Review
Pharmacology & Pharmacy
Liam King, David Christie, Wendy Dare, Nijole Bernaitis, Russ Chess-Williams, Catherine McDermott, Amanda Forbes, Shailendra Anoopkumar-Dukie
Summary: Drug repurposing, including alpha-1 adrenoreceptor blockers, is increasingly used to identify new cancer treatments, with some drugs in this class showing potential cytotoxic properties for cancer therapy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Editorial Material
Oncology
Grace E. Mishkin, Elise C. Kohn
Summary: This commentary offers additional insights to the report by Nixon and colleagues, focusing on critical definitions, assay and analytical quality control, interpretation, and available resources to advance biomarker development for specific purposes.
CLINICAL CANCER RESEARCH
(2022)
Review
Cardiac & Cardiovascular Systems
Zhilin Qu, James N. Weiss
Summary: Cardiac alternans is a result of instabilities in the electrical and calcium cycling systems of the heart, and can lead to ventricular arrhythmias and sudden cardiac death. This review integrates clinical observations, theory, and experiments to provide a comprehensive understanding of the underlying mechanisms, arrhythmic manifestations, and electrocardiographic signatures of cardiac alternans. The review summarizes the cellular and tissue mechanisms that have been demonstrated theoretically and experimentally, and discusses their relevance to different disease conditions and their impact on electrocardiographic characteristics observed in patients. The main conclusion is that alternans is not only a predictor but also a causal mechanism of potentially lethal ventricular and atrial arrhythmias across a wide range of arrhythmia mechanisms.
CIRCULATION RESEARCH
(2023)
Review
Medicine, Research & Experimental
Miao Wang, Jie Rao, Meng Wang, Xiaosong Li, Kaili Liu, Mark F. Naylor, Robert E. Nordquist, Wei R. Chen, Feifan Zhou
Summary: The combination of targeted therapy and immunotherapy is considered an ideal strategy for treating metastatic cancer, with phototherapy emerging as a promising targeted therapy that can initiate antitumor immune responses through induced immunogenic tumor cell death. The use of phototherapy in conjunction with immunoadjuvant therapy has shown to induce a systemic antitumor immune response, controlling residual tumor cells at the treatment site and distant metastases.
Article
Chemistry, Medicinal
Christopher R. Gardner, Katherine A. Davies, Ying Zhang, Martin Brzozowski, Peter E. Czabotar, James M. Murphy, Guillaume Lessene
Summary: Necroptosis is a regulated caspase-independent form of necrotic cell death that leads to an inflammatory phenotype. It plays a significant role in the pathophysiology of various diseases. The key components of necroptosis signaling, such as RIPK1, RIPK3, and MLKL, have been identified, and they hold promise as therapeutic targets.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Immunology
Aziz A. Chentoufi, Nisha R. Dhanushkodi, Ruchi Srivastava, Swayam Prakash, Pierre-Gregoire A. Coulon, Latifa Zayou, Hawa Vahed, Hiba A. Chentoufi, Kathy K. Hormi-Carver, Lbachir BenMohamed
Summary: This review reexamines the status of ocular herpes vaccines in clinical trials and discusses recent scientific advances in understanding the immune response to HSV infection. It also sheds light on a novel asymptomatic herpes approach based on protective immune mechanisms. The use of a prime/pull vaccine strategy combined with immune checkpoint blockade shows promise for a successful herpes vaccine approach.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Physiology
Paolo Jose Cesare Biselli, Fernanda Degobbi Tenorio Quirino Dos Santos Lopes, Renato Fraga Righetti, Henrique Takachi Moriya, Iolanda Ftima Lopes Calvo Tiberio, Milton Arruda Martins
Summary: Lung physiology research has made significant advancements in the past 100 years, contributing to our understanding of the respiratory system and the development of mechanical ventilators. This review examines the application of respiratory mechanics in studying asthma and COPD, as well as its role in clinical care and the development of modern mechanical ventilators. The analysis also includes the exploration of laboratory-developed technologies that have the potential to become part of clinical practice in the future, and the challenges faced by intensive care doctors in managing respiratory failure.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Johny Nicolas, Carlo Andrea Pivato, Mauro Chiarito, Frans Beerkens, Davide Cao, Roxana Mehran
Summary: Coronary stents have revolutionized the treatment of coronary artery disease. The introduction of new-generation drug-eluting stents has greatly improved the safety and efficacy compared to bare-metal stents. There are now over 20 different DES types available, each with its unique features and characteristics. The clinical implications of stent design in high-risk subsets of patients are also discussed.
CARDIOVASCULAR RESEARCH
(2023)
Review
Medicine, Research & Experimental
Dawei Wang, Wei Rao
Summary: Transarterial chemoembolization (TACE) has proven to be beneficial for patients with unresectable hepatocellular carcinoma (HCC), but there are limitations with conventional TACE. To improve TACE, new materials with additional functions such as degradability, drug-loading and releasing properties, detectability, targetability, and multiple therapeutic modalities have been introduced. This review provides a comprehensive overview of current and emerging particulate embolization technology, with a focus on micro/nano materials, for TACE. The development routes and future outlooks of these micro/nano embolic materials are also discussed.
Review
Neurosciences
Stefanie Geisler
Summary: Vincristine and bortezomib are effective chemotherapeutics for hematological cancers, but they can cause peripheral neuropathy as a main side effect, leading to potential permanent disability. Research using various cellular and animal models has shown that bortezomib induces transcriptional programs in the dorsal root ganglia, resulting in neuroinflammatory pathways and central sensitization, while vincristine has direct toxic effects on axons. These findings provide insights into the molecular mechanisms of vincristine- and bortezomib-induced neuropathies and potential avenues for developing treatments to prevent or reverse them, ultimately improving patients' quality of life during and after cancer therapy.
EXPERIMENTAL NEUROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Anne Sibille, Jean-Louis Corhay, Renaud Louis, Vincent Ninane, Guy Jerusalem, Bernard Duysinx
Summary: This review examines the biological properties of eosinophils in non-small cell lung cancer (NSCLC) and their roles in both tumor promotion and inhibition. The potential value of eosinophils as prognostic and predictive biomarkers is discussed, along with the need for stronger clinical data. Perspectives on clinical and translational research topics in this area are also provided.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Theresa Suckert, Sindi Nexhipi, Antje Dietrich, Robin Koch, Leoni A. Kunz-Schughart, Emanuel Bahn, Elke Beyreuther
Summary: This review discusses the main research topics of proton radiobiology and the challenges related to preclinical experiments, summarizing the different available preclinical models. These models range from cell culture models to animal studies and computer simulations, providing insights for meaningful research studies in the future to improve patient treatment.
Review
Oncology
Aubhishek Zaman, Trever G. Bivona
Summary: Advancements in technology and high throughput molecular data have led to a more quantitative and multidisciplinary approach in biology, accelerating the translation of laboratory findings into practical applications. The use of quantification and statistical analysis is crucial in understanding the effects and mechanisms behind translational applications. Adherence to guidelines proposed in this manuscript can improve assay design and reduce errors in translational biomarker and therapeutic applications.
Article
Oncology
Shi-Ming Tu, Sunny R. Singh, Konstantinos Arnaoutakis, Sindhu Malapati, Sajjad A. Bhatti, Aron Y. Joon, Omar T. Atiq, Louis L. Pisters
Summary: This article discusses the application of the stem cell theory of cancer in cancer research and care. By amending translational research and emphasizing the scientific method, the theory has the potential to enhance cancer research and improve patient care. It considers the genetic makeup of cancer in relation to cellular context and microenvironment.
Review
Oncology
Lucia Gandullo-Sanchez, Alberto Ocana, Atanasio Pandiella
Summary: HER3 protein is closely associated with the development of various tumors, and targeting HER3 has therapeutic relevance in promoting cell proliferation. Different types of agents targeting HER3 have been developed, including antibodies, aptamers, and vaccines. This article reviews the preclinical and clinical development of drugs targeting HER3.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Review
Biotechnology & Applied Microbiology
Manoj K. Pandey, Subash C. Gupta, Deepkamal Karelia, Patrick J. Gilhooley, Mehdi Shakibaei, Bharat B. Aggarwal
BIOTECHNOLOGY ADVANCES
(2018)
Editorial Material
Integrative & Complementary Medicine
Ji Hye Kim, Gorkem Kismali, Subash C. Gupta
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2018)
Review
Medicine, Research & Experimental
Ajaikumar B. Kunnumakkara, Bethsebie L. Sailo, Kishore Banik, Choudhary Harsha, Sahdeo Prasad, Subash Chandra Gupta, Alok Chandra Bharti, Bharat B. Aggarwal
JOURNAL OF TRANSLATIONAL MEDICINE
(2018)
Article
Cell Biology
Amarish Kumar Yadav, Saripella Srikrishna
Review
Oncology
Nikee Awasthee, Vipin Rai, Srinivas Chava, Palanisamy Nallasamy, Ajaikumar B. Kunnumakkara, Anupam Bishayee, Subhash C. Chauhan, Kishore B. Challagundla, Subash C. Gupta
SEMINARS IN CANCER BIOLOGY
(2019)
Article
Oncology
Sonam Kumari, Sheema Khan, Subash C. Gupta, Vivek K. Kashyap, Murali M. Yallapu, Subhash C. Chauhan, Meena Jaggi
Article
Biochemistry & Molecular Biology
Swati Sharma, Rajesh Kumar, Puja Kumari, Ravindra Nath Kharwar, Amarish Kumar Yadav, Srikrishna Saripella
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2019)
Review
Chemistry, Medicinal
Akhand Pratap Singh, Rachna Singh, Sumit Singh Verma, Vipin Rai, Catherine H. Kaschula, Pralay Maiti, Subash Chandra Gupta
MEDICINAL RESEARCH REVIEWS
(2019)
Review
Medicine, Research & Experimental
Ajaikumar B. Kunnumakkara, Devivasha Bordoloi, Bethsebie Lalduhsaki Sailo, Nand Kishor Roy, Krishan Kumar Thakur, Kishore Banik, Mehdi Shakibaei, Subash C. Gupta, Bharat B. Aggarwal
EXPERIMENTAL BIOLOGY AND MEDICINE
(2019)
Review
Biochemistry & Molecular Biology
Ajaikumar B. Kunnumakkara, Choudhary Harsha, Kishore Banik, Rajesh Vikkurthi, Bethsebie L. Sailo, Devivasha Bordoloi, Subash C. Gupta, Bharat B. Aggarwal
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Shruti Mishra, Sumit Singh Verma, Vipin Rai, Nikee Awasthee, Jayadev S. Arya, Kaustabh K. Maiti, Subash C. Gupta
Article
Pharmacology & Pharmacy
Gullanki Naga Venkata Charan Tej, Kaushik Neogi, Sumit Singh Verma, Subash Chandra Gupta, Prasanta Kumar Nayak
EUROPEAN JOURNAL OF PHARMACOLOGY
(2019)
Article
Biotechnology & Applied Microbiology
Akihiko Yamamoto, Amarish K. Yadav, Maxwell J. Scott
Summary: The study aims to generate additional male-only strains of Drosophila suzukii by crossing the original line with a piggyBac jumpstarter strain, in order to achieve species-specific, environmentally friendly suppression of D. suzukii populations.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Richa Yadav, Abhishek Rai, Avinash Kumar Sonkar, Vipin Rai, Subash Chandra Gupta, Lallan Mishra
NEW JOURNAL OF CHEMISTRY
(2019)
Review
Biochemistry & Molecular Biology
Shruti Mishra, Sumit S. Verma, Vipin Rai, Nikee Awasthee, Srinivas Chava, Kam Man Hui, Alan Prem Kumar, Kishore B. Challagundla, Gautam Sethi, Subash C. Gupta
CELLULAR AND MOLECULAR LIFE SCIENCES
(2019)
