4.4 Article

A randomised controlled trial of the clinical and cost-effectiveness of a contingency management intervention compared to treatment as usual for reduction of cannabis use and of relapse in early psychosis (CIRCLE): a study protocol for a randomised controlled trial

Journal

TRIALS
Volume 17, Issue -, Pages -

Publisher

BIOMED CENTRAL LTD
DOI: 10.1186/s13063-016-1620-x

Keywords

Financial incentives; Contingency management; Cannabis; Psychosis; Early intervention; Substance misuse

Funding

  1. National Institute for Health Research Health Technology Assessment Programme [09/144/50]
  2. National Institute for Health Research [09/144/50, NF-SI-0611-10210] Funding Source: researchfish

Ask authors/readers for more resources

Background: Around 35-45 % of people in contact with services for a first episode of psychosis are using cannabis. Cannabis use is associated with delays in remission, poorer clinical outcomes, significant increases in the risk of relapse, and lower engagement in work or education. While there is a clear need for effective interventions, so far only very limited benefits have been achieved from psychological interventions. Contingency management (CM) is a behavioural intervention in which specified desired behavioural change is reinforced through financial rewards. CM is now recognised to have a substantial evidence base in some contexts and its adoption in the UK is advocated by the National Institute for Health and Care Excellence (NICE) guidance as a treatment for substance or alcohol misuse. However, there is currently little published data testing its effectiveness for reducing cannabis use in early psychosis. Methods: CIRCLE is a two-arm, rater-blinded randomised controlled trial (RCT) investigating the clinical and cost-effectiveness of a CM intervention for reducing cannabis use among young people receiving treatment from UK Early Intervention in Psychosis (EIP) services. EIP service users (n = 544) with a recent history of cannabis use will be recruited. The experimental group will receive 12 once-weekly CM sessions, and a voucher reward if urinalysis shows that they have not used cannabis in the previous week. Both the experimental and the control groups will be offered an Optimised Treatment as Usual (OTAU) psychoeducational package targeting cannabis use. Assessment interviews will be performed at consent, at 3 months, and at 18 months. The primary outcome is time to relapse, defined as admission to an acute mental health service. Secondary outcomes include proportion of cannabis-free urine samples during the intervention period, severity of positive psychotic symptoms, quality-adjusted life years, and engagement in work or education. Discussion: CIRCLE is a RCT of CM for cannabis use in young people with a recent history of psychosis (EIP service users) and recent cannabis use. It is designed to investigate whether the intervention is a clinically and cost-effective treatment for cannabis use. It is intended to inform future treatment delivery, particularly in EIP settings.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.4
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Psychology, Clinical

Associations between primary care recorded cannabis use and mental ill health in the UK: a population-based retrospective cohort study using UK primary care data

Deepiksana Keerthy, Joht Singh Chandan, Juste Abramovaite, Krishna Margadhamane Gokhale, Siddhartha Bandyopadhyay, Ed Day, Steven Marwaha, Matthew R. Broome, Krishnarajah Nirantharakumar, Clara Humpston

Summary: This study investigates the relationship between cannabis exposure and the risks of mental illness diagnoses or treatment and finds that cannabis exposure is associated with an increased risk of developing mental health disorders.

PSYCHOLOGICAL MEDICINE (2023)

Article Psychiatry

Maternal postnatal depression and anxiety and the risk for mental health disorders in adolescent offspring: Findings from the Avon Longitudinal Study of Parents and Children cohort

Isabel Morales-Munoz, Brooklyn Ashdown-Doel, Emily Beazley, Camilla Carr, Cristina Preece, Steven Marwaha

Summary: This study found that mothers with postnatal depression are more likely to have offspring with anxiety at 10 years old, and mothers with postnatal anxiety are more likely to have offspring with psychotic experiences at 12/13 years old.

AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY (2023)

Review Health Care Sciences & Services

Implementation strategies for telemental health: a systematic review

Rebecca Appleton, Phoebe Barnett, Norha Vera San Juan, Elizabeth Tuudah, Natasha Lyons, Jennie Parker, Emily Roxburgh, Spyros Spyridonidis, Millie Tamworth, Minnie Worden, Melisa Yilmaz, Nick Sevdalis, Brynmor Lloyd-Evans, Justin J. J. Needle, Sonia Johnson

Summary: The COVID-19 pandemic has led to the rapid adoption of telemental health care, but there are significant variations and barriers in its implementation. This review aimed to identify strategies for effective implementation and evaluate their impact.

BMC HEALTH SERVICES RESEARCH (2023)

Review Psychiatry

Effectiveness of outpatient and community treatments for people with a diagnosis of 'personality disorder': systematic review and meta-analysis

Panos Katakis, Merle Schlief, Phoebe Barnett, Luke Sheridan Rains, Sarah Rowe, Steve Pilling, Sonia Johnson

Summary: This study aimed to investigate the effectiveness of psychosocial interventions delivered in community and outpatient settings in treating symptoms associated with 'personality disorder', and the moderating effects of treatment-related variables. The results showed that these interventions effectively reduced symptoms of 'borderline personality disorder', anxiety, depression, and global psychiatric symptoms, with all therapeutic approaches showing similar effectiveness. Therefore, mental health services should provide specialized treatments for individuals with complex emotional needs according to availability and patient preferences.

BMC PSYCHIATRY (2023)

Article Multidisciplinary Sciences

Mental health problems and admissions to hospital for accidents and injuries in the UK military: A data linkage study

Zoe Chui, Daniel D. Leightley, Margaret Jones, Sabine T. Landau, Paul McCrone, Richard Hayes, Simon Wessely, Nicola Fear, Laura Goodwin

Summary: Accidents are the most common cause of death among UK military personnel. This study found that mental health problems, such as common mental disorders and post-traumatic stress disorder, were associated with an increased risk of hospital admissions for accidents and injuries. Additionally, smoking was also associated with more visits to accident and emergency departments. Therefore, healthcare professionals should consider mental health and health damaging behaviors when treating military personnel after an accident.

PLOS ONE (2023)

Letter Medicine, General & Internal

Britain can afford the NHS: health is a handicraft industry

Paul McCrone

BMJ-BRITISH MEDICAL JOURNAL (2023)

Article Psychiatry

Service use preceding and following first referral for psychiatric emergency care at a short-stay crisis unit: A cohort study across three cities and one rural area in England

Lucy Pollyanna Goldsmith, Katie Anderson, Geraldine Clarke, Chloe Crowe, Heather Jarman, Sonia Johnson, Jo Lomani, David McDaid, A-La Park, Jared G. Smith, Steven Gillard

Summary: Internationally, hospital-based short-stay crisis units have been introduced to provide a safe space for stabilisation and further assessment for those in psychiatric crisis. This study assessed changes to service use following a service user's first visit to a unit, characterised the population accessing these units, and examined equality of access to the units. The results showed that short-stay crisis units are typically accessed by a young population, including those who previously were unknown to mental health services, who proceed to access a broader range of mental health services following discharge.

INTERNATIONAL JOURNAL OF SOCIAL PSYCHIATRY (2023)

Editorial Material Primary Health Care

Primary care and bipolar disorder

Judy Shakespeare, Sharon Dixon, Steven Marwaha

BRITISH JOURNAL OF GENERAL PRACTICE (2023)

Review Cardiac & Cardiovascular Systems

Chest pain symptoms during myocardial infarction in patients with and without diabetes: a systematic review and meta-analysis

Abhinav Kumar, Amrit Sanghera, Balpreet Sanghera, Tahira Mohamed, Ariella Midgen, Sophie Pattison, Louise Marston, Melvyn M. Jones

Summary: Patients with diabetes mellitus are at increased risk of myocardial infarction but may experience less chest pain, leading to delayed treatment and worse outcomes. A meta-analysis of 22 studies showed that patients with diabetes mellitus are less likely to have chest pain during myocardial infarction compared to those without.

HEART (2023)

Article Multidisciplinary Sciences

Reliability of the retrospective Clinical Interview Schedule Revised (rCIS-R) to assess relapse in depression in primary care patients

Larisa Duffy, Louise Marston, Gemma Lewis, Glyn Lewis

Summary: We developed a retrospective Clinical Interview Schedule Revised (rCIS-R) to assess depression relapse in the previous 12 weeks, and found that it has excellent test-retest reliability and construct validity. The rCIS-R can be used in randomized controlled trials due to its simplicity and self-report format.

PLOS ONE (2023)

Article Psychiatry

Mental health service use and costs associated with complex emotional needs and a diagnosis of personality disorder: analysis of routine data

Joseph Botham, Alan Simpson, Paul McCrone

Summary: This study aimed to estimate the costs of care for individuals with a personality disorder diagnosis, and compare service use and costs between those receiving specialist input and those receiving generic care. Service use data was collected from records and costs were calculated. Comparisons were made between individuals receiving care from specialist personality disorder teams and those who did not. Regression modeling identified demographic and clinical factors that predicted costs. Results showed that mean total costs before diagnosis were £10,156 for the specialist group and £11,531 for the non-specialist group. Post-diagnosis costs were £24,017 and £22,266 respectively. Costs were associated with specialist care, comorbid conditions, and living outside of London.

BJPSYCH BULLETIN (2023)

Article Health Care Sciences & Services

Online remote behavioural intervention for tics in 9-to 17-year-olds: the ORBIT RCT with embedded process and economic evaluation

Chris Hollis, Charlotte L. Hall, Kareem Khan, Marie Le Novere, Louise Marston, Rebecca Jones, Rachael Hunter, Beverley J. Brown, Charlotte Sanderson, Per Andren, Sophie Bennett, Liam R. Chamberlain, Bethan Davies, Amber Evans, Natalia Kouzoupi, Caitlin Mckenzie, Isobel Heyman, Joseph Kilgariff, Cristine Glazebrook, David Mataix-Cols, Eva Serlachius, Elizabeth Murray, Tara Murphy

Summary: This study aimed to investigate the clinical and cost-effectiveness of an online-delivered, therapist- and parent-supported therapy for young people with tic disorders. The results showed that this therapy was clinically and cost-effective in reducing tics, with durable benefits extending up to 18 months.

HEALTH TECHNOLOGY ASSESSMENT (2023)

Article Psychology, Clinical

Clinical factors associated with relapse in depression in a sample of UK primary care patients who have been on long-term antidepressant treatment

Larisa Duffy, Gemma Lewis, Louise Marston, Tony Kendrick, David Kessler, Michael Moore, Nicola Wiles, Glyn Lewis

Summary: The number of previous episodes and residual symptoms of depression were associated with an increased likelihood of relapse, while older age of onset was associated with a reduced rate of relapse.

PSYCHOLOGICAL MEDICINE (2023)

Review Psychology, Clinical

Review: Systematic review and metasynthesis of qualitative literature on young people's experiences of going to A&E/emergency departments for mental health support

Gianna Cadorna, Norha Vera San Juan, Heather Staples, Sonia Johnson, Rebecca Appleton

Summary: Emergency departments have been unable to meet the mental health needs of young people, exacerbating their distress and making them feel like a burden or unworthy of treatment, with consequent poor outcomes.

CHILD AND ADOLESCENT MENTAL HEALTH (2023)

Article Psychiatry

Investigating the association between characteristics of local crisis care systems and service use in an English national survey

Antonio Rojas-Garcia, Christian Dalton-Locke, Luke Sheridan Rains, Ceri Dare, Cedric Ginestet, Una Foye, Kathleen Kelly, Sabine Landau, Chris Lynch, Paul Mccrone, Shilpa Nairi, Karen Newbigging, Patrick Nyikavaranda, David Osborn, Karen Persaud, Nick Sevdalis, Martin Stefan, Ruth Stuart, Alan Simpson, Sonia Johnson, Brynmor Lloyd-Evans

Summary: This study aims to develop a typology of mental health crisis care systems and explore the relationship between crisis care service models and psychiatric hospital admissions and detentions.

BJPSYCH OPEN (2023)

No Data Available