Article
Medicine, Research & Experimental
Xiaolong Tang, Lin Liu, Yan Li, Siyu Hao, Yueshui Zhao, Xu Wu, Mingxing Li, Yu Chen, Shuai Deng, Shuang Gou, Dan Cai, Meijuan Chen, Xiaobing Li, Yuhong Sun, Li Gu, Wanping Li, Fang Wang, Zhuo Zhang, Lei Yao, Jing Shen, Zhangang Xiao, Fukuan Du
Summary: Polygonum perfoliatum L. is an herbal medicine that has been extensively used in traditional Chinese medicine to treat various health conditions. It exhibits significant anti-tumor, anti-inflammatory, anti-bacterial, and anti-viral effects. However, the underlying mechanisms of its anti-liver cancer effects remain poorly understood.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Guanjie Liu, Ling Chang, Yihan Qian, Jiacheng Lin, Zhi Shang, Min Xu, Fang Wang, Xuehua Sun, Yun Jiang, Yueqiu Gao, Xiaoni Kong
Summary: The study found that Polygonum perfoliatum L. (PPL) can protect against hepatic steatosis, lipid peroxidation, and glucose-lipid metabolism dysfunction in NAFLD mice. This is achieved through altering the PPARs/CPT1A/CPT2-mediated hepatic fatty acid beta-oxidation process. The active components of PPL with anti-NAFLD activity were identified using UPLC/QE-HFX.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Anhui Yang, Ping Zhang, Zhen Sun, Xin Liu, Xinrui Zhang, Xingkai Liu, Di Wang, Zhaoli Meng
Summary: The study demonstrated that lysionotin exhibited significant anti-liver cancer effects by potentially involving the caspase-3 mediated mitochondrial apoptosis pathway.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Chou-Yuan Ko, Po-Chang Shih, Po-Wei Huang, Yi-Hsin Lee, Yen-Fu Chen, Ming-Hong Tai, Chi-Hao Liu, Zhi-Hong Wen, Hsiao-Mei Kuo
Summary: Sinularin was found to effectively inhibit the growth of hepatocellular carcinoma SK-HEP-1 cells at a concentration of 10 μM, inducing DNA fragmentation and apoptosis, as well as affecting cell migration and colony formation. Additionally, it altered the expression levels of various proteins related to cell signaling and metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Ambily Anna Mathew, Zahara T. Zakkariya, Anusha Ashokan, Maneesh Manohar, Pavithran Keechilat, Shantikumar V. Nair, Manzoor Koyakutty
Summary: The researchers used various strategies to reverse the non-immunogenic character of the cold tumor, including photodynamic therapy, TAM repolarization, immune checkpoint inhibition, and MDSC depletion. Among them, low-dose 5-fluorouracil chemotherapy showed significant anti-tumor effects, primarily due to the increased infiltration of CD8+ cytotoxic T-cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Yuqing Wang, Lin Long, Linsheng Zhuo, Honghua Zhang, Tian Luo, Jiedan Deng, Yuying Wang, Zhao Li, Zhen Wang, Xue Peng
Summary: In this study, 18 derivatives of 1-styrene-isoquinoline were synthesized from resveratrol and iso-quinoline. Compound 1c exhibited significant anti-tumor activity against Huh7 and SK-Hep-1 cells. It could inhibit cell proliferation, induce apoptosis, and inhibit cell migration and invasion through regulating EMT. Compound 1c also showed potential in inhibiting tumor growth in vivo and could regulate mitochondrial apoptosis pathway and PI3K/Akt/mTOR signaling pathway.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Immunology
Yang Ying, Wu Hao
Summary: Polysaccharides extracted from natural resources have significant potential in biomedical research and pharmaceutical fields due to their medical values in anti-tumor, immunomodulation, drug delivery, and other aspects. They can exert direct anti-tumor effects or regulate the host immune system to indirectly inhibit tumors. Some polysaccharides also modulate the tumoral niche to inhibit the proliferation and metastasis of tumor cells. This article focuses on the biomedical application potential of natural polysaccharides, reviews their immunomodulation function, and highlights the importance of their signaling transduction feature for antitumor drug development.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
X. Zhen, N. K. Pandey, E. Amador, W. Hu, B. Liu, W. Nong, W. Chen, L. Huang
Summary: Potassium iodide (KI) enhances the anti-hepatocellular carcinoma effect of copper-cysteamine (Cu-Cy) nanoparticles based photodynamic therapy (PDT) by increasing the release of reactive oxygen species (ROS) and affecting mitochondrial function. KI also regulates gene and protein expression to enhance the anti-tumor efficacy.
MATERIALS TODAY PHYSICS
(2022)
Article
Environmental Sciences
Ming Pan, Zi-Wei Cheng, Chen-Guang Huang, Zhu-Qing Ye, Li-Jun Sun, Hua Chen, Bei-Bei Fu, Kai Zhou, Zhi-Rui Fang, Zi-Jian Wang, Qing-Zhong Xiao, Xue-Sheng Liu, Feng-Qin Zhu, Shan Gao
Summary: This study investigated the role of excessive copper accumulation in mitochondrial damage and cell apoptosis inhibition in the heart. The results showed that copper accumulation leads to mitochondrial injury and apoptosis, resulting in heart damage.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Nanoscience & Nanotechnology
Won Young Kim, Miae Won, Seyoung Koo, Xingcai Zhang, Jong Seung Kim
Summary: The novel theranostic agent TA1 can be used for anti-inflammatory therapy and precise diagnosis, showing its functional applicability in gene editing and cell treatment.
NANO-MICRO LETTERS
(2021)
Article
Multidisciplinary Sciences
Christopher J. LaFargue, Paola Amero, Kyunghee Noh, Lingegowda S. Mangala, Yunfei Wen, Emine Bayraktar, Sujanitha Umamaheswaran, Elaine Stur, Santosh K. Dasari, Cristina Ivan, Sunila Pradeep, Wonbeak Yoo, Chunhua Lu, Nicholas B. Jennings, Vinod Vathipadiekal, Wei Hu, Anca Chelariu-Raicu, Zhiqiang Ku, Hui Deng, Wei Xiong, Hyun-Jin Choi, Min Hu, Takae Kiyama, Chai-An Mao, Rouba Ali-Fehmi, Michael J. Birrer, Jinsong Liu, Ningyan Zhang, Gabriel Lopez-Berestein, Vittorio de Franciscis, Zhiqiang An, Anil K. Sood
Summary: This study identifies CD5L as an important gene that is upregulated in response to antiangiogenic therapy, leading to adaptive resistance. By targeting CD5L with an RNA-aptamer and monoclonal antibody, the researchers successfully inhibit the pro-angiogenic effects of CD5L in both in vitro and in vivo settings. Furthermore, increased expression of vascular CD5L is associated with bevacizumab resistance and worse overall survival in cancer patients.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Mei-Kuang Lu, Chi-Hsein Chao, Yu-Chi Hsu, Chia-Chuan Chang
Summary: Na10_SPS-F3 extracted from Antrodia cinnamomea is a sulfated polysaccharide with anti-inflammatory and anti-cancer activities. It inhibits the secretion of tumor necrosis factor and interleukin-6 in macrophages, and suppresses lung cancer cell signaling pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Sudeshna Nandi, Arghya Adhikary, Krishnendu Acharya
Summary: The study focused on the novel triterpene astrakurkurol isolated from Astraeus hygrometricus and its potential anticancer effects, particularly in HepG2 cells. Astrakurkurol demonstrated significant anti-proliferative, pro-apoptotic, and anti-migratory effects on HepG2, with mechanisms involving apoptosis induction and cell cycle arrest. These findings suggest astrakurkurol as a promising candidate for the development of new treatments against hepatocellular carcinoma.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Jue Tu, Yanfei He, Huifang Zhang, Juanjuan Wang, Zhenhao Li, Hongxiang Sun
Summary: Two polysaccharides (PCSPA and PCSPB) from Crocus sativus petals were found to have immunopotentiation activity and improve innate immunity in mice. In this study, the anti-tumor activity of PCSPB was evaluated using a S180 sarcoma-bearing mouse model. PCSPB not only showed low toxicity to tumor cells but also significantly suppressed the growth of S180 sarcomas by inducing tumor cell necrosis, apoptosis, and vessel disruption, and by reprogramming tumor-associated macrophages from a tumorigenic M2 phenotype to an antitumorigenic M1 phenotype.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Gui Wang, Yamei Qiao, Yunyan Zhao, Yuanyuan Song, Mengyang Li, Min Jin, Dong Yang, Jing Yin, Junwen Li, Weili Liu
Summary: Beauvericin inhibits the growth of hepatocellular carcinoma (HCC) by inducing apoptosis via the PI3K/AKT pathway, suggesting its potential as an anti-HCC agent.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)