Article
Immunology
Fatima A. H. Al-Jaberi, Cornelia Geisler Crone, Thomas Lindenstrom, Nicolai Skovbjerg Arildsen, Emilia Saederup Lindelov, Louise Aagaard, Eva Gravesen, Rasmus Mortensen, Aase Bengaard Andersen, Klaus Olgaard, Jessica Xin Hjaltelin, Soren Brunak, Charlotte Menne Bonefeld, Martin Kongsbak-Wismann, Carsten Geisler
Summary: Tuberculosis is a serious health issue affecting a significant portion of the global population, with a quarter being infected with Mycobacterium tuberculosis. Vitamin D plays a crucial role in the immune response against M. tuberculosis, but research is hindered by a lack of suitable experimental models. Studying families with hereditary vitamin D-resistant rickets (HVDRR) provides unique insights into the immunoregulatory effects of vitamin D. A case study of an HVDRR patient with impaired cathelicidin production highlights the importance of vitamin D in combating M. tuberculosis pathophysiology.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Pavithra Sampath, Krisna Moorthi Periyasamy, Uma Devi Ranganathan, Ramalingam Bethunaickan
Summary: The utilization of miRNA as essential biomarkers in early diagnosis and treatment of tuberculosis highlights their importance in studying disease progression and immune regulation. The research on monocytes provides valuable insight into tuberculosis pathogenesis and biomarker efficiency.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Keun Woo Park, Hyunwoo Ju, Il-Doo Kim, John W. Cave, Yang Guo, Wei Wang, Zhuhao Wu, Sunghee Cho
Summary: The study found that monocyte-derived macrophages (MDMs) play a role in the progressive stroke-induced injury and repair processes. Manipulating monocyte entry at different stroke stages may be an effective immune-based strategy to limit injury propagation in chronic stroke.
Article
Geriatrics & Gerontology
Yu Zhang, Li-hua Tang, Jia Lu, Li-ming Xu, Bao-li Cheng, Jun-yu Xiong
Summary: The study showed that ABT-263 treatment improved the survival rate of sepsis in aged mice, which was related to autophagy, and blocking autophagy could eliminate this effect. ABT-263 enhanced the phagocytic ability of peritoneal macrophages by increasing the Trem-2 receptor, and induced Beclin-1-dependent autophagy by blocking the binding of Bcl-2 to Beclin-1.
Article
Environmental Sciences
Youjing Yang, Shuhui Wei, Kaimiao Chu, Qianmin Li, Yujia Zhou, Yu Ma, Lian Xue, Hailin Tian, Shasha Tao
Summary: The study identifies the harmful effect of crystalline silica on lung tissue and the protective mechanism of vitamin D involving M2 macrophages autophagy that mitigates crystalline silica-induced lung injury.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Immunology
Jun-Hao Wen, Dong-Yi Li, Shan Liang, Chen Yang, Ji-Xin Tang, Hua-Feng Liu
Summary: This article summarizes the role of macrophages in organ fibrosis and the importance of autophagy in maintaining macrophage homeostasis. It discusses the heterogeneity of macrophages in different organs and highlights the potential of macrophage autophagy in fibrosis treatment. The article also briefly discusses important unresolved issues in this field.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Yufei Xie, Jiajun Xie, Annemarie H. Meijer, Marcel J. M. Schaaf
Summary: The study found that synthetic glucocorticoid beclomethasone could potentially increase bacterial burden and decrease the phagocytic activity of macrophages, leading to a greater severity of bacterial infections, such as tuberculosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Jiao Liu, Siqi Ming, Weifeng Song, Xiaojun Meng, Qiang Xiao, Minhao Wu, Yongjian Wu, Hanbin Xie, Jie Zhou, Haibo Zhong, Xi Huang
Summary: BTLA promotes host defense against mycobacteria by enhancing autophagy, which may provide potential therapeutic interventions against tuberculosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
John M. Barbaro, Simone Sidoli, Ana Maria Cuervo, Joan W. Berman
Summary: HIV-NCI is a debilitating condition that affects people with HIV, and the use of methamphetamine can worsen the neurocognitive impairment. Meth inhibits phagocytosis and dysregulates autophagy in HIV-infected macrophages, leading to increased neurotoxicity. Despite the limited effects of commonly used ART drugs, targeting differentially expressed proteins may provide new intervention strategies for improving neurocognition in HIV-NCI patients using meth.
Article
Immunology
Denho Ravi, Erato Ntinopoulou, Nessim Guetta, Manuela Weier, Verena Vogel, Barbara Spellerberg, Parham Sendi, Sandrine Gremlich, Thierry Roger, Eric Giannoni
Summary: This study compares the response of newborn and adult macrophages to GBS. The findings show that newborn macrophages exhibit higher levels of cytokine release in response to GBS, and may play a significant role in the progression of GBS infection in newborns.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Jun Fang, Chunsheng Dong, Sidong Xiong
Summary: This study demonstrates that Rv0790c, a protein encoded by Mycobacterium tuberculosis, promotes bacterial survival by facilitating cellular autophagy at its early stage. This finding provides insights into the mechanisms through which Mycobacterium tuberculosis evades host immune responses and offers potential targets for tuberculosis treatment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Medicine, Research & Experimental
Andreea-Daniela Meca, Simona Stefanescu, Maria Bogdan, Adina Turcu-Stiolica, Floarea Mimi Nitu, Marius Matei, Ramona Cioboata, Ana Maria Buga, Catalina-Gabriela Pisoschi
Summary: Tuberculosis (TB) remains a public health burden, and there is a suggested relationship between vitamin D (VD) status and TB susceptibility. A study found that newly diagnosed pulmonary TB patients had lower 25-(OH)-D levels before first-line anti-TB treatment, which increased after two months of therapy. Additionally, culture-negative TB patients showed lower levels of LL-37, beclin-1, and M30 compared to culture-positive patients after two months of treatment. This suggests that monitoring VD status and host defense mechanisms could improve the outcomes of anti-TB treatment.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Immunology
Ligu Mi, Yan Wang, Hui Xu, Yu Wang, Jia Wu, Hui Dai, Yu Zhang
Summary: Prak deficiency impairs various functions of macrophages, including bactericidal activity and ROS production, affecting the clearance of intracellular pathogens in mice.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shao-Liang Yang, Hai-Xia Tan, Tian-Tian Niu, Yu-Kai Liu, Chun-Jie Gu, Da-Jin Li, Ming-Qing Li, Hai-Yan Wang
Summary: The study revealed that IFN-gamma promoted autophagy and macrophage phagocytosis in cervical cancer cells. This effect was achieved possibly through the promotion of IDO1 expression and kynurenine metabolism by IFN-gamma.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Cell Biology
Anindita Bhattacharya, Purnam Ghosh, Arpana Singh, Arnab Ghosh, Arghya Bhowmick, Deepak Kumar Sinha, Abhrajyoti Ghosh, Prosenjit Sen
Summary: The mTOR-dependent classical autophagy is crucial in guiding the differentiation of monocytes into macrophages. Autophagy influences monocyte differentiation through protein degradation and intricately interacts with cell-cycle arrest during the differentiation process.
CELLULAR SIGNALLING
(2021)