Journal
TRENDS IN MOLECULAR MEDICINE
Volume 22, Issue 3, Pages 242-253Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2016.01.006
Keywords
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Funding
- Israel Cancer Research Fund (ICRF)
- Wolfson Family Charitable Fund
- Earlier.org - Friends for an Earlier Breast Cancer Test
- Claire and Amedee Maratier Institute for the Study of Blindness and Visual Disorders
- I-CORE Program of the Planning and Budgeting Committee, The Israel Science Foundation [41/11]
- Israeli Ministry of Defense, Office of Assistant Minister of Defense for Chemical, Biological, Radiological and Nuclear (CBRN) Defense
- Foundation Fighting Blindness
- Saban Family Foundation, Melanoma Research Alliance
- Binational Science Foundation (BSF)
- Israel Cancer Research Fund (ICRF) Acceleration Grant
- Israel Cancer Association (ICA)
- Donation from the Kateznik K. Association Holocaust
- Margot Stoltz Foundation through the Faculty of Medicine grants of Tel-Aviv University
- Varda and Boaz Dotan Research Center in Hemato-Oncology, Idea Grant
- 'Lirot' Association in Israel
- Interdisciplinary grant of the Israeli Ministry of Science, Technology and Space on the Science, Technology and Innovation for the Third Age
- Edmond J. Safra Center for Ethics at Tel-Aviv University
- Check Point Institute for Information Security
- Joint Core Program of Research on the Molecular Basis of Human Disease, Shabbetal Donnolo Fellowships - Italian Ministry of Foreign Affairs
- Edmond J. Safra Center for Bioinformatics at Tel-Aviv University
- Research Career Development Award (RCDA)
- Consortium for Mapping Retinal Degeneration Disorders in Israel
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Schizophrenia (SZ) is a complex and strongly heritable mental disorder, which is also associated with developmental-environmental triggers. As opposed to most diagnosable diseases (yet similar to other mental disorders), SZ diagnosis is commonly based on psychiatric evaluations. Recently, large-scale genetic and epigenetic approaches have been applied to SZ research with the goal of potentially improving diagnosis. Increased computational analyses and applied statistical algorithms may shed some light on the complex genetic and epigenetic pathways contributing to SZ pathogenesis. This review discusses the latest advances in molecular risk factors and diagnostics for SZ. Approaches such as these may lead to a more accurate definition of SZ and assist in creating extended and reliable clinical diagnoses with the potential for personalized treatment.
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