokine receptor interaction, TNF signaling pathway, and MAPK signaling pathway.
FRONTIERS IN GENETICS
(2023)
Article
Oncology
Katharina Prieske, Malik Alawi, Anna Jaeger, Maximilian Christian Wankner, Kathrin Eylmann, Susanne Reuter, Patrick Lebok, Eike Burandt, Niclas C. Blessin, Barbara Schmalfeldt, Leticia Oliveira-Ferrer, Simon A. Joosse, Linn Woelber
Summary: The number of women diagnosed with vulvar cancer, especially younger women, has been increasing due to HPV infection. Limited genetic information on VSCC hampers treatment advances, particularly personalized treatments. By exploring RNA expression profiles, potential therapeutic targets for VSCC could be identified for a deeper understanding of its carcinogenesis.
Article
Genetics & Heredity
Randy B. Kang, Yansui Li, Carolina Rosselot, Tuo Zhang, Mustafa Siddiq, Prashant Rajbhandari, Andrew F. Stewart, Donald K. Scott, Adolfo Garcia-Ocana, Geming Lu
Summary: Single-cell RNA sequencing provides valuable insights into human islet cell types and their gene expression profiles, but it requires cell dissociation, limiting its in vivo application. In contrast, single-nucleus RNA sequencing is compatible with frozen samples, eliminates dissociation-induced stress responses, and provides enhanced information from intronic sequences for identifying pre-mRNA transcripts.
Review
Oncology
Kumiko Umemoto, Yu Sunakawa
Summary: Promising targets and novel therapeutic drugs have been identified in KRAS wild-type PC, including NRG1 fusion and other potentially actionable alterations. Targeted therapies for NRG1 fusion-positive tumors and aberrations like BRAF, NTRK, and ALK fusion in KRAS wildtype PC have shown activity in clinical trials.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Genetics & Heredity
Yinan Wang, Xinyao Miao, Zicheng Zhao, Yonghui Wang, Shuaicheng Li, Changfa Wang
Summary: Donkeys, important livestock with economic value, have a transcriptomic landscape that contributes to understanding molecular mechanisms and phenotype traits.
FRONTIERS IN GENETICS
(2021)
Article
Oncology
Lily Nguyen, Sophie Dobiasch, Gunter Schneider, Roland M. Schmid, Omid Azimzadeh, Kristiyan Kanev, Dominik Buschmann, Michael W. Pfaffl, Stefan Bartzsch, Thomas E. Schmid, Daniela Schilling, Stephanie E. Combs
Summary: The study aimed to elucidate the mechanisms of radioresistance in pancreatic cancer cells, revealing that increased cell viability and reduced oxidative stress may contribute to the development of radioresistance.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Yao Xu, Juan Fu, Mackenzie Henderson, Fei Lee, Noelle Jurcak, Anja Henn, Joachim Wahl, Yingkuan Shao, Jianxin Wang, Melissa Lyman, Vanessa Funes, Birginia Espinoza, Rui Zhang, India Washington, Sophia Y. Chen, Haley Zlomke, Junke Wang, Nan Niu, Pan Li, Fengxi Meng, William Burns, Matthias Friedrich, Sabine Stienen, Julie M. Bailis, Lei Zheng
Summary: AMG 910, a CLDN18.2-targeted BiTE molecule, demonstrated potent anti-tumor activity in preclinical models of gastric cancer and pancreatic ductal adenocarcinoma. Combination therapy with a PD-1 inhibitor enhanced the therapeutic effect of AMG 910. Moreover, infusion of Tregs enhanced the anti-tumor efficacy of AMG 910.
Article
Oncology
Luciana W. Zuccherato, Christina M. T. Machado, Wagner C. S. Magalhaes, Patricia R. Martins, Larissa S. Campos, Leticia C. Braga, Andrea Teixeira-Carvalho, Olindo A. Martins-Filho, Telma M. R. F. Franco, Salua O. C. Paula, Israel Tojal da Silva, Rodrigo Drummond, Kenneth J. Gollob, Paulo Guilherme O. Salles
Summary: This study identified differential gene expression signatures in cervical cancer stem-like cells as potential biomarkers for intrinsic chemoradioresistance in cervical cancer. Analysis of 31 patients with locally advanced cervical cancer revealed 1050 differentially expressed genes, with implications for cancer recurrence and treatment outcome. Genes overlapping between the highest AUC and pAUC loci revealed potential biomarkers with strong capacity for identifying non-responders versus responders to chemoradiotherapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Mastan Mannarapu, Begum Dariya, Obul Reddy Bandapalli
Summary: Pancreatic cancer is the third leading cause of cancer-related deaths globally, with its aggressive nature and heterogeneity posing challenges for researchers studying its molecular mechanisms. Single-cell sequencing technology has now become an important tool for analyzing cellular biology, identifying evolutionary relationships between cells, and uncovering tumor cell heterogeneity, offering potential benefits for personalized treatment strategies and disease prediction.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)